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Zebrafish in Medical News

Transparent zebrafish help researchers track breast cancer

What if doctors could peer through a patients skin and see a cancer tumor growing? Theyd be able to study how tumor cells migrate: how they look, how they interact with the blood system to find nourishment to grow and spread through the body. Scientists at the University of California, San D...

NIH awards Phylonix phase II SBIR to develop zebrafish models for eye diseases

Cambridge, MA October 2, 2007 Phylonix Pharmaceuticals, Inc. today announced that it has been awarded a $1,092,031 Phase II Small Business Innovation Grant (SBIR) from the National Eye Institute of the National Institutes of Health (NIH) to develop zebrafish eye disease models for drug screening...

Microbiotic technology developed for microinjection of zebrafish embryos

Funded by an NSERC Idea to Innovations grant and an Ontario Early Researcher Award, Prof. Yu Suns group, the Advanced Micro and Nanosystems Laboratory ( http://amnl.mie.utoronto.ca ) at the University of Toronto (U of T) recently developed a microrobotic technology for automated microinjection of ...

Secret to Treating Tinnitus in Vets May Be Unlocked in Zebrafish

Researcher trying different drugs to ease condition in water creature THURSDAY, May 8 (HealthDay News) -- For millions of Americans, including thousands of Iraq War veterans, ringing in the ears is a condition that is annoying at best and disabling at worst. Now, a researcher says h...

Phylonix granted broad European patent for transplanting human cells into zebrafish

Cambridge, MA -- December 18, 2007 -- Phylonix Pharmaceuticals today announced that it recently received a broadly issued European patent EP 1 135 531 B1: Methods for Introducing Heterologous Cells into Fish. The patent, which has issued in key European countries, encompasses 68 claims, including...

New Studies On Zebrafish Could Aid in Treating Birth Defects

In a new study published in the journal, Cell Metabolism, researchers have described the discovery of a mutation in the zebrafish that are remarkably similar to those observed// in children suffering from Menkes disease that could aid in finding new therapies for the disease. The finding ha...

Cocaine Exposure can Alter Neuronal Development in Zebrafish

Researchers from Boston University School of Medicine (BUSM) have shown that prenatal cocaine exposure in zebrafish (which share the majority of the same genes with humans) can alter neuronal development and acutely dysregulate the expression of circadian genes and those affecting melatonin signal...

2009 recipient of minority scholar award begins clinical research on leukemia

...nesis of T-Cell Acute Lymphoblastic Leukemia Using zebrafish Genetics and Small Molecule Screens," and will focus on harnessing the strengths of the zebrafish model system to unravel the molecular pathogenesis... survival of MYC-overexpressing thymocytes using a zebrafish small molecule screen, and in uncovering the funct...

Two Fred Hutchinson Cancer Research Center Scientists Receive Presidential Early Career Award

... Malik, the Hutchinson Center is home to three other Presidential Early Career Award recipients: basic scientist Cecilia Moens, Ph.D., who studies the zebrafish as a model of vertebrate developmental biology; clinical researcher William Grady, M.D., who studies the mechanisms of colorectal-cancer development; ...

New interdisciplinary volume focuses on advances in stem cell research

... COLD SPRING HARBOR, N.Y. - In a variety of organisms, from zebrafish to fruit flies to humans, stem cells have the potential to differentiate into a variety of tissues--and, in some cases, to give rise to a complete new...
Zebrafish in Medical Technology

Researchers Create First Targeted Knockout Rats Using Zinc Finger Nuclease Technology

... in site-specific changes in the DNA sequence. Previously, ZFNs were used to knock out specific genes in fruit flies, worms, cultured human cells and zebrafish embryos and are now in human clinical trials for the treatment of HIV/AIDS. This is the first example of successful gene editing in mammalian embryos...

SuperGen to Highlight Oncology Pipeline Data in Multiple Presentations at AACR

... small molecule Poster inhibitors for Jak2 Section 30 Monday, 8 a.m. - 12 p.m. zebrafish as a model #2229 April mechanistic screen 16 for small molecule Poster ...

Data Show SuperGen's Multi-Targeted Tyrosine Kinase Inhibitor Suppresses Critical Double-Stranded DNA Repair Protein, Rad51

... studies for small molecule inhibitors of DNMT1 in zebrafish (Abstract 2229), data from its preclinical compoun...her human cancer cell lines. Abstract No. 2229 zebrafish as a model mechanistic screen for small molecule inhibitors of DNMT1 Data suggest that the zebrafish model offers a fast and reliable method to identif...
Zebrafish in Medical Dictionary

Chromosomes

...ed with a specialized region of ... On a single chromosome end, he said, there might be eight to 24 POT1 molecules ... DGI leads in applying the zebrafish model organism to determine gene functions ... a gene into vertebrate (human) chromosomes in order to confer a new function or ... ...
Zebrafish in Biological News

Drug-proof zebrafish reveal secrets of addiction

The effects of amphetamines on gene expression in zebrafish have been uncovered. This new study, published in BioMed Central's open access journal Genome Biology , provides clues to the genetics that underlie susceptibility to addiction by describing the nad zebrafish mutant, which does not feel ...

Pitt team finds molecule that regulates heart size by using zebrafish screening model

PITTSBURGH, July 5 Using zebrafish, researchers at the University of Pittsburgh have identified and described an enzyme inhibitor that allows them to increase the number of cardiac progenitor cells and therefore influence the size of the developing heart. The findings are described in the advance...

AZTI-Tecnalia coordinates a platform promoting the use of zebrafish in scientific research

This release is available in Spanish . AZTI-Tecnalia is coordinating the First Spanish Technological Platform on the promotion of zebrafish as an animal model in all fields of scientific research. The platform, known as DareNET, has the support of the Spanish Ministry of Science and Innov...

NIH grants Phylonix Phase II SBIR to develop high-throughput in vivo zebrafish assays

Cambridge, MA January 7, 2009 Phylonix Pharmaceuticals, Inc. today announced that it has been awarded a $1,250,369 Phase II Small Business Innovation Research Grant (SBIR) from the National Institute of General Medical Sciences of the National Institutes of Health (NIH) to develop in vivo zebra...

Digital zebrafish embryo provides the first complete developmental blueprint of a vertebrate

Researchers at the European Molecular Biology Laboratory (EMBL) have generated a digital zebrafish embryo - the first complete developmental blueprint of a vertebrate. With a newly developed microscope scientists could for the first time track all cells for the first 24 hours in the life of a zebr...

A screening strategy using zebrafish targets genes that protect against hearing loss

A small striped fish is helping scientists understand what makes people susceptible to a common form of hearing loss, although, in this case, its not the fishs ears that are of interest. In a study published on February 29 in the open-access journal PLoS Genetics, researchers at the University of ...

Study shows how the zebrafish gets his stripe

Scientists have discovered how the zebrafish (Danio rerio) develops one of its four stripes. Their findings add to the growing list of tasks carried out by an important molecule that is involved in the arrangement of everything from nerve cells to reproductive cells in the developing embryo. ...

Deadly genetic disease prevented before birth in zebrafish

By injecting a customized "genetic patch" into early stage fish embryos, researchers at Washington University School of Medicine in St. Louis were able to correct a genetic mutation so the embryos developed normally. The research could lead to the prevention of up to one-fifth of birth defects ...

Key to zebrafish heart regeneration uncovered

When a portion of a zebrafish's heart is removed, the dynamic interplay between a mass of stem cells that forms in the wound and the protective cell layer that covers the wound spurs the regeneration of functional new heart tissue, Duke University Medical Center scientists have found. The scienti...

How does a zebrafish grow a new tail?

If a zebrafish loses a chunk of its tail fin, it'll grow back within a week. Like lizards, newts, and frogs, a zebrafish can replace surprisingly complex body parts. A tail fin, for example, has many different types of cells and is a very intricate structure. It is the fish version of an arm or leg...

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Zebrafish in Biological Technology

Glowing zebrafish help researchers track role of sugars in the cell

Berkeley -- Using artificial sugar and some clever chemistry, University of California, Berkeley, researchers have made glow-in-the-dark fish whose internal light comes from the sugar coating on their cells. This novel method of fluorescently tagging the sugar chains, or carbohydrates, that coa...

Transgenic Zebrafish by Electroporation

Russell J. Buono and Paul J. Linser, Whitney Marine Laboratory, University of Florida, 9505 Ocean Shore Blvd., St. Augustine, Florida 32086, 904-461-4000 The production of transgenic animals has proven to be a powerful tool in the study o...

OMT announces a breakthrough in the development of a novel human antibody platform

...e- specific changes in the DNA sequence. Up to now, ZFNs have been used to edit specific genes in fruit flies, worms (C. elegans), cultured cells and zebrafish embryos, but this is the first example of successful, permanent, heritable gene-editing in a mammal. ...

It's a Bug's Life, as Flawless Photo of Wasp Wins Worldwide Olympus BioScapes Competition : Winning Sure Doesn't Sting - Olympus BioScapes 2008 Competition

... honorees. Across the spectrum are other images that reflect the latest advances in neuroscience and cell biology, including the Fourth Prize image of zebrafish neurons captured by Albert Pan of Harvard University, using the "Brainbow" imaging technique, one of the most advanced fluorescence imaging ...

Sangamo BioSciences and Sigma-Aldrich Announce Research and License Agreement With Roche for the Use of ZFN Technology for Generation of Transgenic Animals

... generation of fish in which the ZFN-targeted gene has been eliminated or 'knocked out'. Apart from the mouse, the majority of other animals including zebrafish have historically lacked methods for precision targeted mutagenesis. This publication demonstrates that ZFNs present a powerful solution to this probl...

NIH collaborates with EPA to improve the safety testing of chemicals

...ibe the possibility of shifting from reliance on animal testing to biochemical- and cell-based assays, as well as those using lower organisms, such as zebrafish and roundworms. Data collection to determine chemical toxicity currently relies heavily on whole-animal tests. The growing number of new chemicals...

ChemoCentryx Demonstrates Recently Discovered Chemokine Receptor CXCR7 is Essential in Tumor Growth

... in a broad range of malignancies. Observations around CXCR7's role in tumor vasculature formation were further evidenced in knockout experiments in a zebrafish model, strongly suggesting that CXCR7 is central to the formation of new blood vessels during development (a process known to resemble aspects of new ...

A new wide field-of-view confocal imaging system and its applications in drug discovery and pathology

...ng large tissue specimens, tissue microarrays, and zebrafish sections, are reported in this paper. K...ng large tissue specimens, tissue microarrays, and zebrafish sections, are also reported in this paper. ...ge tissue section, a tissue microarray, a slide of zebrafish larva sections, a whole mouse embryo slide, a DNA ...

Biolistic Gene Transfer to Generate Transgenic Schistosomes, Rev A

...plate for gene silencing, Cell 101, 235238 (2000) Buono RJ and Linser PJ, Transient expression of RSVCAT in transgenic zebrafish made by electroporation, Mol Mar Biol Biotechnol 1, 271275 (1992) Davis RE et al., Transient expression of DNA and RNA in parasit...
Zebrafish in Biological Products

Zebrafish Vitellogenin ELISA System from GE Healthcare, formerly Amersham Biosciences

Description:... zebrafish Vitellogenin ELISA System, 96 wells. ELISARange: 0.5-100 ng/ml.Sensitivity: 0.3 ng/ml.Sample volume: 100 ul.Suitable for use with zebrafish plasma samples.3-h protocol.Store at 2-8 C. Category: Drug Screening & Cell...
Company:GE Healthcare, formerly Amersham Biosciences

COPAS 500 from Union Biometrica

Description:...rs, but are designed to accommodate much larger objects, up to 1500 microns. Such objects include small model organisms (e.g. C. elegans, Drosophila, zebrafish embryos), cells, cell clusters, seeds, pollen, combinatorial chemistry beads, and many more. COPAS instruments differ technically from traditional...
Company:Union Biometrica
Zebrafish in Biological Definition

Biology

...tomy . Model organisms for developmental biology include the round worm Caenorhabditis elegans , the fruit fly Drosophila melanogaster , the zebrafish Brachydanio rerio , the mouse Mus musculus , and the weed Arabidopsis thaliana . Physiology of organisms Main articles: Physiology...

Developmental biology

...el organisms Often used model organisms in developmental biology include the following: Chordates Lancelet Branchiostoma lanceolatum zebrafish Danio rerio Frogs Xenopus laevis Chicken Gallus gallus Mouse Mus musculus ( Mammalian embryogenesis ) Invertebrates...

Neuroscience

...erived nervous system gets organized in the adult animal. The primary subjects of investigation are the fruit fly Drosophila melanogaster and the zebrafish Danio rerio . Cognitive neuroscience and systems neuroscience - These two fields are interested in explaining the link between the mind and ...
Zebrafish in Biological Dictionary

Tubulin

...ulin Polymerization with GTP/GMPCPP/Taxol. I. Solutions & Supplies ... GMPCPP is the best current GTP analog for tubulin polymerization. ... zebrafish protein-coding gene LOC572064. Represented by 26 ESTs from 16 cDNA libraries. ... Tubulin beta (LOC572064) SELECTED PROTEIN SIMILARITIES ... No...

Transposon

...oson (genetics), ...Genes carried on plasmids can find their way onto the bacterial chromosome and become a stable ... DGI leads in applying the zebrafish model organism to determine gene functions ... The Sleeping Beauty Transposon ™ System (SBTS) is a non-viral carrier of genetic ... Knock Out ...

Recombinant DNA

...ific advancement and safety in the ... Recombinant DNA Advisory Committee: Public, in-depth review of the scientific, ... GloFish are a type of zebrafish with recombinant DNA . ... Recombinant DNA technology allows scientists to transplant a gene for a ... The development of recombinant D...

Myotome

...the dorsal neural tube ... The myotome in zebrafish retains a permanent record of original somite .....s absence drives ... The myotome of the adult zebrafish is composed of five distinguishable layers of ... ...to become ... ... pattern of cells within the zebrafish myotome , however, has remained obscure. ... cel...

Linkage group

...linkage groups , MAPMAKER considers linkage transitive. ... 4> group Linkage Groups at min LOD 3.00, max Distance 50.0 ... We assigned zebrafish genetic linkage groups to specific chromosomes using ... Table 2 Chromosomes and Linkage Groups According to Size. TelGen2 Home ... Maxim...

Gene knockout

...means that ... ... the genomic research community with a comprehensive zebrafish gene knockout bank. ... ultimate goal of a knockout for every gene in the zebrafish genome a ... Vega Biolab is a gene targeting service company providi...

Gastrula

... by Jim Anderson for his comic strip Bungo n' Rusti Get ... ... chimeric zebrafish embryos by transplantation at the blastula or gastrula stage. ... chimera, zebrafish embryo, gastrula , blastula, targeted, transplantation ... Transplantat...

Exons

...nge of ... New protein-coding exons evolve at a high rate, as evidenced by the initially ... About 70,000 exons are common to humans, fugu, and zebrafish and so represent ... Usage of exons 2 and 3 was identical for the two mRNA species. ... The first and second exons are noncoding, while the thi...
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