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triphosphate in Medical News

Pharmasset Nominates PSI-938 as a New Nucleotide Analog Inhibitor of Hepatitis C for Preclinical Development

...se purine analogs are also active against the S282T resistant variant selected in vitro by the pyrimidine analogs, and are metabolized to the active triphosphate form through a different phosphorylation pathway than the pyrimidines. Given these characteristics, purine and pyrimidine analogs have the potential t...

Unique Collaboration Between TB Alliance and Tibotec To Accelerate Tuberculosis Drug Development

...itro studies show that it is highly active against Mycobacterium tuberculosis ( M.tb) . TMC207 has a unique mechanism of action targeting adenosine triphosphate (ATP) synthase, which M.tb , requires to generate its energy supply. Currently, TMC207 is being studied in a Phase II clinical trial in people with M...

Pharmasset Initiates Phase 1b Multiple Ascending Dose Clinical Trial of PSI-7851 in Chronic Hepatitis C Patients

...51 have not shown evidence of any mitochondrial or other cellular toxicities that may be associated with some nucleoside analogs. The half-life of the triphosphate in primary human hepatocytes is approximately 38 hours, which suggests the possibility for once-daily dosing. Like R7128, PSI-7851 has demonstrated i...

Cordex Receives Special Protocol Assessment Approval from FDA for ATPace(TM)

...rma, Inc. Cordex is a specialty pharmaceutical company that develops new cardiovascular medicines based upon the emerging pharmacology of adenosine triphosphate (ATP) and nitric oxide (NO). These two molecules play critical roles in cellular metabolism and signal transduction, the manipulation of which consti...

Cordex Pharma to Collaborate with BG Medicine in a Clinical Study of Heart Failure Biomarkers

...arma, Inc. Cordex is a specialty pharmaceutical company that develops new cardiovascular medicines based upon the emerging pharmacology of adenosine triphosphate (ATP) and nitric oxide (NO). These two molecules play critical roles in cellular metabolism and signal transduction, the manipulation of which constit...

Midbrook Introduces ATP Cleanliness Testing

...pabilities to include ATP Testing, a form of testing that can be utilized in a variety of different fields including the medical arena. Adenosine triphosphate (ATP) is the chemical substance that powers reactions within cells. ATP is present in all life forms except viruses and prions. Viruses require living...
triphosphate in Medical Technology

Cordex Signs European Development Partnership for ATPotent(TM) Sperm Motility Drug

...rma, Inc. Cordex is a specialty pharmaceutical company that develops new cardiovascular medicines based upon the emerging pharmacology of adenosine triphosphate (ATP) and nitric oxide (NO). These two molecules play critical roles in cellular metabolism and signal transduction, the manipulation of which constit...

Three Independent Studies Include the ImmuKnow(R) Assay to Manage and Optimize Immunosuppression Therapy in Transplant Patients

...esses cellular immune status by detecting cell-mediated immunity (CMI) in adult immunosuppressed patients. It measures the concentration of adenosine triphosphate (ATP) released from CD4 cells following cell stimulation. The ImmuKnow test is a qualitative assay and does not directly quantify the level of immuno...

Living Donor Kidney Transplants Using Alemtuzumab Pre-Conditioning and Tacrolimus Monotherapy: Long-Term Safety and Efficacy

...sesses cellular immune status by detecting cell-mediated immunity (CMI) in adult immunosuppressed patients. It measures the concentration of adenosine triphosphate (ATP) released from CD4 cells following cell stimulation. The ImmuKnow test is a qualitative assay and does not directly quantify the level of immunos...

An Independent Study Reports on the Utility of ImmuKnow(R), the Cylex(TM) Immune Cell Function Assay, for Monitoring Heart Transplant Recipients

...sesses cellular immune status by detecting cell-mediated immunity (CMI) in adult immunosuppressed patients. It measures the concentration of adenosine triphosphate (ATP) released from CD4 cells following cell stimulation. The ImmuKnow test is a qualitative assay and does not directly quantify the level of i...

Pharmasset Initiates First Time in Human Study of PSI-7851 for the Treatment of Hepatitis C (HCV)

...51 have not shown evidence of any mitochondrial or other cellular toxicities that may be associated with some nucleoside analogs. The half-life of the triphosphate in primary human hepatocytes is approximately 38 hours, which suggests the possibility for once-daily dosing. Like R7128, PSI-7851 has demonstrated i...

Cordex Pharma Announces Strategic Master Services Equity Agreement With Cato BioVentures

...a, Inc. Cordex is a specialty pharmaceutical company that develops new cardiovascular medicines based upon the emerging pharmacology of adenosine triphosphate (ATP) and nitric oxide (NO). These two molecules play critical roles in cellular metabolism and signal transduction, the manipulation of which constit...
triphosphate in Biological News

Protein regulates movement of mitochondria in brain cells

...nding how the brain responds to a pathological state." Mitochondria are cellular power plants that generate most of the cell's supply of adenosine triphosphate (ATP), which is used as a source of chemical energy. While mitochondria are present in all of the body's cells, some cells because of their size and...

Models of eel cells suggest electrifying possibilities

...d by engineering proteinsalready have been demonstrated by other researchers. Like the natural counterpart, the cells energy source would be adenosine triphosphate (ATP), synthesized from the bodys sugars and fats using tailored bacteria or mitochondria. ...

Biosensing nanodevice to revolutionize health screenings

...nder is part of a complex of proteins key to creating energy in all living things, including photosynthesis in plants. F1-ATPase breaks down adenosine triphosphate (ATP) to adenosine diphospahte (ADP), releasing energy. Previous studies of its structure and characteristics have been the source of two Nobel Prizes...

Researchers probe a DNA repair enzyme

...of genes and chromosomes). They do so by moving along strands of DNA, much the same way cars move on roads, using an energy-packed molecule, adenosine triphosphate (ATP) as a fuel source. Their primary function is to unzip double-stranded DNA, allowing replication and repair of the strands. DNA is a fragil...

Researchers create artificial enzyme that mimics the body's internal engine

...lls known as mitochondria. Embedded in the membrane of each mitochondrion is a structure called the electron transport chain, which produces adenosine triphosphate (ATP), a molecule that is the source of the cell's energy. The transport chain is made up of a series of proteins known as electron carriers. Each car...

Nobel Laureate finds 'elegant' explanation for DNA transcribing enzyme's high fidelity

...rocess. The researchers found that a portion of the enzyme known as the trigger loop acts like a “trap door,?swinging beneath a matching nucleoside triphosphate (NTP) building block, to close off the active center and form an extensive network of interactions with the NTP and other parts of the enzyme. Those i...
triphosphate in Biological Technology

Phase II Trial Demonstrates Elacytarabine May Increase Survival Threefold in Patients With Late-Stage Leukaemia

...lacytarabine is thought to be mediated through increased cellular uptake, decreased deactivation and prolonged exposure to the active metabolite ara-C triphosphate (ara-CTP) within the cell. In the Phase II trial, Elacytarabine was given as a single agent to patients with late stage AML who had received tw...

PeriCor Therapeutics Reports Positive Preclinical Results of GP531 at the European Heart Failure Congress in Nice

...nous adenosine -- during episodes of cellular stress. Cellular stress, as occurs with ischemia and tissue hypoxia, triggers the breakdown of adenosine triphosphate (ATP). ATP is the key energy molecule of living cells. Endogenous adenosine has been termed a "retaliatory metabolite" that targets multiple pathways ...

Serial Monitoring With ImmuKnow(R) is Useful in the Risk Assessment of Kidney Transplant Recipients

...esses cellular immune status by detecting cell-mediated immunity (CMI) in adult immunosuppressed patients. It measures the concentration of adenosine triphosphate (ATP) released from CD4 cells following cell stimulation. The ImmuKnow test is a qualitative assay and does not directly quantify the level of immuno...

Idenix Pharmaceuticals Reports Data From Three Hepatitis C Development Programs at the 44th Annual Meeting of the European Association for the Study of the Liver

...ed, oral nucleotide prodrug designed to enhance the formation of its active triphosphate in the liver, while minimizing systemic exposure to IDX184 and the resultin...a half-life of the nucleoside metabolite were similar to that of its active triphosphate measured in vitro in human hepatocytes. In this healthy volunteer study, ...

Cordex Pharma Forms Heart Failure Medical Advisory Board

...a, Inc. Cordex is a specialty pharmaceutical company that develops new cardiovascular medicines based upon the emerging pharmacology of adenosine triphosphate (ATP) and nitric oxide (NO). These two molecules play critical roles in cellular metabolism and signal transduction, the manipulation of which consti...

Cordex Pharma Presents 'New Frontiers in Cardiovascular Medicines' on January 29

...rma, Inc. Cordex is a specialty pharmaceutical company that develops new cardiovascular medicines based upon the emerging pharmacology of adenosine triphosphate (ATP) and nitric oxide (NO). These two molecules play critical roles in cellular metabolism and signal transduction, the manipulation of which consti...
triphosphate in Biological Products

Flow Cytometry Kit for Apoptosis from Sigma-Aldrich

Description:...-dUTP is incorporated more readily into the DNA fragments than deoxyuridine triphosphate labeled with larger dyes such as FITC, biotin or digoxigenin. One of the bi...fy apoptotic cells by labeling the 3'-hydroxyl sites with bromodeoxyuridine triphosphate (Br-dUTP). Br-dUTP is enzymatically attached to the 3-hydroxyl sites of do...
Company:Sigma-Aldrich

ApoBrdU Red DNA Fragmentation Kit from MBL International

Description:...rol cells for conveniently detecting DNA fragmentation by fluorescence microscopy or flow cytometry. The kit utilizes Br-dUTP (bromolated deoxyuridine triphosphate nucleotides) which is more readily incorporated into DNA strand breaks than other larger ligands (e.g., fluorescein, biotin or digoxigenin). The great...
Company:MBL International

ApoBrdU DNA Fragmentation Assay Kit from MBL International

Description:...rol cells for conveniently detecting DNA fragmentation by fluorescence microscopy or flow cytometry. The kit utilizes Br-dUTP (bromolated deoxyuridine triphosphate nucleotides) which is more readily incorporated into DNA strand breaks than other larger ligands (e.g., fluorescein, biotin or digoxigenin). The great...
Company:MBL International

ScriptCap m7G Capping System from EPICENTRE Biotechnologies

Description:... ScriptCap™ m7G Capping system features the Vaccinia capping enzyme and all of the components needed to produce a Cap 0 on the end of di- or triphosphate RNA transcripts. These kits feature high efficiency capping (virtually 100%) at a significantly better price than competitive capping enzymes....
Company:EPICENTRE Biotechnologies

Apo-BrdU Apoptosis Detection Kit from eBioscience

Description:...ssay; terminal deoxynucleotidyl transferase enzyme (TdT), bromodeoxyuridine triphosphate (Br-dUTP), and fluorescein labeled anti-BrdU antibody for labeling DNA brea...optotic cells by labeling the 3'-hydroxyl ends with bromolated deoxyuridine triphosphate nucleotides (Br-dUTP). The enzyme terminal deoxynucleotidyl transferase (Td...
Company:eBioscience

APO-DIRECT™ Kit from BD Biosciences Pharmingen

Description:...and rinsing buffers for processing individual steps in the assay; terminal deoxynucleotidyl transferase enzyme (TdT); fluorescein labeled deoxyuridine triphosphate (FITC-dUTP) and propidium iodide (PI)/RNase solution for staining total DNA....
Company:BD Biosciences Pharmingen
triphosphate in Biological Definition

Adenosine triphosphate

For other uses of the initials ATP, see ATP (disambiguation) Adenosine triphosphate ( ATP ) is the nucleotide known in biochemistry as the " molecular currency" of intracellular energy transfer; that is, ATP is able to store and transport chemical energy within cells . ATP a...

Coenzyme A

... Coenzyme A ( CoA , CoASH , or HSCoA ) is adapted from pantothenic acid and adenosine triphosphate and used in metabolism in areas such as fatty acid oxidization and the citric acid cycle . Its main function is to carry acyl groups such a...

ATP synthase

... An ATP synthase ( EC 3.6.3.14) is a general term for an enzyme that can synthesize adenosine triphosphate (ATP) from adenosine diphosphate (ADP) and inorganic phosphate by utilizing some form of energy. The overall reaction sequence is: ADP + P i ...

ATPase

... are a class of enzymes that catalyze the decomposition of adenosine triphosphate (ATP) into adenosine diphosphate (ADP) and a free phosphate ion . Th...a molecule of adenosine diphosphate (ADP) to form a molecule of adenosine triphosphate (ATP). This enzyme works when a proton moves down the concentration gradien...

Electron transfer chain

...d electrons into a cross-membrane proton gradient. This proton motive force created by the ETC is used to power membrane transporters and adenosine triphosphate synthesis by ATP synthase (aka the F 0 F 1 particle). They are used in photophosphorylation and respiration . In eukaryotes , including hu...

Photosynthesis

...ng an electron transport chain , similar to that involved in respiration. Their energy is used for photophosphorylation , which produces adenosine triphosphate (ATP), the main "energy currency" in cells. In photosystem I, the electrons are returned to the chlorophyll. In photosystem II, they are used to d...
triphosphate in Biological Dictionary

Adenosine triphosphate

Adenosine -5'- triphosphate (ATP) is a multifunctional nucleotide, and plays an important role in cell biology as a coenzyme that is the "molecular unit of currency" of intracellular energy transfer. In this role, ATP... ATP ( ) n. An adenosine -derived nucleotide, C 10 H ...

Skeletal muscle

... ... Anatomy and Physiology of Skeletal Muscle . Produce movement of joints by contracting. ... Produce heat (through the splitting of Adenosine triphosphate (ATP) ... The strength of skeletal muscle is directly proportional to its length and cross ... Skeletal muscle cells are stimulated by ac...

Respiration

...set of the metabolic reactions and processes that take place in organisms' cells to convert biochemical energy from nutrients into adenosine triphosphate (ATP), and then release waste products. The... Cellular respiration , the process in which molecules are converted into usable energy ... Carbon...

Phosphorylation

... cancer and... Oxidative phosphorylation is a metabolic pathway that uses energy released by the oxidation of nutrients to produce adenosine triphosphate (ATP). Although the many forms of life on earth use a range of different nutrients,... In living cells phosphorylation is associated with respi...

Mitochondrion

...ryotic cells (cells with clearly defined nuclei), the primary function of which is to generate large quantities of energy in the form of adenosine triphosphate (ATP). Mitochondria are typically round to oval in shape and range in size from 0.5 to10 μm. In addition to producing energy,... In cell biology,...

Deoxyribonucleotide

...cleotides ... Deoxyribonucleotide - Wikipedia, the free encyclopedia. A deoxyribonucleotide is the monomer, or single ... Deoxyribonucleotide triphosphate (dNTP) definition ... Spectra Stable Isotopes:Catalog of Products: ... Individual Deoxyribonucleotide 5'-triphosphates are purified to >95% ch...
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