Study finds that using wakefulness tests to detect daytime sleepiness in drivers may be unreliable

Westchester, Ill. A study in the Feb. 15 issue of the Journal of Clinical Sleep Medicine shows that a 40 minute protocol for the Maintenance of Wakefulness Test (MWT40) is superior to a 20-minute protocol (MWT20) at detecting excessive daytime sleepiness (EDS) in adults who may be unable to main...

NUVIGIL Jet Lag Disorder Data Presented at the SLEEP 2009 23rd Annual Meeting of the Associated Professional Sleep Societies

...armodafinil) Tablets [C-IV] significantly improved wakefulness in people with excessive sleepiness associated wit...ington. NUVIGIL is currently indicated to improve wakefulness throughout the day for the millions of patients wh... The data showed NUVIGIL significantly improved wakefulness in the participants, as assessed by the MSLT avera...

Inspire Medical Systems Completes $17 Million Series B Financing

...als from sleep and reduced oxygen levels in the blood. This happens in patients with OSA because the muscles that normally hold the airway open during wakefulness relax during sleep and allow the airway to collapse. When the airway is partially closed and/or the muscles relax too much, inhalation can completely ...

Cephalon Announces the Availability of NUVIGIL for the Treatment of Excessive Sleepiness Associated with Treated Obstructive Sleep Apnea, Shift Work Disorder and Narcolepsy

...ormulation of modafinil, is now available. NUVIGIL is indicated to improve wakefulness throughout the day for the millions of patients who struggle with excessive...icer at Cephalon. About NUVIGIL NUVIGIL is indicated to improve wakefulness in patients with excessive sleepiness associated with treated obstructive s...

Combating weight gain caused by antipsychotic treatments

...s evaluated the effect of modafinil on olanzapine-associated weight gain in normal volunteer subjects. Modafinil is a drug currently used to increase wakefulness in individuals with sleep disorders, such as narcolepsy. All of the subjects received olanzapine, and half also received modafinil treatment while th...

Drive Alert, Arrive Safe - Better Sleep Could Cut Serious Road Accidents By A Third

...re similarly deadly." To help cut the risk of sleepiness while driving, Ware emphasizes the importance of understanding what is needed to ensure wakefulness when driving. "Just as important as knowing how to get a good night of sleep, is learning what it takes to stay awake. These include getting sufficie...

Less costly, more accessible and as effective: Simplified treatment for sleep apnea

...ts. They also assessed other outcomes of sleep, including quality of life measures, executive neurocognitive function on maze tasks and maintenance of wakefulness tests and CPAP adherence. In all, the study assessed almost 200 patients with moderate to severe OSA who were randomly assigned to the simplified or t...

'America's Super Fruit' May Help Reset Body Clock

...help regulate the body's sleep-wake cycle. Produced naturally by the body in small amounts, melatonin plays a role in inducing sleepiness at night and wakefulness during the day. Recent studies have revealed that frozen tart cherries - "America's Super Fruit" - are one of the few known researched food sources o...

Inspire Medical Systems Completes First Implant of the Inspire II System to Treat Obstructive Sleep Apnea

...als from sleep and reduced oxygen levels in the blood. This happens in patients with OSA because the muscles that normally hold the airway open during wakefulness relax during sleep and allow the airway to collapse. When the airway is partially closed and/or the muscles relax too much, trying to inhale will comp...

High levels of prenatal smoking exposure affect sleep patterns in preterm neonates

...ooms. Researchers measured sleep period time, beginning at the first sleep onset and the ending at the last awakening; the percentage and frequency of wakefulness after sleep onset and total sleep time. Special attention was paid to the number and duration of body movements. Findings indicate that even afte...

wakefulness in Medical Technology

Cephalon Submits NUVIGIL Supplemental New Drug Application for the Treatment of Excessive Sleepiness Associated with Jet Lag Disorder

...nil) Tablets [C-IV] for the indication of improved wakefulness in patients with excessive sleepiness associated w..., there are no FDA-approved medications to improve wakefulness in travelers who experience the excessive sleepine...ed States in June 2009 and is indicated to improve wakefulness in patients with excessive sleepiness associated w...

Addrenex Pharmaceuticals Expands Product Pipeline by Licensing New Drug to Treat Narcolepsy

...brupt and temporary episode of weakness that can result in collapse. ADX-N05 also exhibited the potential to decrease DREM, the direct transition from wakefulness to an REM sleep state. In extensive clinical and toxicology studies, ADX-N05 was demonstrated to be safe and well tolerated. "We are delighted to...

Cephalon Announces Positive Results From a Phase Two Study of NUVIGIL in Bipolar Depression

... Cephalon is preparing to launch NUVIGIL, the longer-lasting isomer of modafinil, in the third quarter of 2009. NUVIGIL is indicated to improve wakefulness in patients with excessive sleepiness associated with treated obstructive sleep apnea (OSA), shift work sleep disorder, also known as shift work disor...

Phase III Data Show Vanda Pharmaceuticals' Tasimelteon (VEC-162) Significantly Improves Sleep in Patients with Chronic Insomnia

...hers believe that the interplay between the MT-1 and MT-2 pathways and environmental signals such as external light-dark cues results in the drive for wakefulness during daytime hours and sleepiness during night-time hours.(1) In patients with insomnia or CRSD, the regulation of the sleep/wake cycle is disrupted...

New AMITIZA 8 mcg Phase III Studies Demonstrated Overall Symptom Improvement in Adult Women with Irritable Bowel Syndrome with Constipation (IBS-C)

...maceutical Company Limited, the largest pharmaceutical company in Japan. In the United States, TPNA currently markets products for diabetes, insomnia, wakefulness and gastroenterology. The company has a robust pipeline with compounds in development for diabetes, cardiovascular disease and other conditions. TPNA ...

Sucampo Pharmaceuticals, Inc. Begins Pivotal Phase III Studies of Oral Lubiprostone to Treat Opioid-Induced Bowel Dysfunction (OBD)

...ceutical Company Limited, the largest pharmaceutical company in Japan. In the United States, Takeda currently markets products for diabetes, insomnia, wakefulness and gastroenterology. The company has a robust pipeline with compounds in development for diabetes, cardiovascular disease and other conditions. Taked...

New Study Presented at WorldSleep 2007 Demonstrates Ramelteon Has Sustained Efficacy Over Six Months in Adults With Chronic Insomnia

...ceutical Company Limited, the largest pharmaceutical company in Japan. In the United States, Takeda currently markets products for diabetes, insomnia, wakefulness and gastroenterology. Through the Takeda Global Research & Development Center, Inc. the company has a robust pipeline with compounds in development fo...

MEDIA ADVISORY: Subsets of Landmark Diabetes Trials Investigating MacroVascular Outcomes Presented at the American Diabetes Association 67th Scientific Sessions

...cal Company Limited, the largest pharmaceutical company in Japan. In the United States, Takeda currently markets oral products for diabetes, insomnia, wakefulness and gastroenterology. Through the Takeda Global Research & Development Center, Inc., the company has a robust pipeline with compounds in developme...

wakefulness in Medical Dictionary

Irregular sleep

...ptoms of sleep -wake syndrome include irregular periods of sleep and wakefulness ... or not following a normal sleep schedule, ultimately leading to a pat... Sleep -wake syndrome is indicated by irregular periods of sleep and wakefulness ... number of factors which, if not remedied, may lead to chronic slee...

Amphetamine

...Amphetamine is a psychostimulant drug that is known to produce increased wakefulness and focus in association with decreased fatigue and appetite. Amphetamin...amphetamine is a psychostimulant drug which is known to produce increased wakefulness and focus in association with decreased fatigue and decreased appetite. D...

wakefulness in Biological News

Circadian clock may be critical for remembering what you learn, Stanford researchers say

...hm that quietly pulses inside us all, guiding our daily cycle from sleep to wakefulness and back to sleep again, may be doing much more than just that simple metro...ose that calm it. The circadian clock controls the daily cycle of sleep and wakefulness by inhibiting different parts of the brain by releasing GABA. But if the...

Expecting an afternoon nap can reduce blood pressure

...eep. The session in which the volunteer was allowed to fall asleep was delineated into three phases: Phase 1: A five-minute period of relaxed wakefulness before lights were turned off (volunteers had been lying on the bed for a minimum of 15 minutes before this phase) Phase 2: The period between li...

Extended wakefulness, combined with alcohol, severely impairs driving performance

... WESTCHESTER, Ill. The combination of extended wakefulness and low-dose alcohol has significant adverse effec...ested state (12-15 hours awake) and after extended wakefulness (18-21 hours awake) during two sessions. Alcohol ...deprived state, and at 0.03 percent after extended wakefulness (at 1 a.m. and at 3 a.m.). During the second sess...

Out-of-body experiences may be caused by arousal system disturbances in brain

...ing a near death experience as it is to occur during the transition between wakefulness and sleep. Nelson suggests that phenomena in the brain's arousal system, wh...d to allowing intrusion of REM sleep elements during the transition between wakefulness and sleep. Sleep paralysis is a common form of REM intrusion, which ca...

Need to pull an all-nighter?

...ceptors with caffeine prevented this nitric-oxide-induced slumber. Rosenberg sees the most pharmaceutical promise in developing drugs that prolong wakefulness by curbing production of nitric oxide or scavenging the gas once it's produced. The opposite ?a sleeping pill made from nitric oxide donors -- would b...

New mechanism explains glucose effect on wakefulness

... by the long and honored custom of the siesta. However, scientists have understood little about how the basic energy molecule, glucose, regulates such wakefulness and other energy-related behaviors. Now, in an article in the June 1, 2006, Neuron, Denis Burdakov of the University of Manchester and his colleague...

Studies suggest new brain protein may help in treating schizophrenia, insomnia and anxiety

... A small protein in the brain that has only recently been discovered and, paradoxically, induces both profound wakefulness and a less anxious state, may represent a novel target for the treatment of psychotic behavior and schizophrenia, according to new research presented ...

Unlike other mammals, newborn dolphins and orcas stay active 24/7 during first months of development

...tal function in adults. The ability to remain active and responsive after birth has several apparent advantages for newborn cetaceans: Movement and wakefulness reduce danger from predators, help maintain body temperature until mass and blubber insulation develop, allow frequent respiration at the surface, and...

Brain-mapping technique aids understanding of sleep, wakefulness

...ty induced consolidation of wakefulness. Some neurons in the basal forebrain produce the chemical acetylcholine. These cells are very active during wakefulness when an animal or human is aroused and attentive. Previous studies have shown that orexin neurons project to these cells, sending positive signals dow...

Wisconsin researchers identify sleep gene

...wake and asleep. Tononi's team also conducted EEGs on the flies and found evidence of the same electrophysiological changes occurring during sleep and wakefulness as in humans. "The electrical changes in humans look different that they do in flies because our brains are organized differently," Cirelli says. "...

wakefulness in Biological Technology

AMITIZA(R) (lubiprostone) 8 mcg Now Available to Treat Irritable Bowel Syndrome with Constipation in Adult Women

...ceutical Company Limited, the largest pharmaceutical company in Japan. In the United States, Takeda currently markets products for diabetes, insomnia, wakefulness and gastroenterology. The company has a robust pipeline with compounds in development for diabetes, cardiovascular disease and other conditions. Taked...

Takeda Pharmaceuticals Establishes $3 Million Endowment with AGA Foundation

...ceutical Company Limited, the largest pharmaceutical company in Japan. In the United States, Takeda currently markets products for diabetes, insomnia, wakefulness and gastroenterology. Through the Takeda Global Research & Development Center, Inc. the company has a robust pipeline with compounds in development fo...

JCI table of contents: Dec. 3, 2007

...ls that support wakefulness, but how they might contribute to the prolonged wakefulness that occurs upon sleep deprivation is not clear. However, in a new study, X...the signals telling the brain that it is time to sleep. TITLE: Prolonged wakefulness induces experience-dependent synaptic plasticity in mouse hypocretin/orexin...

'Move to AMITIZA' Advertising Campaign Underscores the Power of Not Letting Chronic Constipation Slow People Down

...ceutical Company Limited, the largest pharmaceutical company in Japan. In the United States, Takeda currently markets products for diabetes, insomnia, wakefulness and gastroenterology. The company has a robust pipeline with compounds in development for diabetes, cardiovascular disease and other conditions. Taked...