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Sitagliptin in Medical News

Amylin Pharmaceuticals to Present Compelling Efficacy and Safety Data From Diabetes Programs at ADA 2009

... (6:30 PM ET). Poster Late Breaker: "DURATION-2: Exenatide Once Weekly Demonstrated Superior Glycemic Control and Weight Reduction Compared to sitagliptin or Pioglitazone after 26 Weeks of Treatment" will be presented by Richard Bergenstal, M.D., during a poster session on Saturday, June 6 from 11:30 AM ...

Two Studies at AACE 2009 Annual Meeting Highlight Effects of Welchol(R) (colesevelam HCl) on Blood Glucose and LDL-C in Patients with Type 2 Diabetes

...m HCl (Welchol(R)), Rosiglitazone (Avandia(R)), or sitagliptin (Januvia (R) ) in Patients with Type 2 Diabete...ol 3.75 g/d (n=57), rosiglitazone 4 mg/d (n=56) or sitagliptin 100 mg/d (n=56). This study was designed to evalu...1C between the groups. Welchol, rosiglitazone and sitagliptin each significantly reduced mean A1C (p<0.05, &l...

Popular diabetes treatment could trigger pancreatitis, pancreatic cancer

...in humans. Januvia is marketed by Merck & Co. Inc. sitagliptin is a member of a new class of drugs that enhance t...used human IAPP transgenic (HIP) rats to test both sitagliptin and metformin; metformin, a member of an older, di...ced insulin sensitivity in the test rats. With the sitagliptin alone, however, the rats had abnormally high rates...

New Study Data: JANUVIA&#8482; (sitagliptin) Significantly Reduced Blood Sugar Levels and Was Not Associated with Hypoglycemia in Elderly Patients with Type 2 Diabetes

...controlled factorial study of initial therapy with sitagliptin in combination with metformin, the incidence of hy...ients given placebo, 0.6 percent in patients given sitagliptin alone, 0.8 percent in patients given metformin alone and 1.6 percent in patients given sitagliptin in combination with metformin. Dosing of JAN...

Cost of Diabetes Care Has Doubled

...ssue of the Archives of Internal Medicine . The dramatic increase in cost is due to the high cost of commonly prescribed newer drugs. For example, sitagliptin (Januvia) costs $160 per prescription and exenatide (Byetta) costs $210 per prescription. That's eight to 11 times higher than older, generic drugs su...

Two-in-one Diabetic Drug Approved by FDA

...investigational oral medicine combining Januvia or sitagliptin phosphate, with the older widely-used generic drug...min (at least 1,500 mg daily). In this study, sitagliptin phosphate 100 mg once daily added to patients inad...lso observed that the concurrent administration of sitagliptin phosphate with metformin was generally well tolera...

Sitagliptin, Under Investigation For Type 2 Diabetes

...d and not when blood glucose is low). If approved, sitagliptin would be a member of a new class of antihyperglyca...e similar to placebo. In addition, patients taking sitagliptin experienced no significant weight gain and a low r...ight into the efficacy and tolerability profile of sitagliptin over a longer period of time. ...
Sitagliptin in Medical Technology

Exenatide Once Weekly Provided Superior Glucose Control With Weight Loss Compared to Sitagliptin or Pioglitazone in Head-to-Head DURATION-2 Study

SAN DIEGO, INDIANAPOLIS and CAMBRIDGE, Mass., March 31 /PRNewswire-FirstCall/ -- Amylin Pharmaceuticals, Inc. (Nasdaq: AMLN ), Eli Lilly and Company (NYSE: LLY ) and Alkermes, Inc. (Nasdaq: ALKS ) today announced positive results from DURATION-2, the second in a series of studies designed to...

Research: Popular Diabetes Medications Associated with Increase in Bone Fractures

...dict Pancreatitis Risk from Incretin Mimetics New research suggests that the medications known as incretin mimetics -- which include exenatide and sitagliptin -- do not increase the risk of pancreatitis in patients with diabetes, contradicting previous case reports concerning the drug class that led to stron...

DURABLE Clinical Trial Results Show GlycoMark is Key Test for Managing Patients with Diabetes

...ramlintide-Treated Subjects Reference: American Association of Clinical Endocrinologists 2007 Annual Meeting (Cameron Lush) Efficacy and Safety of sitagliptin Monotherapy in Japanese Patients with Type 2 Diabetes Reference: Diabetes Research and Clinical Practice 2008 (Kenji Noaka) Does serum 1,5-AG esta...

Metabolex Initiates Phase 1 Trial of MBX-2982

...owever, MBX-2982 can be delivered orally. In addition, MBX-2982 may provide additional benefit when used in combination with a DPP-4 inhibitor such as sitagliptin (Januvia(R)), or other oral therapies. "We have identified a number of potent GPR119 agonists that improve glucose control in normal and diabetic an...

FDA Accepts Investigational New Drug Application for ARI-2243 and a First in Man Clinical Trial Set to Begin During the First Half of 2008

...ion from the enzyme is very slow. Such kinetics confer potency and long activity. During OGTT in normal mice, ARI- 2243 was 250 times more potent than sitagliptin and maximally lowered blood glucose by 88%. Additionally, in ZDF rats, an animal model that develops overt diabetes, ARI-2243 significantly reduced he...

Late Breaking Data Released at ADA Showed that the Investigational Use of Januvia and Metformin as Initial Combination Therapy Provided Significant Glucose Lowering Efficacy over 54 Weeks in Patients with Type 2 Diabetes

.... There are no contraindications for JANUVIA. sitagliptin is also a component of JANUMET(TM) (sitagliptin/me... who are not adequately controlled on metformin or sitagliptin alone or in patients already being treated with th... important and useful information about the use of sitagliptin and metformin, in addition to diet and exercise, i...

An Investigational Study Released at ADA Showed that Initial Combination Therapy with Januvia (sitagliptin) and Metformin Led to Improvement in Markers of Beta Cell Function in Patients with Type 2 Diabetes

...ngs. There are no contraindications for JANUVIA. sitagliptin is also a component of JANUMET(TM) (sitagliptin/me... who are not adequately controlled on metformin or sitagliptin alone or in patients already being treated with th...therapy and for those not adequately controlled on sitagliptin is 50 mg...
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