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subunit in Medical News

Immune responses to flu vaccine are diminished in lupus patients

...Led by Albert Holvast, of the University of Groningen in The Netherlands, the study involved 54 patients with SLE and 54 healthy controls who received subunit flu vaccine, out of a total of 78 patients in each group. Patients were randomized 2:1 to receive a flu vaccine or serve as a nonvaccinated control. ...

Caltech chemists say antibody surrogates are just a 'click' away

...king"smaller subunits together. To create a capture agent for a particular protein, the scientists devised a stepwise approach in which the first subunit of the capture agent is identified, and that unit, plus the protein, is used to identify the second subunit, and so on. For the first subunit, a fluor...

DOR BioPharma Appoints Christopher P. Schnittker, CPA, as Vice President of Administration and Controller

..., DOR is developing biomedical countermeasures pursuant to the Project BioShield Act of 2004. DOR's biodefense products in development are recombinant subunit vaccines designed to protect against the lethal effects of exposure to ricin toxin, botulinum toxin and anthrax. DOR's ricin toxin vaccine, RiVax(TM),...

Defeating nicotine's double role in lung cancer

...rs (nAChRs), may serve as an anticancer agent. The antagonist, called d-tubocurarine/α-Cobratoxin (α-CbT), specifically targeted the α7 subunit of nAChRs, the area primarily associated with increased cell proliferation. In this study, the authors took the research a step further and showed ...

DOR BioPharma Announces Potential $30 Million North American Partnership Agreement with Sigma-Tau Pharmaceuticals for orBec(R) in the Treatment of Graft-versus-Host Disease

..., DOR is developing biomedical countermeasures pursuant to the Project BioShield Act of 2004. DOR's biodefense products in development are recombinant subunit vaccines designed to protect against the lethal effects of exposure to ricin toxin, botulinum toxin and anthrax. DOR's ricin toxin vaccine, RiVax(TM),...

Nose-spray vaccine against botulism effective in first tests

...se. Secondly, the hope is that a new, well-defined subunit vaccine will enable authorities to provide an effe...s, we believe the design of a safe and inexpensive subunit vaccine can now proceed rapidly." The study was...dding greatly to cost and slowing the process. subunit vaccines like the one in the current study include...
subunit in Medical Technology

Proteolix, Inc. Drug Candidate, PR-957, Prevents Disease Progression in Rheumatoid Arthritis Models by Selective Inhibition of the Immunoproteasome

...ed: A Selective Inhibitor of the Immunoproteasome subunit LMP7 Blocks Cytokine Production and Attenuates Pro...f the immune system. PR-957 selectively targets a subunit of the immunoproteasome, known as LMP7. Inhibition of this subunit results in a decrease of the immune cell signaling...

DOR BioPharma Receives EMEA Agreement on the Design of its Confirmatory Phase 3 Clinical Trial of orBec(R) in GI GVHD

..., DOR is developing biomedical countermeasures pursuant to the Project BioShield Act of 2004. DOR's biodefense products in development are recombinant subunit vaccines designed to protect against the lethal effects of exposure to ricin toxin, botulinum toxin and anthrax. DOR's ricin toxin vaccine, RiVax(TM),...

Intercell Starts a Phase I Clinical Trial for a New Streptococcus pneumoniae Vaccine

... candidate IC47 to prevent disease caused by the bacterium Streptococcus pneumoniae has started. Intercell's vaccine candidate is a recombinant subunit vaccine consisting of three conserved surface proteins from Streptococcus pneumoniae . Two of these proteins were discovered using Intercell's propri...

DOR BioPharma, Inc. Executes $400,000 Equity Investment Agreement With Numoda Corporation

..., DOR is developing biomedical countermeasures pursuant to the Project BioShield Act of 2004. DOR's biodefense products in development are recombinant subunit vaccines designed to protect against the lethal effects of exposure to ricin toxin, botulinum toxin and anthrax. DOR's ricin toxin vaccine, RiVax(TM),...

Aerovance Initiates Phase IIb Clinical Trial with Aerovant(TM) for the Treatment of Uncontrolled Asthma

...f asthma. For more information, visit www.aerotrial.com . Aerovant is a recombinant human IL-4 variant that is a potent inhibitor of the alpha subunit of the IL-4 receptor (IL-4R alpha), a shared component of both the IL-4 and IL-13 receptor complexes. Aerovance acquired the worldwide rights to the ...

ATL/TV1102 Trial Results Presented at World Congress on Treatment and Research in Multiple Sclerosis

...hat inhibit the expression of proteins by sequence-specific binding to the protein's mRNA. ATL1102 is a 2nd generation antisense inhibitor of CD49d, a subunit of Very Late Antigen 4 (VLA-4) which plays a key role in cell adhesion to vessel walls. VLA-4 blockade, as shown by monoclonal antibodies such as nata...
subunit in Medical Products

Alpha Subunit of Pituitary Glycoprotein Hormones

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

ALS, Total ELISA Test

Description:... Acid-labile subunit (ALS) is a GH dependent protein which is produced in the liver as a 578 ami...ting of IGFBP-3, a molecule of IGF-I or IGF-II, and this unique acid-labile subunit (ALS) [1-6]. The first description of ALS was based on the observation tha...
Company:Diagnostic Systems Laboratories, Inc.

Free Activin AB ELISA Test

Description:...bins are heterodimers consisting of a common a-subunit linked to either a A subunit (Inhibin A) or B subunit (Inhibin B) by disulfide bridges, and in contrast to the Activins, inhibit ...
Company:Diagnostic Systems Laboratories, Inc.

Free Activin A ELISA Test

Description:...bins are heterodimers consisting of a common a-subunit linked to either a A subunit (Inhibin A) or B subunit (Inhibin B) by disulfide bridges, and in contrast to the Activins, inhibit ...
Company:Diagnostic Systems Laboratories, Inc.

Free Activin B ELISA Test

Description:...bins are heterodimers consisting of a common a-subunit linked to either a A subunit (Inhibin A) or B subunit (Inhibin B) by disulfide bridges, and in contrast to the Activins, inhibit ...
Company:Diagnostic Systems Laboratories, Inc.

Inhibin B ELISA Test

Description:...alpha-subunit and betaB-subunit. Only the dimeric forms of the molecule, containing both the alpha and beta subunits, are bioactive, although the free subunit forms exist in circulation. Inhibins are secreted by ovarian granulosa cells in females and by testicular Sertoli cells in males [1]. Both inhibin A...
Company:Diagnostic Systems Laboratories, Inc.
subunit in Biological News

Baumann lab identifies elusive telomere RNA subunit in single cell model

The Stowers Institutes Baumann Lab has identified the long-sought telomerase RNA gene in a single-cell research model. Their findings have been posted to the Web site of the journal Nature Structural & Molecular Biology and will appear in a future print edition. Chromosomes shorten with every ...

Study finds DNA barcoding requires caution without closer examination

... still much debate over which gene sequence region should be used and its reliability. In animals, the 5' segment of mitochondrial cytochrome oxidase subunit I (COI) is relatively established as a barcoding marker, but Spooner highlights many groups where COI fails to distinguish species. The COI region fa...

TRAPping proteins that work together inside living cells

... tail -- also known as the C-terminus of the alpha subunit -- touches anything else in the core of the RNA po...the beta subunit, suggesting the tail of the alpha subunit makes contact with the beta subunit as it plugs along. This interaction had never been...

Protein analysis methods, viral vectors featured in Cold Spring Harbor Protocols

...cular weight. In conjunction with differential in-gel electrophoresis (DIGE), BN-PAGE can be used to quantify changes in protein complex abundance or subunit composition between different samples. The article presents detailed methodology for BN-PAGE, SDS-PAGE, and DIGE. It is freely available on the webs...

Getting down to cancer basics

... structure, called chromatin, is not simply a scaffold, but plays an active role in controlling gene activity. The UTX protein alters a key organising subunit component of chromatin, called a histone. The protein is likely to be involved in both turning genes on and off, making it a key regulator of the yin-...

A paradigm shift in immune response regulation

...oordinates the gene expression necessary for the cell's immune response. NF-κB is activated by an enzyme (IkappaB-Kinase, IKK) with a regulatory subunit that brings to mind the mysterious captain in Jules Verne's science fiction novels: NEMO. The question that had to be answered was how does NEMO ac...
subunit in Biological Technology

DOR BioPharma Receives FDA Orphan Drug Designation for orBec(R) for the Treatment of Chronic Gastrointestinal GVHD

..., DOR is developing biomedical countermeasures pursuant to the Project BioShield Act of 2004. DOR's biodefense products in development are recombinant subunit vaccines designed to protect against the lethal effects of exposure to ricin toxin, botulinum toxin and anthrax. DOR's ricin toxin vaccine, RiVax(TM),...

DOR BioPharma Announces Issuance of European Patent for its LPM(TM) Oral Drug Delivery Technology

..., DOR is developing biomedical countermeasures pursuant to the Project BioShield Act of 2004. DOR's biodefense products in development are recombinant subunit vaccines designed to protect against the lethal effects of exposure to ricin toxin, botulinum toxin and anthrax. DOR's ricin toxin vaccine, RiVax(TM),...

DOR BioPharma Announces Publication of orBec(R) Clinical Pulmonary Data in Bone Marrow Transplantation

..., DOR is developing biomedical countermeasures pursuant to the Project BioShield Act of 2004. DOR's biodefense products in development are recombinant subunit vaccines designed to protect against the lethal effects of exposure to ricin toxin, botulinum toxin and anthrax. DOR's ricin toxin vaccine, RiVax(TM),...

Lytix Biopharma and KAEL-GemVax Announce Joint Clinical Trial to Combine LTX-315 and GV1001 Cancer Immunotherapy

...hase I study will document the utility of LTX-315 as an immune stimulator in patients vaccinated with GV1001, a vaccine directed against the catalytic subunit of human telomerase. Telomerase is a universal tumour antigen expressed in 85-90% of cancer tissues. Corporate Enquiries: Anders Fugelli,...

DOR BioPharma Reports 1st Quarter 2009 Financial Results and Reviews Recent Accomplishments

..., DOR is developing biomedical countermeasures pursuant to the Project BioShield Act of 2004. DOR's biodefense products in development are recombinant subunit vaccines designed to protect against the lethal effects of exposure to ricin toxin, botulinum toxin and anthrax. DOR's ricin toxin vaccine, RiVax(TM),...

DOR BioPharma Reports Year-End 2008 Financial Results and Reviews Recent Accomplishments

..., DOR is developing biomedical countermeasures pursuant to the Project BioShield Act of 2004. DOR's biodefense products in development are recombinant subunit vaccines designed to protect against the lethal effects of exposure to ricin toxin, botulinum toxin and anthrax. DOR's ricin toxin vaccine, RiVax(TM),...
subunit in Biological Products

Anti-Sodium Channel, NaB2 (B2 subunit of Voltate-Gated Na+ Channel, Scn2b) Polyclonal Antibody, Unconjugated from CHEMICON

Description: Recognizes Nabeta2. The epitope specific for Nabeta2 is not present in any other known proteins. SPECIES REACTIVITIES: It is expected to work on human because the immunogen sequence is highly conserved (17/19 residues). Reactivity with other species has not yet been tested....
Company:CHEMICON

Chicken Anti-Guanine nucleotide-binding protein G(k), alpha subunit Polyclonal Antibody, Unconjugated from GenWay Biotech, Inc.

Description: Guanine nucleotide-binding protein G(k), alpha subunit...
Company:GenWay Biotech, Inc.

Chicken Anti-G4-1 (Hypothetical protein FLJ20644, likely ortholog of mouse phosphatase subunit gene g4-1) Polyclonal Antibody, Unconjugated from GenWay Biotech, Inc.

Description: G4-1, Affinity-Purified Polyclonal IgY Antibodies Hypothetical protein FLJ20644, likely ortholog of mouse phosphatase subunit gene g4-1 Protein Accession #: NP_060387.1 gi number query: 8923600 Genbank Definition: chromosome 14 open reading frame 10; likely ortholog of mouse phosphatase su...
Company:GenWay Biotech, Inc.

Rabbit Anti-Human Protein Kinase-A (PKA) Regulatory subunit IIB Antibody, Unconjugated from CEDARLANE Laboratories Limited

Description: Anti-Protein Kinase-A (PKA) Regulatory subunit IIB; rabbit host...
Company:CEDARLANE Laboratories Limited

Mouse Anti-Verotoxin II (Shiga-like) A subunit (SLT-2a) Monoclonal Antibody, Unconjugated, Clone 557 from Meridian Life Science, Inc.

Description: MAb to Verotoxin II (SLT-2a) Verotoxin II (Shiga-like) A subunit (SLT-2a)...
Company:Meridian Life Science, Inc.

Mouse Anti-Human Non-SMC condensin II complex, subunit D3 (NCAPD3) Monoclonal Antibody, Unconjugated from Lifespan Biosciences

Description: Anti-NCAPD3 Monoclonal AntibodyOther Sub-Family: not assigned-Other Applications: Immunoprecipitation, Western Blot...
Company:Lifespan Biosciences

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subunit in Biological Definition

Allostery

... two models differ most in their assumptions about subunit interaction. Concerted model The concer... in such a way that a conformational change in one subunit is necessarily conferred to all other subunits. Th...er the R state The binding of substrate to one subunit causes all other subunits to assume the R state, t...

Allostery

... two models differ most in their assumptions about subunit interaction. Concerted model The concer... in such a way that a conformational change in one subunit is necessarily conferred to all other subunits. Th...er the R state The binding of substrate to one subunit causes all other subunits to assume the R state, t...

ATP synthase

...being the F 1 particle, the stalk being the gamma subunit of F 1 , and the base and "roots" being the F O p...es the F O particle to rotate, rotating the gamma subunit of F 1 , while the major F 1 subunits are fixed i...plest known form of ATP synthase, with 8 different subunit types. Yeast ATP synthase Yeast ATP syntha...

Enzyme

...regions can also inactivate the product). This has the additional effect of making each region act, relative to mutation, somewhat like an independent subunit which can be duplicated, deleted, moved, or 'mixed-and-matched' with other such regions, generating new proteins to be tested for evolutionary success...

Fungus

...Lane, L. Simon, S. Stickel, T. M. Szaro, W. G. Weisburg, and M. L. Sogin. 1993. Evolutionary relationships within the fungi: analysis of nuclear small subunit rRNA sequences. Molecular Phylogenetics and Evolution 1:231 241. Hawksworth, D. L. 1991. The fungal dimension of biodiversity: magnitude, significa...

Ion channel

...l links Basic features An ion channel is an integral membrane protein or more typically an assembly of several proteins. Such "multi- subunit " assemblies usually involve a circular arrangement of identical or related proteins closely packed around a water-filled pore through the plane of ...
subunit in Biological Dictionary

Transmembrane proteins

... ... oligomeric transmembrane alpha-helical protein ... heteropentameric transmembrane alpha-helical protein ; 4 transmembrane helices per subunit ... ...

Structural gene

...nheritance in living organisms. ... Mouse protein-coding gene Eif2s3x. Represented by 612 ESTs from 166 cDNA libraries. ... initiation factor 2, subunit 3, structural gene X-linked. M. musculus ... operon ( ) n. A unit of genetic material that functions in a coordinated manner by means of an o...

Splicing factor

...lso mediates... a b "Entrez Gene: SF3B1 splicing factor 3b, subunit 1, 155kDa" ... Molecular architecture of the multiprotein splicing ...splicing factor 1 of m, r and h origin ... Splicing factor SF3A subunit 1 was characterized as a component of the ER-AF1 ... Krämer A (1993) Separa...

Spliceosome

...eosome [529 gene products] ... ... factor 3B subunit 1 ( Spliceosome associated protein 155) (SAP155) (SF3b155) ... Splicing factor 3A subunit 3 ( Spliceosome associated protein 61) (SAP61) ...ion. Correlation coefficient. O14547 ... factor 3B subunit 2 ( Spliceosome associated protein 145) (SAP145...

SnRNA

...can direct U6 snRNA to the minor spliceosome ... U1 and U2 snRNA are RNA polymerase II transcripts, and U2 transcriptional ... of SNAP50, a subunit of the snRNA -activating protein complex SNAPc. ... snRNA molecules are RNA helpers that edit the primary transcript, removing ... Several for...

Self-splicing

...A intron ... We report the occurrence of self - splicing group I introns in viruses that infect ... A self - splicing intron in the small subunit rRNA gene of Pneumocystis carinii. ... The Tetrahymena pre-rRNA self - splicing intron is shown to function in the ... In addition, even the ...
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