Signaling protein builds bigger, better bones in mice
In a new study, researchers present a “cautionary tale?about what may go wrong when using the fledgling science of proteomics to devise a diagnostic test for cancer. In the February 16 issue of the Journal of the National Cancer Institute, researchers from The University of Texas M. D. Anderson Cancer Center detail why an experimental test intended to identify early ovarian cancer from a...Bound for destruction: Ubiquitination protects against improper Notch signaling
The is an important molecular signaling mechanism whose existence has beenknown, or at least hinted at, for nearly a century since theidentification of a mutant strain of Drosophila fruit flies with“notched?wings in Thomas Hunt Morgan’s lab in 1910. Later studiesrevealed that the Notch gene encodes a receptor protein tha...Viral protein influences key cell-signaling pathway
New research shows that a protein produced by a cancer-causing virus influences a key signaling pathway in the immune cells that the virus infects. This stimulates the cells to divide, helping the virus spread through the body. T...Computational Method Speeds Mapping of Cell Signaling Networks
For decades, scientists have been studying how external information gets transmitted from outside of cells to the control centers inside them that trigger particular responses. But cell signaling networks are so complex that mapping them has been a slow, arduous process. Now, a research team from Stanford, MIT and Harvard has developed a new method for charting cellular signaling networks...Researchers find promising cancer-fighting power of synthetic cell-signaling molecule
Novel anti-cancer compounds called Enigmols suppress the growth of human cell lines representing cancers of the prostate, breast, colon, ovary, pancreas, brain and blood, and reduce tumors in three animal studies, new research shows. In addition, Enigmols did not show side effects at effective doses, according to the research conducted at the Georgia Institute of Technology, Emory Universi...Rabbit Anti-alpha-N-Catenin Polyclonal Antibody, Unconjugated from Cell Signaling Technology
Description:alpha-N-Catenin Antibody -20C...Anti-SHP-2 Antibody, Unconjugated from Cell Signaling Technology
Description:SHP-2 Antibody...Cell Lysis Buffer (10X) from Cell Signaling Technology
Description:Cell Lysis Buffer is used to lyse cells under nondenaturing conditions....beta-galactosidase Colorimetric Assay Kit from Cell Signaling Technology
Description:...Chemical Signaling Helps Regulate Sensory Map Formation In The Brain
Researchers at the University of Chicago have discovered an important mechanism used by the developing brain to design nerve connections in the section of the brain that interprets visual signals.// In the process, they have hit upon the first experimental evidence for a decades-old model of how neurons establish distant connections in a way that can consistently relay spatial informati...Hh Signaling May Play Role In Fat Formation
Mammals and insects might have a lot in common while gaining fat. The hedgehog (Hh) signaling pathway may also have a prominent role when it comes to fat formation in the case of mice and flies, according to a new research. // The research also reveals the effect that genes have on fat storage. The Hh pathway in mammals also decides as to whether adult stem cells are meant for the bone or fat. <b...Birth Defects Caused By Deficiencies In Cell Signaling Pathway
Cell signaling pathways are particularly essential for proper embryo development and disorders in these cellular pathways// can lead to birth defects such as cleft palate, spina bifida, reports a new study. The research is a collaborative effort of the University of Colorado, Health Sciences Center, and the Howard Hughes Medical Research Institute. The findings of the research report,...Sensors placed at home capable of signaling onset of early signs of dementia in elderly
Portland: An Oregon Health & Science University study has demonstrated that motion and door sensors placed in elders' homes can assist in keeping// a tab on the pattern of activity associated with memory changes, which make up the initial signs of onset of dementia. The study results, which were made available to the public at the 10th International Conference on Alzheimer's Disease and Related D...Key Signaling Switch Identified in Allergic Disease
A research team has identified a key enzyme responsible for triggering a chain of events that results in allergic reaction, according to new study findings published online// this week in Nature Immunology. The work by researchers from Virginia Commonwealth University, the Hospital for Special Surgery and Weill Cornell Medical College in New York sets the stage for development of new...