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Adult stem cell changes underlie rare genetic disease associated with accelerated aging

Adult stem cells may provide an explanation for the cause of a Hutchinson-Gilford Progeria Syndrome (HGPS), a rare disease that causes premature aging in children, according to researchers at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH). These findings, the...

Carnegie Mellon develops innovative method to detect genetic causes of complex diseases

...its. "This approach will provide a more comprehensive genetic and molecular view of complex diseases," Xing said, "so we can identify the genes that underlie disease processes, understand the role of genes in determining the severity of disease and develop improved methods for diagnosing disease." Xing, a...

Alzheimer's Disease is the Focus of TBSI Annual Neuroscience Symposium

...eimer's unit at MassGeneral Institute for Neurodegenerative Disease, with the goal of understanding the neuropathophysiologic and genetic factors that underlie dementia. He received both his Ph.D. in biochemistry and M.D. from the University of Iowa. Dr. Snowdon is best known for his key role as direc...

Fetal Alcohol Disorders Often Misdiagnosed as ADHD

...or scientist in neurosciences and mental health at the Hospital for Sick Children. These problems with social cognition and emotion processing "may underlie the severe conduct problems" seen in children with FASD, including behaviors such as lying, cheating and stealing, she suggested. "It is imperative...

Deep Budget Cuts Will Add to Unemployment Rolls at Wrong Time

... dollar of economic activity. As a result, tax increases do not hit the economy dollar-for-dollar like budget cuts do. "Basic economic principles underlie Governor Ed Rendell's proposal to balance the state's budget in part through an increase in the state's personal income tax," Price said. "The alterna...

American Orthopaedic Society for Sports Medicine (AOSSM) Presents Prestigious Research Awards at Annual Meeting

...h project or pilot study in the amount of $20,000. This year's winner, Dr. Joseph Hart of the University of Virginia, will investigate mechanisms that underlie quadriceps strength gains in ACL-reconstructed patients exhibiting persistent quadriceps weakness and inhibition. Aircast Award for Basic Science ...

Black gay men may be at increased HIV risk

...oks at the current levels of sexual mixing between racial and ethnic groups of men who have sex with men in San Francisco, and identifies reasons that underlie these sexual mixing patterns. A total of 1,142 gay men took part in computer-assisted interviews. They were asked about their own ethnicity, the ra...

AAHSA Statement on House Ways and Means Committee Hearing

...his makes it simply unaffordable to care. While health reform discussions have focused on the acute care system, we note that the principles that underlie this draft bill resonate in the long term services and supports field and mirror AAHSA's public policy and the policy adopted by well over 100 organiz...

17 of America's Most Promising Scientists Selected as 2009 Pew Scholars in the Biomedical Sciences

...touch and pain Jon P . B oy l e, Ph. D . U nive r s i ty o f P i t tsb u rgh Host-pathogen interactions that underlie Toxoplasmosis Z ev D. Bryant, Ph. D . Sta n ford U n iv e r s ity Biophysics, bioengineering of molecular motors Qin...

Despite Generic Erosion of Key Brands, the Hospital-Acquired Gram Negative Infections Drug Market Will Increase by $1 Billion from 2008 to 2018

... clearly demonstrated efficacy against key gram-negative pathogens to command a high price and favorable formulary position -- two key attributes that underlie commercial success in this market." About Decision Resources Decision Resources ( www.decisionresources.com ) is a world leader in market r...
underlie in Medical Technology

Pixantrone in Combination with Chemotherapy Regimens Produces Overall Response Rates of 58-74% with Complete Remission Rates of 37-57% in Relapsed/Refractory Aggressive or Indolent NHL

...d binding to topoisomerase II enzyme, a key target for anthracycline mediated tumor death. These modifications are also hypothesized by the authors to underlie the drugs' low cardiotoxicity profile in preclinical animal studies when compared to standard anthracycline drugs. Five phase I/II studies in whi...

Mutant Genes in High-Risk Childhood Leukemias Identified

...he gene IKZF1 -- which they had earlier found to underlie such cases. "Our studies of these leukemia su...y mutations in kinase genes and other enzymes that underlie high-risk ALL, as well as explore how these abnorm... cancers. The discovery that mutations in JAK underlie some cases of high-risk ALL is enough to warrant c...

Pharmacyclics announces Global Strategic Alliance with Les Laboratoires Servier

...o chemotherapy and radiation. PCYC has patented the predictive use of the biomarker RAD51 which was found by Pharmacyclics' scientists to potentially underlie resistance to therapy and may be used as a predictive measure of HDAC inhibitor activity that could be useful in the clinic. NOTE: This announcem...

BioMarin Announces Positive Results From Phase 2A Clinical Study of 6R-BH4 in Sickle Cell Disease

...ients with sickle cell disease. The secondary objective was to evaluate changes in physiological and biochemical markers of endothelial function which underlie some key aspects of SCD. PAT scores were measured at the end of each 4 week dose period and compared to the baseline PAT score for statistical purpose...

Michael J. Fox Foundation Awards $2 Million for Research on Cognitive and Mood Symptoms of Parkinson's Disease

...rkinson's has been hindered by a lack of preclinical models to explain these features of the disease; a lack of basic knowledge of the mechanisms that underlie these symptoms; inadequate understanding of the clinical features of these symptoms in PD; and a need for relevant clinical scales to improve diagnosi...

Gene That Causes Childhood Cancer Neuroblastoma Is Found

... of chromosome 6 raise a child's risk of developing sporadic neuroblastoma. "Together with this current study, we are defining the genetic events that underlie this childhood cancer," said Maris. "Better understanding of these biological pathways will guide our efforts to develop more effective treatments." ...

VioQuest Pharmaceuticals Announces Dosing of First Patient in Phase IIa Solid Tumor Study for Lenocta(TM), a Novel Protein Tyrosine Phosphatase Inhibitor

...protein tyrosine phosphatase superfamily of enzymes functions in a coordinated manner with protein tyrosine kinases to control signaling pathways that underlie a broad spectrum of fundamental physiological processes and represent a new class of therapeutic targets. The PTPases SHP-1 and SHP-2 modulate progeni...

Rosetta Genomics and Weizmann Institute Scientists Identify Role of microRNA in Cancer Suppression

.... As a transcription factor, p53 can increase or repress the transcription of many hundreds of protein-encoding genes, and this ability is believed to underlie in great part its tumor suppressor functions. About microRNAs MicroRNAs (miRNAs) are a recently discovered, naturally occurring form of RNAi. Thes...

NIEHS Researchers Identify Enzyme Critical in DNA Replication

... higher organisms such as yeast and perhaps even humans. The study places us one step closer to understanding the origins of genome instability that underlie certain environmental diseases in humans, said NIEHS Director David A. Schwartz, M.D. NIEHS is part of the National Institutes of Health. The resear...
underlie in Medical Dictionary

Estrogen

...minance ... Estrogen plays a key role in my theory of thyroid disease. ... I see estrogen as an accelerator of the nutritional imbalances that underlie thyroid disease. ... Women on estrogen replacement were compared to control groups of women on other ... Postmenopausal therapy with estrogen ...
underlie in Biological News

Tryptophan deficiency may underlie quinine side effects

Researchers have found that the anti-malarial drug quinine can block a cell's ability to take up the essential amino acid tryptophan, a discovery that may explain many of the adverse side-effects associated with quinine. Once confirmed, these findings would suggest that dietary tryptophan suppleme...

Recruitment of reproductive features into other cell types may underlie extended lifespan in animals

In the sense that organisms existing today are connected through a chain of life through their parents, grandparents and other ancestors almost a billion years back to the first animals of the pre-Cambrian era, an animal's reproductive cells can be considered to be immortal. These germline cells...

Mayo Clinic: Brain disorder suggests common mechanism may underlie many neurodegenerative diseases

JACKSONVILLE, Fla. A Mayo Clinic-led international consortium has found a mechanism that may help explain Parkinson's and other neurological disorders. Studying just eight families worldwide, the international team of researchers have discovered a genetic defect that results in profound depre...

Iron-moving malfunction may underlie neurodegenerative diseases, aging

ANN ARBOR, Mich.---A glitch in the ability to move iron around in cells may underlie a disease known as Type IV mucolipidosis (ML4) and the suite of symptoms---mental retardation, poor vision and diminished motor abilities---that accompany it, new research at the University of Michigan shows. ...

Complex dynamics underlie bark beetle eruptions

Forest management that favors single tree species and climate change are just two of the critical factors making forests throughout western North America more susceptible to infestation by bark beetles, according to an article published in the June 2008 BioScience. Bark beetle epidemics have becom...

Antioxidant overload may underlie a heritable human disease

Despite the popular notion that antioxidants, such as vitamins C and E, offer health-promoting benefits by protecting against damaging free radicals, a new study in the August 10 issue of the journal Cell reveals that, in fact, balance is the key. The researchers show in mice that an overload of n...

'Guardian of the genome' protein found to underlie skin tanning

A protein known as the "master watchman of the genome" for its ability to guard against cancer-causing DNA damage has been found to provide an entirely different level of cancer protection: By prompting the skin to tan in response to ultraviolet light from the sun, it deters the development of mela...

Different strategies underlie the ecology of microbial invasions

Infectious disease can play a key role in mediating the outcome of competition between rival groups, as seen in the effects of disease-bearing conquistadors in the New World--or, on a much smaller ecological scale, the ability of bacteria to spread their viruses to competing bacteria. In a new stud...

Brain difference in psychopaths identified

...brain imaging such as DT-MRI now offer neuroscientists the potential to move towards a more coherent understanding of the possible brain networks that underlie psychopathy, and potentially towards treatments for this mental disorder.' ...

Drug-proof zebrafish reveal secrets of addiction

...s open access journal Genome Biology , provides clues to the genetics that underlie susceptibility to addiction by describing the nad zebrafish mutant, which d...dinated gene regulation that influences the response to amphetamine and may underlie the susceptibility to addiction. ...
underlie in Biological Technology

Beyond associations: Colorectal cancer culprit found

... the risk of colorectal cancer and its functional implications, shedding new light on the basis of this deadly disease. Hunting down the genes that underlie diseases such as colorectal cancer is extremely difficult, owing to the genetic heterogeneity of cancer cells. Numerous mutations can be found in a ...

Cell Biosciences Announces Publication in Nature Medicine

... system from Cell Biosciences. "Current protein research methods have difficulty detecting subtle changes in oncoprotein activation, changes that underlie critical cancer signaling processes," explained lead author Dr. Alice Fan. "To develop new therapeutics for cancer, we need better tools for understan...

New insights into cellular reprogramming revealed by genomic analysis

...University, Whitehead Institute, and the Broad Institute of MIT and Harvard has uncovered significant new information about the molecular changes that underlie the direct reprogramming process. Their findings are published online in the journal Nature. We used a genomic approach to identify key obstacles ...

deCODE Discovers Fourth Major Set of Common Genetic Variants Linked to Risk of Estrogen Receptor-Positive Breast Cancer

... annual magnetic- resonance imaging (MRI) scans as well as mammograms. "Within the past two years we have identified specific sequence variants that underlie much of the inherited risk of the common forms of breast cancer, the most frequently diagnosed cancer in women. And we have now reached a long awaited...

Society for Biological Engineering Holds First International Conference on Stem Cell Engineering

...oprocesses for usable stem cell therapeutics. Among other topics, speakers will describe advances in the understanding of biological mechanisms that underlie stem cell processes, the technologies employed to study stem cell function, and the development of bioprocesses to culture stem cells for commercial a...

Evotec Provides Update on Planned NASDAQ Listing in the Context of its Announced Acquisition of Renovis

...iled a registration statement on Form F-4 to register with the US Securities and Exchange Commission (SEC) the Evotec AG ordinary shares. These shares underlie the Evotec AG American Depositary Shares, or ADSs, that Renovis stockholders will receive in connection with the proposed merger. The Evotec ADSs are ...

The closest look ever at native human tissue

.... We can now see details at the scale of a few millionths of a millimetre. In this way we have gained a new view on the interactions of molecules that underlie cell adhesion in tissues a mechanism that has been disputed over decades. So far, the only information available about a proteins position and i...

The Great Offshore Outsourcing Debate

... worse, it looks like this falls election could be a referendum on the offshore outsourcing question and the broader economic issues and policies that underlie it. Lets hope this debate rises above the rhetoric we are hearing lately from people on both sides of the issue like outsourcing jobs is just anot...

UW-Madison releases open 3D collaboration environment

...hitects of the system. This year, Kay won the 2004 Kyoto Prize, and the 2004 Turing and Draper Awards for his role in developing the technologies that underlie Croquet. We are moving beyond the Web page and exploring how best to use the power of the graphics capability and high-speed connectivity of todays...

Detection of Apolipoprotein Gene Variants by DGGE Using the DCode System

... Introduction In a number of fields, techniques are required for searching candidate genes for mutations that underlie hereditary diseases. We have used the denaturing gradient gel electrophoresis method (DGGE) 1 using the Bio-Rad DCode system to...
underlie in Biological Definition

Gene

... a particular DNA strand, there are many ways to have genetic mutations. For example, natural variations within regulatory sequences appear to underlie many of the heritable characteristics seen in organisms. The influence of such variations on the trajectory of evolution through natural selection ...

Ion channel

...iological role Because "voltage-gated" channels underlie the nerve impulse and because "transmitter-gated...lls swell or shrink. Such channels are believed to underlie touch sensation and the transduction of acoustic v...ss, which includes the voltage-gated channels that underlie the nerve impulse, consists of four subunits with ...

Mendelian inheritance

... Mendelian inheritance (or Mendelian genetics or Mendelism ) is a set of primary tenets that underlie much of genetics developed by Gregor Mendel in the latter part of the 19th century . Mendel (1822-1884), an Austrian monk , was interested in...

Neuroscience

...concern of neuroscience includes such diverse topics as the operation of neurotransmitters at the synapse ; the biological mechanisms that underlie learning (both declarative learning and motor learning ); how genes contribute to neural development in the embryo and throughout life ...

Quaternary structure

...mples include nucleosomes and microtubules . Changes in quaternary structure are called conformational changes . It is through such changes, which underlie cooperativity and allostery in "multimeric" enzymes, that many proteins undergo regulation and perform their physiological function. The above...

Synapse

...napses form the circuits in which the neurons of the central nervous system interconnect. They are thus crucial to the biological computations that underlie perception and thought. They also provide the means through which the nervous system connects to and controls the other systems of the body. The wor...
underlie in Biological Dictionary

Pentadactyl

...ywords. pentadactyl limb. This keyword was found on the following pages: ... theology • pandaÎs thumb • pentadactyl limb • suboptimality. ... underlie some of the important changes in the pentadactyl pattern during evolution. ... pentadactyl developmental bauplan appears canalised, suggest ... ...

Olfactory bulb

...zo ... receptors continue to establish new connections in the adult olfactory bulb . ... As described below, olfactory bulb changes may also underlie learning involved ... In the olfactory bulb , cholinergic fibers terminate in all layers, although they ... Information and resources pertaining...

Membrane transporter

...biology terms,biology abbreviations ... to power membrane transporters and adenosine ... ... in the membrane transporter gene sequences underlie ... Natural Variation in Membrane Transporter Genes Reveals Evolutionary and Functional Constraints. ... Amazon.com: Membrane Transporters ...

Estrogen

...e sample. Estrogen plays a key role in my theory of thyroid disease. ... I see estrogen as an accelerator of the nutritional imbalances that underlie thyroid disease. ... Estrogen ... Estrogen increases the risk that you will develop endometrial cancer (cancer of ... Before you begin taking...

Chaperone Proteins

...erone proteins , on what ... Muscles Need Chaperone ' Proteins , But More Not Always Better ... Dysregulation of this chaperone protein may underlie the type of wasting seen in ... The European ... Proteins are produced in the cytoplasm as precursors, and ... of the bacterial protein expor...

Chaperone protein

... specifically in diseased ... Muscles Need Chaperone ' Proteins , But More Not Always Better ... Dysregulation of this chaperone protein may underlie the type of wasting seen in ... Yeast chaperone protein and mad cow disease. Article highlights or off-site fulltexts 1, 2 ... Chaperone -supe...

Allostery

...ible allostery between the CT-L and the PGPH ... 3.2 Methods that measure the size of the intact complex directly ... through such changes, which underlie cooperativity and allostery in "multimeric" ... Dynamics of Biomedical Molecules in Vision, Allostery , and Folding ... Allostery down regul...
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(Date:4/17/2014)... study published today in PLOS Pathogens , children ... is common can mount an immune response to infection ... repeated bouts of high fever and illness and partially ... The findings may help researchers develop future interventions that ... parasite. , Each year, approximately 200 million cases of ...
(Date:4/17/2014)... Two recent papers by a University of Colorado ... scientists develop treatments or vaccines for Dengue fever, ... other disease-causing flaviviruses. , Jeffrey S. Kieft, PhD, ... the School of Medicine and an early career ... colleagues recently published articles in the scholarly journals ...
(Date:4/17/2014)... Northwestern University synthetic biology team has created a ... programmable therapeutics that could travel the body and ... , Engineering cell-based, biological devices that monitor and ... clinical synthetic biology. However, no existing technology enabled ... patient,s physiological state and respond in a customized ...
(Date:4/17/2014)... as 10 million older Americans suffer from depression, often ... However, new research a project that followed the ... years found that Internet use among the elderly ... 30 percent. , "That,s a very strong effect," said ... information studies and media who led the project. "And ...
(Date:4/17/2014)... 2014 By discovering a new mechanism that allows ... researchers at UC Irvine and the Salk Institute have ... or prevent stroke-induced brain damage. , A complex and ... death and primary reason for disability in the U.S. ... and lets blood-borne material into the brain, causing the ...
Breaking Medicine News(10 mins):Health News:Study sheds light on how the immune system protects children from malaria 2Health News:CU researchers discover target for treating dengue fever 2Health News:Building 'smart' cell-based therapies 2Health News:Internet use can help ward off depression among elderly 2Health News:Study IDs new cause of brain bleeding immediately after stroke 2
(Date:4/18/2014)... world population predicted to reach 9 billion by ... that considers human-altered landscapes such as farmland, according ... habitat that supports it might be an increasingly ... three-quarters of the land surface is directly affected ... human-caused impacts such as climate change. But what ...
(Date:4/18/2014)... R.I. [Brown University] Asteroid and comet impacts can ... on regional or even global scales. But new research ... the signatures of ancient life at the time of ... geologist Pete Schultz has found fragments of leaves and ... several ancient impacts in Argentina. The material could provide ...
(Date:4/17/2014)... infection , Respiratory syncytial virus (RSV) is ... generating life-threating illness in very young and elderly ... RSV enters host cells through the fusion protein ... Small interfering peptides that prevent bundle formation limit ... highly susceptible to degradation. In this issue of ...
Breaking Biology News(10 mins):Stanford researchers rethink 'natural' habitat for wildlife 2Stanford researchers rethink 'natural' habitat for wildlife 3Stanford researchers rethink 'natural' habitat for wildlife 4Impact glass stores biodata for millions of years 2Impact glass stores biodata for millions of years 3JCI online ahead of print table of contents for April 17, 2014 2JCI online ahead of print table of contents for April 17, 2014 3JCI online ahead of print table of contents for April 17, 2014 4JCI online ahead of print table of contents for April 17, 2014 5JCI online ahead of print table of contents for April 17, 2014 6
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