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silico in Medical News

In silico modeling helps predict severity of mitochondrial disease

A team of researchers in Australia, the United Kingdom and the United States has revealed how mitochondrial diseases are passed from the mother to the next generation in a mouse model system. The study, which was published on-line in Nature Genetics*, shows for the first time how mitochondrial dis...

EPIX Pharmaceuticals, Inc. Announces August 25, 2009 for the Auction Sale of Equipment and September 30, 2009 for the Auction Sale of the Intellectual Property

... EPIX's products and services focus on the discovery and development of novel therapeutics through the use of its proprietary and highly efficient in silico drug discovery platform. The company has a pipeline of internally-discovered drug candidates currently in clinical development to treat diseases of ...

URI awarded $13 million grant to develop vaccines for emerging infectious diseases

...formatics, said the new Translational Immunology Research and Accelerated Vaccine Development (TRIAD) program will integrate vaccine design studies in silico (via computer simulation) with in vitro and in vivo research. "While the NIH grant is Professor De Groot's first award since joining the URI facul...

EPIX Pharmaceuticals, Inc. Assigns all Its Assets to Joseph F. Finn, Jr., C.P.A. for the Benefit of Its Creditors

... EPIX's products and services focus on the discovery and development of novel therapeutics through the use of its proprietary and highly efficient in silico drug discovery platform. The company has a pipeline of internally-discovered drug candidates currently in clinical development to treat diseases of ...

Cambridge Healthtech Institute's 7th Annual Bio-IT World Conference & Expo Enabling Technology - Leveraging Data - Transforming Medicine

...hnology and scientific presentations. The program features six parallel tracks in the areas of: IT Infrastructure, Genomic Medicine, Predictive and in silico Science, Computational Chemistry, Clinical and Medical Informatics, and Health IT. Keynote presentations will be featured by Chris Dagdigian, Fo...

Also in the Jan. 27 JNCI

...at is able to predict in vitro interactions between tyrosine kinases and their natural ligands and inhibitors," the authors write. "Accordingly, an in silico approach could be used to predict the biological response to new molecules conceived as small-molecule inhibitors of tyrosine kinases in the future." ...

Gene Network Sciences Announces Creation of Spin-off Entity Focused on Quantitative Finance and E-Commerce

...ual components in the system interact with one another (Reverse Engineering). These computer-assembled models are then simulated using billions of in silico queries (Forward Simulation) to discover the highest-impact components and to predict outcomes for previously unseen scenarios. About Gene Net...

Gene Network Sciences Announces Drug Development Collaboration with Biogen Idec

...nteract with one another in the complete system (Reverse Engineering). These computer-assembled models are then queried rapidly through billions of in silico experiments (Forward Simulation) to discover the highest-impact molecular targets for the disease being studied and the corresponding efficacy and tox...

Salivary diagnostics, the 'magic mirror' to your health ... at your personal computer

...onvenience, and non-invasiveness are the most critical characteristics for any diagnostic tool. A new concept, Salivaomics Knowledge Base (SKB), an in silico (i.e., performed on computer or via computer simulation) saliva diagnostic atlas, is launching today during the 37th Annual Meeting of the American As...

American Chemical Society's Weekly PressPac -- March 5, 2008

...e sorted out without losing considerably more drugs in the succeeding steps, the researchers say. MTS ARTICLE #3 FOR IMMEDIATE RELEASE Gradual in silico Filtering for Druglike Substances DOWNLOAD FULL TEXT ARTICLE http://dx.doi.org/10.1021/ci700351y CONTACT: Michael C. Hutter Saarland Unive...

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silico in Medical Technology

Data Support use of SuperGen's CLIMB Technology in Lead Development and Optimization

...were made into a substrate for screening a large, virtual small molecule library. This process generated a subset of leads that were screened using in silico algorithms to identify "druggable" candidates to pursue. Poster C208 (Abstract No. 985) A small molecule inhibitor of Pim-1 kinase with activity in ...

Data Show SuperGen's Multi-Targeted Tyrosine Kinase Inhibitor Suppresses Critical Double-Stranded DNA Repair Protein, Rad51

...arge, virtual small molecule library. This process generated a subset of leads based on calculated binding energies. These leads were then screened in silico to determine "druggable" candidates. Cell-based activity was determined in HEL, K562, MO7 and other human cancer cell lines. Abstract No. 2229 Zeb...

New Flu Vaccine From PepTcell Could Provide Immunity Against All Strains of Influenza Virus

...es for Editors About the European Journal of Immunology Gregory A Stoloff, Wilson Caparros-Wanderly: Synthetic multiepitope peptides identified in silico induce protective immunity against multiple influenza serotypes. European Journal of Immunology. 2007. Copyright Wiley-VCH Verlag GmbH & Co. KGaA....

New Flu Vaccine from PepTcell Could Provide Immunity Against All Strains of Influenza Virus

...ES FOR EDITORS About the European Journal of Immunology Gregory A Stoloff, Wilson Caparros-Wanderly: Synthetic multiepitope peptides identified in silico induce protective immunity against multiple influenza serotypes. European Journal of Immunology. 2007. Copyright Wiley-VCH Verlag GmbH & Co. KGaA....
silico in Biological News

Application of Genomatix in silico methods reveals novel cancer associated genes

Genomatix Software GmbH, an in silico systems biology company with headquarter in Munich (Germany), released today that researcher in Dublin, Ireland and Boston, U.S.A. identified novel cancer associated genes, based on strategies and products developed and promoted by Genomatix. Experimental verif...

New e-science service could accelerate cancer research

... at The University of Manchester provides access to over 3,500 Web Services that can be composed by scientists for constructing and enacting their in silico experiments. But one of the main issues that hinders the wide adoption and use of Web Services is the difficulty in locating those that perform th...

Malfunction of the respiratory epithelium is a cause of allergy?

...xpensive and produce much more raw data than hypothesis-derived approaches thus generating an overflow of data. However, the urgent need to develop in silico data managing and analysis environments has been recognized by several research groups and biocompanies. ...

Researchers iron out new role for serotonin

...ues also demonstrates the utility of a powerful in silico approach for discovering novel traits linked to su...linked with the low functioning SERT. From this in silico approach, Blakely and colleagues identified multip...d. The study also demonstrates the power of an in silico approach combined with traditional experimentatio...

Research-based undergraduate course expands beyond Washington University

...enewed in 2006. With that support, she set out to make the course available to undergraduates at institutions across the country. Researching in silico Biology majors at Washington University often begin their research by spending a summer in the laboratory under the guidance of a faculty, gradua...

Researchers apply systems biology and glycomics to study human inflammatory diseases

...he glycome reaction network that controls the final glycan structure that appears on cells," Neelamegham explained. "This approach then provides an in silico tool that can be applied to perturb the system of interest, such as the glycosylation network." Those studies, in turn, he continued, can then gener...

New lab manual focuses on essential methods for purifying and characterizing proteins

...new manual, Basic Methods in Protein Purification and Analysis , integrates established in vitro and in vivo molecular techniques with more modern in silico methods. It takes the user from the initial steps of obtaining cellular and subcellular extracts, through the purification and isolation steps approp...

Work with power grids leads to cell biology discovery

...utational scientists now are beginning to develop quantitative models of biological systems that allow them to predict cellular behavior. In one in silico experiment (via computer simulation) with E. coli, the researchers found that the deletion of one gene is lethal to the cell but when that same gene i...

Researchers discover the structural alphabet of RNA

...arisien, a graduate student in his laboratory, to propose a radically different approach to model RNA structure. Their idea: assemble the structure in silico starting from motifs that combine all the possible interactions between a nucleotide and its neighbors. The researchers implemented a first algori...

From stem cells to organs: The bioengineering challenge

..., you have a much better understanding of it than if you just observe it," he says. "And it's also a powerful way to test many different hypotheses in silico before going into the lab and doing the much more difficult experiments in vitro." Dr. Zandstra, the Canada Research Chair in Stem Cell Bioenginee...

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silico in Biological Technology

DNA Software, Inc. Awarded $2.5 M in NIH Funding to Develop Pioneering Nucleic Acid-based Technologies

...tional Institutes of Health to develop original in silico technologies to predict 3D structures of RNA-based...tional Institutes of Health to develop original in silico technologies to predict 3D structures of RNA-based...lutions from this nucleic acid information. In silico 3D Structure Prediction to Improve and Accelerate ...

Genedata Launches Expressionist with Expanded Mass Spectrometry Biomarker Discovery Capabilities

...h# 133 at the Pennsylvania Convention Center. Philadelphia, PA (PRWEB) June 1, 2009 -- Genedata , a leading provider of in silico solutions for pharmaceutical R&D and related life sciences, today announced the release of Expressionist 5.2 with enhanced capabilities for Mass ...

DNA Software, Inc. Honored as One of the 2009 "Michigan 50 Companies to Watch"

...iagnostics, and therapeutics. OMP™ (Oligonucleotide Modeling Platform™), the core engine that runs all of DNA Software's tools, models in silico the folding and hybridization of nucleic acids with exception accuracy. Visual OMP™ is a platform program for the design, simulation, and analy...

GeneGo Announces Systems Tox Relationship With Entelos

...neration predictive technologies to revolutionize the way medicines are discovered, developed, and utilized. The Company leverages its proprietary in silico disease models, "virtual human" technology, and toxicology reference systems to develop safer and more effective drugs, improve the quality of health...

Prous Institute Presents Innovative Approach to Drug Discovery

...iven drug discovery from natural sources, covering type 2 diabetes, psychological stress and asthma. The Institute's computational tools enable the in silico screening of thousands of natural products in a rapid, reliable and cost-effective manner, as well as the discovery of new targets and new uses for ex...

Sirnaomics and GRL Establish Partnership for the Development of Two Multi-Targeted RNAi Therapeutics Products

...therapeutic products, following the successful identification of siRNA inhibitors for multi-targeted siRNA cocktail approaches, through a series of in silico and in vitro studies, using Sirnaomics' Tri-Blocker(TM) technology. Under the terms of the agreement, Sirnaomics and GRL will jointly focus on devel...

Lethal Human H5N1 Influenza Virus Replikin Gene Still Upregulated

...be concentrated in specific genomic areas. The area of each genome with the highest concentration of continuous replikin peptides has been isolated in silico and named a Replikin Peak Gene (RPG). Using proprietary computer algorithms constructed to identify, count, and track historically this class of prote...

Pharsight Expands Strategic Consulting Services Team

...ve will further enhance the services that we can provide to our clients." Dr. Struemper comes to Pharsight from Entelos Incorporated, where he led in silico research and development projects in rheumatoid arthritis, obesity and diabetes. He has broad experience in biomarker identification and evaluation, d...

Americas Third Coast nurtures biotechnology

...o-guanosine to simplify identification. MasterCatalog is a genome software analysis system that uses a patented genetic evolutionary technology for in silico protein prediction. The software predicts protein function by computing the evolutionary characteristics associated with 130 specific genomes. Gen...

Multiplexed Quantitative Peptide Assays for Protein Biomarkers of Cardiovascular Disease in Human Plasma

.../MS spectra. For the remaining candidates, MRMs were developed either by in silico design, based on gene or protein sequences, or by targeted, direct detectio...rmined either experimentally from previously obtained proteomics data or in silico by using the MIDAS workflow software designer. From the protein sequence, t...

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silico in Biological Products

MIDAS TRAQ System with 4000 Q TRAP LC/MS/MS System from Applied Biosystems

Description:...usly even in complex tissue, proximal fluid, or plasma samples. Design in silico Multiplexed MRM Assays Based on Gene or Protein Sequences. MIDASs Workflow Designer Software enables you to design in silico multiplexed MRM (multiple reaction monitoring) assays based on gene or prot...
Company:Applied Biosystems
silico in Biological Definition

Artificial life

... logical form of living systems. Microelectronic technology and genetic engineering will soon give us the capability to create new life forms in silico as well as in vitro , This capacity will present humanity with the most far-reaching technical,theoretical and ethical challenges it has ever confr...

Biology

...h Center - Bachelor of Science - Publications Terms and phrases Omne vivum ex ovo - In vivo - In vitro - In utero - In silico Related disciplines Medicine ( Physician ) - Physical anthropology Outstanding problems Origin of life - Unsolved problems in...
silico in Biological Dictionary

In silico

In silico is an expression used to mean "performed on computer or via computer simulation." The phrase is coined in analogy to the Latin phrases in vivo and in vitro which are commonly used in biology and refer to experiments done in living organisms and outside of... In...

Prophage

..... prophage . Prophages. Prophages. Prophages. Prophalangopsidae. propham ... In the case of prophage t712 it has been demonstrated that the in silico ... The prophage sequences occupy various positions in the genomes of L. lactis subsp. ... Prophage information including symptoms, causes, di...
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