Molecule tracking reveals mechanism of chromosome separation in dividing cells
...es before cell division. The apparatus is called a spindle because it looks like a tiny wool-spinner with thin strands of microtubules or spindle fibers sticking out. The lengthening and shortenin...te on each chromosome that mechanically couples to spindle fibers. "Kineochores are also regulatory hubs,"...From mother to daughters: A central mystery in cell division solved
...n muscle. During cell division, the genome is replicated and the two copies are separated to opposite sides of the cell by the mitotic spindle. The spindle then directs the assembly of a contractile ring, which forms a belt around the cell middle. As happens during muscle contraction, the myosin fila...Lack of CHFR gene expression sets stage for breast cancer
...nstructions for two new daughter cells. If the spindle doesn't form correctly, genetic material becomes u...containing too many chromosomes. The fact that the spindle is affected is important, because some cancer drugs interact with the mitotic spindle as a way to curb cell division. Research detai...Damon Runyon Cancer Research Foundation awards prestigious fellowships to 14 top young investigators
...nsors Kenneth E. Prehoda, PhD, and Chris Q. Doe, PhD, at the University of Oregon, Eugene, Oregon, is investigating the molecular mechanism of mitotic spindle orientation during asymmetric cell division of model progenitor stem cells. Failure in this process can lead to aberrant cell division and subsequent...NYP/Columbia physician-scientists present at ASCO 44th annual meeting
... or following reduced-intensity AlloSCT in standard-risk AML. Kinesin spindle Protein (KSP) for Hodgkin's Lymphoma Dr. Owen O'Connor Director of Lymph...e of Physicians and Surgeons A Phase 1 dose-escalation trial of Kinesin spindle Protein (KSP), a drug that targets a unique aspect of cancer cell division,...Physical Therapists Offer Tips for Proper Bike Fit in Support of National Bike to Work Day
... function the cyclist will have and with less stress on the knee. -- Foot to Pedal. The ball of the foot should be positioned over the pedal spindle for the best leverage, comfort, and efficiency, Moen notes. A stiff-soled shoe is best for comfort and performance. Pedaling is a skilled ac...Key factor in brain development revealed, offers insight into disorder
...point of cell division. Specifically, Lis 1 makes sure that the mitotic spindle is oriented perpendicular to the top and base components of the neuroepithe...esults in reduced and weakened microtubules and an inability of the mitotic spindle to rotate the microtubules properly in the apical-basal axis. Of note, ...Cell division studies hint at future cancer therapy
...minants to one side of the mother cell and directs spindle orientation. In work published in Nature Cell B...Cell, he detailed a group of proteins critical for spindle organization and positioning in mammalian cells. ...they cooperate with other proteins to organize the spindle and direct its orientation. These details may e...'Network' approach identifies potential breast cancer susceptibility gene
...e abnormal spindles, but why this is so has been unclear. The fact that HMMR interacts strongly with BRCA1 on a functional level and is involved in spindle formation suggests a connection. Cells whose centrosomes assemble improperly often develop aneuploidy, a condition in which there is an extra or missi...EntreMed Commences Phase 2 Study With MKC-1 in Ovarian/Endometrial Cancers
...tumor growth inhibition or regression in multiple preclinical models, including paclitaxel-resistant models. MKC-1 has been shown to inhibit mitotic spindle formation, prevent chromosome segregation in the M-phase (mitosis) of the cell cycle, and induce apoptosis. Furthermore, MKC-1 inhibits the Akt-mTOR s...EntreMed Commences Phase 2 Study with MKC-1 in Pancreatic Cancer
...oad-acting antitumor effects, including tumor growth inhibition or regression, in multiple preclinical models. MKC-1 has been shown to inhibit mitotic spindle formation, prevent chromosome segregation in the M-phase (mitosis) of the cell cycle, and induce apoptosis. Carolyn F. Sidor, M.D., M.B.A., EntreMed...EntreMed Presents Data for Phase 2 Study of MKC-1 in Metastatic Breast Cancer
...n intracellular target important in cellular trafficking that has been shown to be involved in cell division. MKC- 1 has been shown to inhibit mitotic spindle formation, prevent chromosome segregation in the M-phase of the cell cycle, and induce apoptosis in multiple cell lines, consistent with a mechanism i...Cytokinetics Announces Non-clinical Data to be Presented at the 2007 AACR Annual Meeting
...cs and will present data evaluating ispinesib, a novel inhibitor of Kinesin spindle Protein (KSP), in models of multiple myeloma, data evaluating GSK-923295, a...t 2007 AACR Annual Meeting Ispinesib: Abstract #1435: Kinesin spindle Protein Inhibition for the Treatment of Multiple Myeloma. (Poster dis...EntreMed Presents Preclinical Data for MKC-1 in Hematological Cancers
...g tumor growth inhibition or regression in multiple preclinical models, including paclitaxel-resistant models. MKC-1 has been shown to inhibit mitotic spindle formation, prevent chromosome segregation in the M-phase (mitosis) of the cell cycle, and induce apoptosis. These effects are consistent with mechanis...Cytokinetics Reports Additional Clinical Trials Data for Ispinesib
...y prostate cancer. Ispinesib is a novel small molecule inhibitor of kinesin spindle protein (KSP), a mitotic kinesin essential for proper cell division. Ispin...om this program, ispinesib and SB-743921, each a novel inhibitor of kinesin spindle protein (KSP), a mitotic kinesin. Ispinesib has been the subject of a broa...Slicing chromosomes leads to new insights into cell division
...e through mitosis, during which the DNA-containing chromosomes separate between the resulting daughter cells. Forces in a structure called the mitotic spindle guide the replicated chromosomes to opposing sides as one cell eventually becomes two. "Each cell needs the right number of chromosomes. It's centr...Scientists deconstruct cell division
...sts have tried for years to unravel the process of spindle assembly. Now, researchers at Carnegie's Departmen...nctions, are essential to regulate assembly of the spindle matrix. "The mechanisms that cells use during d...s adult tissues, such as skin and bones. Forming a spindle requires the assembly of a 'skeleton' from tube-li...Dartmouth researchers find new protein function
...its own, it hitches a ride on the ends of microtubules which results in a dynamic cross-linking between the arms of chromosomes and the cell's growing spindle of microtubules. If NOD doesn't function properly, then the two cells end up with either both or none of that particular chromosome, which is lethal [...How chemo kills tumors: research to reduce side effects
...are published in the journal Cancer Cell (August 2008), have shown how different tumours respond to the anti-mitotic drugs which target the mitotic spindle (the structure that separates the chromosomes during cell division) and revealed that the variation in cell behaviour was far greater than previously...Analysis of RNA role in spreading disease advances study of damaging plant infections
...to look at all of the loops of a viroid RNA and see how each one functions, Ding said. The viroid model used for this research is called the Potato spindle tuber viroid, and its infection was studied in a tobacco-like plant called Nicotiana benthamiana for the experiment. Lead study author Xuehua Zhong, a...Oosight microscope enables embryonic stem cell breakthrough
...alipovs team to clearly see and remove the meiotic spindle (and the attached genetic material) from 304 femal... the problem was always that you could not see the spindle in the egg, Mitalipov says. The only way to see it...id-crystal polarized light technology to image the spindle noninvasively, with high contrast and quality. ...Green algae -- the nexus of plant/animal ancestry
...wo lineages. The flagella are equivalent to the cilia and centrioles in animal cells. Centrioles are structures involved in cell division; they form a spindle apparatus, which helps separate genetic material into two new cells during mitosis. Cilia are important to many animal functions. The study identif...A unique arrangement for egg cell division
...ith the correct number of chromosomes is a bipolar spindle consisting of protein filaments, called microtubules that are part of the cells skeleton. spindle microtubules attach themselves to the chromosomes,...te. They predetermine the bipolar structure of the spindle that is essential to extrude exactly half of the c...Researchers shed light on shrinking of chromosomes
...o the cell to block the late condensation, more separation defects appeared. “Sometimes chromosomes get stuck and cannot be fully separated by the spindle that normally distributes them into the daughter cells,” says Felipe Mora-Bermúdez, who carried out the experiments in Ellenberg’s lab, “we think that...Molecular motors and brakes work together in cells
...tal Biology. "This study lets us have a more complete picture." Microtubules are structures that help give shape to many types of cells, form the spindle -- a structure important in cell division -- and act as a railroad, of sorts, upon which molecular motors move protein packages for waste removal and ...EntreMed's MKC-1 Meets Primary Efficacy Endpoint in Non-Small Cell Lung Cancer Clinical Trial
...tumor growth inhibition or regression in multiple preclinical models, including paclitaxel-resistant models. MKC-1 has been shown to inhibit mitotic spindle formation, prevent chromosome segregation in the M-phase (mitosis) of the cell cycle, and induce apoptosis. Furthermore, MKC-1 inhibits the Akt-mTOR s...Oncolytics Biotech Inc. Investigators Present Interim U.S. REOLYSIN(R) Phase II Sarcoma Trial Data
...---------- Chordoma 5* SD ------------------------------------------------------------------------- Unspecified spindle Cell 5* SD ------------------------------------------------------------------------- * patients still on study An oral presenta...JCI online early table of contents: March 6, 2008
...structural components of a cell. Consistent with a role for SBDS in mitotic spindle stability, BMSCs from individuals with SDS exhibited increased abnormal mit... a new approach to the treatment of individuals with SDS. TITLE: Mitotic spindle destabilization and genomic instability in Shwachman-Diamond syndrome AU...Mouse Brain or Impressionist Painting?
...maging Research at UCSD for his photos of rat tongue and cerebellum; Pat Wadsworth of the University of Massachusetts for her depiction of the mitotic spindle in a diving cell; Earl Nishiguchi of the University of Hawaii for his fruit fly testis image; Jan Schmoranzer of Columbia University for his photo of ...Chippewa Valley Technical College helps pioneer nanotech program, incubator
...y," Ihlenfeldt said. "We've put out a ton of machine tool people in this region, and they need to know how to operate in an environment where you have spindle speeds up to 40,000 RPM, working with a product that you really can't see, and if you touch it, becomes scrap. We will have a certificate that will gi...Using the SpectraMax Plus for USP Dissolution Calibration (MaxLine Application Note #27)
... Dissolution. 1 Each individual apparatus (i.e. spindle or basket) must be tested with disintegrating type...ering, deaeration, verification of temperature and spindle speed). Prepare the samples and standards ...d easily for different calibrators, lot numbers or spindle speeds. The Calculation dial...Assessing Gene Function with siRNA Libraries
...s likely corresponds to activation of the well-studied spindle assembly checkpoint, which monitors the correct, functional interactions between spindle microtubules and kinetochores in preparation for metap...