silences

Holmes Silences Pregnancy Rumours

Hollywood actress and wife of superstar Tom Cruise, Katie Holmes has silenced rumours that she is pregnant by showing off her figure in a revealing swimsuit. Hollywood.com reports that there were rumours that Holmes was in the early stages of pregnancy after she looked like she had a round...

Commonplace Sugar Compound Silences Seizures

Though in clinical use for decades, a small, sweet-tasting compound is revealing a startling new face as a potential cure for epilepsy.// 2-deoxy-glucose, or 2DG, has long been used in radio labeling, medical scanning and cancer imaging studies in humans. But now, researchers at the Universit...

The future of personalized cancer treatment: An entirely new direction for RNAi delivery

...esultant fusion protein to enter the cell and deliver the siRNA into the cytoplasm where it specifically targets mRNAs from cancer-promoting genes and silences them. To determine the ability of this PTD-DRBD fusion protein to deliver siRNA, the researchers generated a human lung cancer reporter cell line...

Fast-Track of Socialized Healthcare Imminent

... Procedural Trickery Changes the Rules and silences Opposition Debate CHESAPEAKE, Va., April 28 /PRNewswire-USNewswire/ -- The following was released today by Grassfire.org: Fearing they will ...

Colon cancer shuts down receptor that could shut it down

...like the newly found GPR109A receptor, cancer also silences the SLC5A8 butyrate transporter. In his current st...butyrate produced by bacteria to come inside so it silences the transporter. It also does no want butyrate to act on the cell from the outside so it silences the receptor," Dr. Ganapathy says. "It does not wa...

Gene Behind Childhood Anemias Found

...re some hemoglobin production, turning these life-threatening diseases into manageable chronic conditions. "We have identified a gene that directly silences the fetal hemoglobin gene," said lead researcher Dr. Stuart Orkin, an investigator at the Howard Hughes Medical Institute and Children's Hospital Bost...

Americans United for Life Urges State Legislatures to Oppose Federal Power Grab: Provides Model Resolution Denouncing Freedom of Choice Act (FOCA)

...ce Act' endangers women's health. It protects and promotes the abortion industry, sacrifices the health of women to a radical political ideology, and silences the voices of everyday Americans who want to engage in a meaningful public discussion on abortion." AUL and its legislative arm AUL Action ar...

Grapefruit Compound Inhibits Hepatitis C Virus

... Flavonoid called naringenin silences infection pathway, hints of new disease treatments TUESDAY, May 6 (HealthDay News) -- The grapefruit flavonoid naringenin inhibits the sec...

Researchers identify and shut down protein that fuels ovarian cancer

...proteins. siRNAs are short, double-stranded bits of RNA capable of halting that process. The team confirmed in a lab experiment that a specific siRNA silences IL-8 and then tested it against two lines of ovarian cancer in a mouse model. Sood, Gabriel Lopez-Berestein, M.D., professor in M. D. Anderson's ...

Drug Strategy Makes Cancer Genes Get Lost in Translation

...e that targets such weak mRNA, preferentially interrupting its translation into active proteins. As a result, the molecule, called 4EGI-1, effectively silences oncogenes, which have links to cancer. They also found evidence that the small molecule inhibitor exhibits activity against multiple cancer cell lines...

silences in Medical Technology

Thermo Fisher Scientific Introduces Breakthrough in RNA-Interference Technology

...y cells without the use of conventional delivery methods such as transfection reagents, viruses or electroporation. Dharmacon Accell siRNA effectively silences genes in all cell types tested to date. RNAi is a powerful technology used to silence, or knock down, target genes and the proteins they produce, re...

Fragile X, Down Syndromes Linked to Faulty Brain Communication, Stanford Researcher Finds

...sually more severely affected when Fmr1 is mutated. Girls are not immune to the condition, however. A phenomenon called X-inactivation, which randomly silences one member of every X chromosome pair, creates a mosaic of affected and unaffected nerve cells in the brain. In some conditions linked to the X chro...

silences in Medical Products

2100 Pulse Oximeter

Features:... alarm limits for SpO2 and pulse rate A temporary alarm silence feature; silences audible alarms for 120 seconds An "all mute" alarm silence feature; silences audible alarms continuously until deactivated Status and alarm informatio...
Company:Dolphin Medical, Inc.

silences in Biological News

Mount Sinai researchers discover technology that silences genes

Mount Sinai researchers have developed a new gene silencing technology that could be used to target genes that can lead to the development of certain diseases. This technology could pave the way for preventing diseases where gene dysfunction plays a role. The groundbreaking research was led by Min...

MIT: Pulsing light silences overactive neurons

Scientists at the MIT Media Lab have invented a way to reversibly silence brain cells using pulses of yellow light, offering the prospect of controlling the haywire neuron activity that occurs in diseases such as epilepsy and Parkinson's disease. Such diseases often must be treated by removing ne...

Researchers find protein that silences genes

A team of researchers, including biologists at Washington University in St. Louis, has discovered the key role one protein plays in a major turn-off –in this case, the turning off of thousands of nearly identical genes in a hybrid plant. Studying the phenomenon of nucleolar dominance, in which o...

Interfering RNA silences genes in 'slippery' immune cells

A technical advance in laboratory techniques may provide biology researchers broader access to RNA interference, a process of blocking the activity of targeted genes. RNA interference has recently emerged as an important tool in studying how genes function in normal biological processes and in dise...

Used in a new way, RNA interference permanently silences key breast cancer gene

In laboratory mouse experiments, researchers at The University of Texas M. D. Anderson Cancer Center have developed a way to use RNA interference (RNAi) so that it permanently hampers breast cancer development. The technique permanently silences activated STAT3, a crucial gene found in some human b...

A miR boost enables acute leukemia cells to mature

...uction of the DNMT1 protein. Thus, low levels of the miR may result in lots of Sp1 protein and of DNMT1, which busily adds the chemical units that silences genes. High levels of the miR, on the other hand, may keep the amount of Sp1 low, so there is little DNMT1 and much less gene silencing. "Our paper...

Newly found enzymes may play early role in cancer

...I investigator and professor of oncological sciences at the University of Utah. "You can think of DNA methylation as an on-and-off switch. Methylation silences or 'shuts off' genes that need to be turned off or are not functioning as they should, whereas the reverse process called demethylation 'turns on' hea...

Newly-discovered mechanism can explain the Beckwith-Wiedemann syndrome

... Researchers from Uppsala University have discovered a mechanism that silences several genes in a chromosome domain. The findings, published in today's on-line issue of Molecular Cell , have implications in understanding the hum...

MGH researcher Gary Ruvkun named a co-recipient of the Lasker Award

...n plants and animals. In 2000 Ruvkun's team discovered let-7, another tiny regulatory RNA that shuts down its target gene the same way that lin-4 silences lin-14. They also found that the let-7 RNA sequence had been snipped out of a larger RNA molecule that folds back on itself in a hairpin shape. Late...

Class of antibiotics can enhance gene-silencing tool

...w RISC works, Jin and his co-workers inserted a gene for a fluorescent protein into a cell line, and then added a short piece of RNA that incompletely silences the inserted gene. That way, if a potential drug tweaked the silencing process, the researchers could see it quickly. They found that enoxacin can ...

silences in Biological Technology

Research Using Thermo Fisher Scientific RNA-Interference Technology Unveils Potential New Targets for HIV Drugs

...chool and its affiliates. The siGENOME siRNA Library is a collection of more than 21,000 siRNAs targeting every gene in the human genome. Each siRNA silences or disrupts the gene's ability to produce a specific protein. The siGENOME siRNA Library is currently used by many of the world's leading research ins...

RNAi: Size Does Matter

... Everyone wants to design the dsRNA that most efficiently silences the gene of interest. But how does dsRNA length correlate with silencing efficiency? Ambion scientists addressed this qu...

RNAi: A How To for New Users

...on.com/catalog/CatNum.php?4605"> Silencer GAPDH siRNA is an ideal positive control. This siRNA efficiently silences GAPDH expression and its effects can be easily monitored by qRT-PCR or other methods at the mRNA level, or b...

A New Way to Assess siRNA Delivery Efficiency

...cess. Ambions Silencer GAPDH siRNA is an ideal positive control for transfection optimization studies because it efficiently silences GAPDH--a ubiquitously and highly expressed gene--in human, mouse, and rat cells. Now Ambion has developed a new assay to rapidly...

silences in Biological Products

microRNA Expression Profiling - Comprehensive Service from LC Sciences

Description:... small RNAs and designer gene/DNA library synthesis. (1) Vagin VV, Sigova A, Li C, Seitz H, Gvozdev V, Zamore PD. (2006) A Distinct Small RNA Pathway silences Selfish Genetic Elements in the Germline. Science 313(5785), 320-324. (2) Saito, Y., Liang, G., Egger, G., Friedman, JM., Chuang, JC., Coetzee, GA.,...
Company:LC Sciences

Small Non-coding RNA Discovery Microarray - Comprehensive Service from LC Sciences

Description:... small RNAs and designer gene/DNA library synthesis. (1) Vagin VV, Sigova A, Li C, Seitz H, Gvozdev V, Zamore PD. (2006) A Distinct Small RNA Pathway silences Selfish Genetic Elements in the Germline. Science 313(5785), 320-324....
Company:LC Sciences

silences in Biological Definition

Lyon hypothesis

..., the paternal X chromosome is always inactivated. Inactivation is achieved by methylation of the X chromosome DNA, a common way in which the cell silences particular genes. Certain animals have their coloring patters dictated by this phenomenon. For example, female Calico cats have unique patterns of f...