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A Fit of Laughter Silenced by an Unusual Surgery

Anastasia Lagala's was quite a spectacle when she had epileptic seizures, almost 30 a day. What made her stand apart was - during her fit , her face had a scowl and a guttural sinister laughter would emanate from her throat, as she convulsed. This had led her to be named as "The Joker face,...

Researchers Developing New Therapy to Re-activate Silenced Genes

Researchers at the University of Illinois at Chicago and Cornell University are developing a new therapy to re-activate silenced genes in patients who suffer from Neurodegenerative diseases or stroke . During and after a stroke, certain cellular events take place that lead to the death of b...

A ‘Fit’ of Laughter Silenced by an Unusual Surgey

Anastasia Lagala's was quite a spectacle when she had epileptic seizures, almost 30 a day. What made her stand apart was - during her fit//, her face had a scowl and a guttural sinister laughter would emanate from her throat, as she convulsed. This had led her to be named as "The Joker face,"...

Scientists identify gene in breast cancer pathway

...luding breast, colorectal, and non-small cell lung cancers; but the gene is silenced in metastasizing cancer cells, as was shown by Dr. Singer and another Einst...purpose of the current study was to find how the ZBP1 gene is activated and silenced and how it influences the spread of breast cancer. After examining mouse...

Fast-Track of Socialized Healthcare Imminent

...buchar, Byrd, Lincoln, Landrieu, Levin, Bayh, Ben Nelson, Casey and Pryor. "Once again statist politicians have carved out a deal in darkness and silenced opposition debate," says Elliott. "A shift this monumental needs to be debated in clear view of the public -- not hidden behind a closed door on Capit...

Gene Studies Reveal Cancer's Secrets

... common in women," Liang said during the teleconference. "It is mainly found in smokers." DNA methylation is a process in which genes can be either silenced or activated in cancer. For the study, researchers measured DNA methylation in 12 patients who did not have bladder cancer, 52 patients with non-invas...

Progen Technology Switches on Cancer Fighting Genes and Inhibits Tumor Growth

...sfully developed PG11144 that inhibits LSD1 and reactivates (expresses) the silenced genes that are inactivated in cancer. Progen's Chief Scientific Office...ysine-specific demethylase 1 (LSD1), induce re-expression of epigenetically silenced genes, and inhibit the growth of established human tumors in vivo Present...

Colon cancer shuts down receptor that could shut it down

...hat causes inflammation, a precursor to cancer. "We know the receptor is silenced in cancer but it's not like the gene goes away," says Dr. Vadivel Ganapathy...te transporter. In his current study, the researcher found the receptor was silenced in 15 of 18 colon cancer patients. "Colon cancer does not want butyrate ...

World-first high blood pressure treatment trialled in Melbourne

... is carried out under local anaesthetic and uses radio energy frequency, delivered to the targeted nerve area via catheter. As a result the nerves are silenced in the renal artery, which supplies blood to the kidneys. Researchers had long-believed that this region was a key regulator of blood pressure, but...

Cancer stem cells generated by cancer outgrowth

...hat cancer stem cells may be generated as a direct function of the outgrowth of cells in the animal. "To our knowledge, this is the first example that silenced endogenous embryonic stem cell genes can be spontaneously reactivated in differentiated cells," says Dr. Dean. "We propose that the loss of cell conta...
silenced in Medical Technology

Cloned Human Embryos Successfully Reprogrammed Using Human - But Not Animal - Eggs

...f the key differentially-expressed genes were activated in the human clones. In distinct contrast, the majority of these genes were down-regulated or silenced in the human-animal hybrids. "We examined the factors recently used to reprogram skin cells (to induce pluripotent stem cells)," said Robert Lanz...

Gene Marker May Improve Odds of Stem Cell Therapies for Disease

...o Institute for Cancer Research and Molecular Medicine at Temple University . "Next we will work to confirm our data by seeing the impact when Rb2 is silenced in these stem cells." The Human Health Foundation (HHF) ( www.hhfonlus.org ) is a nonprofit organization designed to develop and fund biomedical ...

Presentation of Data on Progen's Cancer Epigenetic Targets Platform

..., may activate genes that protect against tumor development. These LSD-1 inhibitors are the first to demonstrate effective re-expression of aberrantly silenced genes by targeting this recently discovered cancer gene regulator. Dr. Laurence Marton, Progen's Chief Scientific Officer, said, "We have discovered...

MDS Patients on Five-Day Vidaza(R) Dosing Schedules Achieve Transfusion Independence Consistent with Seven-day Schedule

...ion is inhibited by MGCD0103. The epigenetic approach to cancer therapy is that rather than using molecules that kill both normal and tumor cells, the silenced genes are reactivated through targeted epigenetic therapy, re-establishing the cancer cell's natural mechanisms to control abnormal growth. About My...

SuperGen's Novel Hypomethylating Agent Highlighted at AACR Plenary Session

...itabine in human plasma. S110 demonstrated similar or improved activity compared to decitabine in re-expression of p15, p16, and MLH1 genes, which are silenced in cancer through methylation. S110 delivers decitabine with improved preclinical pharmacokinetics, and has a similar impact on HbF in non-human prima...

SuperGen to Highlight Oncology Pipeline Data in Multiple Presentations at AACR

...lls by the proteasomal pathway and re-express silenced tumor suppressor genes Wed., 8 a.m. - 12 p.m. Dual inhibition of #5421 April ...

Alnylam Announces Advancement of a New RNAi Therapeutic Development Program for the Treatment of Liver Cancer

... percent after a single injection of a KSP-specific siRNA in a rodent model; and -- Halting of human cancer cell proliferation in vitro when KSP was silenced by a target-specific siRNA. Alnylam's RNAi therapeutic, ALN-VSP01, is comprised of two small interfering RNAs, or siRNAs, the molecules that mediate...

Data Show SuperGen's Multi-Targeted Tyrosine Kinase Inhibitor Suppresses Critical Double-Stranded DNA Repair Protein, Rad51

...e I (DNMT1) in human cancer cells by the proteasomal pathway and re-express silenced tumor suppressor genes Researchers have discovered a novel class of quino...3B that have been discovered. This addresses an issue with re-activation of silenced tumor suppressor genes by 5-Azacytidine (5-AzaC or Vidaza) and its congener...

Clinical Data Reported on Vidaza in Hematologic Malignancies and Advanced Solid Tumors

...that rather than using molecules that kill both normal and tumor cells, the silenced genes are reactivated through targeted epigenetic therapy, re-establishing ...that rather than using molecules that kill both normal and tumor cells, the silenced genes are reactivated through targeted epigenetic therapy, re-establishing ...
silenced in Medical Definition

Ramón Carrillo

... during this year he still produced works on philosophical anthropology . Defamed by them as a "gasoline robber", his figure and accomplishments were silenced until Perón's brief third presidential period (1973-1974). In this stage Carrillo was recognized, although only as architect and achiever of a Natio...
silenced in Biological News

Restoring silenced suppressor gene kills lung-cancer cells

A new study suggests that restoring a gene often silenced in lung cancer causes the cells to self-destruct. The findings could lead to a new strategy for treating the disease. The research focused on a gene known as WWOX, which is lost or silenced in a large majority of lung cancers, and in canc...

Protein that promotes cancer cell growth identified

... on the outside of cells," said Darren Finlay, Ph.D., first author on the paper. "Although Caspase-8 is involved in apoptosis, it is rarely deleted or silenced in tumors, suggesting that it was giving cancer cells a leg up in some other way. Our studies suggest that Caspase-8 does so by activating the MAPK pa...

Specific genetic cause of fetal alcohol-related developmental disorders found

...ol exposure disrupts the epigenetic "imprinting" of Dio3. In this process, Dio3 normally originates from the father's gene, while the maternal gene is silenced by epigenetic control. But alcohol exposure changes the paternal-maternal dosage of Dio3, which increases the amount of the enzyme present in specific...

A miR boost enables acute leukemia cells to mature

...cells can reverse gene changes that trap the cells in an immature, fast growing state of development. The study discovered how the miR reactivates silenced genes, which enables the leukemic cells to differentiate and mature, important steps that precede their death. The findings suggest that miR-29b could...

Mayo Clinic researchers discover and manipulate molecular interplay that moves cancer cells

...ure, enabling it to migrate and invade. The researchers found that if PKD1 is active, tumor cells cannot move, a finding they say explains why PKD1 is silenced in some invasive cancers. During metastasis, invasive cancer cells respond to biological signals to move away from a primary tumor. Multiple resear...

Malaria immunity trigger found for multiple mosquito species

...the mosquito gut. Rel 2 is activated by the immune deficiency pathway (Imd) which, in turn, is negatively regulated by the caspar gene; when caspar is silenced the Rel 2 is activated. The researchers found that silencing of the caspar gene through the manipulation of gene expression resulted in mosquitoes tha...

Researchers take first look at the genetic dynamics of inbreeding depression

...lled alleles. If the maternal and paternal alleles differ, one of them usually dominates, conferring all of its qualities to the offspring. The other, silenced allele is called "recessive." Some alleles are detrimental to health. Most of these are recessive, meaning that they do not cause problems unless t...

CRG buys Genomatix' Next Generation Sequencing analysis solution

...ch as BRCA1 and BRCA2 exerted their biological effects. Our second avenue of research entails the delineation of the mechanisms by which the genome is silenced through chromatin modification and small regulatory RNA. The laboratory's goal is to understand the epigenetic regulation of gene expression in mammal...

Large DNA stretches, not single genes, shut off as cells mature

... Nature Genetics online on Jan. 18. Since the silenced stretches varied greatly between the different typ...cells, in which about 40 percent of the genome was silenced by LOCKs, the embryonic stem cells had no LOCKs. ...th organisms had remarkably similar regions of DNA silenced by LOCKs, suggesting that the same genes necessary...

Study links molecule to muscle maturation, muscle cancer

...says. The study is published in a recent issue of the journal Cancer Cell . Guttridge and his colleagues discovered that the gene for miR-29 is silenced by the action of a protein, called NF-B (pronounced, NF kappa B). Their study shows that this protein is present at high levels in rhabdomyosa...
silenced in Biological Technology

SuperGen Reports 2007 Fourth Quarter and Annual Financial Results

...cleotide compound, S110, activates an important fetal hemoglobin biomarker in baboons, confirming the product's ability to activate a specific silenced gene (Abstract 571). An oral presentation by Donald Lavelle, Ph.D., of the University of Illinois at Chicago, provided evidence that S110 incr...

Pharmion's Oral Azacitidine Granted Fast Track Status for Myelodysplastic Syndromes

...gene expression reactivation. The epigenetic approach to cancer therapy is that rather than using molecules that kill both normal and tumor cells, the silenced genes are reactivated through targeted epigenetic therapy, re-establishing the cancer cell's natural mechanisms to control abnormal growth. About Pha...

Pharmion and MethylGene Announce Collaboration to Develop Sirtuin Inhibitors as Anti-Cancer Agents

...ne silencing in cancer cells. Inhibition of sirtuins allows reexpression of silenced tumor suppressor genes, leading to reduced growth of cancer cells, and anti... traditional anticancer agents, targeted epigenetic therapy reactivates the silenced tumor suppressor genes thereby re-establishing the cancer cell's natural me...

RNA Interference and Gene Silencing: History and Overview

...s. In PTGS, the transcript of the silenced gene is synthesized but does not accumulate becaus...e and antisense strands of the gene being silenced (24 ). ...iptional silencing is transmitted by grafting from silenced stocks to non-silenced scions. EMBO J ...

Efficient Delivery of siRNAs to Human Primary Cells: Electroporation vs. Chemical Transfection

...siRNAs targeting CDK2, p53, and JAK1 were individually electroporated into the same set of primary cells. All three genes were efficiently silenced (Figure 4). Figure 2. Electroporation of HUVEC Primary Cells. A Cy3-labeled GAPDH siRNA (1.33 g) was ad...

Efficient RNAi-mediated gene silencing in neuronal cells using QIAGEN siRNA and TransMessenger Transfection Reagent*

...es and Alexa Fluor 488-conjugated goat anti-mouse secondary antibody (MAP2) and Alexa Fluor 594-conjugated phalloidin. The cell with silenced MAP2 expression (arrowed) exhibits severely defective filopodial elaboration. MAP2 has been shown to be required...
silenced in Biological Definition

Gene

...lled regulatory elements . So, to be expressed, our DNA strand needs to be properly regulated by other DNA strands. The DNA strand may also be silenced through DNA methylation or by chemical changes to the protein components of chromosomes (see histone ). This is a permanent form of regulation of...
silenced in Biological Dictionary

DNA methylation

...ules of information and ... Several reviews of DNA methylation have appeared recently that are considered ... Most Tumor Suppressor Genes (TSG) silenced by DNA methylation ... Current DNA Methylation Profiling Methods. Bisulfite-Sequencing OR Bisulfite-PCR ... (CNIO) (Madrid, Spain), are DN...
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