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Signaling in Medical News

A new take on growth factor signaling in tamoxifen resistance

Differences in growth factor (GF) signaling may cause the poor prognosis in some breast cancer cases. A new study, published in the open access journal BMC Medical Genomics , suggests that some estrogen receptor-positive breast cancers respond poorly to tamoxifen because of increased GF signaling...

Mayo researchers discover mechanism of cell type-specific signaling in tumor development

ROCHESTER, Minn. Mayo Clinic researchers have discovered the mechanisms behind two key checkpoints in cell growth and development factors that may ultimately allow investigators to benchmark progression of tumor cells or stop them from further development. The findings appear in the current onli...

Schizophrenia linked to signaling problems in new brain study

Schizophrenia could be caused by faulty signalling in the brain, according to new research published today in the journal Molecular Psychiatry . In the biggest study of its kind, scientists looking in detail at brain samples donated by people with the condition have identified 49 genes that work ...

Dynatronics Reports Profitable Second Quarter - Signaling Significant Improvement Over Prior Year Results

SALT LAKE CITY, Feb. 13 /PRNewswire-FirstCall/ -- Dynatronics Corporation (Nasdaq: DYNT ) today announced results for its fiscal second quarter and six months ended December 31, 2008. Operating results showed significant improvement over the three and six months ended December 31, 2007. Pr...

Neuroscientists show insulin receptor signaling regulates structure of brain circuits

A team of neuroscientists at Cold Spring Harbor Laboratory (CSHL) has demonstrated for the first time in living animals that insulin receptors in the brain can initiate signaling that regulates both the structure and function of neural circuits. The finding suggests a significant role for thi...

Blocking signaling protein prevents prostate cancer spread, Jefferson scientists find

(PHILADELPHIA) Researchers at the Kimmel Cancer Center at Jefferson in Philadelphia have shown that by blocking a signaling protein, they can prevent prostate cancer cells from metastatic dissemination. The work opens the door to future studies examining the protein as a target for therapies aimed...

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Signaling in Medical Technology

SF1126, Semafore's PI3 Kinase Inhibitor, Found to Block Angiogenic Signaling From Both VEGF and Bv8 in Multiple Cell Lines

INDIANAPOLIS, Aug. 26 /PRNewswire/ -- Semafore Pharmaceuticals Inc. announced data presented at the Seventh International Congress on Targeted Therapies in Cancer in Washington, D.C., showing additional antiangiogenic activity of vascular-targeted PI3 kinase (PI3K) inhibitor SF1126, by blockin...

St. Jude Finds Signaling System That Halts the Growth of a Childhood Brain Cancer

Researchers discover that proteins BMP2, BMP4 and BMP7 inhibit the growth of medulloblastoma tumors, while inducing malignant cells to develop into normal neurons, a finding that may lead to better treatments for the cancer MEMPHIS, Tenn., March 14 /PRNewswire-USNewswire/ -- A discovery by...

Nature Publication Reports on Key Role of Bile Acids in Glucose Metabolism and Insulin Signaling

Intercept Pharmaceuticals is Advancing Bile Acid-Derived Small Molecules with Potential Applications in Treating Metabolic Diseases NEW YORK, Aug. 7 /PRNewswire/ -- Historically, bile acids have been recognized primarily as natural detergents that regulate the absorption of dietary lipid...

AGI Dermatics Clinical Data Indicate Bicyclic Monoterpene Diols Suppress MMP1 and Stimulate Collagen Through TNF-a Signaling

Clinical Data Presented at the 66th Annual Meeting of the American Academy of Dermatology FREEPORT, N.Y., Feb. 11 /PRNewswire/ -- AGI Dermatics clinical research indicates that the ability of bicyclic monoterpene diols (BMTds) to reduce collagenese MMP-1 secretion an...

Radius' Investigational Bone Anabolic Agent, BA058, Increased Bone Mineral Density (BMD) at Key Fracture Sites in Phase 2 Clinical Trial in Postmenopausal Osteoporosis

...ct through the same receptor, PTHrP and its analogs play a distinct biological role from the PTH (parathyroid hormone) peptide by activating different signaling responses--PTH regulates calcium homeostasis and bone resorption by acting primarily on target cells in bone and kidney, whereas PTHrP and its analogs...

FDA Issues Complete Response Letter for INTUNIV(TM) (guanfacine) Extended Release for the Treatment of ADHD in Children and Adolescents

...997;18:211-219. 6. Wang M, Arnsten AF, Brennan A, et al. ÿ±2A-adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortex. Cell. 2007;129:397-410. 7. Arnsten AF, Li BM. Neurobiology of executive functions: catecholamine influences on prefrontal...
Signaling in Medical Dictionary

Slit

... Look up slit in Wiktionary, the free dictionary. ... in clothing, slit is a vertical cut from hem of the ... The midline repellant signaling molecule Slit . ... Double- slit experiment. Davisson–Germer experiment. Stern–Gerlach experiment ... In quantum mechanics, the double- s...

Physiology

...or books: new ~ used ~ paperbacks ~ NYTBS. Buy Human Physiology for $134.99 now & save. ENDOCRINE PHYSIOLOGY AND METABOLISM. RECEPTORS AND signaling PATHWAYS ... COMPARATIVE AND EVOLUTIONARY PHYSIOLOGY . SLEEP AND BIOLOGICAL RHYTHMS ... In October 2002, The Nobel Prize in Physiology or Medic...

Neuron

... on NEURON the software program used by neuroscientists to create models... A comprehensive theory and description of the neural system from the signaling ... Go to MAJOR CONCEPTUAL CHANGES introduced by the Electrolytic Theory of the neuron ... Welcome to Neuron Skates home to vintage and collec...

Intracellular

...with the virion lysates on ... About 0.1-0.2% of the intracellular levels of endophilin were recovered in virus, ... A number of intracellular signaling chemicals are fixed to subcellular ... Protective Role of Intracellular Zinc in Myocardial Ischemia/Reperfusion Is ... Information about intrac...

Insulin

...ension, a peer reviewed journal, provides a forum for scientific inquiry of the highest standard in the fields of hypertension and ... Insulin signaling pathway (KEGG); Type II diabetes mellitus (KEGG); Type I ... Insulin is an anabolic (part of metabolism that builds larger molecules) ... Di...

Floaters

...ch the open ... To test yourself for floaters , look up at the sky (or wall) and slowly move your ... Floaters and flashes can be warning signs signaling a more severe problem in your eye, including retinal tears and detachments. Floaters are little "cobwebs" or specks that float about in your fie...
Signaling in Biological News

'Disordered' amino acids may really be there to provide wiggle room for signaling protein

Sections of proteins previously thought to be disordered may in fact have an unexpected biological role providing certain proteins room to move -- according to a study published by researchers at Fox Chase Cancer Center in this month's issue of the journal Structure (Cell Press). The resea...

Burnham researchers discover 'on switch' for cell death signaling mechanism

LA JOLLA, Calif., January 5, 2009-- Scientists at Burnham Institute for Medical Research (Burnham) have determined the structure of the interactions between proteins that form the heart of the death inducing signaling complex (DISC), which is responsible for triggering apoptosis (programmed cell d...

Breast cancer treatment resistance linked to signaling pathway

PHILADELPHIA -- Activation of the Src signaling pathway may cause resistance to standard medical treatment in some patients with breast cancer, and inhibition of this pathway holds the potential to overcome that resistance, according to data presented here at the American Association for Cancer Re...

Imiquimod, an immune response modifier, is dependent on the OGF-OGFr signaling pathway

Researchers at The Pennsylvania State University College of Medicine, Hershey, Pennsylvania have discovered that the efficacy of imiquimod, a clinically important immune response modifier with potent antiviral and antitumor activity, is dependent on the Opioid Growth Factor (OGF)-OGF receptor (OGF...

MIT probe may help untangle cells' signaling pathways

CAMBRIDGE, Mass.--MIT researchers have designed a new type of probe that can image thousands of interactions between proteins inside a living cell, giving them a tool to untangle the web of signaling pathways that control most of a cell's activities. "We can use this to identify new protein par...

Proteins that stop a major signaling pathway can also generate new proteins

DURHAM, N.C. Duke University Medical Center researchers have recently discovered that a crucial communications pathway in cells not only stops cells from making proteins, it also makes them go. The team was able to define the way in which proteins called beta arrestins (for their role in stopping...

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Signaling in Biological Technology

Novocell Announces Discovery Linking Key Cancer Cell Signaling Pathways With Proliferation and Self-Renewal of Human Embryonic Stem Cells

- Findings Published in Blood - SAN DIEGO, Aug. 30 /PRNewswire/ -- Novocell Inc., a stem cell engineering company, today announced research findings that for the first time identify two prominent cancer cell signaling pathways as essential for the efficient proliferation an...

Data Published in Cell Stem Cell Demonstrates Potent Anti-Cancer Activity for OncoMed Pharmaceuticals' Lead Antibody

...and recurrence." OMP-21M18 is a monoclonal antibody that blocks DLL4 signaling to reduce tumor growth two ways: by reducing cancer stem cell frequency an...ut OMP-21M18 OMP-21M18 is a monoclonal antibody optimized to block a key signaling pathway in cancer stem cells. Specifically, OMP-21M18 selectively targets ...

Keryx Biopharmaceuticals, Inc. Announces Second Quarter 2009 Financial Results

...X-0401 (perifosine), a novel, potentially first-in-class, oral anti-cancer agent that inhibits the phosphoinositide 3-kinase (PI3K)/Akt pathway, a key signaling cascade that has been shown to induce cell growth and cell transformation. KRX-0401 has demonstrated both safety and clinical efficacy in numerous adu...

Keryx Biopharmaceuticals, Inc. to Hold Conference Call on Second Quarter 2009 Financial Results on Thursday, August 6, 2009 at 8:30am EDT

...X-0401 (perifosine), a novel, potentially first-in-class, oral anti-cancer agent that inhibits the phosphoinositide 3-kinase (PI3K)/Akt pathway, a key signaling cascade that has been shown to induce cell growth and cell transformation. KRX-0401 has demonstrated both safety and clinical efficacy in numerous adu...

Cardium Announces New Orthobiologics Product Initiative Extending Gene Activated Matrix Technology to Deliver Bone Growth Factors

...tor proteins stimulate cellular proliferation and cellular differentiation. Growth factors regulate a variety of cellular processes, as well as other signaling molecules, which play key roles in the regeneration and repair of soft tissues (skin, ligaments, tendons and cartilage) and hard tissues (bone). Base...

Histogen Hair Regrowth Clinical Trial Presented at ISHRS Annual Meeting

...s Wnt proteins and other growth factors important to hair follicle maintenance and growth," said Dr. Gail K. Naughton, CEO of Histogen. "Wnt signaling has been shown by a number of experts in the field to be responsible for initiating epidermal stem cells to form new hair follicles in mice, and to be...
Signaling in Biological Products

Rabbit Anti-Evolutionarily conserved signaling intermediate in Toll pathway Polyclonal Antibody, Unconjugated from GenWay Biotech, Inc.

Description: Evolutionarily conserved signaling intermediate in Toll pathway...
Company:GenWay Biotech, Inc.

Rabbit Anti-Shh Polyclonal Antibody, Unconjugated from Cell Signaling Technology

Description: Shh Antibody Shipping Temperature: HOT Storage Temperature: -20C...
Company:Cell Signaling Technology

Anti-PERK, phospho (Thr980) Antibody, Unconjugated from Cell Signaling Technology

Description: Phospho-PERK (Thr980) Antibody...
Company:Cell Signaling Technology

Rabbit Anti-Chk1, phospho (Ser296) Polyclonal Antibody, Unconjugated from Cell Signaling Technology

Description: Phospho-Chk1 (Ser296) Antibody Shipping Temperature: HOT Storage Temperature: -20C...
Company:Cell Signaling Technology

Mouse Anti-PDK1 Docking Motif, phospho (Ser / Thr) Monoclonal Antibody, Unconjugated, Clone 18A2 from Cell Signaling Technology

Description: Phospho- (Ser/Thr) PDK1 Docking Motif (18A2) Mouse mAb...
Company:Cell Signaling Technology

Anti-FKHR, phospho (Thr24) / FKHRL1, phospho (Thr32) Antibody, Unconjugated from Cell Signaling Technology

Description: Phospho-FKHR (Thr24)/FKHRL1 (Thr32) Antibody...
Company:Cell Signaling Technology

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Signaling in Biological Definition

Actin

...Arp2/3 proteins , which serve as sites for nucleation, stimulating the formation of G-actin trimers. All of these three proteins are regulated by cell signaling mechanism. Organization Actin filaments are assembled in two general types of structures: bundles and networks. Actin-binding proteins dictat...

Apoptosis

...ord and the floor plate secrete a gradient of the signaling molecule Sonic hedgehog (Shh), and it is this gr...is factor ( TNF ), a 157 amino acid inter-cellular signaling molecule ( cytokine ) produced mainly by activated...asL results in the formation of the death-inducing signaling complex (DISC), which contains the Fas-associated ...

Cell growth

...sion of myocyes. Some of the key proteins are important for cell adhesion between myocytes and some are involved in adhesion-dependent cell-to-cell signaling that allows for a cascade of cell fusion events. Oocytes can be unusually large cells in species for which embryonic development takes place awa...

Cilium

... called " Primary cilium " that has been neglected for a long time. Recent studies led scientists to re-evaluate its physiological role(s) in the cell signaling and the control of cell growth and development. A cilium has an outer membrane that surrounds a core called an axoneme , which contains nine ...

Morphogenesis

...yncytial blastoderm. Cells that make Engrailed can make the cell-to-cell signaling protein Hedgehog (green in the figure to the left). Hedgehog is not free ...ze Engrailed expression after the cellular blastoderm forms. The reciprocal signaling by Hedgehog and Wingless stabilizes the boundary between each segment. The ...

Lipase

... cell biology . Furthermore, lipases are involved in diverse biological processes ranging from routine metabolism of dietary triglycerides to cell signaling and inflammation . Several different types of lipases are found in the human body , including pancreatic lipase, hepatic lipase, lysosomal lipase, ...
Signaling in Biological Dictionary

Transmembrane receptor

...he the cell and the outside world. Extracellular signaling molecules attach to the receptor , triggering... ...idine kinases and ... mechanism of transmembrane signaling by the aspartate receptor : a model. ... PolyM...nsmembrane receptor protein tyrosine kinase signaling pathway ... 3.1.2 Signal transduction of tra...

Transmembrane proteins

...ne receptors are specialized integral membrane proteins that take part in communication between the the cell and the outside world. Extracellular signaling molecules attach to the receptor, triggering... Transmembrane protein A transmembrane protein is a protein that spans the entire biologic...

Streptavidin

...ilized via covalent binding of primary amino ... Streptavidin is a 53,000 dalton tetrameric protein purified from the bacterium ... This Cell signaling Technology product is useful for the detection of biotinylated proteins (1,2). Conjugation of horseradish peroxidase (HRP) to streptavidin is ... ...

Spermatogenesis

...process by ... Spermatogenesis ... This page covers the topic of spermatogenesis , the production of the male gametes. ... Hedgehog homeobox signaling in Spermatogenesis Deletion of Dhh, a hedgehog ... Spermatogenesis summary with 9 pages of encyclopedia entries, essays, summaries, research in...

SiRNA

...edule ... SignalSilence<sup>®</sup > Akt siRNA I from Cell signaling Technology (CST) allows the researcher to specifically inhibit Akt express...ion using RNA interference, a ... SignalSilence® MEK1 siRNA from Cell signaling Technology allows the researcher to specifically inhibit MEK1 expression ...

Signal transduction

... page is an annotated index of major online resources dealing with cell signaling ... Signal Transduction at Cell Membranes: Protein Kinases/Phosphatases...al transduction page provides a brief discussion of various biological signaling molecules and pathways. ... and Phospholipids in Signal Transduction .....
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