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secretory in Medical News

Peptide discovered in scorpion venom may hold key to secretory diseases

Researchers have discovered a peptide in scorpion venom that may hold the key to understanding and controlling cystic fibrosis and other secretory diseases. In the December 28 issue of the Journal of Biological Chemistry, an international team of researchers describes how this novel peptide, ca...

Pitt, Berkeley researchers reconstruct seashells to model nervous system function

... understand the neurons connecting the sensing cells in the mantle with the secretory cells that produce calcium carbonate and pigmented proteins. The team found...d inhibitory synapseswhich promote or diminish cell activitysurrounding the secretory cells and the cells' firing thresholds act as a neural network that determi...

Curemark Receives Investigational New Drug Clearance for CM-AT for Autism

...n the treatment of neurological and other diseases especially those with dysautonomic components by addressing certain key gastrointestinal/pancreatic secretory deficiencies. The company's initial products are based upon breakthrough observations by its founder, Dr. Joan Fallon, which revealed a lack of prote...

Cellular senescence a double-edged sword

...blic Library of Science (PLoS) in a paper entitled: "Senescence-Associated secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53... and her co-authors branded this set of proteins as a senescence-associated secretory phenotype, or SASP, and determined that it occurs not only in cultured cell...

Curemark to Present at the 2008 Life Sciences & Healthcare Venture Summit 2008

... Curemark is a biotechnology company focused on the treatment of neurological and other diseases by addressing certain key gastrointestinal/pancreatic secretory deficiencies. The company's initial products are based upon breakthrough observations by its founder, Dr. Joan Fallon. The company is currently prepar...

Curemark Appoints Dr. Elisa J. Zinberg as Vice President of Operations

... Curemark is a biotechnology company focused on the treatment of neurological and other diseases by addressing certain key gastrointestinal/pancreatic secretory deficiencies. The company’s initial products are based upon breakthrough observations by its founder, Dr. Joan Fallon. The company is currently ...
secretory in Medical Technology

Anthera's Varespladib Meets Primary Endpoint in Phase 2 FRANCIS Trial for the Treatment of Acute Coronary Syndrome

...ng placebo. Varespladib is a potent and highly selective oral inhibitor of secretory phospholipase A2 (sPLA2), an inflammatory enzyme implicated in ACS, vascula...us clinical trials, varespladib, a potent and highly selective inhibitor of secretory phospholipase A2 (sPLA2), has demonstrated marked improvements in independe...

Following Encouraging Results Anthera to Continue IMPACTS Trial for the Prevention of Acute Chest Syndrome in Patients With Sickle Cell Disease

...ry Syndrome (ACS) event." About A-001 A-001 is a potent inhibitor of secretory phospholipase A2(sPLA2) activity¿ including groups IIA¿ V¿ and X. The U.S. ... and Acute Coronary Syndrome A-002 (varespladib) is a potent inhibitor of secretory phospholipase A2(sPLA2) activity, which in two previously completed studies...

Anthera Completes Special Protocol Assessment With FDA and Receives EMEA Scientific Advice on Development Path Toward Varespladib Approval

...f cardiovascular risk (LDL-C) coupled with reductions in PLA2." In previous clinical trials, varespladib, a potent and highly selective inhibitor of secretory phospholipase A2 (sPLA2), has demonstrated marked improvements in independent markers of cardiovascular risk including, a near complete suppression of...

Anthera Pharmaceuticals Advances Global Development Strategy for Varespladib in Patients With Acute Coronary Syndrome With the Initiation of FRANCIS Trial

... C-reactive protein, a known marker of inflammation. "We are pleased with the continued progress of our varespladib cardiovascular program targeting secretory phospholipase A2," said Paul Truex, President and Chief Executive Officer of Anthera Pharmaceuticals, Inc. "The FRANCIS trial was designed with input ...

DSMB Supports Continuation of Anthera Phase II Impacts Trial for the Prevention of Acute Chest Syndrome in Patients With Sickle Cell Disease

...paring to submit our registration protocols to FDA as part of the Special Protocol Assessment process." About A-001 A-001 is a potent inhibitor of secretory phospholipase A2(sPLA2) activity, including groups IIA, V, and X. The U.S. Food and Drug Administration granted A-001 orphan drug status for the preve...

Napo Announces Successful Clinical Results in Phase 2 Study of Crofelemer in Acute Adult Infectious Diarrhea

...ientific Officer of Napo added, "The effects of crofelemer in this study of secretory diarrhea caused by infectious pathogens provides additional support and con...rk trial will provide a new pathway to a therapy for both acute and chronic secretory diarrhea. Glenmark expects to file for approval of crofelemer for the CRO-I...
secretory in Medical Products

Calcitonin IRMA Test

Description:... Calcitonin is synthesized in the parafollicular C-cells of the thyroid gland and is packaged in secretory granules. The major action of calcitonin is to lower plasma calcium concentrations, by inhibiting osteoclast activity, resulting in decreased mobiliza...
Company:Diagnostic Systems Laboratories, Inc.

Progesterone EIA Test

Description:...pregnancy by the placenta, serves several independent physiologic functions related to its ability to convert estrogen-primed uterine endometrium into secretory endometrium [3]. These functions include preparation of the uterine endometrium for implantation of the fertilized oocyte and maintenance of the endom...
Company:Diagnostic Systems Laboratories, Inc.

Progesterone RIA Test

Description:...pregnancy by the placenta, serves several independent physiologic functions related to its ability to convert estrogen-primed uterine endometrium into secretory endometrium [3]. These functions include preparation of the uterine endometrium for implantation of the fertilized oocyte and maintenance of the endom...
Company:Diagnostic Systems Laboratories, Inc.

Calcitonin, Ultra-Sensitive RIA Test

Description:... Calcitonin is synthesized in the parafollicular C-cells of the thyroid gland and is packaged in secretory granules. The major action of calcitonin is to lower plasma calcium concentrations, by inhibiting osteoclast activity, resulting in decreased mobiliza...
Company:Diagnostic Systems Laboratories, Inc.

Calcitonin RIA Test

Description:... Calcitonin is synthesized in the parafollicular C-cells of the thyroid gland and is packaged in secretory granules. The major action of calcitonin is to lower plasma calcium concentrations, by inhibiting osteoclast activity, resulting in decreased mobiliza...
Company:Diagnostic Systems Laboratories, Inc.

One-Step Gonorrhea Antigen Test

Description:... The One-Step Gonorrhea Antigen Tests are qualitative immunoassays for detecting the Gonorrhea Antigen (NGH) in secretory products (swab)....
Company:IND Diagnostic, Inc.
secretory in Medical Dictionary

Vesicle

... to contain all ... ... play roles in both vesicle trafficking and in regulating actin ... A role for phosphatidylinositol transfer protein in secretory vesicle formation. ... Although the vesicle trafficking protein VAMP-2 only partially overlapped with ... Insulin signaling: GLUT4 vesicles...

Neoplasm

... of the covering of the brain and spinal cord. ... Adenoid cystic carcinoma (ACC) is an uncommon form of malignant neoplasm that arises within secretory glands, most commonly the major and minor salivary glands of ... ...

Leukocytes

... ... Definition of Leukocytes . Leukocytes : Cells that help the body fight infections and other ... ... in stool samples) and those causing secretory diarrhea (no fecal leukocytes ) ... Inhibition of chemotaxis of neutrophil leukocytes to interleukin-8 by endotoxins ... A large percentage...

Hormone

...ly, Antidiuretic hormone , also known commonly as arginine vasopressin, is a nine ... Within hypothalamic neurons, the hormone is packaged in secretory vesicles with ... Only a small amount of hormone is required to alter cell metabolism. ... Epinephrine (adrenaline), a catecholamine-type h...

Glands

...d different types of treatment ... Acne is a disorder of the hair follicles and sebaceous glands . ... Glands are organized arrangements of secretory cells. ... Although most glands give the appearance of being "solid" tissue, their ... Salivary glands produce the saliva used to moisten yo...

Exocrine glands

...of exocrine glands are generally arranged into secretory units in the ... Exocrine glands are glan...he tissue is a compound exocrine gland , with secretory units and ducts. ... Detailed information on ...epithelium ... no submucosal glands present ... secretory ( exocrine ) cells. Cuboidal cells that bulge into...
secretory in Biological News

Study: Well-known protein helps stem cells become secretory cells

Johns Hopkins researchers have discovered that a single protein regulates secretion levels in the fruit fly's salivary gland and its skin-like outer layer. Described in the May 15 issue of Development, the finding improves understanding of how cells become specialized for secretion, which is a c...

American Chemical Society's Weekly PressPac -- May 20, 2009

... medications or vaccines to treat and prevent the condition, the study says. ARTICLE #1 FOR IMMEDIATE RELEASE "Immunoproteomic Identification of secretory and Subcellular Protein Antigens and Functional Evaluation of the Secretome Fraction of Mycobacterium immunogenum, a Newly Recognized Species of the ...

Mollusks taste memories to build shells

... the network of neurons connecting the sensing cells in the mantle with the secretory cells that produce calcium carbonate and proteins many of them colored pig...n modeled the size of the excitatory and inhibitory regions surrounding the secretory cells and the cells' firing thresholds nine parameters in all as a neural...

Lean and mean biomass-degrading fungus reveals capabilities for improved biofuel production

...by DOE JGI at LANL, and at the University of New Mexico. Subsequently, he and his colleagues turned their attention to the complexities of T. reeseis secretory pathway components, which they had a hunch played an important role in the organisms success. While little appears to have changed in the secretio...

Proteins may predict lung transplant rejection

...me promising results An earlier study from the laboratory had found that elevated levels of human neutrophil peptide (HNP), declining Clara cell secretory protein and some previously unidentified proteins were highly correlated with chronic lung rejection. In particular, the researchers found that HNP wa...

Natural anti-viral enzyme helps keep cancer cells alive, researchers find

...ercent of pancreatic cancers. The UT Southwestern scientists knew that RalB interacts with a protein complex called the exocyst, which helps small secretory packets in cells fuse to the cell membrane. The team isolated this complex, then chemically analyzed the proteins attached to it. One protein the...
secretory in Biological Technology

Recombinant C-Reactive Protein

...e in the initiation and progression of cardiovascular disease. r-hCRP is produced into culture medium by DNA recombinant procedure in E. Coli as secretory protein. By expressing kil gene, the outer membrane of E. Coli becomes permeable, allowing recombinant C-Reactive Protein to be excreted without cell ...

Anthera Completes Enrollment and Dosing of Varespladib Cardiovascular Trial

... the continued progress of our varespladib cardiovascular program targeting secretory phospholipase A2," said Paul Truex, President and Chief Executive Officer o...us clinical trials, varespladib, a potent and highly selective inhibitor of secretory phospholipase A2 (sPLA2), has demonstrated marked improvements in independe...

Anthera's Varespladib Demonstrates Significant Anti-Inflammatory Effect and LDL Reduction in Patients With Coronary Heart Disease

...ater than 20% relative reduction in C-reactive protein -- Varespladib had a substantial reduction in the target enzyme and pro- inflammatory marker, secretory phospholipase A2 (84%, p<.0001) -- Varespladib resulted in a significant reduction in LDL in CHD patients (15%, p=.0006) -- Varespladib caused a s...

Novel compound may treat acute diarrhea

...nd - a pyridopyrimidine derivative - targets acute secretory diarrhea caused by E. coli and other enterotoxigen...a pill for adults and in a liquid for children. secretory diarrhea describes the condition when the small in...ion, shock and death. There are many causes of secretory diarrhea. The most common, by far, is infestation ...

Anthera Presents Data on Varespladib at ATVB Meeting

.... Anthera has completed Phase II trials in Varespladib for the treatment of coronary heart disease. Posters include: -- Effects of a Selective secretory Phospholipase A2 Inhibitor on Low-Density Lipoproteins in CHD Patients with Diabetes. -- The Synergistic Inhibition of Atherogenesis in ApoE-/- M...

Cytosolic expression of Green Fluorescent Protein (GFP) and its derivatives in the yeast Saccharomyces cerevisiae: Detection in vivo using the Varian Cary Eclipse

... a reporter of gene expression and protein localisation. It was used to illuminate cellular organelles, the cytoskeleton, and the secretory pathway (reviewed by Gerdes and Kaether 2 ). Since then, a rapidly increasing variety of applications for GFP and its derivative...
secretory in Biological Products

Rabbit Anti-Human Secretory Component Antibody, Unconjugated from ABR-Affinity BioReagents

Description: Immunogen: Secretory component isolated from human colostrum. Storage: 4 C...
Company:ABR-Affinity BioReagents

Rabbit Anti-Human Secretory Carrier Membrane Protein 2 (SCAMP2) Polyclonal Antibody, Unconjugated from Lifespan Biosciences

Description: Rabbit Anti-Human Secretory Carrier Membrane Protein 2 (SCAMP2 Polyclonal AntibodyOther Sub-Family: not assigned-Other Applications: Western Blot...
Company:Lifespan Biosciences

Mouse Anti-Secretory Component Glycoprotein Monoclonal Antibody, Unconjugated, Clone SPM217 from Abcam

Description:... Mouse monoclonal [SPM217] to secretory Component Glycoprotein ( Abpromise for all tested applications)....
Company:Abcam

pYD1 Yeast Display Vector from Invitrogen

Description:... construct is transformed into the EBY100 S. cerevisiae strain (supplied transformed with AGA1). Aga1 and the Aga2-fusion protein associate within the secretory pathway and are displayed on the cell surface....
Company:Invitrogen

Mast Cell Degranulation colorimetric Assay Kit from CHEMICON

Description:..., is a key step in the inflammatory response of leukocytes (e.g. basophils, neutrophils, eosinophils, and mast cells). In addition to histamine, these secretory granules contain many proinflammatory mediators including heparin, cytokines, chemokines, and many proteases (Hallgren, 2001). Tryptase, a tetrameric ...
Company:CHEMICON

EBY100 S. cerevisiae Strain from Invitrogen

Description:... construct is transformed into the EBY100 S. cerevisiae strain (supplied transformed with Aga1). Aga1 and the Aga2-fusion protein associate within the secretory pathway and are displayed on the cell surface (Figure 1)....
Company:Invitrogen
secretory in Biological Definition

Antibody

...s also a polypeptide of the same molecular mass (1,5 kD) that is called the secretory chain and is produced by the epithelial cells . It is also possible to fin...s primarly found in serum, however of the J chain it is also important as a secretory immunoglobulin. Due to its polymeric nature, IgM possesses high avidity, an...

Disulfide bond

...s, disulfide bonds are formed in the lumen of the RER (rough endoplasmic reticulum) but not in the cytosol . Thus disulfide bonds are found only in secretory proteins, lysosomal proteins, and the exoplasmic domains of membrane proteins. Disulphide bonds are also formed within and between protamines in th...

Endoplasmic reticulum

... the peptidylpropyl isomerase family . Only properly folded proteins are transported from the RER to the Golgi complex . Transport of proteins secretory proteins are moved across the ER membrane. Proteins that are transported by the ER and from there throughout the cell are marked with an address tag ...

Flagellum

...ve into their respective positions. The filament grows at its tip rather than at the base. The basal body has many traits in common with some types of secretory pore which have a hollow rod-like "plug" in their centers extending out through the plasma membrane, and it is thought that bacterial flagella may h...

Golgi apparatus

...e, (8) Golgi apparatus , (9) Cis face of the Golgi apparatus, (10) Trans face of the Golgi apparatus, (11) Cisternae of the Golgi apparatus, (12) secretory vesicle, (13) Plasma membrane, (14) Exocytosis , (15) Cytoplasm, (16) Extracellular space. The structure and internal function of the Golgi appar...

Insulin

...and calcium flows into the cells An increased calcium level in the cells causes release of previously synthetised insulin, which has been stored in secretory vesicles The calcium level also regulates expression of the insulin gene via the calcium responsive element binding protein ( CREB ). Th...
secretory in Biological Dictionary

Transport vesicle

... We have isolated vesicles that mediate protein transport from the ER ... Immuno-isolation of Sec7p-coated transport vesicles from the yeast secretory pathway. ... transport vesicles . In a very general sense a transport vesicle could be any ... transport vesicles are usually refered ...

Signal Sequence

...ng differs for some ER transmembrane proteins. ... ... that will be completely synthesized in the cytosol do not have a signal sequence . ... secretory protein is a signal sequence but the nascent polypeptide of ... The major difference is the fact that it has a hydrophobic signal sequen...

Seminal vesicles

...and behind the ... T3c: Tumor invades the seminal vesicle (s) ... SVI: see seminal vesicle invasion. ... The seminal vesicles are paired secretory glands just posterior to the bladder. ... seminal vesicles can be unilateral or bilateral. Bilateral seminal vesicle ... How the prostate...

Rough ER

...e framework of the history ... Rough ER is the site of manufacture of secretory proteins as well as proteins ... The rough appearance under electr... endoplasmic reticulum . ... The rough ER manufactures membranes and secretory proteins. ... ... analyses of peroxisomal and rough ER vesicle fra...

Pancreas

... regulation. ... Figure 1. The human pancreas . (A) View of the pancreas showing clusters of acinar cells (i.e. ... ( B) An enlargement of a secretory region of the pancreas . ... ...

Lysosome

...am-Webster Online Dictionary with audio pronunciations, thesaurus, Word of the Day, and word games. Function of cell lysosomes , peroxisomes and secretory vesicles. ... Uncontrolled release of lysosome contents into the cytoplasm is also a component ... The lysosome is a small, round structure c...
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Breaking Medicine News(10 mins):Health News:Patient Engagement in Hospital Infection Control: Online Toolkit Provides a New Solution 2Health News:New Standing Desk Anti-fatigue Mats from Martinson-Nicholls Reduce Leg Fatigue and Discomfort Working at Standing and Sit-to-Stand Desks 2Health News:Preemies May Have Higher Risk of Blood Clots, Even as Adults 2Health News:Preemies May Have Higher Risk of Blood Clots, Even as Adults 3Health News:Healthy 'Brown Fat' May Cut Odds for Obesity, Diabetes 2Health News:Study helps compare risks of treatments for early esophageal cancer 2Health News:Study helps compare risks of treatments for early esophageal cancer 3
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Breaking Biology News(10 mins):Wyss Institute's technology translation engine launches 'Organs-on-Chips' company 2Wyss Institute's technology translation engine launches 'Organs-on-Chips' company 3Dinosaurs fell victim to perfect storm of events, study shows 2Study: Climate change and air pollution will combine to curb food supplies 2Study: Climate change and air pollution will combine to curb food supplies 3
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