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Surrogate in Medical News

New Life Agency, Inc. Continues to Trial Against Beitler Services, Inc. in Pursuit of Payments for Surrogate Maternity Claims

LOS ANGELES, May 19 /PRNewswire/ -- New Life Agency filed suit against Beitler Services on November 10, 2008 for breach of contract. This lawsuit grew out of a previous contractual relationship between New Life Agency and Beitler Services which ended in December 2005. Once New Life Agency ass...

Hyperferritinemia is another surrogate marker of advanced liver disease

High serum ferritin, being a hallmark of hereditary hemochromatosis , is frequently found in chronic hepatitis C, alcoholic or non-alcoholic steatohepatitis and non-alcoholic fatty liver disease patients . A study in Italy has investigated the link between ferritin and steatosis in a non-obese coh...

Court Refuses to Intervene for Law on Surrogate Motherhood

The Delhi High Court Wednesday asked a woman advocate, seeking judicial intervention for enactment of a law on the issue of surrogate motherhood and hiring of wombs// in India, to instead approach the government. A division bench of Chief Justice M.K. Sarma and Justice Sanjiv Khanna directed ...

Mice model becomes surrogate for human prostate

Another importance of stem cells comes to the fore front as claimed by Australian scientists who have grown a human prostate in mice. This is the first time in the world that such a feat has been accomplished. // The feat is to grow a human prostate gland in mice using embryonic stem cells. ...

Islamic Medical Ethics opposes Irreversible contraceptive and surrogate motherhood.

During a workshop on Islamic Medical Ethics new rules and flexibility to certain existing rules were done. The workshop was attended by national and international physicians who wanted the Islamic Medical Ethics little comfortable and flexible. //Dr. Malika Haque, Clinical Professor Pediatrics, Ohi...

Lilly Receives Fourth FDA Approval for ALIMTA(R) (pemetrexed for injection)

... indication was approved under 21 CFR 314.500 et seq (Subpart H - Accelerated Approval of New Drugs for Serious or Life-Threatening Illnesses) using a surrogate endpoint. (5) American Cancer Society, "What Is Non-Small Cell Lung Cancer?," October 15, 2007, American Cancer Society, http://www.cancer.org/docr...

BioArts International Clones 9-11 Hero Dog - Owner to Receive Five Cloned Puppies June 17 in Los Angeles

... unrelated dogs with genes from Trakr, stimulated the resulting "couplets" to develop into embryos, then transferred the embryos to dogs who served as surrogate mothers. After normal pregnancies, they gave birth to puppies that are genetically identical to Trakr, the first of which was born December 8, 2008 a...

AMP urges inclusion of molecular diagnostic tests in comparative effectiveness research

...d the continued advancement of quality measures in laboratory medicine; the development of proficiency testing methods as alternatives to distributing surrogate test specimens; and, the development of appropriate quality assurance measures for new technologies such as whole genome sequencing. Finally, as Dr...

Indiana U. research at the American College of Sports Medicine conference

...acebo an hour before running on a treadmill. Pulmonary function tests were conducted 15 minutes before the a eucapnic voluntary hyperpnea challenge (a surrogate for an exercise challenge) and then again 1, 5, 10, 15 and 30 minutes afterward. For someone weighing 150 pounds, 3 to 9 milligrams of caffeine per ...

Avastin Shows No Benefit Against Early Stage Colon Cancer

...control group. Other experts inserted notes of caution. "Avastin in an adjuvant setting in this trial did not meet its endpoint which is a good surrogate endpoint for overall survival," said Dr. Vincent Chung, assistant professor of medical oncology at City of Hope Cancer Center in Duarte, Calif. "We ne...
Surrogate in Medical Technology

Landmark Study for GSK's Cervical Cancer Vaccine Published in The Lancet

...he probability the abnormal cells will become cancer cells. CIN 1, 2 and 3 refers to mild, moderate or severe cell changes respectively. CIN 2+ is the surrogate marker for cervical cancer. Worldwide, more than 500,000 women will be newly diagnosed with cervical cancer and 280,000 women will die from it each ye...

ALP Life Sciences, LLC Announces Nanoveson(TM) Patent Filing and Whitepaper Availability on Proposed Therapy for Non-Alcoholic Fatty Liver Disease (NAFLD) and Comorbid Diseases

...ory metabolism. Orphan disease indication targets for inflammatory diseases may be pursed through clinical trials focused on arachidonic acid specific surrogate end points. David K. Barker, Founder and CEO of ALP Life Sciences, LLC stated, "The preliminary evidence for the Nanoveson(TM) hypotheses is very...

Amicus Therapeutics Commences Phase 3 Trial Evaluating Amigal(TM) for the Treatment of Fabry Disease

... reached agreement with the U.S. Food and Drug Administration (FDA) on the key protocol design elements of the pivotal trial, including the use of the surrogate primary endpoint of the change in the amount of kidney interstitial capillary GL-3, the substrate that accumulates in the cells of Fabry patients. In...

Tolerx Presents Data at 69th Scientific Sessions of the American Diabetes Association

...ils Dose Optimization of Pre-Clinical Otelixizumab surrogate NEW ORLEANS, June 8 /PRNewswire/ -- Tolerx, I...-clinical dose-optimization study conducted with a surrogate of its Phase 3 anti-CD3 monoclonal antibody, oteli...rve beta cell function as measured by c-peptide, a surrogate measure of beta cell function. The primary endpoi...

Perceptive Informatics Enhances Investigator Application of New RECIST Version in Imaging-Based Oncology Trials

...on of the new RECIST 1.1 criteria. These experts will address medical, scientific, and regulatory solutions to improve the use of medical imaging as a surrogate endpoint in oncology trials. "Independent review using RECIST is an essential part of pivotal oncology trials," said Kenneth G. Faulkner, Ph.D.,...

TargeGen Announces Successful Completion of Patient Enrollment in Clinical Trial of JAK2 Inhibitor TG101348 in Myelofibrosis Patients and Scheduled Presentation of Preliminary Trial Data at EHA Conference in Berlin

... included identification of a maximum tolerated dose (MTD) in the dose-escalation phase and accumulation of safety data, assessments of drug effect on surrogate markers, biomarkers, and presumptive clinical endpoints in both phases of the study. Preliminary trial data presented at the 2008 ASH conference indic...

Perceptive Informatics Introduces Medical Imaging Methodology to Accelerate Development Decisions About Alzheimer's Treatments

...possible for new compounds. Medical imaging is increasingly being used as a surrogate endpoint or biomarker of drug efficacy in all phases of CNS trials. With th... Informatics Medical Imaging Group has helped to develop and validate novel surrogate endpoints for a variety of CNS disorders. Perceptive offers a range of capa...

Cepheid Announces European Release of First On-Demand Molecular Test for Simultaneous Detection of Mycobacterium tuberculosis (TB) and Resistance to Rifampicin

...y identify Mycobacterium tuberculosis (MTB) and resistance to rifampicin (RIF), a common first-line drug for treatment of the disease and a reliable surrogate marker of strains that are multidrug-resistant (MDR-TB). Xpert MTB/RIF is expected to enable clinicians to dramatically improve patient outcomes...

CSL Behring Receives Orphan-Drug Exclusivity for RiaSTAP(TM), First and Only Approved Treatment of Acute Bleeding Episodes in Patients with Congenital Fibrinogen Deficiency

...brinogenemia. Approval was based on a pivotal phase II prospective, open-label pharmacokinetic (PK) and safety study using maximum clot firmness as a surrogate endpoint for hemostatic efficacy. "As a leader in developing safe, effective and high-quality biologic therapies, CSL Behring is committed to me...

FDA Submission of B-R-A-H-M-S MR-proANP Kryptor

...rohormone fragment: the Mid-Regional pro-Atrial Natriuretic Peptide (MR-proANP). In contrast to the mature peptide, MR-proANP is a stable and reliable surrogate measurement of atrial natriuretic peptide levels. The clinical benefits of MR-proANP were analyzed within an international, multi-center, prosp...
Surrogate in Medical Definition

Surrogate markers

...ed that this article or section be merged into surrogate endpoint . ( Discuss ) A surrogate marker (or surrogate end point ) is term used in medical research for a...
Surrogate in Medical Dictionary

Surrogate

A surrogate mother is the woman who is pregnant with the child and intends to ... Presently, the idea of surrogate motherhood has gained some societal acceptance ... A surrogate key in a database is a unique identifier for either an entity in the modeled world or an object in the data...
Surrogate in Biological News

Two-pronged model could help foil tough cystic fibrosis infections

... Last year, the DMS researchers reported that it took far more tobramycin to destroy biofilm pockets than can be delivered to the lungs. Using a surrogate tissue culture system they created to simulate human airways, they determined that up to 10 times the maximum tobramycin dosage was needed. They were ...

Highlights from the March editions of ESA journals

...veness of fire fuel reduction methods under the U.S. National Fire and Fire surrogate Study. Four articles examine the effects of prescribed burns, mechanical tr...McIver J., A. Youngblood, S. L. Stephens. (2009) The National Fire and Fire surrogate Study: ecological consequences of fuel reduction methods in seasonally dry ...

Adiponectin is a metabolic link between obesity and bone mineral density

... developed by Dr. P. Scherer's research group at Albert Einstein College of Medicine, N.Y. Bone mineral density and biomechanical strength properties, surrogate measures of fracture risk at multiple skeletal sites, were the outcomes used to assess bone development. Female mice overexpressing adiponectin had we...

Running on rocket fuel

...roduction. However, staying in nature's fast lane isn't easy, and necessitates that evolution comes up with a "business plan" to bank energy (nature's surrogate for wealth!) to survive. In the face of bigger competitors like lions and hyenas, whose larger stomachs cater for irregular meals, and which maximize ...

Southern Sierra Science Symposium planned for Visalia

...ence Advisory Board for the new Giant Sequoia National Monument and the steering committee for the National Study of the Consequences of Fire and Fire surrogate Treatments. Additionally, he is a founding member and steering committee member of CIRMOUNT (the Consortium for Integrated Climate Research in Western...

Genome of simplest animal reveals ancient lineage, confounding array of complex capabilities

...erkeley. "Trichoplax has had just as much time to evolve as humans, but because of its morphological simplicity, it is tempting to think of it as a surrogate for an early animal," said Mansi Srivastava, the study's first author, a graduate student under the direction of Rokhsar, at the Center for Integrativ...

Newly identified role for 'power plants' in human cells could lead to targeted therapies

...from the cytoplasm to the mitochondria was restored. "These were cells from an actual patient, so this also makes the argument that we don't need a surrogate system from other organisms to set the import process in motion," Alfonzo said. ...

Tests show LLNL detection instrument can monitor the air for all major terrorist threat substances

... of each other without reconfiguring the SPAMS instrument." (In some cases, surrogate materials were used.) Last spring, the researchers announced that their ...rax); diethyl phthalate (a nerve agent surrogate), natural cobalt powder (a surrogate for Cobalt 60 and other radioactive metals) and trinitro-1,3,5-triazinane (...

Tooth loss strongly linked to risk of esophageal, head and neck, and lung cancer

...own to increase risk for stroke and heart disease. Tooth loss is a common consequence of chronic bacterial infection and may, therefore, serve as a surrogate for chronic infection and inflammation, which in turn may be important to the pathogenesis of cancer, said the studys lead author, Akio Hiraki, Ph.D.,...

Using ground-penetrating radar to observe hidden underground water processes

...ponents, the presence of water in the soil principally governs GPR wave propagation. Therefore, GPR-derived dielectric permittivity is usually used as surrogate measure for soil water content. In the areas of unsaturated zone hydrology and water resources, GPR has been used to identify soil layering, locat...
Surrogate in Biological Technology

Dendreon Publishes Manuscript on CD54 as a Surrogate Marker of Antigen Presenting Cell Activation

SEATTLE, March 3 /PRNewswire-FirstCall/-- Dendreon Corporation (Nasdaq: DNDN) announced the publication of a manuscript titled, "CD54 is a surrogate marker of antigen presenting cell activation" in Cancer Immunology, Immunotherapy. The manuscript describes and supports the use of CD54 as a s...

Amicus Therapeutics Announces Second Quarter 2009 Financial Results

... reached agreement with the U.S. Food and Drug Administration (FDA) on the key protocol design elements of its pivotal trial, including the use of the surrogate primary endpoint of the change in the amount of kidney interstitial capillary GL-3, the substrate that accumulates in the cells of Fabry patients. In...

VIA Pharmaceuticals Receives Anticipated Notice From NASDAQ

...n expected timetables and the outcomes of such clinical trials; complexities in designing and implementing cardiometabolic clinical trials using surrogate endpoints in Phase 1 and Phase 2 clinical trials which may differ from the ultimate endpoints required for registration of a candidate drug; the...

Rules-Based Medicine, Inc. Launches DiscoveryMAP(TM) Service for Drug and Diagnostic Development

...hers require sensitive and quantitative data to pinpoint the biomarker patterns that are either directly involved in the disease process or are useful surrogate markers. When those patterns can be reliably measured, the efficiency of drug development is accelerated while achieving greater efficacy and safety....

Celsense, Inc Receives NIH Grant to Translate Cell Imaging Technology for Clinical Use

...y the number of labeled cells in a user-specified region of interest. It is expected that in vivo cellular imaging will routinely be used to provide a surrogate biomarker for certain cellular therapeutic and drug trials. About Celsense, Inc. Celsense, Inc. is a biotechnology company offering novel pre-cli...

OncoGenex Pharmaceuticals Announces OGX-427 Treatment Demonstrates Safety, Evidence of Declines in Circulating Tumor Cells and Reductions in Tumor Markers in a Phase 1 Cancer Trial

...) with prostate cancer and a reduction in CA-125 levels was observed in 3 of 5 patients (60%) with ovarian cancer. "CTCs are emerging as an exciting surrogate of anti-cancer activity. The frequent decreases in total and Hsp-27 positive CTC counts, coupled with decreases in serum PSA and CA-125 levels in pati...

Cepheid Announces Symposium Speakers and Program Highlights for 19th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)

...esistant to rifampicin, a commonly used first-line drug for treatment of the disease. Many studies have shown that rifampicin resistance is a reliable surrogate marker of strains that are multidrug-resistant TB (MDR-TB), and the frequency of MDR-TB is increasing in the EU. The test is expected to enable clinic...

Transgenomic Completes Licensing Option With Dana-Farber Cancer Institute on Cold-PCR for Enrichment of DNA Mutations

...llele ratio detection in a routine, cost-effective and high throughput protocol. This level of detection will allow straightforward tumor analysis via surrogate tissues such as blood and urine. About Transgenomic Transgenomic is a global biotechnology company that provides unique products and servic...

Amicus Therapeutics Presents Positive Results From Phase 2 Extension Study of Amigal(TM) for Fabry Disease at ACMG 2009 Annual Meeting

...DA supports a Phase 3 clinical trial comparing Amigal to placebo based on a surrogate primary endpoint of the change in the amount of kidney GL-3, the substrate ...inability to reach final agreement with regulatory agencies on the use of a surrogate endpoint and phase 3 trial design for Amigal, the potential that the interi...

Cepheid Announces New Diagnostic Technology to Aid World Efforts in Halting the Spread of Mycobacterium Tuberculosis (TB)

...ts the presence of TB, but also identifies whether it is resistant to Rifampicin, a common first-line drug for treatment of the disease and a reliable surrogate marker of strains that are multidrug-resistant (MDR-TB). The test is expected to enable physicians to dramatically improve patient outcomes -- possibl...
Surrogate in Biological Definition

Cloning

...uccessful. In 2000 , a cow named Bessie gave birth to a cloned Asian guar, an endangered species; this provided hope that similar techniques (using surrogate mothers of another species) might be used to clone extinct species; in anticipation of this possibility, the last bucardo, a Spanish mountain goat, wa...

Infertility

...and placed in one of the fallopian tubes, along with the man's sperm. This allows fertilization to take place inside the woman's body. Use of a surrogate mother to carry the child. Ethics There are many ethical issues associated with infertility and its treatment. High-cost treatments are o...
Surrogate in Biological Dictionary

Genomic complexity

...k-order between species genomic complexity is VSV < E. coli < S. ... Genomic complexity scores were derived and correlated with the surrogate ... In multivariate analysis, genomic complexity emerged as an independent risk ... PLoS ONE: an inclusive, peer-reviewed, open-access resource...

Endemism

...e Merriam-Webster Online Dictionary with audio pronunciations, ... Learn more about " endemism " and related topics at Britannica.com ... posted to surrogate relation endemism biodiversity by liucun on 2009-01-08 01:22: ... Areas of endemism and patterns of diversity for aphids of the Qinghai-Tibetan ...

Egg

... excitement, ... EGG follows the cast and crew of the new musical "Traps! ... Facilitates egg donation and surrogacy. Accepting egg donor and surrogate applications. to egg (third-person singular simple present eggs , present participle egging, ... ( genitive singular eggs , plural egg ) (zool...
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(Date:10/22/2014)... HealthDay Reporter , TUESDAY, Oct. 21, ... may lead to increased blood pressure, according to a new ... in blood pressure for young adult women or for teenagers, ... drank lightly or moderately, their risk of high blood pressure ... parallels studies in older adult men and women," said lead ...
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(Date:10/16/2014)... Cancer constantly wages war on the human body. ... a stalemate. In pancreatic cancer, this stalemate—known as ... becoming aggressively malignant, a phenomena that is poorly ... in the laboratory of Salvatore Torquato, a Professor ... the conditions surrounding tumor dormancy and the switch ...
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Breaking Biology News(10 mins):Modeling tumor dormancy 2New report synthesizes best available science on management of moist mixed-conifer forests 2Plant communities produce greater yield than monocultures 2Plant communities produce greater yield than monocultures 3
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