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CEL-SCI Expands Testing of Its Vaccine to Determine Efficacy Against More Virulent Strain of H1N1 Swine and Other Influenza Viruses

VACCINE USING L.E.A.P.S.(TM) TECHNOLOGY PLATFORM IS DESIGNED TO ADDRESS MUTATED FORMS OF SWINE INFLUENZA AND CAN ACT AS BOTH PREVENTATIVE AND THERAPEUTIC VACCINE VIENNA, Va., June 9 /PRNewswire-FirstCall/ -- CEL-SCI Corporation (NYSE Amex: CVM ) announced today that it is expanding the pr...

Clostridium difficile Infection in Primary Care: Tackling a Virulent Pathogen

Complimentary Continuing Education Virtual Lecture for Healthcare Professionals VOORHEES, N.J., March 23 /PRNewswire/ -- The epidemiology of Clostridium difficile infection (CDI) is changing rapidly and has been marked by a significant increase in incidence and severity. Management of CDI c...

H5N1 Virus Replikin Gene Counts Indicate a New More Virulent Influenza Cycle Has Begun

Replikins Ltd. has found that H5N1 virus replikin peak gene counts in 2007 in Hong Kong, Russia, Indonesia, Vietnam and Israel indicate that a new replikin cycle has begun. The mean replikin count exceeded the maximum of the previous cycle identified by the company. Although several conditions ar...

Surgical Masks Help Ward Off Flu, Maybe

... task of finding ways to prevent infection more urgent. Many fear the swine flu pandemic, still causing only relatively mild illness, will become more virulent in the fall. The face mask and hand hygiene study involved 407 people arriving at one of 45 clinics in Hong Kong with flu-like symptoms and who had...

K-State Researcher, Collaborators Study Virulence of Pandemic H1N1 Virus; Work at K-State Would Protect Pig Industry If the Virus Jumps to Swine Populations

...ico, Richt and his collaborators found that the California isolate was more virulent than the Mexico isolate. Both pandemic H1N1 viruses are more virulent than seasonal H1N1 flu viruses. "With different isolates, there are ...

Paper Highlights Antimicrobial Effectiveness of Medical-Grade Honey in Topical Wound Care

...vels too low to kill bacteria) does not induce resistance. The activity that this particular species of honey demonstrates against typically resistant virulent pathogens, makes medical-grade active Leptospermum honey a compelling option for clinicians in their management of surgical site infections and diab...

Aethlon Medical Announces U.S. Army Agreement

...clude determining the therapeutic efficacy of the Hemopurifier(R) in non-human primate studies against hemorrhagic fever viruses, including the highly virulent Zaire strain of Ebola (ZEBOV). Hemorrhagic viruses are potential bioterror and pandemic threats, whose lethality prohibits the ability to conduct hum...

Swine Flu Vaccine on Track for Fall: CDC

... agency said it would focus on new countries experiencing infections, with an eye out for genetic mutations that could mean the virus is becoming more virulent and potentially more dangerous. Before it stopped reporting individual cases, the WHO had listed almost 95,000 cases and 429 deaths worldwide. ...

Swine Flu Vaccine Taking Longer Than Expected

...he World Health Organization put the number of deaths globally at 429. Health officials are worried that the H1N1 virus could mutate, becoming more virulent and dangerous. The WHO last month formally declared a pandemic, triggered by the rapid spread of the H1N1 virus across North America, South America...

Cepheid Receives FDA Clearance for First On-Demand Molecular Diagnostic Test for Clostridium difficile Infection

...asured against the true gold standard of toxigenic culture, delivered on that vision." As CDI rates continue to rise throughout the world, a more virulent epidemic strain, known as 027/NAP1/BI, has now been detected in at least 48 states, Canada, and throughout Europe. The Xpert C. difficile test has b...
virulent in Medical Technology

Cystic Fibrosis - Liposomal Tobramycin Receives Second Orphan Drug Designation Within Weeks

... control practices, B. cepacia infections still occur in cystic fibrosis patients and can lead to fatal sepsis. The cell envelopes of these especially virulent bacteria are impermeable to most antibiotics, which makes them particularly difficult to treat. Due to its unique mode of action, which allows the ant...

MJFF's Rapid Response Innovation Awards Hit Mid-2009 With Over $1 Million Funded in High-Risk/High-Reward Approaches to Parkinson's Disease

...phenylbutyrate may slow disease progression. Richard Smeyne, PhD, of Saint Jude Children's Research Hospital will test the hypothesis that the virulent H5N1 ("bird flu") strain of influenza virus can play a role in inducing parkinsonism. There is significant literature, mostly based on cases from the ...

Swine Flu (H1N1) Infectivity to Increase Markedly and Lethality to Remain Low According to Latest Replikin* Peptide Genomic Data

...evelops and markets novel forecasting tools and synthetic vaccines to fight virulent rapidly replicating diseases including bird flu, malaria, and HIV. The comp...eases. The company has designed unique products to predict the emergence of virulent strains of particular diseases (FluForecast(TM)) and is designing synthetic...

Optimer Pharmaceuticals Presents Results From Fidaxomicin Phase 3 Study for the Treatment of Clostridium difficile Infection

...t of C. Difficile diarrhea, including treatment of infection by the hyper virulent NAP1/ribotype 027 outbreak strain. Moreover, compared to vancomycin, recurr...e similar between the fidaxomicin and Vancocin arms. The BI/NAP1/027 hyper virulent strain of C. difficile was present in 36% of patients in the study. 46% o...

British Midlands University Announces Use of Gene Technology to Fight Lethal Hospital Acquired Infection

...vere diarrhea. However, there is very little known about the ways in which the bacteria operate and why the strain should be more severe than its less virulent cousins. Leading the study, Professor Nigel Minton in The University of Nottingham's School of Molecular Medical Sciences, said: "These hyperviru...

Nationwide Progress Poll Reveals Increased Efforts by Hospitals to Control MRSA Infection

... aureus (MRSA) in the last year, but 54% said their institutions are not doing as much as they could and should be doing to prevent the spread of this virulent pathogen, according to an online survey conducted by the Association for Professionals in Infection Control and Epidemiology (APIC). MRSA is a type ...

Quigley Announces Successful Poultry Study of Chickens With Infectious Bronchitis; Plans to Approach the Poultry Industry for Potential Commercialization

... Dr. Jackwood stated: "The reduction of clinical signs and detection of fewer virus particles in chickens challenged with an extremely infectious and virulent strain of IBV was quite remarkable. There are many different types of IBV but generally one type of IBV vaccine only protects against the same virus t...

Intercell AG to Acquire Iomai Corporation to Expand Late Stage Product Pipeline and Strengthen Leadership in Vaccine Innovation

...ito-borne flaviviral infection, is the leading cause of childhood encephalitis and viral encephalitis in Asia. The Japanese Encephalitis virus remains virulent in this region and has recently spread to countries not previously affected. About Intercell AG: Intercell AG is a growing biotechnology company w...

Survey Finds U.S. Healthcare Facilities Not Doing Enough to Curb MRSA

...Infections.org ). "MRSA could be beat if the leadership at hospitals moved more aggressively to adopt strategies proven to protect patients from these virulent infections. We need to require hospitals to report their infection rates so the public can see if they are achieving results." Consumers Union has...

Isis Announces $1.2 Million Award to Its Ibis Subsidiary to Expand Influenza Detection Capabilities and Enable Large-Scale Influenza Transmission Studies

...s grant will enable us to continue to advance our research in understanding the transmission of viral particles in order to prevent pandemic spread of virulent respiratory diseases, including influenza," said Frederick T. Koster, M.D., Associate Scientist, Infectious Diseases Program, Lovelace Respiratory Res...
virulent in Medical Definition

Medicine

...lisation of disease forces the human to become a lifelong patient . [3] Other less radical philosophers have voiced similar views, but none were as virulent as Illich. Another example can be found in Technopoly: The Surrender of Culture to Technology by Neil Postman , 1992, which criticises overreliance...
virulent in Medical Dictionary

Typhoid Fever

.... Typhoid fever — Comprehensive overview covers symptoms, treatment of this serious intestinal illness. ... Typhoid fever is caused by a virulent bacterium ... Clinical overview of the disease with sections on differentials, treatment, medications, and follow-up care. Describes the ill...

Infections

...uses, treatment, prevention of these potentially lethal infections . Comprehensive overview including symptoms, causes, and treatment of this virulent staph infection called methicillin-resistant Staphylococcus aureus (MRSA) ...
virulent in Biological News

African thicket rat malaria linked to virulent human form

Even though the most deadly form of malaria for humans, Plasmodium falciparum , has been linked to malaria found in chimpanzees, this group has been fairly isolated on the malarial family treeuntil now. A new phylogenetic analysis from the Sackler Institute for Comparative Genomics at the America...

CSHL scientists identify new drug target against virulent type of breast cancer

Tumor cells in a particular subset of breast cancer patients churn out too much of a protein called ErbB2 -- also often called HER2 -- which drives the cells to proliferate unchecked. Patients unlucky enough to be in this group -- about one in four -- have poorer prognoses and clinical outcomes t...

Scripps research scientists identify blood component that turns bacteria virulent

LA JOLLA, CA, November 20, 2008Scientists from the Scripps Research Institute have discovered the key chemical that signals Bacillus anthracis , the bacterium that causes anthrax, to become lethal. This finding opens up new avenues of exploration for the development of treatments for bacterial in...

New test for most virulent HPV strains under study

A test for the two strains of human papillomavirus responsible for most cervical cancers is under study. The molecular assay uses a cervical scraping, like that for a liquid-based Pap smear, to test for HPV types 16 and 18, responsible for 70 percent of cervical cancers, says Dr. Daron G. Ferris...

New cellular flaw found in some virulent breast cancers

Researchers at Dana-Farber Cancer Institute have identified a molecular interaction that triggers a particularly aggressive form of breast cancer, and suggest that attacking this target with selective drugs might improve treatment. In the January issue of Cancer Cell, a team led by Qunyan Yu, MD...

Less virulent strains of avian influenza can infect humans

In findings with implications for pandemic influenza, a new study reports for the first time that a less-virulent strain of avian influenza virus can spread from poultry to humans. The research appears in the October 1 issue of The Journal of Infectious Diseases, now available online. Crossing t...

Scientists take aim at virulent bacteria by decoding machinery of key control enzyme

By deciphering the ingenious mechanism used by a particular enzyme to modify bacterial chromosome chemistry, scientists have come a step closer to designing a new kind of drug that could stop virulent bacterial infections in their tracks. Their research will be published in the May 6 issue of the j...

K-State researcher, collaborators study virulence of pandemic H1N1 virus

...ico, Richt and his collaborators found that the California isolate was more virulent than the Mexico isolate. Both pandemic H1N1 viruses are more virulent than seasonal H1N1 flu viruses. "With different isolates, there are diff...

C. difficile spores spread superbug

... model system. This will be invaluable in determining the role of spore formation in transmission and how and why some C. difficile strains are more virulent and transmissible than others." "It will also facilitate determining the host factors important in disease and will lead to better diagnosis and tr...

K-State researcher finds 1918 flu resulted in current lineage of H1N1 swine influenza viruses

...s known to induce a lethal infection in ferrets and macaques, is not highly virulent in pigs, indicating a potential resistance of swine to highly virulent influenza viruses," Richt said. "It also suggests that pigs could have play...
virulent in Biological Technology

CEL-SCI Files Patent Application to Support Company's Treatment for More Virulent Strain of H1N1 Swine and Other Influenza Viruses

VIENNA, Va., June 24 /PRNewswire-FirstCall/ -- CEL-SCI CORPORATION (NYSE AMEX: CVM ) announced today that it has filed a provisional U.S. patent application covering its L.E.A.P.S.(TM) immune therapy drugs (vaccines) for the prevention/treatment of H1N1, swine, bird flu, Influenza A and/or ev...

Separation and Comparison of Proteins From Virulent and Nonvirulent Strains of the Fish Pathogen Flavobacterium psychrophilum, Using a 2-D Electrophoretic Approach

Kenneth D. Cain 1 , Leslie Grabowski 1 , and Scott E. LaPatra 2 1 Department of Fish and Wildlife Resources, University of Idaho, Moscow, ID USA 2 Clear Springs Foods Inc., Research Division, PO Box 712, Buhl, ID USA ...

Clostridium difficile Infection: Strategic Approaches for Better Outcomes

... antimicrobial use, infection control practices, or other factors. It is critical for healthcare professionals to be aware of the epidemiology of this virulent pathogen and apply evidence-based principles for diagnosis, treatment, and prevention. To address the need for current education on CDI, Robert M...

Lethality of H1N1 Influenza Virus Increasing According to Latest Analysis of Virus Peptide Genomic Data

... develop and market novel forecasting tools and synthetic vaccines to fight virulent rapidly replicating diseases including bird flu, malaria, and HIV. The comp...eases. The company has designed unique products to predict the emergence of virulent strains of particular diseases (FluForecast(TM)) and is designing synthetic...

CEL-SCI Developing Immune-Based Treatment Against Swine and Other H1N1 Flu Viruses Using Proprietary L.E.A.P.S. Technology

...utside of the traditional windows for the flu, we are working diligently to provide a solution as it is expected that the disease may become even more virulent later this year during the traditional flu season." The reason why the L.E.A.P.S. technology lends itself to creating a much more effective immu...

Swine Flu (H1N1) Infectivity to Increase Markedly and Lethality to Remain Low According to Latest Replikin* Peptide Genomic Data

...evelops and markets novel forecasting tools and synthetic vaccines to fight virulent rapidly replicating diseases including bird flu, malaria, and HIV. The comp...eases. The company has designed unique products to predict the emergence of virulent strains of particular diseases (FluForecast™) and is designing synthe...

Tips from the journals of the American Society for Microbiology

...ague Researchers from the Institut Pasteur in Paris, France used a less virulent ancestor to the highly infectious bubonic plague to develop a potentially s...is shares a genetic identity rate of 95% with Y. pestis, but is much less virulent and rarely attributed to disease-related fatalities. In the study 41 strai...

Tips from the journals of the American Society for Microbiology

...ague Researchers from the Institut Pasteur in Paris, France used a less virulent ancestor to the highly infectious bubonic plague to develop a potentially s...is shares a genetic identity rate of 95% with Y. pestis, but is much less virulent and rarely attributed to disease-related fatalities. In the study 41 strai...

Medarex and Massachusetts Biologic Laboratories Announce Primary Objective Achieved in Phase 2 Trial of Monoclonal Antibody Combination for the Treatment of Clostridium difficile Associated Diarrhea (CDAD)

...imates of over 500,000 cases in the United States, and approximately 15,000 deaths caused or contributed by C. difficile.(2) The emergence of a highly virulent epidemic strain that produces much higher levels of toxins A and B has also been associated with morbidity and mortality in younger, healthier, and no...

Isis' Ibis Biosciences Subsidiary Highlights the Power of the Ibis T5000 Pathogen Identification and Characterization System at the ICAAC/IDSA Meeting

...ng the ability of the Ibis T5000(TM) Biosensor System to rapidly and accurately detect and characterize pathogens, including drug-resistant and highly virulent pathogens, for use in a broad array of applications, such as healthcare-associated infection (HAI) control. Seven posters and oral presentations will ...
virulent in Biological Definition

Avian influenza

... Avian influenza (also known as bird flu ) is a type of influenza virulent in birds . It was first identified in Italy in the early 1900s and i...). The incubation period is 3 to 5 days. Symptoms in animals vary, but virulent strains can cause death within a few days. Avian influenza in humans...

Escherichia coli

...re or have recently been sick, or in people taking certain medications, an unfamiliar strain can cause serious illness and even death. A particularly virulent example of such a strain of E. coli is E.coli O157:H7 . Because of its ubiquity, E. coli is frequently studied in cellular biology . Its st...

Excretion

...contain about one-third bacteria , most of which are harmless, even beneficial while in the gut , but dangerous to others and they may also contain virulent and even deadly pathogens in the form of bacteria, viruses , amoebae , and various parasitic worms . Urine, on the other hand, contains excess ...

Louis Pasteur

...anthrax , which affected cattle , and aroused interest in combating other diseases. The notion of a weak form of a disease causing immunity to the virulent version was not new: this had been known for a long time for smallpox . Inoculation with smallpox was known to result in far less scarring and greatl...

Phage

...lle in 1917. d'Herelle continued his research and development in Stalin 's Soviet Union . Phages infect only specific bacteria. Some phages are virulent , meaning that upon infecting a cell they immediately begin reproducing, and within a short time lyse (destroy) the cell, releasing new phages. (A f...

Shigella

...causing shigellosis . Depending on age and condition of the host, as few as 10 cells can be enough to cause an infection. The disease is caused when virulent Shigella organisms attach to, and penetrate, epithelial cells of the intestinal mucosa. After invasion, they multiply intracellularly, and spread to...

Vaccine

...ines [1] : Inactivated - these are previously virulent micro-organisms that have been killed with chemica... been cultivated under conditions to disable their virulent properties. They typically provoke durable immuno...n, destroys them, and 'remembers' them. When the virulent version of an agent comes along, the immune syste...
virulent in Biological Dictionary

Virulence

... the relative ability of a pathogen to cause disease. The noun virulence derives from the adjective virulent. In discussing disease, the adjective virulent is used to describe effect severity, and in discussing... virulence ( ′virələns ) ( microbiology ) The disease-producing power of a microorgani...

Silent Mutation

...tion , even though ... New vaccines are being developed that promise to be safer than traditional vaccines, which work by exposing patients to less virulent versions of viruses.1 The new ... The article talks about silent mutations in protein-coding regions. ... Long-held assumptions about " silent ...

Shigella

...d Medications ... an infection with shigella (a rod-shaped ... Poor sanitary conditions promote the spread of shigella . ... Disease occurs when virulent Shigella organisms are consumed and invade the ... Some Shigella strains produce enterotoxin and Shiga-toxin (very much like the ... If you or ...

Microbe

...ly used in explosives and rocket propellants as well ... Information about microbe in the free online English dictionary and encyclopedia. ... So virulent is the microbe of party politics, even in a peaceable old man, that ... Refer the the Microbe "Cabinet Design" section for more details on the ...

Kwashiorkor

... Kwashiorkor is a virulent form of childhood malnutrition characterized by edema, irritability, anorexia, ulcerating dermatoses, and an enlarged liver with fatty infiltrates. ...
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