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Ninety-one Percent of BARACLUDE(R) (entecavir) Treated Patients in a Four-Year Cohort Demonstrated Virologic Suppression to Undetectable Levels

- In this Cohort of Nucleoside-Naive Chronic Hepatitis B e-Antigen (HBeAg) Positive Patients, Resistance Monitoring Identified One Patient with Genotypic Resistance to BARACLUDE - BOSTON, Nov. 2 /PRNewswire-FirstCall/ -- Bristol-Myers Squibb Company (NYSE: BMY ) today announc...

96-Week Safety and Efficacy Findings Presented for INTELENCE(TM) (etravirine) As Part of HIV Combination Therapy

...RTI) and protease inhibitor (PI) resistance had an undetectable viral load (<50 HIV-1 RNA copies/mL) while taki...57 percent of patients in the INTELENCE arm had an undetectable viral load (<50 copies/mL) compared to 36 perce...he proportion of patients who achieved a confirmed undetectable viral load (less than 50 copies/mL). P...

New HIV Study Shows That Large Numbers of Women and People of Color Can Be Successfully Enrolled In U.S. HIV Clinical Studies

...ed that 51 percent of treatment-experienced HIV-1 infected women reached an undetectable viral load (<50 copies/mL) at week 48, compared with 59 percent of men, ...nsored (non-VF censored-TLOVR), 73 percent of both women and men reached an undetectable viral load (p=not significant). There were no clinically relevant differenc...

DaVita Study Demonstrates Clinical Application of Sysmex Reticulocyte Hemoglobin Equivalent (RET-He) Parameter

...l for assessing iron status or setting broad therapeutic targets in large patient populations. Day of the week effects are minimal for HB and Hct, and undetectable for other analytes. "The advantages inherent in directly assessing immature cells are potentially under-recognized. The publication of this study...

Aethlon Medical Releases Shareholder Letter to Discuss the Treatment of Hepatitis-C Virus (HCV)

.... HCV infection is considered cured when a SVR of undetectable viral load is maintained more than six months afte...nt strategy to rapidly reduce viral load to low to undetectable levels. Thus, increasing the likelihood that HCV ...ignificantly higher cure rates. RVR is defined as undetectable viral load at day 30 of SOC treatment. In fact, ...

NEJM study points to new era in hepatitis C treatment

...-blinded trial followed 250 patients with untreated hepatitis C genotype 1. Researchers measured rates of sustained viral response or viral cure -- an undetectable quantity of hepatitis C virus -- 24 weeks after the end of completion of therapy. They compared a 12-week regimen of telaprevir combined with two diff...

New Product Detects Early Bed Bug Infestations

...tensive field and laboratory testing. Because bed bugs bite once every 7 to 10 days, a new infestation of a few bed bugs often goes unnoticed. It is undetectable by the person being bitten and by the most expert professionals in the field. At first, the person thinks the bite is a pimple, then a rash. By the ...

Study: Women with hard to diagnose chest pain symptoms at higher risk for cardiovascular events

... by microvascular angina and endothelial dysfunction, affecting blood vessels in which the layers of the cells are not functioning properly and may be undetectable by standard testing. Researchers believe endothelial dysfunction to be the earliest stage of coronary artery disease. The study authors recommend ...

Universal Capital Management Reports Vystar(TM) Corporation Receives FDA Clearance for Envy(TM) Natural Rubber Latex Condom Made with Vytex(TM) NRL

...r's patented Vytex(TM) NRL, which has less than 2 micrograms/dm2, virtually undetectable levels, of the antigenic proteins that can cause an allergic response, whil...allergic reactions to natural rubber latex have been reduced to a virtually undetectable level." Doyle added that, "Natural rubber latex is known to be the bes...

'Project Runway' Designer in Chicago to Educate About Living with HIV and Combat Stigma Associated with the Disease

... to educate people living with HIV about the main concerns with today's HIV disease management issues; lowering the amount of virus in the blood to an undetectable level, boosting the body's immune response, while maintaining a good quality of life," said Dr. Dan Berger. "It is an exciting time with many adv...
undetectable in Medical Technology

Baraclude (entecavir) Therapy Resulted in Undetectable Levels of Hepatitis B Virus in Cohort of Patients Who Re-Started Treatment

93 Percent of Nucleoside-Naive Chronic Hepatitis B e-Antigen (HBeAg)-Negative Patients Achieved Undetectable Viral Load by Week 48 of Re-Treatment PRINCETON, N.J., April 13, 2007 /PRNewswire-FirstCall/ -- Bristol-Myers Squibb Company today announced data from a cohort of nucleoside-naive HBeAg-neg...

Schering-Plough Highlights Hepatitis C Clinical Data Presentations at the European Association for the Study of the Liver (EASL) Annual Meeting

...0 reduction in viral load at treatment week 12 and undetectable virus at treatment week 24. In this large, prospe...roved duration) or 72 weeks (n=73). Patients with undetectable virus at week 12 (complete early virologic respons...ETOL: (1) These indications are based on achieving undetectable HCV-RNA after treatment for 24 or 48 weeks and mai...

Human Genome Sciences Reports Positive Late-Breaker Results at EASL from ACHIEVE Phase 3 Trials of Albuferon(R) in Patients with Chronic Hepatitis C

...he ACHIEVE 2/3 trial included 24 weeks of treatment. The primary efficacy endpoint for both trials was sustained virologic response (SVR), defined as undetectable viral load (HCV RNA<10 IU/mL) at 24 weeks following the completion of treatment - Week 72 for ACHIEVE 1, and Week 48 for ACHIEVE 2/3. About A...

Roche and Pharmasset Initiate Phase IIb Clinical Trial of R7128, Most Advanced Nucleoside Polymerase Inhibitor in Development for Chronic Hepatitis C

...portion of patients who achieve an SVR, defined as undetectable levels of HCV (measured by Roche TaqMan assay) 24 ...t at week 24 if they have achieved RVR, defined as undetectable levels of HCV at week 4 (a strategy known as "RVR-guided" treatment), and maintain undetectable levels of HCV until week 22. Patients who do not a...

Final Results of Boceprevir Phase II HCV SPRINT-1 Study Showed Significantly Higher SVR Rates Compared to Standard of Care in Treatment-Naive Genotype 1 Hepatitis C Patients

...e 28-week regimen achieved SVR. RVR is defined as undetectable virus (HCV RNA) in plasma at 4 weeks after the add...ETOL: (1) These indications are based on achieving undetectable HCV-RNA after treatment for 24 or 48 weeks and mai...ry efficacy endpoint, is defined as achievement of undetectable HCV-RNA at 24 weeks after the end of treatment. P...

FDA Approves an Expanded Indication for Peginterferon-Based Combination Therapy for Patients With Chronic Hepatitis C

...ical study supporting the approval, achievement of undetectable virus (HCV-RNA) at treatment week 12 was a strong ...hly unlikely to achieve SVR. "Patients with undetectable virus at week 12 have a better chance for success ...t-treatment. Response to treatment was defined as undetectable HCV-RNA at 24 weeks post-treatment. The ove...

Human Genome Sciences Announces Positive Results in Second of Two Phase 3 Trials of Albuferon(R) in Chronic Hepatitis C

...fa-2a treatment group. The trial included 48 weeks of treatment, and the primary efficacy endpoint was sustained virologic response (SVR), defined as undetectable viral load (HCV RNA<10 IU/mL) at Week 72 (24 weeks following completion of treatment). A total of 2,264 patients with chronic hepatitis C have par...

Rosetta Genomics Reports First Ever In-Vivo Efficacy Data for a Systemic MicroRNA Therapeutic for Liver Cancer

...ssed microRNA. Using this animal model, the scientists have shown that the targeted microRNA was markedly decreased in mice livers and was practically undetectable within the tumor itself, and that the tumor mass was significantly reduced two-fold, within 40 days of treatment. Interestingly, the researcher...

Video: Tasigna(R) Demonstrates Rapid Response as Initial Therapy in Life-Threatening Form of Leukemia

...ukemia (Ph+ CML) in early chronic phase achieved a complete cytogenetic response (CCyR) after six months of Tasigna treatment(1,2). CCyR is defined as undetectable Philadelphia chromosome cells in a patient's bone marrow. Although CCyR remains the primary goal of therapy, achieving major molecular respon...

Schering-Plough Provides Update on Boceprevir Clinical Development and Introduces Potent Next-Generation Oral HCV Protease Inhibitor for Treating Patients With Chronic Hepatitis C

...evir P/R lead-in regimen and had rapid virologic response (RVR), defined as undetectable virus (HCV-RNA) in plasma after 4 weeks of boceprevir treatment, SVR was 94... protocol specified primary efficacy endpoint, is defined as achievement of undetectable HCV-RNA at 24 weeks after the end of treatment. Per protocol, if a patient...
undetectable in Medical Products

MIS/AMH ELISA Test

Description:...to a relatively low post-puberty value (2). In the female, serum MIS/AMH is undetectable using immunoassay until the onset of puberty. Thereafter, circulating MIS/A...relatively low levels until menopause, at which time MIS/AMH falls again to undetectable levels (as measured by immunoassay). Potential clinical applications for...
Company:Diagnostic Systems Laboratories, Inc.

Intact hCG IRMA Test

Description:...d disorders [1,2,3]. Healthy, non-pregnant individuals have low (5 IU/L) to undetectable hCG concentrations in serum. During pregnancy, hCG concentrations increase ...nder of the pregnancy. After delivery, hCG returns to 5 IU/L and is usually undetectable several days postpartum [4,5,6]. Frances R & Batzer MD. Fertil. Steril....
Company:Diagnostic Systems Laboratories, Inc.

Intact hCG ELISA Test

Description:...d disorders [1,2,3]. Healthy, non-pregnant individuals have low (5 IU/L) to undetectable hCG concentrations in serum. During pregnancy, hCG concentrations increase ...nder of the pregnancy. After delivery, hCG returns to 5 IU/L and is usually undetectable several days postpartum [4,5,6]. Frances R & Batzer MD. Fertil. Steril....
Company:Diagnostic Systems Laboratories, Inc.

KRONUS META-Tg ELISA test kit

Description:...LISA procedure offers sensitivity of 0.03 ng/mL (functional sensitivity), providing for accurate establishment of post-ablation serum Tg levels, often undetectable by conventional methods. Furthermore, with the ability to accurately detect Tg concentrations as little as 0.03 ng/mL, the ability to detect disease r...
Company:KRONUS

Contour Design Eyelid Implants (Platinum)

Description:...mit added freedom in suturing position. The overall dramatically lower profile of the new ThinProfile™ Eyelid Implant design permits a virtually undetectable postoperative eyelid appearance....
Company:FCI Ophthalmics Inc.
undetectable in Medical Dictionary

Blood in the semen

... in the semen , called hematospermia, may be undetectable (microscopic) or visible in the ejaculation flui... in the semen , called hematospermia, may be undetectable (microscopic) or visible in the ejaculation flui... in the semen , called hematospermia, may be undetectable (microscopic) or visible in the ejaculation flui...
undetectable in Biological News

Sports cheats beware -- new test detects previously undetectable drug

Injecting performance enhancing corticosteroid hormones for other than medical treatment is banned, and tests exist that can detect injected hormones. Injecting synacthen, which stimulates the body to produce extra amounts of its own corticosteroid hormones is also banned. But until now there has b...

Faster, more cost-effective DNA test for crime scenes, disease diagnosis

...sue of Analytical Chemistry , a semi-monthly journal. In the new study, Naohiro Noda and colleagues note that PCR works by "amplifying" previously undetectable traces of DNA almost like photocopiers produce multiple copies of documents. With PCR, crime scene investigators can change traces of DNA into amounts...

Biolex presents Locteron US Phase 2a hepatitis C data at EASL

...n cohorts were comparable. Anti-viral effects were comparable among the Locteron and PEG-Intron cohorts, although three of the four patients achieving undetectable virus were in the 640 g cohort. "The PLUS trial clearly met its objectives and sets the stage for extended evaluation of Locteron in larger...

Potential new HIV drug may help patients not responding to treatment

...the simian form of HIV were able to reduce the virus levels in the blood to undetectable levels, by treating the monkeys with a molecule called D-1mT alongside Anti...se they were not responding completely to the treatment. However, three had undetectable viral loads (fewer than 50 copies of the virus per millilitre of blood), be...

American Chemical Society's Weekly PressPac -- Sept. 3, 2008

...o alter urine samples to hide evidence of marijuana, cocaine, and other illegal drugs. Some are supposed to dilute evidence of illicit drugs to levels undetectable by conventional tests. Others used adulterants advertised to inactivate or destroy chemical markers used to identify drugs. Drug-testers are respon...

Using live fish, new tool a sentinel for environmental contamination

...ttack your cells. Similarly, fish and other organisms are affected by contaminants before behavioral changes appear. Our technology detects heretofore undetectable changes to act as an early warning system." In a study published online last week in the journal Environmental Science and Technology, the system...

Consumption of nut products during pregnancy linked to increased asthma in children

... in children, but other factors such as health-consciousness and consumption of prenatal vitamins may have been contributing factors in ways that were undetectable in this study's design. "These findings emphasize the critical important of additional investigations into the environmental exposures for both mot...

URI researcher: China can't fully fix air quality problem for Olympics

...he Paralympic Games in late September. A test run of the transportation component of the pollution reduction plan conducted last summer resulted in undetectable air quality improvements. "I sympathize with them. They're doing all the right things, but unfortunately the right things may not be good enough,"...

Deadly dose: Rensselaer heparin expert helps uncover source of lethal contamination

...urnal Nature Biotechnology -- a complex carbohydrate named oversulfated chondroitin sulfate, which has a structure so similar to heparin it was nearly undetectable to less advanced technology. "Days after the deaths were first linked to heparin, we had the drugs in our hands from the FDA and our nuclear magnet...

Researchers bridge the 'terahertz gap' with new tunable metamaterial

...he frequency for imaging and other applications. Potential applications could lie in medical imaging or security screening, said Padilla. Materials undetectable through x-ray scans such as chemicals, biological agents, and certain explosives can provide a unique fingerprint when struck by radiation in the fa...
undetectable in Biological Technology

New force-fluorescence device measures motion previously undetectable

CHAMPAIGN, Ill. A hybrid device combining force and fluorescence developed by researchers at the University of Illinois has made possible the accurate detection of nanometer-scale motion of biomolecules caused by pico-newton forces. By combining single-molecule fluorescence resonance energy tran...

Anadys Pharmaceuticals Receives FDA Clearance of Phase II Protocol to Study ANA598 in Combination With Interferon-Alpha and Ribavirin in HCV Patients

...ill continue to receive SOC. Patients who achieve undetectable levels of virus at weeks 4 and 12 will be randomiz...nt of the study is the proportion of patients with undetectable virus at week 12 (defined as c omplete E arly V...ability as well as the proportion of patients with undetectable virus at week 4 (defined as R apid V irological ...

Anadys Pharmaceuticals Reports Second Quarter 2009 Financial Results and Program Highlights

...er week 12, patients will continue to receive SOC alone. Patients who have undetectable levels of virus at weeks 4 and 12 will be randomized to stop all treatment ...The primary endpoint of the study is the proportion of patients who achieve undetectable levels of virus at week 12 ( c omplete E arly V irological R esponse or ...

Anadys Pharmaceuticals, Inc. Announces Strategic Restructuring to Focus Operations on Continuing the Advancement of ANA598

...ected to continue to receive SOC alone. The primary endpoints of the study are designed to be safety, tolerability and the percentage of patients with undetectable virus at four weeks (defined as R apid V irologic R esponse, or RVR) and 12 weeks (defined as E arly V irologic R esponse, or EVR). For patients...

Mach One BioPharm Process Operating Group Receives Contract From American Beef Processors

...ll soon be installing a pathogen deactivating process capable of reducing pathogen (E.coli O157:H7, Listeria Monocytogenes, Salmonella) populations to undetectable levels (pathogen population reductions of >6Log). This anti-microbial process is also unique, incorporating a process of rapid, alternating immersi...

Cell Biosciences Launches Next-Generation Protein Characterization System

... is a private life sciences company focused on nanoproteomics. We develop instrumentation systems, software, and assay products that reveal previously undetectable information about cellular control pathways. Our customers include leading institutions in the fields of cancer research, stem cell biology, and diabe...

Cell Biosciences Announces Publication in Nature Medicine

... is a private life sciences company focused on nanoproteomics. We develop instrumentation systems, software, and assay products that reveal previously undetectable information about cellular control pathways. Our customers include leading institutions in the fields of cancer research, stem cell biology, and diabe...

Cell Biosciences Closes $10 Million Series C Financing

...is a private life sciences company focused on nanoproteomics. We develop instrumentation systems, software, and assay products that reveal previously undetectable information about cellular control pathways. Our customers include leading institutions in the fields of cancer research, stem cell biology, and diab...

Aethlon Medical Announces Data Supported Strategy to Increase Hepatitis-C (HCV) Cure Rates

...ifier(R) treatment can reduce viral load to low to undetectable levels, thus improving the likelihood that HCV pat... viral load of 7 million iu/ml would be reduced to undetectable HCV levels after approximately three days of conti...oad of 2 million iu/ml would be projected to reach undetectable levels in approximately 2.5 days of continuous tre...

Safer nanoparticles spotlight tumors, deliver drugs

...afer nanoparticles in mice, they saw tumors glow for several hours, then dim as the particles broke down. Levels dropped noticeably in a week and were undetectable after four weeks, they report in Nature Materials February 22. This is the first sudy to image tumors and organs using biodegradable silicon nano...
undetectable in Biological Products

Prostaglandin E1-d4 from Cayman Chemical

Description:...f PGE1 by GC- or LC-mass spectrometry. PGE1 is the theoretical cyclooxygenase metabolite of dihomo-γ-linolenic acid (DGLA), but it is virtually undetectable in the plasma of normal humans or other animals. Its pharmacology includes vasodilation, hypotension, and anti-platelet activities. The IC50 of PGE1 f...
Company:Cayman Chemical
undetectable in Biological Dictionary

Semen

... ... For this purpose, the semen can be fresh or gathered ... Blood in the semen - Overview, Blood in the semen , called hematospermia, may be undetectable (microscopic) or visible in the ejaculation fluid. You are guaranteed top quality semen from Thorne Ranch sires. ... Thank you Blue Feather Ranch...

Avidin

...a deglycosylated version of avidin , with a mass of approximately 60,000 daltons. As a result of carbohydrate removal, lectin binding is reduced to undetectable levels, yet biotin binding affinity is retained because the carbohydrate is not necessary for this activity. NeutrAvidin has a near-neutral pI (6....
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