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synthetase in Medical News

aTyr Pharma Raises an Additional $12 Million

...hetases and a successful biotechnology entrepreneur, began discovering the novel functions in this ancient class of proteins he realized that the tRNA synthetase resectins represented a rich source of proteins that had therapeutic potential. According to Jeff Watkins, CEO of aTyr Pharma, "This new financial su...

Hyperion Therapeutics Raises $60 Million Series C

... prevalent urea cycle disorders: carbamylphosphate synthetase (CPS), ornithine transcarbamylase (OTC), and argininosuccinic acid synthetase (AS) deficiencies. HPN-100, which is dosed orally ...orders involving deficiencies of carbamylphosphate synthetase (CPS), ornithine transcarbamylase (OTC), or argini...

Hyperion Therapeutics Announces Results of Phase I Study in Patients With Liver Cirrhosis

...of patients with the most prevalent urea cycle disorders: carbamylphosphate synthetase (CPS), ornithine transcarbamylase (OTC) and argininosuccinic acid synthetase (AS) deficiencies. HPN-100, which is dosed orally in liquid form, is under ...

Hyperion Therapeutics Completes Phase 2 Data Analysis and Schedules End of Phase 2 Meeting With FDA for HPN-100 in the Chronic Treatment of Urea Cycle Disorders

...ients with urea cycle disorders involving deficiencies of carbamylphosphate synthetase (CPS), ornithine transcarbamylase (OTC), or argininosuccinic acid synthetase (AS). BUPHENYL(R) should not be administered to patients with known hyperse...

Replidyne Pipeline Featured at 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy

...m difficile: Identification and Synthesis of REP3123." -- Poster F1-2113, titled "REP3123 is a Potent and Selective Inhibitor of Methionyl tRNA synthetase from Clostridium difficile." -- Poster F1-2114, titled "Co-crystal Structure of REP3123 Bound to Clostridium difficile Methionyl tRNA Synthetas...

Researchers Devise New Compound to Treat Fungal Infections

...the message. This requires the help of molecules called tRNAs, which link the code of the messenger RNA to the correct amino acid. Leucyl-tRNA synthetase is one of a group of enzymes called aminoacyl-tRNA synthetases that attach the correct amino acid to each tRNA. Some of these enzymes have two main fu...
synthetase in Medical Technology

Fruitfly Model of a Neuropathic Disease Demonstrates Novel Role for Proteins in the Family of aTyr Pharma's Product Class

...hila) by introducing mutations in the tyrosyl-tRNA synthetase which correspond to disease associated mutations i...ill trying to understand how mutations in the tRNA synthetase gene disrupt the neurological system of a complex ... humans and this fruit fly model, the tyrosyl-tRNA synthetase gene encodes a distinct function involved in the c...

Hyperion Therapeutics Receives Orphan Drug Designation for HPN-100 for the Treatment of Urea Cycle Disorders

...ients with urea cycle disorders involving deficiencies of carbamylphosphate synthetase (CPS), ornithine transcarbamylase (OTC), or argininosuccinic acid synthetase (AS). BUPHENYL should not be administered to patients with known hypersensi...

Hyperion Therapeutics Announces Results for Phase II Study in Urea Cycle Disorders

...ients with urea cycle disorders involving deficiencies of carbamylphosphate synthetase (CPS), ornithine transcarbamylase (OTC), or argininosuccinic acid synthetase (AS). BUPHENYL(R) should not be administered to patients with known hypers...

Trius Antibiotics to be Highlighted in 18 Presentations at ICAAC/IDSA

...1-336: Advanced Microbiology Study of Rx100472, A Novel Methionyl-tRNA synthetase (MetRS) inhibitor -- F1-337: In Vivo Efficacy of Rx100472, A Novel Methionyl-tRNA synthetase (MetRS) Inhibitor Sunday, October 26th (Poster Session 92, 11:15 am...

Hyperion Therapeutics Completes Enrollment in Phase 1/2 Clinical Trial in Patients With Urea Cycle Disorders

... transcarbamylase (OTC), and argininosuccinic acid synthetase (AS). HPN-100, which is dosed orally in liquid for...orders involving deficiencies of carbamylphosphate synthetase (CPS), ornithine transcarbamylase (OTC), or argininosuccinic acid synthetase (AS). BUPHENYL(R) should not be administered to pa...

Replidyne Provides Strategic Update

...um antibacterial agent that in vitro prevents the growth of C. difficile by inhibiting an essential enzyme in the bacterial cell called methionyl tRNA synthetase that blocks the organism from synthesizing proteins. In preclinical studies, REP3123 has been shown to inhibit growth, toxin production and spore-form...

Hyperion Therapeutics Announces Enrollment of First Patient in Phase 1/2 Clinical Trial of GT4P in Patients With Urea Cycle Disorders

...orders involving deficiencies of carbamylphosphate synthetase (CPS), ornithine transcarbamylase (OTC), or argininosuccinic acid synthetase (AS)), and a pre-prodrug of phenylacetate (PAA). ...orders involving deficiencies of carbamylphosphate synthetase (CPS), ornithine transcarbamylase (OTC), or argini...

Replidyne's Investigational Antibacterial Agent REP3123 Prevents Toxin Production in Clostridium difficile

...iting an essential enzyme in the bacterial cell called methionyl tRNA synthetase, which blocks the organism from synthesizing proteins. Methionyl tRNA synthetase is a novel target that has not been previously exploited by antibiotics and REP3123 shows no cross-resistance to currently marketed antibacterial agen...

Replidyne's Investigational Antibacterial Agent REP3123 Prevents Sporulation in Clostridium difficile

...iting an essential enzyme in the bacterial cell called methionyl tRNA synthetase, which blocks the organism from synthesizing proteins. Methionyl tRNA synthetase is a novel target that has not been previously exploited by antibiotics and REP3123 shows no cross-resistance to currently marketed antibacterial agen...
synthetase in Biological News

Scripps Research scientists observe human neurodegenerative disorder in fruit flies

... need them to grow, divide, and survive." When mutations in tyrosyl-tRNA synthetase were linked to Charcot-Marie-Tooth disease a few years ago, scientists deba...is one. He reckoned that, if one could first show that a CMT-causing mutant synthetase was active for protein synthesis, then recreating the same disease in anoth...

A new mouse model provides insight into genetic neurological disorders

...tanding and treating the diseases. The researchers made a mutation in a protein, which is part of the protein building machinery, called glycyl-tRNA synthetase (GARS). As described in their study in Disease Models & Mechanisms (DMM), dmm.biologists.org> mice with mutations in the GARS gene have some of the s...

Duke software dramatically speeds enzyme design

... has had a long collaboration with Amy Anderson of the University of Connecticut to biochemically test the algorithm's accuracy using the Gramicidin S synthetase enzyme system, which produces the natural antibiotic in Bacillus brevis bacteria. In the new PNAS report, Ivelin Georgiev, Donald's computer scie...

'Fishy' clue helps establish how proteins evolve

...s make proteins, a tightly coordinated pair of molecules a tRNA and a tRNA synthetase ensure that the correct amino acid is added in a growing protein chain. Th... Sciences, which partially supported the work. "The unique way in which the synthetase binds its tRNA substrate is a testament to the ancient roots of this remark...

UC Davis researchers discover Achilles' heel in pancreatic cancer

...man pancreatic tumors, they measured levels of an enzyme argininosuccinate synthetase required to synthesize arginine. The enzyme was not detected in 87 perc...ancreatic cell lines that represent the varying levels of argininosuccinate synthetase observed in human tumor specimens. Focusing on the lines with lowest levels...

Loss of a universal tRNA feature reported

... differs considerably from similar enzymes in other organisms. We have indeed been able to detect an impact on particular regions of the histidyl-tRNA synthetase that are critical for recognizing tRNA." The researchers used bioinformatic tools such as a computer script ?specifically written by the group...

Leukemic cells find safe haven in bone marrow

...logy department. Downing is a co-author of "The Journal of Clinical Investigation" paper. The "ASNS" gene controls production of the enzyme asparagine synthetase (ASNS), which leukemic cells use to make asparagine. The study’s findings also suggest that drugs now being developed to block ASNS should be tes...

Tearing down the fungal cell wall

... secondary metabolism, commented: "The finding that a non-ribosomal peptide synthetase is integral to conidial morphology further illustrates the versatile and es...our knowledge, this is the first report that a fungal non-ribosomal peptide synthetase is associated with cell wall construction in fungal spores. The putative se...

'Sticky' mice lead to discovery of new cause of neurodegenerative disease

...ti region, we decided to look closer at the tRNA synthetase gene. And there it was." To set aside any dou...bts they might have had about the role of the tRNA synthetase gene, Ackerman and her colleagues showed that they... techniques to insert a normal version of the tRNA synthetase gene. To understand the specific defect in th...

Transgenic plants remove more selenium from polluted soil than wild plants, new tests show

...ines were engineered to produce more of the enzymes gamma-glutamyl cysteine synthetase (ECS) and glutathione synthetase (GS), both of which play key roles in the production of glutathione. Glutat...
synthetase in Biological Technology

Scripps Research Institute Highlights Groundbreaking Work of aTyr Pharma Scientific Co-Founder

... cytokine-disrupting mutations in the tyrosyl tRNA synthetase do not disturb the activity required for protein s...gnaling activities that are normally masked in the synthetase enzymes. The novel cell signaling activities associated with the tyrosyl tRNA synthetase extends to the whole family of synthetases and is ...

Replidyne Announces 2007 Fourth Quarter and Full Year Results

...ntingent supply agreement costs related to the faropenem program and $1.5 million of product acquisition cost in 2006 to complete the purchase of tRNA synthetase technology from GlaxoSmithKline which includes Replidyne's C. difficile program and REP8839. Sales, general and administrative expenses for the four...

Hyperion Therapeutics, Inc. Announces Senior Management Team and $15M Financing Event

...ents with urea cycle disorders involving deficiencies of carbamylphosphate synthetase(CPS), ornithine transcarbamylase (OTC), or argininosuccinic acid synthetase (AS). BUPHENYL should not be administered to patients with known hypersensitivity to sodium phenylbutyrate or any component of this preparation. The m...

Oragene is compatible with TaqMan SNP genotyping

... well with TaqMan SNP Genotyping Assays. SNPs in the thymidylate synthetase and apolipoprotein E genes were reliably detected. ... Figure 1 shows the allelic discrimination plot for the thymidylate synthetase assay and Figure 2 shows the plot for the apolipoprotein E assay...

Oragene and Whole Genome Amplification with GenomiPhi

...sis for a 560 bp fragment of the human thymidylate synthetase gene. SNP genotyping ... A TaqMan SNP Genotyping Assay for the thymidylate synthetase (TYMS) gene was obtained from Applied B...an allelic discrimination plot for the thymidylate synthetase assay. The plot is presented as the sig...

Designing Controls for siRNA Experiments

...ed. One way is to assess levels of 2'5'-oligoadenylate synthetase mRNA (6). 2'5' oligoadenylate synthetase catalyzes the synthesis of 2'-5' polyadenylic acid, wh...
synthetase in Biological Products

Rabbit Anti-Asparagine synthetase Monoclonal Antibody, Unconjugated, Clone EP282Y from Abcam

Description: Rabbit monoclonal [EP282Y] to Asparagine synthetase ( Abpromise for all tested applications). Antigen: Synthetic peptide corresponding to residues in the C-terminus of Human Asparagine synthetase. Entrez GeneID: 440 SWISS Protein ID: P08243...
Company:Abcam

Rabbit Anti-Asparagine synthetase Monoclonal Antibody, Unconjugated, Clone EP282Y from Abcam

Description: Rabbit monoclonal [EP282Y] to Asparagine synthetase ( Abpromise for all tested applications). Antigen: Synthetic peptide corresponding to residues in the C-terminus of Human Asparagine synthetase. Entrez GeneID: 440 SWISS Protein ID: P08243...
Company:Abcam

Rabbit Anti-Leucyl tRNA synthetase Polyclonal Antibody, Unconjugated from Abcam

Description: Rabbit polyclonal to Leucyl tRNA synthetase ( Abpromise for all tested applications). Antigen: L930-H1176 denatured human recombinant LRS. Entrez Gene ID: 3926 Swiss Protein ID: Q9P2J5...
Company:Abcam

Rabbit Anti-Tryptophanyl tRNA synthetase Polyclonal Antibody, Unconjugated from Abcam

Description: Rabbit polyclonal to Tryptophanyl tRNA synthetase ( Abpromise for all tested applications). Antigen: Recombinant full length protein (Human): Tryptophanyl tRNA synthetase Entrez Gene ID: 7453 Swiss Protein ID: P23381...
Company:Abcam

Baker's yeast (S. cerevisiae) S-Acetyl-coenzyme A synthetase from Sigma-Aldrich

Description: Acetate: CoA ligase (AMP forming), Acetate thiokinase Packaging: Package size based on protein content. Physical form: Lyophilized powder containing stabilizers as potassium phosphate, sucrose and reduced glutathione Preparation Unit Definition: One unit will form 1.0 mol of S-acetyl coenzyme...
Company:Sigma-Aldrich

Rabbit Anti-Human MTHFD1 Polyclonal Antibody, Unconjugated from Atlas Antibodies

Description:...ynthase) [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)]. [Source:Uniprot/SWISSPROT;Acc:P11586] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
Company:Atlas Antibodies

Pyrophosphate Fluorometric (Blue) Assay Kit, EnzChek® from Molecular Probes (Invitrogen)

Description:...spectrophotometric determination of aminoacyl-tRNA synthetase activity.3 In addition, we have tested the ability... the PPi liberated by the activities of acetyl-CoA synthetase (Figure 3) and luciferase (Figure 4). In these exp...we have detected as few as 5 10-5 U of acetyl-CoA synthetase activity and 10-2 U of luciferase activity....
Company:Molecular Probes (Invitrogen)

Ribonucleic acid, transfer from baker's yeast (S. cerevisiae) from Sigma-Aldrich

Description:... Analysis Note: Evaluated for its amino acid acceptor activity using aminoacyl-tRNA synthetase and a mixture of amino acids Ala, Asp, Gly, Ile, Lys, Pro, Thr, Val, Arg, Glu, His, Leu, Phe, Ser, Tyr. Preparation Unit Definition: One unit will yie...
Company:Sigma-Aldrich
synthetase in Biological Definition

ATPase

...rocess is considered active transport . ATP synthetase The ATP synthetase (or ATP synthase ) of mitochondria and chlorop...motion bonds ADP and P together to create ATP. ATP synthetase can also function in reverse; that is, use energy ...

Citric acid cycle

...;-Ketoglutarate dehydrogenase Oxidative decarboxylation NAD + + CoA-SH NADH + H + + CO 2 VI. Succinyl-CoA 6. Succinyl-CoA synthetase Hydrolysis GDP + P i GTP + CoA-SH VII. Succinate 7. Succinate dehydrogenase Oxidation FAD FADH 2 V...

Citric acid cycle

...;-Ketoglutarate dehydrogenase Oxidative decarboxylation NAD + + CoA-SH NADH + H + + CO 2 VI. Succinyl-CoA 6. Succinyl-CoA synthetase Hydrolysis GDP + P i GTP + CoA-SH VII. Succinate 7. Succinate dehydrogenase Oxidation FAD FADH 2 V...

Proton pump

...e ATPase proton pumps of other cellular membranes, ATP itself powers this transport. The F 0 F 1 ATP synthase of mitochondria and the CF 1 ATP synthetase of chloroplasts, in contrast, usually conduct protons from high to low concentration across the membrane while drawing energy from this flow to synthe...

Urea cycle

.... Reactions of cycle: NH 3 (ammonia) + CO 2 + 2 ATP → carbamoyl phosphate + 2 ADP + P i ( catalyzed by carbamoyl phosphate synthetase ) carbamyl phosphate + ornithine → citrulline + P i citrulline + aspartate + ATP → argininosuccinate + AMP + PP i ( c...
synthetase in Biological Dictionary

Elongation factor

...nd to the formation of the last one. Interaction of elongation factor -1alpha and pleckstrin homology domain of ... Mammalian valyl-tRNA synthetase forms a complex with the first elongation factor . ... Transcription elongation factor SII. Wind M, Reines D. ... Transcriptional Elong...
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