A Fit of Laughter Silenced by an Unusual Surgery
Anastasia Lagala's was quite a spectacle when she had epileptic seizures, almost 30 a day. What made her stand apart was - during her fit , her face had a scowl and a guttural sinister laughter would emanate from her throat, as she convulsed.
This had led her to be named as "The Joker face,...
Researchers Developing New Therapy to Re-activate Silenced Genes
Researchers at the University of Illinois at Chicago and Cornell University are developing a new therapy to re-activate silenced
genes in patients who suffer from Neurodegenerative diseases or stroke .
During and after a stroke, certain cellular events take place that lead to the death of b...
A ‘Fit’ of Laughter Silenced by an Unusual Surgey
Anastasia Lagala's was quite a spectacle when she had epileptic seizures, almost 30 a day. What made her stand apart was - during her fit//, her face had a scowl and a guttural sinister laughter would emanate from her throat, as she convulsed.
This had led her to be named as "The Joker face,"...
Scientists identify gene in breast cancer pathway
...luding breast, colorectal, and non-small cell lung cancers; but the gene is silenced
in metastasizing cancer cells, as was shown by Dr. Singer and another Einst...purpose of the current study was to find how the ZBP1 gene is activated and silenced
and how it influences the spread of breast cancer.
After examining mouse...
Fast-Track of Socialized Healthcare Imminent
...buchar, Byrd, Lincoln, Landrieu, Levin, Bayh, Ben Nelson, Casey and Pryor.
"Once again statist politicians have carved out a deal in darkness and silenced
opposition debate," says Elliott. "A shift this monumental needs to be debated in clear view of the public -- not hidden behind a closed door on Capit...
Gene Studies Reveal Cancer's Secrets
... common in women," Liang said during the teleconference. "It is mainly found in smokers."
DNA methylation is a process in which genes can be either silenced
or activated in cancer. For the study, researchers measured DNA methylation in 12 patients who did not have bladder cancer, 52 patients with non-invas...
Progen Technology Switches on Cancer Fighting Genes and Inhibits Tumor Growth
...sfully developed PG11144 that inhibits LSD1 and reactivates (expresses) the silenced
genes that are inactivated in cancer.
Progen's Chief Scientific Office...ysine-specific demethylase 1 (LSD1), induce re-expression of epigenetically silenced
genes, and inhibit the growth of established human tumors in vivo
Colon cancer shuts down receptor that could shut it down
...hat causes inflammation, a precursor to cancer.
"We know the receptor is silenced
in cancer but it's not like the gene goes away," says Dr. Vadivel Ganapathy...te transporter. In his current study, the researcher found the receptor was silenced
in 15 of 18 colon cancer patients.
"Colon cancer does not want butyrate ...
World-first high blood pressure treatment trialled in Melbourne
... is carried out under local anaesthetic and uses radio energy frequency, delivered to the targeted nerve area via catheter. As a result the nerves are silenced
in the renal artery, which supplies blood to the kidneys.
Researchers had long-believed that this region was a key regulator of blood pressure, but...
Cancer stem cells generated by cancer outgrowth
...hat cancer stem cells may be generated as a direct function of the outgrowth of cells in the animal. "To our knowledge, this is the first example that silenced
endogenous embryonic stem cell genes can be spontaneously reactivated in differentiated cells," says Dr. Dean. "We propose that the loss of cell conta...
silenced in Medical Technology
Cloned Human Embryos Successfully Reprogrammed Using Human - But Not Animal - Eggs
...f the key differentially-expressed genes were activated in the human clones. In distinct contrast, the majority of these genes were down-regulated or silenced
in the human-animal hybrids.
"We examined the factors recently used to reprogram skin cells (to induce pluripotent stem cells)," said Robert Lanz...
Gene Marker May Improve Odds of Stem Cell Therapies for Disease
...o Institute for Cancer Research and Molecular Medicine at Temple University . "Next we will work to confirm our data by seeing the impact when Rb2 is silenced
in these stem cells."
The Human Health Foundation (HHF) ( www.hhfonlus.org ) is a nonprofit organization designed to develop and fund biomedical ...
Presentation of Data on Progen's Cancer Epigenetic Targets Platform
..., may activate genes that protect against tumor development. These
LSD-1 inhibitors are the first to demonstrate effective re-expression of
genes by targeting this recently discovered cancer gene
Dr. Laurence Marton, Progen's Chief Scientific Officer, said, "We have
MDS Patients on Five-Day Vidaza(R) Dosing Schedules Achieve Transfusion Independence Consistent with Seven-day Schedule
...ion is inhibited by MGCD0103.
The epigenetic approach to cancer therapy is that rather than using
molecules that kill both normal and tumor cells, the silenced
reactivated through targeted epigenetic therapy, re-establishing the cancer
cell's natural mechanisms to control abnormal growth.
SuperGen's Novel Hypomethylating Agent Highlighted at AACR Plenary Session
...itabine in human plasma. S110 demonstrated
similar or improved activity compared to decitabine in re-expression of
p15, p16, and MLH1 genes, which are silenced
in cancer through methylation.
S110 delivers decitabine with improved preclinical pharmacokinetics, and
has a similar impact on HbF in non-human prima...
SuperGen to Highlight Oncology Pipeline Data in Multiple
Presentations at AACR
...lls by the
Wed., 8 a.m. - 12 p.m. Dual inhibition of #5421
Alnylam Announces Advancement of a New RNAi Therapeutic Development
Program for the Treatment of Liver Cancer
after a single injection of a KSP-specific siRNA in a rodent model;
-- Halting of human cancer cell proliferation in vitro when KSP
by a target-specific siRNA.
Alnylam's RNAi therapeutic, ALN-VSP01, is comprised of two small
interfering RNAs, or siRNAs, the molecules that mediate...
Data Show SuperGen's Multi-Targeted Tyrosine Kinase Inhibitor
Suppresses Critical Double-Stranded DNA Repair Protein, Rad51
...e I (DNMT1) in human cancer cells by the
proteasomal pathway and re-express silenced
Researchers have discovered a novel class of quino...3B that have been discovered. This
addresses an issue with re-activation of silenced
genes by 5-Azacytidine (5-AzaC or Vidaza) and its congener...
Clinical Data Reported on Vidaza in Hematologic Malignancies and
Advanced Solid Tumors
...that rather than using molecules that kill both
normal and tumor cells, the silenced
genes are reactivated through
targeted epigenetic therapy, re-establishing ...that
rather than using molecules that kill both normal and tumor cells,
genes are reactivated through targeted epigenetic
therapy, re-establishing ...
silenced in Medical Definition
... during this year he still produced works on philosophical anthropology . Defamed by them as a "gasoline robber", his figure and accomplishments were silenced
until Perón's brief third presidential period (1973-1974).
In this stage Carrillo was recognized, although only as architect and achiever of a Natio...
silenced in Biological News
Restoring silenced suppressor gene kills lung-cancer cells
A new study suggests that restoring a gene often silenced
in lung cancer causes the cells to self-destruct. The findings could lead to a new strategy for treating the disease.
The research focused on a gene known as WWOX, which is lost or silenced
in a large majority of lung cancers, and in canc...
Protein that promotes cancer cell growth identified
... on the outside of cells," said Darren Finlay, Ph.D., first author on the paper. "Although Caspase-8 is involved in apoptosis, it is rarely deleted or silenced
in tumors, suggesting that it was giving cancer cells a leg up in some other way. Our studies suggest that Caspase-8 does so by activating the MAPK pa...
Specific genetic cause of fetal alcohol-related developmental disorders found
...ol exposure disrupts the epigenetic "imprinting" of Dio3. In this process, Dio3 normally originates from the father's gene, while the maternal gene is silenced
by epigenetic control. But alcohol exposure changes the paternal-maternal dosage of Dio3, which increases the amount of the enzyme present in specific...
A miR boost enables acute leukemia cells to mature
...cells can reverse gene changes that trap the cells in an immature, fast growing state of development.
The study discovered how the miR reactivates silenced
genes, which enables the leukemic cells to differentiate and mature, important steps that precede their death. The findings suggest that miR-29b could...
Mayo Clinic researchers discover and manipulate molecular interplay that moves cancer cells
...ure, enabling it to migrate and invade. The researchers found that if PKD1 is active, tumor cells cannot move, a finding they say explains why PKD1 is silenced
in some invasive cancers.
During metastasis, invasive cancer cells respond to biological signals to move away from a primary tumor. Multiple resear...
Malaria immunity trigger found for multiple mosquito species
...the mosquito gut. Rel 2 is activated by the immune deficiency pathway (Imd) which, in turn, is negatively regulated by the caspar gene; when caspar is silenced
the Rel 2 is activated. The researchers found that silencing of the caspar gene through the manipulation of gene expression resulted in mosquitoes tha...
Researchers take first look at the genetic dynamics of inbreeding depression
...lled alleles. If the maternal and paternal alleles differ, one of them usually dominates, conferring all of its qualities to the offspring. The other, silenced
allele is called "recessive."
Some alleles are detrimental to health. Most of these are recessive, meaning that they do not cause problems unless t...
CRG buys Genomatix' Next Generation Sequencing analysis solution
...ch as BRCA1 and BRCA2 exerted their biological effects. Our second avenue of research entails the delineation of the mechanisms by which the genome is silenced
through chromatin modification and small regulatory RNA. The laboratory's goal is to understand the epigenetic regulation of gene expression in mammal...
Large DNA stretches, not single genes, shut off as cells mature
... Nature Genetics online on Jan. 18.
Since the silenced
stretches varied greatly between the different typ...cells, in which about 40 percent of the genome was silenced
by LOCKs, the embryonic stem cells had no LOCKs. ...th organisms had remarkably similar regions of DNA silenced
by LOCKs, suggesting that the same genes necessary...
Study links molecule to muscle maturation, muscle cancer
The study is published in a recent issue of the journal Cancer Cell .
Guttridge and his colleagues discovered that the gene for miR-29 is silenced
by the action of a protein, called NF-B (pronounced, NF kappa B). Their study shows that this protein is present at high levels in rhabdomyosa...
silenced in Biological Technology
SuperGen Reports 2007 Fourth Quarter and Annual Financial Results
...cleotide compound, S110, activates an important fetal hemoglobin biomarker in baboons, confirming the product's ability to activate a specific silenced
gene (Abstract 571). An oral presentation by Donald Lavelle, Ph.D., of the University of Illinois at Chicago, provided evidence that S110 incr...
Pharmion's Oral Azacitidine Granted Fast Track Status for Myelodysplastic Syndromes
...gene expression reactivation. The epigenetic
approach to cancer therapy is that rather than using molecules that kill
both normal and tumor cells, the silenced
genes are reactivated through
targeted epigenetic therapy, re-establishing the cancer cell's natural
mechanisms to control abnormal growth. About Pha...
Pharmion and MethylGene Announce Collaboration to Develop Sirtuin Inhibitors as Anti-Cancer Agents
...ne silencing in cancer
cells. Inhibition of sirtuins allows reexpression of silenced
suppressor genes, leading to reduced growth of cancer cells, and
anti... traditional anticancer agents,
targeted epigenetic therapy reactivates the silenced
tumor suppressor genes
thereby re-establishing the cancer cell's natural me...
RNA Interference and Gene Silencing: History and Overview
...s. In PTGS, the transcript
of the silenced
gene is synthesized but does not accumulate becaus...e and antisense strands of the
gene being silenced
...iptional silencing is transmitted by grafting from silenced
stocks to non-silenced scions. EMBO J ...
Efficient Delivery of siRNAs to Human
Primary Cells: Electroporation
vs. Chemical Transfection...siRNAs targeting CDK2, p53, and JAK1 were individually electroporated
into the same set of primary cells. All three genes were efficiently silenced
Figure 2. Electroporation
of HUVEC Primary Cells. A Cy3-labeled GAPDH siRNA (1.33 g) was ad...
Efficient RNAi-mediated gene silencing in neuronal cells using QIAGEN
siRNA and TransMessenger Transfection Reagent*...es
and Alexa Fluor 488-conjugated goat anti-mouse secondary antibody (MAP2)
and Alexa Fluor 594-conjugated phalloidin. The cell with silenced MAP2 expression
(arrowed) exhibits severely defective filopodial elaboration.
MAP2 has been shown to be required...
silenced in Biological Definition
...lled regulatory elements . So, to be expressed, our DNA strand needs to be properly regulated by other DNA strands.
The DNA strand may also be silenced
through DNA methylation or by chemical changes to the protein components of chromosomes (see histone ). This is a permanent form of regulation of...
silenced in Biological Dictionary
...ules of information and ... Several reviews of DNA methylation have appeared recently that are considered ... Most Tumor Suppressor Genes (TSG) silenced
by DNA methylation ... Current DNA Methylation Profiling Methods. Bisulfite-Sequencing OR Bisulfite-PCR ... (CNIO) (Madrid, Spain), are DN...