Man and mouse share genome structures
In the most detailed large-scale study to date of the proteins that package DNA, researchers have mapped a family of switches that turn genes on and off. Their findings may help scientists understand regulatory mechanisms underlying cancer and human development. The research team includes first author Bradley Bernstein, recipient of a Howard Hughes Medical Institute (HHMI) physician postd...The Shapes Of Life: NIGMS Project Yields More Than 1,000 Protein Structures
The Protein Structure Initiative (PSI), a national program aimed at determining the three-dimensional shapes of a wide range of proteins, has now determined more than 1,000 different structures. These structures will shed light on how proteins function in many life processes and could lead to targets for the development of new medicines. The PSI is a 10-year, approximately $600 million pr...Scientists solve structure of key protein in innate immune response
When bacteria invade the body, a molecule called CD14 binds to substances liberated from the bacteria and initiates the cellular defense mechanisms. In a report published in the Journal of Biological Chemistry, scientists in Korea announced their elucidation of three-dimensional structure of CD14 and showed how it is perfectly suited to bind to certain bacterial products. The research appe...Vascular structure and function improve with diet and exercise
Some structural and functional measures of cardiovascular disease risk may improve by the eighth week of a diet and exercise regimen, according to a study presented today at the American Heart Association's Sixth Annual Conference on Arteriosclerosis, Thrombosis and Vascular Biology. "Our lifestyle management program appears to improve the health of the vasculature, so it might lower the r...Biochemists report discovery of structure of major piece of telomerase; implications for cancer
UCLA biochemists have determined the three-dimensional structure of a major domain of telomerase, the enzyme that helps maintain telomeres ?small pieces of DNA on the ends of chromosomes that act as protective caps -- allowing DNA ends to be copied completely when cells are replicated. This is the first major piece of telomerase for which the structure is known. Telomerase plays a key rol...Efficient Primary Structure Elucidation of Disulfide-bridged Peptides
The primary structure determination of disulfide bridged peptides is greatly facilitated using a combination of the Procise cLC 492 s...No network infrastructure, no Olympics, no nothing
With Chicago and the region trying to add the Olympics to their list of great accomplishments, they better include updating the network infrastructure with more than just a third-party Wi-Fi agreement. The City that Networks has to look beyond national comparisons on Wi-Fi and into the real competition of global cities that have significant investments in fiber opti...Chicago-Milwaukee "mega-metro" infrastructure improvements are critical
There are already commuters from Wi...Fiber-optic infrastructure spurring city economic development
While some municipalities are fighting AT&T about Project Lightspeed and others are looking at Wi-Fi applications, others are looking at major fiber-optic investments. While these fiber investments have paid off in Utah as we mentioned in last week's column, there are others that we don't hear much about in the Midwest. As one CIO in Jacksonville, Fla. <a href="http...Cleft lip and palate are due to abnormality in brain structure
Clefts of the lip and palate are associated with permutation in brain structure that appear to cause cognitive dysfunction, according to a study recently conducted by researchers at the University of Iowa.// Studying 54 adult men with nonsyndromic facial clefts and 54 male control subjects, the researchers used magnetic resonance imaging to study brain volume and tissue composition. T...Three dimensional structure of apolipoprotein revealed
Researchers from Gladstone Institute of Cardiovascular Disease have for the first time created the three dimensional structure of apolipoprotein E using X-ray crystallography. X-ray crystallography technique // is used for determining three dimensional structures so molecules by determining the x-ray diffraction patterns of the crystals present in molecules. Researchers feel that this new discove...Relationship Between Genetic Structure And Quality of Life
Researchers are now suggesting that there might be a relationship between the state of cancer patients’ genetic structure and their quality of life during cancer treatment.// For the study researchers evaluated quality of life in nearly 500 patients who had metastatic colorectal cancer. Before patients ever received chemotherapy, quality of life and genetic marker data were evaluated. P...Abnormal Brain Structure One Of The Reasons For Depression in Adolescents
A new study shows the reason some adolescents experience depression could be abnormal brain structure.// The study states depressed teenagers tend to have a smaller hippocampus -- the part of the brain responsible for memory, learning, emotion and motivation. Researchers sampled nearly 30 adolescents between ages 13 to 18, half of who had been diagnosed with major depressive disorder.Mag...Structure of the brain to increase risk for anxiety disorders
Certain areas of the brain like the ventromedial prefrontal cortex may be associated with how people control their reactions in the face of a traumatic event.// Researchers from Massachusetts General Hospital have identified the size of the brain area as the factor that affects the incidence of people developing anxiety disorders like post-traumatic stress disorder following an accide...