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Tamoxifen-like drug suggests new ways to selectively block estrogen

The ability of an experimental drug known as GW5638 to change the shape of the estrogen receptor is helping researchers understand why drugs like tamoxifen and raloxifene behave the way they do, simulating the effects of estrogen in some tissues and blocking it in others. The finding indicates that this little-known drug may play an important role in preventing, as well as treating, breast cancer...

Gene variation affects tamoxifen's benefit for breast cancer

One of the most commonly prescribed drugs for breast cancer, tamoxifen, may not be as effective for women who inherit a common genetic variation, according to researchers at the University of Michigan and the Mayo Clinic. The genetic variation affects the level of a crucial enzyme that activates tamoxifen to fight breast cancer. The study, co-led by researcher James Rae, Ph.D., at the Univ...

Tamoxifen for breast cancer prevention does not benefit most women

Most women at high risk for breast cancer do not increase their life expectancy by taking the drug tamoxifen, according to a new analysis by researchers from UC Davis, UCSF, the University of Pittsburgh and McMaster University in Ontario, Canada. In addition, the researchers showed that tamoxifen is an extraordinarily expensive cancer-prevention strategy, costing as much as $1.3 million per year...

Pak1 expression increases tamoxifen resistance in breast cancer patients

A protein that activates estrogen receptors in breast cancer may play a role in resistance to therapeutic effects of anti-estrogen tamoxifen treatment, according to a study in the May 17 Pak 1 is a member of a family of proteins involved in many cell functions, such as gene expression, cell movement, and cell death. Previous studies have...

Restoring tamoxifen sensitivity in resistant breast cancer cells

The widely used breast cancer drug tamoxifen (Nolvadex®), which can become less effective over time, might retain its full strength indefinitely if used along with a second drug, according to new research in mice conducted by investigators from the National Cancer Institute (NCI), part of the National Institutes of Health, and their partners. The results appear in the December 11, 2006, issue of...
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Letrozole Beats Tamoxifen in Breast Cancer Therapy

Novartis' Femara (letrozole), one of a new class of breast cancer drugs, worked better than standard therapy with tamoxifen in treating breast cancer in women// with advanced disease. Femara is a member of a new class of drugs called aromatase inhibitors, which work differently to prevent certain kinds of breast cancer than does tamoxifen. This new drug, Letrozole shrank tumors better...

Tamoxifen does not adversely affect the brain

The breast cancer drug tamoxifen does not damage the brains of elderly women, alleviating fears of a neurotoxic effect of such treatment, recent study has revealed. According to researchers, tamoxifen has a similar effect on the brain to oestrogen, which has been linked with potentially neuroprotective action //against cognitive decline. The researchers used proton magnetic resonance s...

Tamoxifen reduces breast cancer risk

In a new study, researchers from Cancer Research Insitiute, UK suggests that women on tamoxifen have a reduced breast cancer risk compared to those on placebo.// They report on a large scale trial of tamoxifen to prevent breast cancer. A group of 6050 women aged 36 to 65 years, from the UK, Australia, New Zealand and Europe took either tamoxifen or placebo for five years. All the women were consi...

Tamoxifen reduces breast cancer risk

In a new study, researchers from Cancer Research Insitiute, UK suggests that women on tamoxifen have a reduced breast cancer risk compared to those on placebo. They report on a large scale trial of tamoxifen to prevent breast cancer. A group of 6050 women aged 36 to 65 years, from the UK, Australia, New Zealand and Europe took either tamoxifen or placebo for five years.// All the women were consi...

Aromatase Inhibitors drug Femara after Tamoxifen therapy protects from breast cancer recurrence

Aromatase Inhibitors drug, Femara given after 5 years of Tamoxifen therapy is found to give protection against occurrence of Breast cancer recurrence. Breast cancer is the second leading cause of cancer// in women. Breast cancer mostly occurs in post menopausal women and various risk factors are attributed for the occurrence of breast cancer. Treatment of breast cancer initially involve...

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First single breast cancer study to show significant survival benefit for women switching from tamoxifen to Arimidex

Anastrozole (ArimidexTM) improves overall survival inpostmenopausal women with early breast cancer receiving treatmentwith tamoxifen – Survival benefit demonstrated for an AI over tamoxifenin a single trial – LUTON, England, Friday 15 June 2007: Analysis of the entirepopulation of a single trial has demonstrated that survival inearly breast cancer can be signific...

Anastrozole (Arimidex) Improves Overall Survival in Postmenopausal Women with Early Breast Cancer Receiving Treatment with Tamoxifen

Survival Benefit Demonstrated for an AI Over Tamoxifen ina Single Trial LUTON, UK, Friday 15 June 2007: Analysis of the entirepopulation of a single trial has demonstrated that survival inearly breast cancer can be significantly improved by switching fromtamoxifen to anastrozole (Arimidex). An analysis of the'Arimidex'-'Nolvadex 95' (ARNO 95) study, published online in TheJourna...
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