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Examination of internal 'wiring' of yeast, worm, and fly reveals conserved circuits

First-of-its-kind analysis published in the Feb. 8 PNAS supports the concept of a basic wiring diagram for all eukaryotes. Researchers in California, Israel, and Germany have compared three distantly related species ?baker's yeast, a worm, and the fruit fly ?and reported that protein "wiring" connections in one species are often conserved in all three. This first-of-its-kind analysis of t...

A puzzle piece found in unraveling the wiring of the brain

The complexity of the brain and, more specifically, how nerve cells form billions of contacts when there are fewer than 30,000 human genes is still a scientific mystery. A team headed by Drs. Robin Hiesinger and Hugo J. Bellen at Baylor College of Medicine in Houston have unraveled a piece of that puzzle by finding a gene that plays a key role in brain wiring. A report on their work appear...

Scientists crack code for motor neuron wiring

Howard Hughes Medical Institute (HHMI) researchers have deciphered a key part of the regulatory code that governs how motor neurons in the spinal cord connect to specific target muscles in the limbs. The researchers said that understanding this code may help guide progress in restoring motor neuron function in people whose spinal cords have been damaged by trauma or disease. The studies su...

Yale scientists decipher 'wiring pattern' of cell signaling networks

A team of scientists at Yale University has completed the first comprehensive map of the proteins and kinase signaling network that controls how cells of higher organisms operate, according to a report this week in the journal Nature. The study is a breakthrough in understanding mechanisms of how proteins operate in different cell types under the control of master regulator molecules call...

Hard-wiring the fruit fly's visual system

Both vertebrate and fruit fly have so-called visual maps in the brain that represent the world they see. These visual maps consist of millions of nerve cell contacts that need to be wired correctly during development in order for the adult animal to see normally. It is generally thought that the complexity of visual maps, like other brain regions, cannot only be genetically programmed but require...

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Rewiring the Heart

A normal heart beats 60 beats to 100 beats per minute (BPM). If the rhythm of the heart goes one beat over 100, a patient’s life is in grave danger. This was the case for Jeffrey Nauser. //His irregular heartbeat was only discovered after repeat trips to the Emergency Room where his life hung in the balance each time. Jeffrey’s story began four years ago while on a job interview. He b...
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