Navigation Links
stromal in Medical News

Gene signature may predict patient response to therapy for gastrointestinal stromal tumors

ORLANDO (May 14, 2009)Researchers at Fox Chase Cancer Center uncovered a genetic pattern that may help predict how gastrointestinal stromal tumor (GIST) patients respond to the targeted therapy imatinib mesylate (Gleevec). Moreover, their findings point to genes that could be suppressed in order ...

Gleevec(R) substantially reduces risk of cancer returning in patients with life-threatening gastrointestinal stromal tumors (GIST), The Lancet reports

- Estimated one-year, recurrence-free survival was 98% for Kit-positive GIST patients taking Gleevec vs. 83% for patients taking placebo(1) - Historically, one in two patients experienced recurrence of GIST(2) within a median of two years after surgery(3) - Gleevec is the only treatment...

Novartis Oncology Launches GIST Alliance™ for Healthcare Professionals Treating Gastrointestinal Stromal Tumors

Novartis Oncology is introducing GIST Alliance™, a unique support program with the goal to help healthcare professionals optimize outcomes in KIT-positive GIST patients. East Hanover, NJ (PRWEB) January 29, 2009 -- Though rare, gastrointestinal stromal tumors (GIS...

Chronic infection persists by targeting stromal cell network in lymphoid organs

One of the biggest challenges to treating infectious diseases and developing preventive vaccines is the ability of many chronic infections to suppress the immune T-cell response over time. An Emory-led team of scientists has discovered one important way in which chronic viral infections are able t...

Study finds survival rates from gastrointestinal tumors improving among African-Americans

...9) New research published in the July issue of the Journal of the American College of Surgeons reveals that African Americans with gastrointestinal stromal tumors (GIST), a rare cancer that begins in the wall of the gastrointestinal tract, now have survival rates equivalent to those of Caucasians. Prior t...

Case Western Reserve University Receives $5M From Third Frontier Commission for the Center for Stem Cell & Regenerative Medicine

...al to evaluate the performance of the cells. Juventas Therapeutics, spin out company from Marc Penn (CC), will develop its lead drug product, stromal cell derived factor 1 (SDF-1), through a Phase I clinical trial for critical limb ischemia. Emerging programs With further ref...

New Prostate Cancer Biomarker Discovered

...ostate cancer revealed that the men had significantly decreased levels of a stromal protein called caveolin-1. The researchers also found that the protein was ...t print issue of Cell Cycle . "We previously showed that the absence of stromal caveolin-1 is also associated with advanced tumor stage, early recurrence a...

PLUS Diagnostics First National Laboratory to Offer Highly Specialized Gastrointestinal Tests

...ces, announced today that it is the first national laboratory to offer a highly specialized test that definitively diagnoses the rare gastrointestinal stromal tumor ("GIST"). Known as the K9 clone DOG-1 immunohistochemical assay, the new test is expected to identify up to 15 percent more people who suffer f...

New Research Sheds Light on Breast Cancer Prognosis

...und that levels of the protein caveolin-1 found in stromal connective tissue near a breast cancer tumor can a...ch plays a role in how cells absorb things, in the stromal cells were linked to a poor patient outcome in a s...issue of the journal, found that a similar lack of stromal caveolin-1 in mice was associated with more aggres...

Bayer to Present Data on Development Compound BAY 73-4506 at 45th Annual Meeting of the American Society of Clinical Oncology

... About BAY 73-4506 (DAST-Inhibitor) BAY 73-4506 is a novel oral multi-kinase inhibitor with a kinase inhibition profile targeting angiogenic, stromal and oncogenic receptor tyrosine kinases (TK). BAY 73-4506 has been shown to inhibit tumor growth in preclinical models by hitting targets along a spe...
stromal in Medical Technology

Bayer Announces New Data on Novel Anti-cancer Compound BAY 73-4506

...BAY 73-4506 is a dual targeted VEGFR2-TIE2 anti-angiogenic oral tyrosine kinase inhibitor (TKI) with a kinase inhibition profile targeting angiogenic, stromal and oncogenic receptor tyrosine kinases (TK). In preclinical studies, BAY 73-4506 has been shown to inhibit tumor growth by hitting targets along a s...

Glivec(R) is the First Adjuvant Treatment Approved in the UK to Delay Return of Gastrointestinal Cancer After Surgery

...atients With KIT (CD117)-Positive Gastrointestinal stromal Tumours (GIST), who are at Significant Risk of the...r resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-contro...port: management of patients with gastrointestinal stromal tumor (GIST)- update of NCCN clinical practice gui...

MicroRNA First Disclosed by Rosetta Genomics may Increase Efficacy of Imatinib (Gleevec(R)(1)) in Glioblastoma

...proved Treatment of Chronic Myelogenous Leukemia (CML) and Gastrointestinal stromal Tumors Manufactured by Novartis, With miR-451 had a Synergistic Effect in I...manufactured by Novartis and approved treatment of CML and gastrointestinal stromal tumors, with miR-451, a synergistic effect has been shown in inhibiting GBM...

Tengion Scientists Publish Key Preclinical Findings Demonstrating the Benefits of Organ Regeneration Vs. Repair

...study conducted with its Neo-Bladder Augment(R) will be featured in the July issue of the Journal of Urology, Vol. 180. The paper, "Early Cellular and stromal Responses in Regeneration Versus Repair of a Mammalian Bladder Using Autologous Cell and Biodegradable Scaffold Technologies," was co-authored by Teng...

New Nexavar Data Presented in Multiple Tumor Types at 44th American Society of Clinical Oncology Annual Meeting

...vania Health System, Philadelphia, PA. (abstract #6026). Gastrointestinal stromal Tumors Activity of Sorafenib in Patients with Imatinib and Sunitinib-Resistant Gastrointestinal stromal Tumors (GIST): A Phase 2 Trial of the University of Chicago Phase 2 Consort...

Southern Research Institute to Present at the 2007 American Association For Cancer Research Annual Meeting

...rn Research will be presenting new data on the different factors that contribute to tumor growth. The discussion titled "VEGF Overexpression Increases stromal Content in Both Primary Tumor and Metastatic Lesions" will be presented on Tuesday, April 17, from 11:25 a.m. - 11:40 a.m. in Room 404 A-B, Los Angele...

Infinity and MedImmune to Present Preclinical Data From Study of Oral Formulation of IPI-504 At AACR

... currently being evaluated as a water-soluble, intravenous formulation in two disease-focused clinical trials involving patients with gastrointestinal stromal tumors (GIST) and NSCLC. An oral presentation of the data, titled "IPI-504, a novel orally administered Hsp90 inhibitor, demonstrates anti-tumor eff...

Positive Results Prompt US National Cancer Institute to Make Gleevec Available To Patients in Post-Surgical Gist Study

...ng after surgery for Kit-positive gastrointestinal stromal tumors (GIST) EAST HANOVER, N.J., April 12, 2007 ...ed participants with Kit-positive gastrointestinal stromal tumors treated with Gleevec following surgery were...forthcoming scientific meeting. Gastrointestinal stromal tumors (GIST) belong to a group of cancers known a...

Positive Results Prompt US National Cancer Institute to Make Glivec Available to Patients in Post-Surgical GIST Study

...given Glivec continued with this therapy but at a higher dose. Study results will be presented at a forthcoming scientific meeting. Gastrointestinal stromal tumors (GIST) belong to a group of cancers known as soft tissue sarcomas that usually arise from the intestinal tract, with the most common site being...

Novel Human Tissue Transgenic Cancer Model May Offer Significant Advance Toward Accurately Modeling Human Cancer

...VEO sought to generate an in vivo model of human breast cancer in mice (HIM) by employing a unique tissue recombinant system comprised of human breast stromal cells and epithelial organoids engineered with defined transgenes. Depending on the combination of transgenes employed, the reconstituted human breast...
stromal in Medical Products

Gastrointestinal Stromal Tumor Mutation

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Anterior Stromal Puncture Cannula, 25 g

Description: Anterior Stromal Puncture Cannula, 25 g. For treatment of recurrent corneal erosion. Overall length 24 mm. 5/box....
Company:Bausch & Lomb Storz

Androstenedione EIA Test

Description:...n demonstrated in virilizing congenital adrenal hyperplasia [4]. Serum androstenedione levels are also increased in polycystic ovary syndrome, ovarian stromal hyperthecosis, 3b-hydroxysteroid dehydrogenase deficiency, and other causes of hirsutism in women [3,5]. Elevated serum androstenedione levels may als...
Company:Diagnostic Systems Laboratories, Inc.

Androstenedione RIA Test

Description:...n demonstrated in virilizing congenital adrenal hyperplasia [4]. Serum androstenedione levels are also increased in polycystic ovary syndrome, ovarian stromal hyperthecosis, 3b-hydroxysteroid dehydrogenase deficiency, and other causes of hirsutism in women [3,5]. Elevated serum androstenedione levels may als...
Company:Diagnostic Systems Laboratories, Inc.

Technolas 217z Zyoptix System

Description:...he Technolas 217z Zyoptix System combines both a 2mm and 1mm truncated Gaussian beam, with an active eye tracker for fast treatment times and a smooth stromal bed. Providing outstanding clinical outcomes in U.S. FDA clinical trials, the Technolas 217z Zyoptix System features a proven custom ablation algorith...
Company:Bausch & Lomb Storz

Clear Cornea 2.8mm Angled CVD Diamond

Description:...cements in diamond technology allow the incredible sharpness of diamonds to be used at a more economical cost. Proven diamond blade sharpness improves stromal reapproximation, enhances healing, and insures a superior postoperative result. The knives offer unlimited uses, and are available in a variety of wid...
Company:Rhein Medical, Inc.

Trapezoid 2.5-3.5mm Angled CVD Diamond

Description:...cements in diamond technology allow the incredible sharpness of diamonds to be used at a more economical cost. Proven diamond blade sharpness improves stromal reapproximation, enhances healing, and insures a superior postoperative result. The knives offer unlimited uses, and are available in a variety of wid...
Company:Rhein Medical, Inc.

LSM-12000 High-Magnification Slit-Lamp Biomicroscope

Description:...High Magnification Slit-Lamp Biomicroscope available today. It can examine ocular tissue from the front of the cornea to the back of the lens. Corneal stromal changes, cataractous changes, and posterior capsule changes can be seen and documented as can corneal endothelial changes. With the LSM-12000 yo...
Company:Bio-Optics

IntraLase FS Femtosecond Laser

Description:...ade slices across to create the flap. The IntraLase FS laser creates the flap under very low vacuum, delivering the laser energy directly to the stromal layer of the cornea through a disposable glass lens. The outer surface of the cornea suffers no trauma, and the procedure is completely painless. In...
Company:IntraLase Corporation (now part of AMO)

Lasik Irrigator - assis

Description:... Unique product designed for LASIK surgery and other types of refractive surgery. Designed to irrigate the corneal interface and/or stromal bed. Flattened tip provides easy insertion under the flap and helps elevate the flap edge. Multiple ports provide multi-directional irrigation.27G x 7...
Company:Hurricane Medical
stromal in Medical Definition

Personalized medicine

...rrived in 2004 and it is known as a targeted cancer drug. In addition because of new molecular testing for c-kit, tumors such as GIST GastroIntestinal stromal Tumours a solid malignancy never associated with blood bourne cancer are also treated with this drug. It works by killing specific cells whereas chemo...
stromal in Medical Dictionary

Ovary

...coma. G. Ovary ... Arrhenoblastoma of Ovary (Androblastoma, Gonadal stromal Tumor, Sex Cord Tumor, stromal Tumor) information center covers causes, prevention, symptoms, diagnosis, ....
stromal in Biological News

Axel Ullrich named winner of 2009 Dr. Paul Janssen Award for Biomedical Research

... of the VEGFR2 kinase function was developed, from which a derivative was approved in 2006 for the treatment of kidney carcinoma and gastro-intestinal stromal tumors. "It is an honor to receive an award of this stature and to be recognized among so many outstanding scientists," said Ullrich. "Dr. Paul i...

CWRU receives $5 million from Ohio Third Frontier Commission

... trial to evaluate the performance of the cells. Juventas Therapeutics, spin out company from Marc Penn (CC), will develop its lead drug product, stromal cell derived factor 1 (SDF-1), through a Phase I clinical trial for critical limb ischemia. Emerging programs With further refinement of alr...

Protein linked to change in tissue that surround and support breast tumors

...lead author, Priscilla Furth, MD, Professor of Oncology and Medicine. "This is significant, because disordered interactions between the epithelial and stromal compartments are being increasingly recognized as an important component of breast cancer risk." A splice variant occurs as the gene is expressed, ...

Gene activity reveals dynamic stroma microenvironment in prostate cancer

...professor in the departments of pathology and urology at BCM and another senior author. "Often in prostate cancer, you don't see much change in the stromal cells," said Ittmann. "However, in this subgroup of patients (in which the stroma become visibly reactive), you see a histologically recognizable chan...

Tips from the American Journal of Pathology

... stromal Caveolin-1 Predicts Breast Cancer Prognosis Tw...ican Journal of Pathology demonstrate the role of stromal caveolin-1 expression as a prognostic marker for b...al therefore examined caveolin-1 expression in the stromal microenvironment of human breast cancer. ...

Stem cell therapy makes cloudy corneas clear, according to Pitt researchers

...ree months after the lumican-deficient mouse eyes were injected with human adult corneal stem cells, transparency was restored. The cornea and its stromal stem cells themselves appear to be "immune privileged," meaning they don't trigger a significant immune response even when transplanted across species...

New lab evidence suggests preventive effect of herbal supplement in prostate cancer

...studying signaling between human prostate cancer cells and their supporting stromal cells as they grow together in laboratory culture. "DHEA effects in the pro... transforming growth factor beta-1 increased testosterone production in the stromal cells and prostate specific antigen protein secretion two to four-fold and ...

Biomedical researchers create artificial human bone marrow in a test tube

...ard balls. Then, they dissolved the spheres to leave the perfect geometry of pores in the scaffold. The scaffolds were then seeded with bone marrow stromal cells and osteoblasts, another type of bone marrow cell. "The geometrical perfection of the polymer molded by spheres is very essential for reprodu...

Intraspinal implant of mesenchymal stem cells may not heal the demyelinated spinal cord

...ome degree of success. "Our results contrast with previously published reports that demonstrated robust Schwann cell remyelination after bone marrow stromal cell injection," reported Dr. Hunt. "An important difference in results may lie in the distinct methodologies used to culture MSCs." Although MSCs ma...

Researchers at UH explore use of fat cells as heart attack therapy

..., they do see the promise of using adipose-derived stromal cells (ADSCs), which are found in fatty tissue, as...tic effects after injections of different types of stromal and stem cells, the common beneficial factor or fa...o use the bioreactor to study to find out how the stromal cells work." In recognition of the invention o...
stromal in Biological Technology

Gleevec Receives FDA Priority Review as First Therapy to Reduce Recurrence of Gastrointestinal Stromal Tumors After Surgery

- Clinical data showing unprecedented 89% reduction in risk of GIST relapse with use of Gleevec after surgery are basis for FDA, EMEA, Swissmedic filings - Historically, one in two patients experienced recurrence of GIST after surg...

Morphotek(R), Inc. and Cancer Innovations, Inc. Announce Evaluation and Option Agreement for Therapeutic Monoclonal Antibodies

...t of core technologies developed by its scientific founders. This exciting technology is based on proprietary discoveries concerning the importance of stromal factors uniquely present within the surrounding microenvironment of malignant tumors. About Morphotek Morphotek((R)), Inc., a subsidiar...

Video: Axel Ullrich Named Winner of 2009 Dr. Paul Janssen Award for Biomedical Research

... of the VEGFR2 kinase function was developed, from which a derivative was approved in 2006 for the treatment of kidney carcinoma and gastro-intestinal stromal tumors. "It is an honor to receive an award of this stature and to be recognized among so many outstanding scientists," said Ullrich. "Dr. Paul ...

AEterna Zentaris to Present Data Supporting Evaluation of AEZS-108 in Prostate Cancer at Upcoming ASCO Meeting

...noma, colorectal cancer and GIST (gastrointestinal stromal tumors). Abstracts selected for presentation ...12 pm (Level 2, West Hall C) Gastrointestinal stromal Tumor (GIST) Sunday, May 31, 2009: #10563: ... patients with imatinib-resistant gastrointestinal stromal tumor (GIST). Lead Author: Anthony Conley, MD ...

Keryx Biopharmaceuticals Announces Poster Presentations Highlighting Clinical Activity of KRX-0401 (Perifosine) at the Upcoming Annual Meeting of the American Society of Clinical Oncology

... Carcinoma, Colorectal Cancer and Gastrointestinal stromal Tumors (GIST) NEW YORK, May 18 /PRNewswire-F...m (Level 2, West Hall C) Gastrointestinal stromal Tumor (GIST) Sunday, May 31 st , 20... patients with imatinib-resistant gastrointestinal stromal tumor (GIST). Lead Author: Anthony Conley, M...

Cryo-Cell International, Inc. Reports First Quarter 2009 Results

... pipeline of research collaborations, which are focused on the development of potential breakthrough therapies that utilize Cryo-Cell's patent-pending stromal menstrual stem cell technology." "Cryo-Cell continues to make substantial progress both strategically and operationally. Our momentum is strong, ...

Israeli Scientists Recipients of 2008 International Adult Stem Cell Award

... help multiple sclerosis and amyotropic lateral sclerosis patients by injecting their spinal fluid with large numbers of adult stem cells (mesenchymal stromal stem cells) taken from their bone marrow and multiplied in culture. Some of the patients' conditions have improved or stabilized in Phase I and II cli...

Bayer and Onyx Announce Nexavar Data Presentations at 44th American Society of Clinical Oncology Annual Meeting

... a.m., S406 - Vista Room -- Activity of sorafenib (SOR) in patients (pts) with imatinib (IM) and sunitinib (SU)-resistant (RES) gastrointestinal stromal tumors (GIST): A phase II trial of the University of Chicago Phase II Consortium -- Lauren Wiebe, MD, fellow, University of Chicago, Chicago, ...

Paloma Pharmaceuticals to Present at the American Association for Cancer Research

..."mTOR and the protein complexes mTORC1 and mTORC2 are excellent targets for cancer therapy because they provide important signaling links to tumor and stromal pathways dysregulated in many cancers," said Dr. Benjamin whose work has helped to understand the mechanism of action of P529. "We have shown in a s...

Stem Cells From Menstrual Blood Show Therapeutic Potential

...one day treat a host of diseases. The study, "Multipotent Menstrual Blood stromal Stem Cells: Isolation, Characterization and Differentiation," was conducted...rding to the study, the stem cells in menstrual blood, known as MenSCs, are stromal stem cells, meaning they have the capability to differentiate into importan...
stromal in Biological Products

Syrian hamster Anti-Mouse stromal cell line Antibody, Unconjugated from Developmental Studies Hybridoma Bank

Description: 8.1.1...
Company:Developmental Studies Hybridoma Bank

Treated Tissue Culture 245 mm x 245 mm Dish, 4/pk from StemCell Technologies, Inc.

Description:... Recommended for supporting the growth of anchorage-dependent cells including human and mouse stromal cells, mesenchymal cells and cell lines....
Company:StemCell Technologies, Inc.
stromal in Biological Definition

Cancer

...m , anus , or appendix , esophageal cancer , endometrial cancer - in the uterus , hepatocellular carcinoma - in the liver , gastrointestinal stromal tumor (GIST), laryngeal cancer , lung cancer , mesothelioma - in the pleura or pericardium , oral cancer , osteosarcoma - in bones , ovar...

Stem cell

...nsform into several different forms. Bone marrow stromal stem cells are known to be able to transform into ...dult stem cells with another group of cells called stromal cells and then adding a growth factor to stimulate...mimic the conditions found in bone marrow by using stromal cells, which provide the structure inside bone mar...
stromal in Biological Dictionary

Small intestine

...0 feet) long. ... Small Intestine . Adenocarcinoma of Duodenum. Adenocarcinoma. G. Small Intestine ... Small Intestine . Gastrointestinal stromal Tumor(GIST) Gluten_Sensitive_Enteropathy ... The Small Intestine . The small intestine is the major site for the ... It most commonly affe...

Bone cell

... Miller, Scott C. and Jee, Webster S. S. (1987) "The bone lining cell : A distinct phenotype? ... Bone marrow stromal stem cells : nature, biology, and potential ... Bones are rigid organs that form part of the endoskeleton of vertebrates. They function to mov...
Other Tags
(Date:11/27/2014)... Two international trainers and lecturers on the ... one person with significant needs but limited means obtain ... Mamaly Reshad of the Anacapa Dental Art Institute in ... devoted to helping dentist learn about using All-on-4™ dental ... devoted to helping a patient who has damaged or ...
(Date:11/27/2014)... “LAB.C” was featured on NewsWatch as part ... coolest technology products available to consumers. Mallory Sofastaii, a technology ... and shared with viewers the company offers a cable ... , Consumers love portability and functionality. A unique mobile ... the iPhone5 and 5S has a portable USB charger built ...
(Date:11/27/2014)... Texas (PRWEB) November 27, 2014 ... report on Global Insulin industry. For an overview ... definition, classification, application, industry chain structure, industry overview, ... on global Insulin industry covers information on ... process, product cost structure and much more. ...
(Date:11/27/2014)... 27, 2014 Allowing children to help with ... school, helps give children responsibility, ownership, boosts self-esteem, and above ... , Now, the real question is, how do you encourage ... According to a study published by Child Development Journal, there ... dramatic effect on a child’s willingness to lend a hand. ...
(Date:11/27/2014)... 27, 2014 RBSEO Services, a ... engine optimization service just at $99. RBSEO Services ... cannot afford costly search engine optimization service. So, ... their affordablity and requirements into consideration. , ... it has not compromised with the service quality. ...
Breaking Medicine News(10 mins):Health News:World-Renowned Oxnard All-on-4™ Dental Implants Experts to Give Away Full Mouth Rehabilitation Annually 2Health News:World-Renowned Oxnard All-on-4™ Dental Implants Experts to Give Away Full Mouth Rehabilitation Annually 3Health News:World-Renowned Oxnard All-on-4™ Dental Implants Experts to Give Away Full Mouth Rehabilitation Annually 4Health News:World-Renowned Oxnard All-on-4™ Dental Implants Experts to Give Away Full Mouth Rehabilitation Annually 5Health News:Top Mobile Friendly Accessories were Featured on NewsWatch Television on October 30, 2014 2Health News:Insulin Industry Analysis (Supply, Consumption) for China, America, Korea, France & Japan Research Now at ReportsnReports 2Health News:Insulin Industry Analysis (Supply, Consumption) for China, America, Korea, France & Japan Research Now at ReportsnReports 3Health News:RBSEO Services Announces SEO Services at $99 Only 2
(Date:11/18/2014)... , Nov. 17, 2014   ... and EMC collaborate to develop The Partners Data ... , The Partners Data Lake will allow researcher ... improve diagnostics, treatment and the lives of patients ... research and clinical activities across the Partners system, ...
(Date:11/11/2014)...  Forensicon, Inc., a Chicago -based ... the promotion of Yaniv Schiff from Senior ... Schiff,s new role as Director, he will lead company ... examiners and provide leadership within the company,s digital forensics ... Schiff joined Forensicon in 2006 ...
(Date:11/6/2014)... paper from a team of Florida State University biologists ... could adapt to and survive environmental swings such as ... latest issue of the journal The Plant Cell ... DNA and proteins) is organized in a cell and ... are turned on and others are turned off. , ...
Breaking Biology News(10 mins):Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5Yaniv Schiff Promoted to Director of Digital Forensics at Forensicon, Inc. 2Maize analysis yields whole new world of genetic science 2
Other Contents