Using nanoparticles, in vivo gene therapy activates brain stem cells
Using customized nanoparticles that they developed, University at Buffalo scientists have for the first time delivered genes into the brains of living mice with an efficiency that is similar to, or better than, viral vectors and with no observable toxic effect, according to a paper published this week in Proceedings of the National Academy of Sciences. The paper describes how the UB scient...First study to show how immune cells 'speak' to each other in vivo
Researchers at the Board of Governors' Gene Therapeutics Research Institute at Cedars-Sinai Medical Center have confirmed the existence of anatomical structures that channel information exchanges between a T cell and its target, an antigen-presenting brain cell, in laboratory rats. This immunologic synapse, or junction where signals are shuttled between two immune cells, has previously only been...Survivors of childhood polio do well decades later as they age
Mayo Clinic researchers have found that years after experiencing childhood polio, most survivors do not experience declines greater than expected in their elderly counterparts, but rather experience only modest increased weakness which may be commensurate with normal aging. "Other researchers have suggested that polio is a more aggressive condition later in life, but we've actually found...Tyrannosaur survivorship -- tough times for teens
A massive dinosaur death bed in Alberta has helped map out the animal's life span and thrown doubt on long-held theories about how one species lived, says new research conducted in part at the University of Alberta. "One of the surprises to me was that the overall pattern of survivorship fits closer to an attritional model rather than the catastrophic model we were expecting," said world-...Inflammation markers identify fatigue in breast cancer survivors
Researchers at the University of California, Los Angeles have defined conditions associated with disabling fatigue that persists for years in almost a third of breast cancer survivors, according to a study in the May 1 issue of "These studies identify a biological basis for...Assess the In Vivo Activation of Signal Transduction Pathways with PathDetect Reporting Systems
Assess the In Vivo Activation of Signal Transduction Pathways withPathDetect Stratagene Signal transduction is essential to many cellular processes, such asgrowth, differentiation, an...In Vivo Signal Transduction Pathway Reporting Systems
Stratagene Cloning Systems, Inc. Stratagene's PathDetect in vivo signal transduction pathway reportingsystems are designed for specific, rapid and convenient assessment of the invivo activation of signal transduction pathways. These r...Quantitative Analysis of Protein-DNA Associations in Vivo Using Real-Time PCR, Rev A
Swarup K Chakrabarti and Raghavendra G Mirmira*, Departments of Medicine and Pharmacology, Division of Endocrinology and Metabolism, University of Virginia Health Sciences Center, 450 Ray C Hunt Dr, Box 801407, Charlottesville, VA 22903 USA *Corresponding author The chr...Gujarat quake-Rescue teams give up hope of finding more survivors
The rescue teams involved in the tedious process of finding survivors of the Gujarat quake, from below the rubble, are fast giving up hope of finding any more survivors. They are now concentrating in clearing the rubble and saving the injured who have been lucky to be saved so far. A miracle baby was saved after nearly 90 hours under the rubble. The baby was 8 months old and was seen hold...Dopamine helps stroke survivors
A drug used in Parkinson's disease also improves the paralysis experienced by stroke survivors.Levodopa is turned into the neurotransmitter dopamine in the body, and this may help brain cells involved in controlling movement to function more normally. It's used as a treatment in Parkinson's disease, but a new trial suggests that levodopa is also helpful in alleviating stroke-induced disab...Breast Cancer Survivors Worry About Infertility
A new survey conducted by the Dana-Farber Cancer Institute shows more than half of young breast cancer survivors overestimated their risk for developing treatment-related infertility problems.// Nearly 700 members of the advocacy organization Young Survival Coalition Group who were 40 years old or younger were surveyed. More than half of the respondents, or 57 percent, said they were...Breast Cancer Survivors Worry About Infertility
A new survey conducted by the Dana-Farber Cancer Institute shows more than half of young breast cancer survivors overestimated their risk for developing treatment-related infertility problems.// Nearly 700 members of the advocacy organization Young Survival Coalition Group who were 40 years old or younger were surveyed. More than half of the respondents, or 57 percent, said they were...An Incentive For Breast Cancer Survivors
Breast cancer survivors can now get up and get moving. Breast cancer survivors who exercised, particularly // older women, reported higher body esteem and better mood than sedentary breast cancer survivors in a new study. Researchers compared 40 women who said they regularly exercised to 79 sedentary women, all early-stage breast cancer survivors. Regular exercisers reported significant...