Prospect Therapeutics, Inc.'s GCS-100 Exhibits a Low Toxicity Profile in Cancer Patients
WELLESLEY HILLS, Mass., May 19 /PRNewswire/ -- Joseph F. Finn, Jr., C.P.A. ("Finn"), announced today that there has been promising initial interest from pharma companies in the intellectual property of Prospect Therapeutics, Inc. ("Prospect").
GCS-100 has demonstrated single-agent activity i...
Metametrix Announces New Toxic Effects Profiles to Help Combat Growing Concerns About Toxicity and Health
DULUTH, Ga., April 27 /PRNewswire/ -- Daily exposure to toxins in the products we use for lifestyle convenience, such as plastics, adhesives, and insecticides, are creating a toxic load on our bodies contributing to chronic illnesses, mood disorders, allergies, and asthma. In light of increased aw...
Taurine: Key to the visual toxicity of an anti-epileptic drug for children?
Vigabatrin (Sabril), first intention molecule for the treatment of epilepsy in children, in many cases produces secondary effects that lead to an irreversible loss of vision. Serge Picaud, head of research at Inserm, and his colleagues of the Institut de la Vision have just discovered the origin o...
Pre-emptive treatment helped curtail skin toxicity with panitumumab
(PHILADELPHIA) With a pre-emptive, prophylactic skin regimen, patients who receive panitumumab for treatment of metastatic colorectal cancer may be able to avoid some of the skin-associated toxicities, according to data presented at the 2009 American Society of Clinical Oncology Gastrointestinal C...
Amira Announces the Successful Completion of GLP Toxicity Studies for a Novel DP2 Antagonist.
Lead candidate on track for IND submission first half of 2009.
SAN DIEGO, Jan. 6 /PRNewswire/ -- Amira Pharmaceuticals, Inc. announced AM211, Amira's internally discovered oral drug candidate for the treatment and control of inflammatory and allergic diseases linked to the arachidonic acid pa...
New Evidence Highlights Dangers of Mercury Toxicity in Fish
SAN FRANCISCO, Oct. 8 /PRNewswire/ -- Dr. Jane Hightower -- widely
acknowledged as the first US physician to recognize low-level mercury
poisoning in patients who regularly consume certain types of fish -- today
released new evidence showing that the FDA has failed to inform and protect
toxicity in Medical Technology
Modigene Announces Positive Results of Pilot Toxicity Study of Its Long-Acting Human Growth Hormone hGH-CTP
- Single Injection in Primates Containing 1,000-Times the Dosage Recommended for Humans Shows No Adverse Effects -
- Half-Life and AUC Support the Potential for Weekly or Bi-Monthly Dosing Frequency -
NES-ZIONA, Israel, Jan. 15 /PRNewswire-FirstCall/ -- Modigene Inc. (OTC Bulletin Board:...
Further Clinical Testing of BZL101 in Advanced Breast Cancer Demonstrates Favorable Efficacy and Toxicity Profiles
- Results Presented at American Society of Clinical Oncology 44TH Annual Meeting -
EMERYVILLE, Calif., June 2 /PRNewswire-FirstCall/ -- Bionovo Inc.
(Nasdaq: BNVI ) today announced results from a second ongoing clinical trial
of BZL101, an oral drug candidate, in...
Phase I/II Study of Targeted Gene Delivery In Vivo - Intravenous Infusions of REXIN-G - Demonstrates Dose-Dependent Anti-Tumor Activity Without Toxicity in Patients With Progressive Chemo-Resistant Bone and Soft Tissue Sarcoma (ASCO 2008)
SAN MARINO, Calif., May 29 /PRNewswire/ -- Epeius Biotechnologies
( http://www.epeiusbiotech.com ) announced today the results of an on-going
Phase I/II study of Rexin-G for metastatic bone and soft tissue sarcoma (J
Clin Oncol 26: 14509, 2008). Rexin-G is the first and so far only targeted
TARGETED GENE DELIVERY IN VIVO: Rexin-G Monotherapy Reveals Significant Biological Activity Without Toxicity in Chemo-Resistant Metastatic Breast Cancer (ASCO 2008)
SAN MARINO, Calif., May 22 /PRNewswire/ -- Epeius Biotechnologies
announced today the promising results of an on-going United States-based
Phase I/II study of Rexin-G for metastatic breast cancer that is refractory
to conventional chemotherapy (J Clin Oncol 26:14509, 2008). This clinical
Interim Analysis of Phase I/II Study of Rexin-G Confirms Efficacy With No Dose Limiting Toxicity in Metastatic Pancreatic Cancer
Second Phase Opens With Higher Dose Regimens
SAN MARINO, Calif., April 21 /PRNewswire/ -- Epeius Biotechnologies
Corporation announced today that Interim Analysis of an on-going Phase I/II
study of Rexin-G for pancreatic cancer confirmed Rexin-G's anti-tumor
activity with no majo...
Three Year Analysis of Treatment Efficacy, Cosmesis, and Toxicity Support use of the Hologic Mammosite Radiation Therapy System
American Society of Breast Surgeons Study Represents Largest Patient Population to Date
BEDFORD, Mass., Feb. 25 /PRNewswire-FirstCall/ -- Hologic, Inc.
(Nasdaq: HOLX ) a diversified medical technologies company specializing in
imaging systems, diagnostics, and inter...
toxicity in Medical Products
Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
TECHNI-CARE Surgical Scrub
Description:...ented efficacy on all gram-negative and gram-positive organisms tested in 30 seconds. Techni-Care represents a new molecular structure and has a lower toxicity
rating than commercial soaps and shampoos....
Company:Care-Tech Laboratories, Inc.
Resolve® Immersion Oil
Description:...available in both low and high viscosity, is non-drying and non-hardening, and has a refractive index of 1.5150. Resolve contains no PCBs, eliminating toxicity
and disposal problems....
ULTRA Evolution Multi-Detection Microplate Reader
Luminescent-based reporter assays and bioluminescence energy transfer-based assays
Cell-based assays including migration, proliferation and toxicity
All general fluorometric and colorimetric assays used in a wide variety of application settings ...
Preservative-Free TheraTears Liquid Gel
Description:...ncern regarding preservative-induced irritation. And because of its patented electrolyte balance, you will never experience the "electrolyte imbalance toxicity
you may get from other products....
Company:Advanced Vision Research, Inc.
Description:...r vision tests. It is specifically designed to detect the subtle red/green or blue/yellow color vision losses that accompany such disorders as retinal toxicity
(that from Plaquenil, for example), early optic neuritis, glaucoma, diabetic retinopathy, and macular degeneration. Additionally it is fast and accura...
Company:LKC Technologies, Inc.
toxicity in Medical Definition
...y (Proteo- [ pref . protein]; -pathy [ suff . disease]; proteopathies pl .; proteopathic adj .). Proteopathy is the abnormal accumulation and toxicity
of proteins in certain disease states.  Also, selective hyperproteolytic diseases have been referred to this category, e.g. critical illness m...
toxicity in Medical Dictionary
Digitalis is a genus of about 20 species of herbaceous perennials, shrubs, and biennials that are commonly called foxgloves. The genus was traditionally placed in the figwort family Scrophulariaceae, but upon review of... Digitalis toxicity
Information from Drugs.com ... Low levels of po...
Vitamin B-12 level
...nston County, North Carolina, NC, Clayton, Apex, Harnett County, ... No toxicity
levels have been reported for vitamin B12 , and no toxicity
symptoms ... vitamins in 1998, it did not establish a Tolerable Upper le...
...e vitamins by the materials that a vitamin will dissolve in. ... Describes what is vitamin A , its functions, as well as deficiency and toxicity
symptoms. Beta-carotene Cannot Substitute for True Vitamin A ... Beta-carotene is a beneficial antioxidant, but not an essential vitamin . .....
is the degree to which a substance is able to damage an exposed organism. toxicity
can refer to the effect on a whole organism, such as an animal, bacterium, ...
...ized information for convenient and enjoyable healthy eating. Has information concerning role vitamin plays in body, importance of, and possible toxicity
signs. ... of foods that contain riboflavin is the best way to ... Brief and Straightforward Guide: What is Riboflavin ? ... Riboflavin hel...
...ions. Pyridoxine deficiency and peripheral neuropathy associated with long-term ... Efficacy of pyridoxine to ameliorate the cutaneous toxicity
associated with ... Pyridoxine Pyridoxine [ 1 ] IUPAC name 4,5-Bis(hydroxymethyl)- 2-methylpyridin- 3-ol Identifiers CAS number [ 65-23-6 ] , ...
toxicity in Biological News
Countries unite to reduce animal use in product toxicity testing worldwide
Representatives from four international agencies, including the director of the U.S. National Toxicology Program (NTP), today signed a memorandum of cooperation that could reduce the number of animals required for consumer product safety testing worldwide. The agreement between the United States, ...
Nanoparticle toxicity doesn't get wacky at the smallest sizes
CHICAGO -- The smallest nano-sized silica particles used in biomedicine and engineering likely won't cause unexpected biological responses due to their size, according to work presented today. The result should allay fears that cells and tissues will react unpredictably when exposed to the finest ...
UC Riverside biochemists devise method for bypassing aluminum toxicity effects in plants
RIVERSIDE, Calif. Aluminum toxicity, a global agricultural problem, halts root growth in plants, severely limiting agricultural productivity for more than half of the world's arable land.
For many years, scientists have puzzled over how toxic levels of aluminum damage the growing root. The pop...
Landmark studies assess risk of exposure to elevated levels of EMS confirm clear toxicity threshold
Basel, 4 August 2008. New data from studies presented at the XVII International AIDS Conference in Mexico City have provided unprecedented insight into the toxicity
of an impurity called ethyl methanesulfonate (EMS). The formation of the EMS impurity is a potential by-product of the manufacturing...
Where there's wildfire smoke, there's toxicity
The health threat to city dwellers posed by Southern California wildfires like those of November 2008 may have been underestimated by officials.
Detailed particulate analysis of the smoke produced by previous California wild fires indicates that the composition posed more serious potential thre...
Biologists find diatom to reduce red tide's toxicity
It's estimated that the red tide algae, Karenia brevis, costs approximately $20 million per bloom in economic damage off the coast of Florida alone. Scientists at the Georgia Institute of Technology have found that a diatom can reduce the levels of the red tide's toxicity
to animals and that the s...
toxicity in Biological Technology
Investigational Urine NGAL Biomarker Shows Promise to Monitor Cyclosporine Toxicity in Cardiac Transplant Patients
CHICAGO, July 22 /PRNewswire-FirstCall/ -- Research presented at the American Association for Clinical Chemistry (AACC) annual meeting today indicates that monitoring cardiac transplant patients with the Urine NGAL assay on Abbott's ARCHITECT immunoassay analyzer may help clinicians to m...
ASCO 2008: Tumor-Targeted Rexin-G Demonstrates Dose-Dependent Anti-Tumor Activity Without Toxicity in Metastatic Pancreatic Cancer
SAN MARINO, Calif., May 19 /PRNewswire/ -- Epeius Biotechnologies
announced today the results of an on-going Phase I/II study of Rexin-G for
metastatic pancreatic cancer (Chawla et al., ASCO meeting, 2008).
Continuing on with the planned dose-escalations of Rexin-G which began in
2005 using lo...
Increased Drug Related Cardiac Toxicity Leads Gwathmey Preclinical Testing Services to Create Novel Cardionomics(TM) Services for Preclinical Cardiac Safety Screening of Drug Candidates
CAMBRIDGE, Mass., May 8 /PRNewswire/ -- In response to ever increasing
found in market drugs, Gwathmey Preclinical Testing
Services, Inc. today announced the launch of new Cardionomics(TM) services
and the formation of its Cardionomics(TM) Advisory Board to provide new
Biochip mimics the body to reveal toxicity of industrial compounds
Troy, N.Y. - A new biochip technology could eliminate animal testing in the chemicals and cosmetics industries, and drastically curtail its use in the development of new pharmaceuticals, according to new findings from a team of researchers at Rensselaer Polytechnic Institute, the University of Cal...
Versatile Transfection Reagent Offers Low Toxicity and Consistent
LipoTAXI transfection reagent: A proven choice
Matt C. Petre
LipoTAXI transfection reagent offers
improved, consistent transfections for both adherent cells and cells growing in
suspension. In this article, we summarize the results of several experiments...
NeurogesX Reports Second Quarter 2009 Results
...ophen to a liver protectant, has been evaluated in vitro and in vivo . Equivalent dose levels of NGX-1576 in mice produced significantly less liver toxicity
than acetaminophen, while additional data demonstrated the production of equivalent plasma levels of acetaminophen.
NGX-6052, the most advanced...
toxicity in Biological Products
In Vitro Toxicity Testing Protocols, Vol 43 from Promega
Description: S. O'Hare & C.K. Atterwill • In vitro toxicity
techniques for regular lab use. Ex vivo techniques are also covered with the aim of reducing and refining the use of animals in the future....
ProteoJuice Protein Transfection Reagent from Novagen
Description:.... ProteoJuice Protein Transfection Reagent is an effective reagent for the transfection of intact functional protein into mammalian cells with minimal toxicity
and broad cell specificity....
Freedom EVO 150 from Tecan
Description:...eening (HTS), ultrahigh throughput screening (UHTS) & secondary screening toxicity
assays Compound management Hit picking and plate reformatting Cell cu...ty Automated assays for Absorption, Distribution, Metabolism, Excretion, toxicity
(ADMET) include: Micosome and hepatocyte metabolic stability assays Ce...
TransIT-TKO siRNA Transfection Reagent from Mirus Bio Corporation
Description:... Designed specifically for high efficiency siRNA delivery in mammalian cells. Low toxicity
reagent proven to work effectively in a wide range of cell types. Results in silencing of greater than 95% of target gene expression. One step, serum ...
Company:Mirus Bio Corporation
Metabolic Profiler from Bruker Daltonics
Description:...organism to distinguish between normal and altered states
Discovery and identification of potential biomarkers
Study mechanism of drug induced toxicity
and/or efficacy at pre-clinical or clinical stages of development
Research in pharmaco-metabolomics, clinical disease diagnosis and prognosis ...
Label IT siRNA Tracker Biotin Intracellular Localization Kit with TransIT-TKO siRNA Transfection Reagent from Mirus Bio Corporation
Description:...500 transfections in 24-well plates. TransIT-TKO Transfection Reagent, which is included in the kit, is designed specifically for high efficiency, low toxicity
siRNA transfections in a variety of cell lines....
Company:Mirus Bio Corporation
toxicity in Biological Definition
6 Physical and chemical properties
8 Chemistry of alcohols
8.1 Preparatio...ly than gasoline or diesel . Because of its low toxicity
and ability to dissolve non-polar substances, etha... the #Chemistry of alcohols section below.
Alcohols often have an odor described as 'bitin...
... by Bacillus pyocyaneus, retarded the growth of other bacteria in situ and was toxic to many disease-causing bacteria. Unfortunately, pyocyanase's own toxicity
and unstable character prevented its use as an effective, safe antibiotic within the human body.
The first effective antibiotic discovered was peni...
... cervical cancer .
Response to stress or DNA damage
Stress conditions (such as starvation) as well as damage to the cell's DNA resulting from toxicity
or exposure to ionizing radiation, such as ultraviolet or X-rays, can induce a cell to begin an apoptotic process. A fascinating example, resulting fr...
2.1 Biological function
2.2 Colchicine as medicine
2.4 Laboratory use
3 External links
The co... cancer , as the dose required would lead to intolerable side-effects.
Poisoning resembles intoxication with arsenic : symptoms start 2 to 5 ho...
... resources or against new competitor species.
Habitat degradation through toxicity
can kill off a species very rapidly, by killing all living members through ...ion or sterilizing them. It can also occur over longer periods at lower toxicity
levels by affecting life span, reproductive capacity, or competitiveness. ...
...ping a deficiency condition, while Vitamin B 1 stores may only last a couple of weeks.
Fat-soluble vitamins may be stored in the body and can cause toxicity
when taken in excess. Water-soluble vitamins are not stored in the body, with the exception of Vitamin B 12 , which is stored in the liver .
toxicity in Biological Dictionary
...Online Medical Dictionary and glossary with medical definitions ... Urea is of major historical significance. ... Ammonium cyanate is urea . ... toxicity
should not be a problem if urea is fed ... Urea can be fed to ruminants as an economical replacement for a part of the protein in a ration. ... ...
...ecessarily due only to the gene directly ... ... Nontarget Organisms , U.S. Fish and Wildlife Service-LaCrosse, WI and The ... lack comparable toxicity
data and have not been tested on nontarget organisms . ... ... and Selected Nontarget Organisms ... and the effects on nontarget organism...
...us Analysis Kits can save weeks of time ... Loats Associates, Inc. creates systems for medical research, specializing in the automation of genetic toxicity
assays; micronuclei assay, comet, metaphase spread ... micronucleus ... micronucleus - A nucleus, distinct from and smaller than the main n...
...is Missouri's most widely used forage crop. ... How does the endophyte affect grazing animals? ... rural heritage vet clinic - endophyte fescue toxicity
in horses ... Additionally, some so-called endophyte -free seeds are derived from infected seed ... when the connection between endophyte in t...
...... in an 11-mm die cavity and core was ... ... was to establish mucoadhesive buccal devices of propranolol hydrochloride (PRH) ... in cases of toxicity
by removing the dosage form from the buccal cavity . ... buccal - Ecology of buccal from A Dictionary of Ecology at Encyclopedia.com ... No ...