Transcriptase

HIV integrase inhibitor effective for patients beginning antiretroviral treatment

...rase inhibitor, is overall as effective as widely used efavirenz, a reverse transcriptase inhibitor, the researchers found. Raltegravir also had faster onset of acti... FDA. Other types of antiretroviral drugs inhibit HIV's protease or reverse transcriptase enzymes. Guidelines from the U.S. Department of Health and Human Service...

96-Week Safety and Efficacy Findings Presented for INTELENCE(TM) (etravirine) As Part of HIV Combination Therapy

...ts from two Phase 3 studies (DUET-1 and DUET-2) showed that significantly more treatment-experienced HIV-1-infected adults with non-nucleoside reverse transcriptase inhibitor (NNRTI) and protease inhibitor (PI) resistance had an undetectable viral load (<50 HIV-1 RNA copies/mL) while taking INTELENCE(TM) (etrav...

Also in the March 24 JNCI

...us Stimulates Telomerase Activity in Tissue Culture Cells Infection with human cytomegalovirus (HCMV) triggers expression of the telomerase reverse transcriptase (hTERT) gene in both normal human cells and tumor cells grown in culture. HCMV has been suspected of causing or promoting cancer, but the mechanism...

Tibotec Submits Application to U.S. Food and Drug Administration Seeking Traditional Approval for INTELENCE(TM) (etravirine)

...plication to the U.S. Food and Drug Administration (FDA) seeking traditional approval for INTELENCE(TM) (etravirine) tablets, a non-nucleoside reverse transcriptase inhibitor (NNRTI). The application for traditional approval includes 48-week data from two Phase 3 studies known as DUET-1 and DUET-2. INTELENCE is ...

Herpes drug inhibits HIV replication, but with a price

... The anti-herpes drug acyclovir can also directly slow down HIV infection by targeting the reverse transcriptase (RT) enzyme, researchers report in this week's JBC . This beneficial effect does pose a risk though, as HIV-infected cells treated with acyclovir pro...

HIV prevention researchers to compare common ARV as a pill and vaginal gel in unique study

...stay of one of the most widely used regimens for treating HIV. The active ingredient in tenofovir belongs to a class of ARVs called nucleotide reverse transcriptase inhibitors (NRTIs), which act against HIV by targeting a key enzyme the virus needs to make a copy of its genetic material an essential step for the ...

Transcriptase in Medical Technology

Ardea Announces Progress with HIV Non-Nucleoside Reverse Transcriptase Inhibitor Program

- Lead Candidate, RDEA806, Demonstrated No Reproductive Toxicity in Preclinical Study - - RDEA427 Selected as Clinical Candidate, Demonstrated a 40 Hour Half-Life with Potential for Once Daily Oral Dosing - SAN DIEGO, May 22 /PRNewswire-FirstCall/ -- Ar...

Ardea Biosciences Presents Preclinical Data Demonstrating Favorable Resistance Profiles for Non-Nucleoside Reverse Transcriptase Inhibitors for the Treatment of Human Immunodeficiency Virus

BOSTON and CARLSBAD, Calif., Feb. 7 /PRNewswire-FirstCall/ -- Ardea Biosciences, Inc. (Nasdaq: RDEA ) today announced that data was presented demonstrating the potent activity of the Company's non-nucleoside reverse transcriptase inhibitor (NNRTI) family of compounds against the human-immunod...

Tibotec Pharmaceuticals Announces Agreement to Develop and Commercialize a New Fixed-Dose Combination of TMC278 and Truvada(R) With Gilead Sciences

...g Tibotec's investigational non-nucleoside reverse transcriptase inhibitor (NNRTI) TMC278 (rilpivirine hydrochlorid...vada) in combination with a non-nucleoside reverse transcriptase inhibitor or a protease inhibitor as a preferred r...MC278 is an investigational non-nucleoside reverse transcriptase inhibitor, and the safety and efficacy of it, in c...

Schering-Plough Expands Vicriviroc Phase II Study in Treatment-Naive Patients With HIV

...ombination product in the nucleoside(tide) reverse transcriptase inhibitor (NRTI) class. The standard of...use two NRTIs with either a non-nucleoside reverse transcriptase inhibitor (NNRTI) or a ritonavir-boosted PI.(4) W... 7 The DAD study group. Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HI...

Idenix Pharmaceuticals and GlaxoSmithKline Sign Worldwide License Agreement for IDX899, a Novel NNRTI for the Treatment of HIV

...usive worldwide rights to IDX899. IDX899 is a novel non-nucleoside reverse transcriptase inhibitor (NNRTI) in Phase II clinical development being developed by Ideni...conditions. About IDX899 IDX899 is a potent non-nucleoside reverse transcriptase inhibitor (NNRTI) being developed for the treatment of HIV-1. Idenix has ad...

A Milestone in Cancer Genetics: deCODE Discovers First Common Genetic Variants Affecting the Risk of Many Types of Cancer

...ed risk of BCC and also with risk of cancer of the lung, bladder and prostate. Rs 2736089 is located in the gene encoding the human telomerase reverse transcriptase (TERT), which directs the addition of repeat DNA sequences to the ends of chromosomes. Importantly, the risk of these different cancers conferred by t...

Transcriptase in Biological News

FANTOM findings boost for biologists

...gsc.riken.jp/4/ ). Further research published in BMC Bioinformatics highlights two new data-driven normalization methods for quantitative reverse transcriptase polymerase chain reaction (qPCR) experiments with larger data sets. Another study published in Genome Biology includes the first genome-wide analysi...

Efavirenz-based initial therapies associated with better outcomes in HIV-infected adults

...e countries in Africa with the majority in South Africa. Current World Health Organization guidelines recommend the use of a non-nucleoside reverse transcriptase inhibitor such as nevirapine or efavirenz in resource limited settings. Nearly 67 percent of countries in sub-Saharan Africa recommend nevirapine-base...

Landmark study opens door to new cancer, aging treatments

...at crystals of a molecule, to determine the three-dimensional structure of the enzyme's active regionthe catalytic component called telomerase reverse transcriptase protein, or TERT. The study revealed surprising features, including the fact that the molecule's three domains are organized into a doughnut shape,...

UGA researchers discover mechanism that explains how cancer enzyme winds up on ends of chromosomes

...and cancer cells in order to identify factors that impact human telomerase localization," said Michael Terns. "Our results indicate that human reverse transcriptase is a key determinant in human telomerase trafficking and is essential for the localization of telomerase RNA both to Cajal bodies and telomeres." W...

New field-deployable biosensor detects avian influenza virus in minutes instead of days

... channel changed creating this phase change, explained Xu. Current methods of identifying infected birds include virus isolation, real-time reverse transcriptase polymerase chain reaction (RRT-PCR) and antigen capture immunoassays. Virus isolation is a sensitive technique, but typically requires five to seven d...

Resistant HIV quickly hides in infants' cells

...ected with drug-resistant HIV transmitted from their mothers—a surprisingly high figure. Of those five, four were resistant to non-nucleoside reverse transcriptase inhibitors (NNRTIs), a common class of antiretroviral drug used to treat HIV infection and to prevent mother-to-child transmission. All had uncommon d...

Transcriptase in Biological Technology

Ardea Presents Preclinical Data on Novel Next Generation Non-Nucleoside Reverse Transcriptase Inhibitors Demonstrating Potent Anti-HIV Activity Against Resistant Viruses

-- Lead NNRTI RDEA806 to begin Phase 2b trial in the second quarter of 2008 -- MONTREAL and SAN DIEGO, April 14 /PRNewswire-FirstCall/ -- Ardea Biosciences, Inc. (Nasdaq: RDEA ) today announced that preclinical data was presented on the Company's next generatio...

Ardea to Present Data on HIV Non-Nucleoside Reverse Transcriptase Inhibitor and Two MEK Inhibitors at Upcoming Medical Conferences

SAN DIEGO, April 7, 2008 /PRNewswire-FirstCall/ -- Ardea Biosciences, Inc. (Nasdaq: RDEA ) today announced that data will be presented on its second generation non-nucleoside reverse transcriptase inhibitors (NNRTIs), at the 21st International Conference on Antiviral Research (ICAR). Addition...

Ardea Biosciences to Present Preclinical Data on Three HIV Non-Nucleoside Reverse Transcriptase Inhibitors During 15th Annual Conference on Retroviruses and Opportunistic Infections

- Activity data on lead NNRTI, RDEA806, and next generation compounds to be discussed - CARLSBAD, Calif., Jan. 29 /PRNewswire-FirstCall/ -- Ardea Biosciences, Inc. (Nasdaq: RDEA ) today announced that preclinical data on the Company's non-nucleoside reverse transcri...

A simple and rapid LC-MS/MS method for the simultaneous determination of nine antiretroviral drugs commonly used in Europe (protease Inhibitors and non-nucleoside reverse transcriptase inhibitors)

Purpose In clinical research, the monitoring of protease inhibitor (PI) and non-nucleoside reverse transcriptase inhibitor (NNRTI) antiretroviral drugs is of significant interest due to the importance of assessing inter-individual and intra-individual metabolism variability. ...

Recombinant HIV Reverse Transcriptase

More thermostable than AMV RT and M-MLV RT Excellent target to evaluate antiviral agents Highly sensitive enzyme for RT-PCR applications Ideal for reverse transcribing transcripts with...

Increase the Power and Sensitivity for Your cDNA Synthesis with the New Transcriptor Reverse Transcriptase

Transcriptor Reverse Transcriptase is a new recombinant reverse transcriptase (RT) expressed in E. coli. The enzyme has RNA-directed DNA polymerase activity, DNA-dependent DNA polymerase activity, unwinding activity, an...

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Transcriptase in Biological Products

SuperScript III RNase H- Reverse Transcriptase from Invitrogen

Description: SuperScript™ III RNase H- Reverse Transcriptase (RT) is an improved version of SuperScript™ II RNase H- RT. Like SuperScript™ II it synthesizes a complementary DNA strand from single-stranded RNA DNA or an RNA:DNA hybrid. SuperScript™ III is genetically e...
Company:Invitrogen

MultiScribe Reverse Transcriptase from Applied Biosystems

Description: MultiScribe Reverse Transcriptase is a recombinant Moloney murine leukemia virus (rMoMuLV) reverse transcriptase. MultiScribe Reverse Transcriptase is similar to MuLV reverse transcriptase but differs in its recommended usage. MuLV reverse transcriptase is a recombinant RNA-dependent DNA polymerase...
Company:Applied Biosystems

M-MLV Reverse Transcriptase from Promega

Description: Moloney Murine Leukemia Virus Reverse Transcriptase (M-MLV RT) is an RNA-dependent DNA polymerase that can be used in cDNA synthesis with long messenger RNA templates (>5kb). The enzyme is a product of the pol gene of M-MLV and consists of a single subunit with a molecular weight of 71kDa. The RNas...
Company:Promega

SuperScript II RNase H- Reverse Transcriptase from Invitrogen

Description: SuperScript™ II RNase H- Reverse Transcriptase (RT) is an improved version of the SuperScript™ RNase H- RT. It is a DNA polymerase that synthesizes a complementary DNA strand from single-stranded RNA DNA or an RNA:DNA hybrid. This enzyme is genetically engineered by the introduction of ...
Company:Invitrogen

SuperScript II RNase H- Reverse Transcriptase from Invitrogen

Description: SuperScript™ II RNase H- Reverse Transcriptase (RT) is an improved version of the SuperScript™ RNase H- RT. It is a DNA polymerase that synthesizes a complementary DNA strand from single-stranded RNA DNA or an RNA:DNA hybrid. This enzyme is genetically engineered by the introduction of ...
Company:Invitrogen

Reverse Transcriptase AMV; RNA dependent DNA polymerase from Roche Applied Science

Description: Request Info...
Company:Roche Applied Science

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Transcriptase in Biological Definition

Enzyme

...osphate group from an amino acid residue of a protein Restriction enzymes : those enzymes which cut DNA or RNA at specific locations Reverse transcriptase : used by retroviruses to transcribe information from RNA into DNA Ribulose bisphosphate carboxylase : fixes carbon in green plants. RNAse...

Gene therapy

...ucing a DNA copy from an RNA molecule is termed reverse transcription . It is carried out by one of the enzymes carried in the virus, called reverse transcriptase . After this DNA copy is produced and is free in the nucleus of the host cell, it must be incorporated into the genome of the host cell. That is, it...

Hepadnaviridae

...NA . They have a peculiar mode of replication, because they replicate through an RNA intermediate (which they translate back into DNA using reverse transcriptase ). Because of this mode of replication, Hepadnaviruses are classified as RNA viruses . ...

Hepatitis B

...sahedral nucleocapsid (core) enclosing a circular, double-stranded DNA genome. The virus is unique amongst the DNA viruses in that it uses a reverse transcriptase to generate the genomic DNA to deliver to its progeny. Additionally, the DNA genome is incomplete on one strand. Hepatitis D infection requires a ...

Lytic cycle

...lf into messenger RNA (mRNA) molecules that are then used to direct the ribosome. In retroviruses , or RNA viruses, a unique enzyme called reverse transcriptase transcribes the viral RNA into DNA, which is then transcribed again into mRNA. Replication and lysis After many virus copies are made, they ar...

Retrovirus

... plus sense RNA molecules. It relies on reverse transcriptase to perform a kind of reverse transcription of i...ly thought to only occur from DNA to RNA, reverse transcriptase transcribes RNA into DNA. The term "retro" in ret... the Central dogma of molecular biology . Reverse transcriptase activity outside of retroviruses has been found in...

Transcriptase in Biological Dictionary

Transcriptase

In biochemistry, a reverse transcriptase , also known as RNA-dependent DNA polymerase, is a DNA polymerase enzyme that transcribes single-stranded RNA into single-stranded DNA. It also helps in the formation of a double helix... Reverse transcriptase inhibitors (RTIs) are a class of ant...

Reverse transcriptase

In biochemistry, a reverse transcriptase , also known as RNA-dependent DNA polymerase, is a DNA polymerase enzyme that transcribes single-stranded RNA into single-stranded DNA. It also helps in the formation of a double helix... Reverse transcriptase inhibitors (RTIs) are a class of a...

Telomerase

...of human aging. Focused on transcriptional regulation of telomerase to re-lengthen telomeres. The significance of human telomerase reverse transcriptase (hTERT) in cancer" ... Regulation of telomerase activity and anti-apoptotic function by protein-protein ... ...

RT-PCR

...rotocol describes DNase treatment, the RT reaction and PCR . ... ... transcriptase ( RT ), however, can be combined with traditional PCR to allow ... The p...the target ... Sigma's RT - PCR kits, based on the DuraScript™ Reverse transcriptase are the most effective tool for reproducible reverse transcription of low...

Reverse transcription

...: How HIV RNA is mapped into host DNA. ... Reverse Transcription : Converting viral RNA into DNA. Viral RNA (yellow) DNA (blue) ... reverse transcriptase n. A polymerase that catalyzes the formation of DNA on ... However, reverse transcription was at odds with the then-popular central dogma ......

Retrovirus

... A retrovirus is an RNA virus that is replicated in a host cell via the enzyme reverse transcriptase to produce DNA from its RNA genome. The DNA is then incorporated into the host's genome by an integrase enzyme. The virus... retrovirus n....