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splice in Medical News

The Novel Cut and Splice Method Is Used To Recognize Different Microbes

Scientists at the U.S. Department of Energy’s Brookhaven National Laboratory have developed a new technique for identifying the many species of microorganisms. They have // explained about their method in the journal of Applied Environmental Microbiology. Microbiology has many applications and one ...

EMBL GeneCore purchases Genomatix's next generation sequencing data analysis solution

... transcript level. A special GenomeThesaurus is also provided for potential splice junctions, which allows for splice junction analysis and identification of new transcriptional units. For gen...

Molecular therapy for spinal muscular atrophy closer to clinical use

... to a gene and inactivate it. Turning the gene "off" reduces competition at splice sites and improves the likelihood of achieving the desired results. "Th...n in Richmond, Va. "We have found that reducing the competition between the splice sites enhances the efficiency of trans-splicing. This strategy provides ins...

Next generation data analysis for next generation sequencing data

... Transcriptome studies result in normalized and quantified expression values and allow for immediate identification of new transcriptional units and splice variants, all integrated and visualized in today's most complete genome annotation ElDorado, which is built into the GGA. The GGA is driven by an e...

Penn researchers gain new insights on spinal muscular atrophy

... cells to bring small RNAs together with specific proteins to form particles called snRNPs (pronounced snurps). snRNPs are the molecular machines that splice different parts of RNA together to form the messenger RNA (mRNA) before it leaves the nucleus to travel to the cytoplasm. Here, mRNAs get translated i...

Researchers identify a gene responsible for cases of Lou Gehrig's disease

...ls have been very useful to study molecular and cellular mechanisms of disease and to test treatments for ALS. TDP-43s normal function is to bind and splice RNA. Two years ago, a team from the University of Pennsylvania discovered TDP-43 in abnormal protein clumps, referred to as aggregates, in motor neuro...

Researchers identify a gene responsible for Lou Gehrig's disease

...ls have been very useful to study molecular and cellular mechanisms of disease and to test treatments for ALS. TDP-43s normal function is to bind and splice RNA. Two years ago, a team from the University of Pennsylvania discovered TDP-43 in abnormal protein clumps, referred to as aggregates, in motor neuro...

RNA-associated introns guide nerve-cell channel production

...e messenger RNA is transported to the cytoplasm and translated into a protein. In 2005, the Penn group first found that dendrites have the capacity to splice messenger RNA, a process once believed to only take place in the nucleus of cells. Now, in the current study, the group has found that an RNA enco...

Rett Syndrome Reversed in Genetic Mouse Model

...by reactivating the MECP2 gene. This was achieved by treating the mice with a drug that caused the enzyme Cre to enter the cell nucleus where it could splice out the cassette. As well as losing overt behavioral defects, the mice also recovered a key electrophysiological function of the brain. This was...

Protein Splicing Upsets the DNA Colinearity Paradigm

...displayed on the cell surface for recognition and destruction by CD8+ T lymphocytes. However, the Belgium/USA team has found that proteasomes can also splice the peptide fragments together in a reverse order to that encoded by the protein’s DNA sequence template. This takes the possible number of antigens f...
splice in Medical Products

Growth Hormone Binding Protein ELISA Test

Description:...ponent of the growth hormone-insulin-like growth factor (IGF) axis. Depending on the species, it is either a cleavage product of the GH receptor or a splice variant of the GH receptor gene. Growth Hormone receptor cleavage /GHBP shedding is effected by TNF-a converting enzyme, a metalloproteinase of the A...
Company:Diagnostic Systems Laboratories, Inc.
splice in Biological News

A splice of life

Waltham, MAIn a new study this week in Nature , researchers at Brandeis University and the MRC Laboratory of Molecular Biology (Cambridge, U.K.) for the first time shed light on a crucial step in the complex process by which human genetic information is transmitted to action in the human cell and...

A splice of the action: Translational role for WT1 isoform

In the June 15th issue of G&D, Dr. Marie-Louise Hammarskjold (UVA) and colleagues lend new insight into the function of the Wilms' Tumor 1 tumor suppressor. The Wilms' Tumor 1 (WT1) protein is important to both normal and pathological human development, with known roles in kidney and urogenital...

Products containing specific probes for detecting alternative splice forms protected

ExonHit Therapeutics, today announced the grant of a major patent, US # 6,881,571, by the United States Patent and Trademark Office on microarray products allowing the specific detection of mRNAs produced by alternative splicing, covering microarrays optimised for the discovery of alternative RNA s...

Protein linked to change in tissue that surround and support breast tumors

...reasingly recognized as an important component of breast cancer risk." A splice variant occurs as the gene is expressed, resulting in deletion of extra ami... examination of mammary tissue, they found that the tissue in mice with the splice variant of AIB1 was thicker than that seen in mice with too much of the par...

MCTP bought Genomatix NextGen Sequencing analysis stations

... the first level analysis solution starting at the raw data from the sequencer, delivering ultra fast mapping, SNP detection, expression profiling and splice analysis. Copy number analysis, small RNA analysis and de-novo assembly are following shortly.Results seamlessly feed into second level analysis with ...

Boehringer Ingelheim uses Genomatix' Next Generation Sequencing data analysis systems

... transcript level. A special GenomeThesaurus is also provided for potential splice junctions, which allows for splice junction analysis and identification of new transcriptional units. For geno...

CSHL scientists clarify editing error underlying genetic neurodegenerative disease

...left out of the final version. An 'atypical' splice site The new discovery stems from a program of...en an intron and its two flanking exons are called splice sites. Such sites are composed of short sequences... RNA splicing machinery is correctly guided to the splice site at the beginning of an intron by one of its c...

Genomatix joins Illumina-Connect program

... transcript level. A special GenomeThesaurus is also provided for potential splice junctions, which allows for splice junction analysis and identification of new transcriptional units.For genom...

Case Western Reserve finds mechanism underlying alt. splicing of premessenger RNA into messenger RNA

...alternative splicing by silencers that modulate 5' splice site competition" is published in the December 24 ... Because the molecular mechanisms responsible for splice site choice remain poorly understood, Nilsen and his colleagues decided to study how some potential splice sites are "silenced," preventing them from forming...

Seemingly suicidal stunt is normal rite of passage for immune cells

... billions of different foreign substances. Immunologists showed that this was because lymphocytes create double-strand DNA breaks that allowed them to splice together their genetic materials in new ways. Material created from the new genetic combinations is used to generate antibodies and other defensive me...
splice in Biological Technology

Jivan Awarded US Patent #7,340,349 for Splice Array Analysis

BERKELEY, Calif., March 7 /PRNewswire/ -- Jivan Biologics Inc., a privately held corporation located in Berkeley, CA, has been awarded US Patent #7,340,349, "Method and System for Identifying Splice Variants of a Gene." The issued claims cover mathematical algorithms for determining the expres...

Professor Wing Wong Elected to the National Academy of Sciences

...ber of our scientific advisory board, Professor Wong has provided invaluable guidance for building aTyr's platform of naturally occurring, therapeutic splice variants of human tRNA synthetases. His work with genomics data has accelerated understanding of biology and paved the way for significant health ad...

Jivan Focuses on Solutions for Transcriptome Sequencing

...s, including exons and exon junctions, Jivan can ensure the capture of all mRNA sequences of each gene of interest, including wildtype transcripts and splice variants. For genes or mRNAs with low expression, Jivan will offer mRNA Prime(TM) PCR primer designs specific to each observed mRNA. To analyze ...

aTyr Pharma to Present at ChinaBio(R) Investor Forum in Hong Kong

... a leader in discovering the many activities, roles and functions for this ancient class of enzymes and reported the first evidence that fragments and splice variants of these proteins have latent extracellular activities distinct from their intracellular roles in protein synthesis. With a wide variety of ...

Dr. James Cai Joins aTyr Pharma to Drive Clinical Development in Asia

... a leader in discovering the many activities, roles and functions for this ancient class of enzymes and reported the first evidence that fragments and splice variants of these proteins have latent extracellular activities distinct from their intracellular roles in protein synthesis. With a wide variety of ...

Amicus Therapeutics Announces First Quarter 2008 Financial Results

...nts with available data, 24 had cells that showed a dose responsive increase in GAA levels including 22 patients who had at least 1 copy of the common splice site mutation IVS1-13T > G. Data from the Phase 1 trials in a total of 72 healthy volunteers showed that AT2220 was generally safe and well tolerated ...

ExonHit Launches Rat Genome SpliceArray(TM) Products to Expand High Resolution Gene Expression Profiling for use in Disease Modeling and Toxicogenomics

...w offered through our portfolio of genomic services. The Rat SpliceArray(TM) monitors over 23,000 genes utilizing over 200,000 exon body and 180,000 splice junction regions. This comprehensive coverage enables investigators to further elucidate the enormous diversity of the rat transcriptome. These new de...

Simple Approaches for Optimization of RT-PCR

...late to yield abundant double-stranded DNA product (1,2,3). RT-PCR is a powerful tool for analysis of gene expression and for characterization of RNA splice variants. RT-PCR is generally carried out as either one-step RT-PCR, in which all reagents are combined in one tube and RT and PCR are conducted seque...

Detection of Mutations in the CYP21 Gene Using the DCode System

...hydroxylase gene mutations in the Spanish population, Hum. Genet., 96 , 198204 (1995). 5. Lajic, S., and Wedell, A., An intron 1 splice mutation and a nonsense mutation (W23X) in CYP21 causing severe congenital adrenal hyperplasia, Hum. Genet., 98 (2):1824 (1996)...

Real-Time PCR: General Considerations, Rev A

...m genomic DNA contamination treat with RNase-free DNase prior to reverse transcription. It is also helpful to design primers at splice junctions to avoid genomic DNA amplification Template and Primer Design Template Design A successful...
splice in Biological Products

Rabbit Anti-mu Opioid Receptor splice variant Antibody, Unconjugated from ABR-Affinity BioReagents

Description: mu Opioid Receptor splice variant Immunogen: Synthetic peptide corresponding to residues K S C M D R G M R N L L P D D G P R Q E of Mu Opioid Receptor. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Company:ABR-Affinity BioReagents

Custom Splice Arrays from ExonHit Therapeutics Inc.

Description: Through its SpliceArray service, ExonHit can design custom microarrays to detect alternative splicing events starting with your gene list. Proprietary algorithms are used to identify splice events and design microarray probes from high quality, spliced cDNAs aligned to the human genome. Each splic...
Company:ExonHit Therapeutics Inc.

SpliceArray Service from ExonHit Therapeutics Inc.

Description:... to rapidly elucidate alternatively spliced events in gene families known to be relevant for drug discovery. The service combines ExonHits proprietary splice variant content, patented probe design and customized analysis with Agilents robust microarray platform. The patented array design monitors the expres...
Company:ExonHit Therapeutics Inc.

Ion Channel SpliceArray Service from ExonHit Therapeutics Inc.

Description:...GPCR SpliceArray monitors 1543 known and potential splice events derived from 441 GPCR genes. splice events are profiled with a patent-protected combin...two possible molecular species resulting from each splice event. The GPCR SpliceArray service is provided ex...
Company:ExonHit Therapeutics Inc.

Apoptosis Pathway SpliceArrays from ExonHit Therapeutics Inc.

Description:...ing pathways involved in apoptosis and cell death. splice variants have been reported that affect both the a...eath SpliceArray monitors 5806 known and potential splice events derived from 609 genes. splice events are profiled with a patent-protected combin...
Company:ExonHit Therapeutics Inc.

GPCR SpliceArray Service from ExonHit Therapeutics Inc.

Description:...GPCR SpliceArray monitors 1543 known and potential splice events derived from 441 GPCR genes. splice events are profiled with a patent-protected combin...two possible molecular species resulting from each splice event. The GPCR SpliceArray service is provided ex...
Company:ExonHit Therapeutics Inc.

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splice in Biological Definition

Alternative splicing

...mRNA. But what is an intron and what is an exon is not decided yet. This decision is made during the splicing process. The regulation and selection of splice sites is done by Serine/Arginine-residue proteins, or SR proteins . The use of alternative splicing factors leads to a modification of the definition...

Gene

... This is a permanent form of regulation of the transcription. The RNA is often edited before its translation into a protein. Eukaryotic cells splice the transcripts of a gene, by keeping the exons and removing the introns . So, the DNA strand needs to be in an exon to be expressed. Because of...

Spliceosome

...icing is what makes our immune systems so diverse (much more diverse, for example, than a simple recombination of our parents immune systems.) splice variants have been used to account for the relatively small number of genes in the human genome . For years the estimate was 100,000 genes, but no...

Splicing (genetics)

...posed of small nuclear ribonuclear proteins (snRNPs (pronounced "snurps")), splice the 3' end of the first exon, form the intron into a lariat , splice the 5' end of the next exon, and fuse the exon-exon junction; Self-splic...
splice in Biological Dictionary

Trans-splicing

...are large numbers of trans - splicing applications, each governed by the ... Such nonspecific trans - splicing can be used to identify alternative splice sites, ... ...

TATA box

... Mouse protein-coding gene Tbp. Represented by 157 ESTs from 81 cDNA libraries. ... Mus musculus TATA - box binding protein N-terminal domain splice variant mRNA, ... The human TATA box -Binding Protein (hTBP) is a requisite protein in the assembly ... The GTFs that recognize the TATA - ...

Spliceosome

...me . splicer. splicing. spliff. spline. Splining. Splining machine. splint. splice ... The spliceosome is comprised of five small nuclear RNAs (snRNAs)—U...mplex ... The major spliceosome splices introns containing GU at the 5' splice site and AG ... Definition of spliceosome from Merriam-Webster's Med...

Splicing

...s are removed and exons are joined. This is needed for the typical eukaryotic messenger RNA before it can be used to produce a... On Wikipedia, splice may refer to Wikipedia:Cut and paste move repair holding pen. ... Rope splicing , joining two pieces of rope or cable by weaving the strands of .....

SnRNP

... Evidence that U5 snRNP recognizes the 3' splice site for ... RNA splicing: intron/exon · snRNP...re-mRNA splicing but arrests ... ... early 5′ splice site/tri- snRNP interaction requires ATP, occurs ...in, TbU1-24K. ... role of the U1 snRNP , early 5' splice site recognition ... snRNP association with...

Small nuclear RNA

...snRNAs) are involved in RNA splicing (see below), and other small RNAs... The U1 small nuclear RNA -protein complex selectively binds a 5' splice site in vitro. ... site of U1 small nuclear RNA processing and ribonucleoprotein ... U2 small nuclear RNA precursors and their ac...

Intein

... B, F, and G) ... strain PCC6803 DnaB intein . ... Intein Prediction: ... Two models for intein prediction has been provided. ... Intein's splice site Prediction: ... An intein -based positive genetic selection system ... Homing endonuclease activity can mobilize an intein ... for lo...

HnRNA

...the unprocessed precursor of the mature, functional mRNA, ... ... complementary to the consensus exon-intron regions of hnRNA and it has been ... splice site of hnRNA , rather than being involved in the alignment of both ends ... ESTABLISHING A CELL CULTURE LAB AT MIT: pre-rRNA, hnRNA , AND POLY...

Group I introns

... ,II, introns ,biological ,biology dictionary,biology terminology,biology terms,biology abbreviations ... Not all group I and group II introns splice without ... ...

Group II introns

... II , introns ,biological ,biology dictionary,biology terminology,biology terms,biology abbreviations ... Not all group I and group II introns splice without ... Group II introns are self-splicing ribozymes believed to be the ancestors of ... Many group II introns encode reverse tra...
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