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siRNAs in Medical News

Quark Pharmaceuticals Presents Data on Synthetic siRNAs for Prevention of Ocular and Inner Ear Sensory Cell Damage

FREMONT, Calif., May 14 /PRNewswire/ -- Quark Pharmaceuticals, Inc., a development-stage pharmaceutical company discovering and developing novel RNA interference (RNAi)-based therapeutics, today announced that Elena Feinstein, M.D., Ph.D., Chief Scientific Officer, presented a study titled, "siRNA...

Quark Pharmaceuticals to Participate in IBC's Oligonucleotide Therapeutics: From Concept to Implementation Conference

... Dr. Thompson's presentation, titled, "Design and Development of Synthetic sirnas for Clinical Applications," will describe Quark's pipeline, which includes ...mically to man; and an overview of Quark's strategies to optimize synthetic sirnas for clinical applications while avoiding off-target effects. The In...

Quark Pharmaceuticals Announces Data Indicating Potential Utility of QPI-1007 for Treatment of Glaucoma

...or QPI-1007 to support initial clinical studies in non-arteritic anterior ischemic optic neuropathy. Quark has the largest portfolio of clinical-stage sirnas and all of our pipeline candidates have exhibited optimal activity and stability while attenuating potential off-target effects." Prof. Di Pol...

The future of personalized cancer treatment: An entirely new direction for RNAi delivery

...nded RNA fragments called siRNAs. But delivery of sirnas has proven difficult due to their size and negativ...ntial for PTDs as a delivery mechanism for getting sirnas into cancer cells. He and his team had previously... tumor-suppressor proteins. "Simply adding the sirnas to a PTD didn't work, because...

4-in-1

... stop the synthesis of proteins required for tumor growth. To achieve this, sirnas (small interfering RNAs) are introduced into the cell. These are short, dou...e mRNA is rapidly degraded by the cell. When bound to nanoparticles, the sirnas are easier to slip into cells. In order to specifically target cancer cells...

Biologist finds plant polymerases IV and V are really variants of Polymerase II

...equences, whereas Pol V makes longer RNAs that are thought to pair with the sirnas at the affected chromosomal sites. Pikaard and his colleagues' wor...a hybrid plant or animal. That study is one of the first to demonstrate how sirnas can play a role in controlling the dosage of vital genes, and not just harm...

Study first to show that RNA interference can facilitate vaccine development

...ve vaccines for other common viral diseases, such as influenza and measles, and may help control outbreaks of emerging infectious diseases. "Making sirnas today is relatively simple because most disease-causing viruses have been sequenced or have closely-related cousins with conserved regions in their ge...

Industry Experts and Global Regulators to Discuss Oligonucleotide-Based Therapeutics Issues

...ory Affairs, Logical Therapeutics, Inc. Sessions will discuss: sirnas Non-Hybridization Dependent Oligonucleotides Antisense Oligonucleot...Substance and Drug Product Novel Chemistry Clinical Applications of sirnas Clinical Opportunities for Manipulating MicroRNAs Pathways Clinical...

Protein thought to promote cancer instead functions as a tumor suppressor

...As (ribonucleic acids) known as "small interfering RNAs" or siRNAs, that are each capable of inactivating a specific gene. The researchers mixed these sirnas with specially engineered human cancer cells that glowed when the cancer-causing malfunction is activated. When an siRNA made a cell glow, the researc...

Researchers identify and shut down protein that fuels ovarian cancer

...e strands of RNA that in turn are "read" by ribosomes to produce proteins. sirnas are short, double-stranded bits of RNA capable of halting that process. The...ent of Experimental Therapeutics, and colleagues are building an arsenal of sirnas capable of silencing genes that produce cancer-promoting proteins. They pac...
siRNAs in Medical Technology

Intradigm Study Shows Ability of siRNAs Systemically Delivered With TargeTran(TM) System to Suppress Tumor-Induced Angiogenesis in Mice

Positive Findings Support Preclinical Development of Intradigm's ICS-283 PALO ALTO, Calif., Oct. 24 /PRNewswire/ -- Intradigm Corporation, a leading developer of targeted, systemic RNA interference (RNAi) therapeutics, today announced study results that demonstrated the company's TargeTran(TM)...

Quark Pharmaceuticals Announces Publication of Study on Use of siRNA against Proprietary Target for Inhibiting Tumor Growth and Sensitization of Cancer Cells to Chemotherapy

... Quark sirnas Examined Alone and in Combination with Chemotherapy FREMONT, Calif. Oct. ...ng siRNA product pipeline. Quark has the deepest clinical-stage pipeline of sirnas under development, with efficacy studies completed for several compounds, m...

Previous Claims of siRNA Therapeutic Effects Called into Question by Report in 'Human Gene Therapy'

...at incorporate suitable controls to differentiate the disease-modulating effect of an siRNA from its ability to stimulate an innate immune response. sirnas have been highly touted for their ability to target very specifically and selectively the disease-causing factors in a range of disorders, from viral ...

Study Shows Intradigm's RNAi Nanoplex Technology To Be Effective Systemic siRNA Delivery Platform for the Treatment of Various Cancer Models

...) carrying each of VEGF-, VEGFR2- or EGFR-targeted sirnas experienced significant tumor growth inhibition th...gy, as well as its ability to systemically deliver sirnas to tumors in a safe and effective manner," said Mo... technology is its ability to incorporate multiple sirnas in a single drug product. These multi-targeted the...

Nastech Completes Enrollment of Phase 2 Clinical Trial of PYY3-36 Nasal Spray to Treat Obesity

...cific protein through use of small interfering RNAs (siRNAs), to develop a new class of therapeutics by identifying key protein targets, designing the sirnas that will turn off the production of the targeted proteins, and creating a formulation for the delivery of the therapeutics. Nastech and its collabora...

Lorus Therapeutics Announces Scientific Presentations for Lead Antisense and siRNA Drug Candidates at International Cancer Conference

...presented on April 17, 2007. In this research, Lorus screened a series of sirnas to select a lead drug candidate, siRNA-1284. siRNA-1284 demonstrated potent...tine cellular tasks essential to development and growth. In mammalian cells sirnas have been shown to be the most effective tools for RNAi, allowing for the d...

Alnylam Announces Advancement of a New RNAi Therapeutic Development Program for the Treatment of Liver Cancer

...our encouraging progress with systemic delivery of sirnas toward liver-expressed target genes," said John Ma...aging pre-clinical data demonstrate the ability of sirnas to silence two well-validated genes critical for t...er and other cancers, statements concerning use of sirnas to achieve therapeutic silencing of genes and stat...
siRNAs in Biological News

Parasites ready to jump

...s function were discovered in the fruitfly. A similar class of molecules has been found in mice. By means of a process called RNA interference, the sirnas enable the cell to recognize and destroy messenger RNAs derived from transposons. The researchers in Frstemann's group were able to identify a protein...

Strong immune response to new siRNA drugs in development may cause toxic side effects

...ilable free online at www.liebertpub.com/oli sirnas are duplex structures comprised of short oligonucl...e discovery that naturally occurring and synthetic sirnas can effectively prevent expression of a disease gene sparked intense interest in developing sirnas as drugs. However, depending on the structure and ...

Small molecules might block mutant protein production in Huntington's disease

...short lengths of RNA called small interfering RNA, or siRNA, to interfere with CAG repeats. In cells from Huntington's patients, the PNAs, LNAs and sirnas decreased the amount of mutant protein produced, in some cases up to 100 percent. The effect was greatest when the compounds interfered with long leng...

Nanotechnology holds promise for STD drug delivery

..."We wanted to develop a new strategy of delivering sirnas with a FDA-approved material." As their name suggests, sirnas interfere and knock out the function of genes in h...obes that may cause STDs. The researchers designed sirnas to target a gene expressed widely in the lining of...

CSHL researchers explain process by which cells 'hide' potentially dangerous DNA segments

...n's Research Hospital, Memphis, has now found that sirnas cannot do the job of heterochromatin assembly by t...am stumbled across Chp1 mutants that would produce sirnas but could not assemble heterochromatin. "These...able to generate siRNAs. This work reveals that sirnas cannot by themselves establish heterochromatin whe...

New therapeutic strategy could target toxic protein in most patients with Huntington's disease

... "That takes away the biggest worry we had, which was that the number of sirnas we would have to test in order to have impact on the disease would be too l...atients who could be helped, he said. The next problem became developing sirnas that could discriminate between target mRNAs and non-target. "That turned o...

Ambati study published in PNAS

...system, a critical component of immune responses. The new study found that sirnas block not only blood vessels but also lymphatic vessels. In the cornea, th...lco and Arturo Brunetti, researchers in Naples, Italy, they also found that sirnas generically block blood and lymphatic vessel growth in muscle tissue as wel...

Scientists at CSHL discover mobile small RNAs that set up leaf patterning in plants

... like morphogens These native, or endogenous, small RNAs are called trans-acting small interfering RNAs (ta-siRNAs). Like microRNAs and endogenous sirnas present in other organisms, they regulate gene activity via a mechanism called RNA interference. Because of their newly discovered properties in leaf ...

Scientists at CSHL discover mobile small RNAs that set up leaf patterning in plants

... like morphogens These native, or endogenous, small RNAs are called trans-acting small interfering RNAs (ta-siRNAs). Like microRNAs and endogenous sirnas present in other organisms, they regulate gene activity via a mechanism called RNA interference. Because of their newly discovered properties in leaf ...

Researchers identify gene linked to aggressive progression of liver cancer

...son Endowed Scholar in Cancer Research at the VCU Massey Cancer Center. sirnas are small inhibitory RNAs that can specifically inhibit targeted mRNA and protein production. sirnas may be used in the future for targeted inhibition of AEG-1 in patients, Sar...
siRNAs in Biological Technology

Using Validated siRNAs in Functional Genomic Assays

Collections of siRNAs targeting key human genes are ideal for studying protein function in cells. To identify genes involved in a given cellular process, cells can be transfected with different siRNAs and assayed f...

Test More siRNAs for Less

No longer must you endure the high cost and long turn-around times required for chemically synthesized siRNA. The new Silencer siRNA Construction Kit (patent pending) saves you both time and money so now you can expand ...

Optimize Transfection of siRNAs for RNAi

By Rich Jarvis, Associate Scientist Low transfection efficiency is the most frequent cause of unsuccessful gene silencing experiments. We have found that by optimizing cell density, transfection agent amount, and siRNA concentra...

Deliver siRNAs Into Primary Cells

siPORT siRNA Electroporation Kit Deliver siRNA into primary cells, cells grown in suspension, and other difficult-to-transfect cells Maintain high cell viability under a wide ...

Matched siRNAs and Assays: Ambion + Applied Biosystems = RNAi Success

Ambion and Applied Biosystems have joined forces to provide a complete convenient, solution for performing gene silencing experiments and validating the results by real-time RT-PCR. Ambion's Silencer Validated and Silencer Pre-designed...

Delivering siRNAs to Difficult Cell Types

Electroporation of Primary, Neuronal and Other Hard-to-transfect Cells Dmitriy Ovcharenko, Rich Jarvis, Kevin Kelnar, David Brown, Ambion, Inc. RNA interference (RNAi) is a powerful exp...

IMPROVE SILENCING SUCCESS: siRNAs THAT WORK BETTER!

High Quality Custom Synthesis of siRNAs Cenix Pre-designed siRNAs to Human, Mouse, and Rat Genomes Silencer Validated siRNAs Silencer siRNA Libraries ...

Efficient Delivery of siRNAs to Human Primary Cells: Electroporation vs. Chemical Transfection

Dmitriy Ovcharenko (Research Associate II, Ambion, Inc.) Gene silencing using small interfering RNAs (siRNAs) has become a powerful method for studying gene function. Human primary cells ...

Cenix-Designed siRNAs for 95% of Human and Mouse Genomes

siRNA designs now available for >95% of all human and mouse genes listed in RefSeq Design algorithm developed by Cenix results in highly effective siRNAs High quality custom siRNA synthes...

Your Data: Silencing Neural Cell Adhesion Genes with In Vitro Transcribed siRNAs

Ambion has developed a system for siRNA synthesis and purification based on in vitro transcription, the Silencer siRNA Construction Kit (patent pending). This kit produces transfection-ready siRNA ...

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siRNAs in Biological Products

Silencer In Vivo Ready siRNAs from Ambion

Description: Ready for formulation or direct injection into animals Provided in convenient 100, 250, 1000 and 10,000 nmol sizes HPLC purified, salt free, sterile filtered, and endotoxin tested ...
Company:Ambion

Silencer In Vivo Ready siRNAs from Ambion

Description: ...
Company:Ambion

Silencer Pre-designed siRNA, HPLC purified, annealed from Ambion

Description:... custom siRNA service provides the premium quality sirnas you need for your gene silencing research. Custom sirnas can be readily ordered online by providing either ...e already designed for you.) For your convenience, sirnas are provided in various formats and amount, and ma...
Company:Ambion

Silencer Pre-designed siRNA, standard purity from Ambion

Description:... custom siRNA service provides the premium quality sirnas you need for your gene silencing research. Custom sirnas can be readily ordered online by providing either ...e already designed for you.) For your convenience, sirnas are provided in various formats and amount, and ma...
Company:Ambion

Custom siRNA, PAGE purified from Ambion

Description:... custom siRNA service provides the premium quality sirnas you need for your gene silencing research. Custom sirnas can be readily ordered online by providing either ...e already designed for you.) For your convenience, sirnas are provided in various formats and amount, and ma...
Company:Ambion

Silencer Pre-designed siRNA, HPLC purified from Ambion

Description:... custom siRNA service provides the premium quality sirnas you need for your gene silencing research. Custom sirnas can be readily ordered online by providing either ...e already designed for you.) For your convenience, sirnas are provided in various formats and amount, and ma...
Company:Ambion

Custom siRNA, PAGE purified, annealed from Ambion

Description:... custom siRNA service provides the premium quality sirnas you need for your gene silencing research. Custom sirnas can be readily ordered online by providing either ...e already designed for you.) For your convenience, sirnas are provided in various formats and amount, and ma...
Company:Ambion

Human siTrio from B-Bridge International

Description:... siTrio siRNA --- a cocktail of 3 sirnas specifically targeted to your target gene of interestis our most popular product. The siTrio reagent guarantees you get more than 75% knockdown of you...
Company:B-Bridge International

Rat siTrio from B-Bridge International

Description:... siTrio siRNA --- a cocktail of 3 sirnas specifically targeted to your target gene of interestis our most popular product. The siTrio reagent guarantees you get more than 75% knockdown of you...
Company:B-Bridge International

Mouse siTrio from B-Bridge International

Description:... siTrio siRNA --- a cocktail of 3 sirnas specifically targeted to your target gene of interestis our most popular product. The siTrio reagent guarantees you get more than 75% knockdown of you...
Company:B-Bridge International
siRNAs in Biological Dictionary

SiRNA

...n of small interfering RNA ( siRNA ) for the induction of RNA interference (RNAi) in a variety of organisms. siRNA Synthesis. Premium quality sirnas ... Made-to-order Silencer Select siRNA Libraries ... siRNA /Target Protein Isolation, Detection, & Quantitation ... Predesigned siRNA and...

RNA interference

... interference (RNAi) pathway. ... RNA interference (RNAi) is the process of mRNA degradation that is induced by ... Introduction of synthetic sirnas can induce RNA interference in mammalian cells. ... An up-to-the-minute listing of publications using of RNA interference ... The following...

Gene silencing

...Today, gene silencing —or RNA interference (RNAi), as it is now known—has ... It turns out that gene silencing through degradation of mRNA by sirnas is not ... The idea of gene silencing gained momentum following a 1998 ... They think that perhaps blocking Nogo activity with gene silencin...

Dicer

...an produce putative guide RNAs, is a member of the RNase ... Human Dicer preferentially cleaves dsRNAs at their termini without a requirement ... sirnas generated by recombinant human Dicer induce specific and significant but ... Peas and Corn ... This food dicer cleans and stores easily. .....

Antisense

...ind to the mRNA of a target protein, inhibiting ... How antisense works ... Natural Antisense RNA. RNA interference (RNAi) Mechanism of RNAi. sirnas and transcription ... Antisense RNA also occurs naturally ... antisense studios specializes in communication, marketing and design. ... Lifet...
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