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Splicing at Biology News

RNA splicing occurs in nerve-cell dendrites

Researchers at the University of Pennsylvania School of Medicine have discovered that nerve-cell dendrites have the capacity to splice messenger RNA (pre-mRNA), a process once believed to only take place in the nucleus of cells. By uncovering this capability in dendrites, the investigators hope to relate this capacity to memory and learning, as well as cognitive dysfunction. Senior author...

Protein splicing upsets the DNA colinearity paradigm

Understanding medical research problems often relies on the direct, linear relationship between the sequence of a protein and the DNA encoding that protein. In fact, colinearity of DNA and protein sequences is thought to be a fundamental feature of the universal genetic code. However, a paper published today in Science by a team from the Brussels Branch of the global Ludwig Institute for Cancer R...

RNA map provides first comprehensive understanding of alternative splicing

It's biology's version of the director's cut. In much the same way that numerous films could be stitched together from a single reel of raw footage, a molecular process called alternative splicing enables a single gene to produce multiple proteins. Now a new RNA map, created by a team of researchers at Rockefeller University and the Howard Hughes Medical Institute and announced in the journal Nat...

RNA splicing factor implicated in ovarian tumor cell growth

An RNA-binding protein that is overproduced in ovarian cancer may present a new target for diagnosis or treatment of ovarian and other cancers, according to researchers at the University of Illinois at Chicago. Researchers in the UIC College of Pharmacy found that interfering with the production of a splicing factor can inhibit the growth and invasiveness of tumor cells in test-tube experi...
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Splicing (genetics)

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Alternative splicing

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Splicing at Biology Dictionary

Trans-splicing

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Splicing factor

The factor is a positive speci...

Splicing

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Self-splicing

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RNA Splicing

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Splicing at Medicine News

Protein Splicing Upsets the DNA Colinearity Paradigm

Understanding medical research problems often relies on the direct, linear relationship between the sequence of a protein and the DNA encoding that protein//. In fact, colinearity of DNA and protein sequences is thought to be a fundamental feature of the universal genetic code. However, a paper published today in Science by a team from the Brussels Branch of the global Ludwig Institute for Cancer...

Alternative Splicing - Molecular Cloning

Alternative splicing is a molecular processwhich enables multiple genes to be produced from a single gene. By regulating this process, //cells can produce a wide variety of proteins from a finite number of genes. A new RNA map, created by researchers at Rockefeller University and the Howard Hughes Medical Institute, shows how the specific location of short snippets of RNA affects the way that alt...

Alternative Splicing in Neuronal Development

In the July 1st issue of G&D, Dr. Douglas Black (UCLA) and colleagues detail how alternative splicing is reprogrammed during neuronal development. Alternative splicing refers to the processing of an RNA transcript into different mRNA molecules by including some exons and excluding others. Specific cell types often have signature patterns of alternative splicing. Polypyri...
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