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scaffolds in Medical News

Frost & Sullivan Lauds Pioneer Surgical Technology for Development of Tissue Scaffold E-Matrix

...ue engineering is the development of biodegradable scaffolds for the growth of cells and tissues. Several synth...ake scaffolds. "Current generation biological scaffolds do not provide tissue promotion besides using inap... primary competitive advantage over other existing scaffolds is its ability to provide excellent handling prope...

IADR and GlaxoSmithKline Consumer Healthcare announce winners of 2009 Innovation in Oral Care Awards

...eptide Hydrogels and Stem Cells for Dentin-Pulp Complex Regeneration." This innovative research will develop and test novel peptide-based hydrogels as scaffolds to promote the differentiation of adult stem cells and the formation of dentin and pulp tissues. This biologically based endodontic therapy offers an ...

'Scaffold' Could One Day Repair Damaged Hearts

... properties of heart tissue, giving it a number of advantages over previous scaffolds designed for heart tissue engineering, according to the MIT team. The ge...ineered tissues. "In the long term, we'd like to have a whole library of scaffolds for different tissues in need of repair," Lisa E. Freed, a principal resear...

Novel hydrogel systems for dentin regeneration

...el properties for the regeneration of the dentin-pulp complex. Importantly, the results will provide the foundation for developing multidomain peptide scaffolds as novel therapeutics for the regeneration of the dentin-pulp complex. ...

Nanoparticles aid bone growth

...nimal model." In the experiments, the researchers implanted two kinds of scaffolds into rabbits. One type was made of a biodegradable plastic called poly(prop...eeks than the PPF. Furthermore, the researchers found the 12-week composite scaffolds contained about two-thirds as much bone tissue as the nearby native bone ti...

ASINEX and CDD Team up for Open Access Data for the Scientific Community

... identification and optimization. The main premise is for new screens, fewer compounds of higher quality are often required. This means more different scaffolds with fewer compounds per scaffold for greater coverage of novel chemical space (novel IP) without creating compounds so lipophilic that they violate t...

'Destruct' triggers may be jammed in tumor cells, UF geneticists say

...orida scientists writing in a recent issue of Developmental Cell. Scientists studying fruit fly cells discovered that slight changes in the protein scaffolds that support the genes reaper and hid aptly named for their roles in triggering cell death cause the cells to become naturally resistant to X-rays d...

In blood vessel stents, innovative materials allow better control, delivery of gene therapy

...at a disease site. In an animal study, the research team used their new synthetic formulation to bind adenoviruses to bare metal stents, tiny metal scaffolds inside the carotid arteries of rats. Adenovirus served as a gene therapy vector to carry genes for an enzyme that significantly reduced restenosis, th...

Reconstructing mandibular defects with bioengineered tooth and bone

...cting both teeth and bone. In 2002, the group first reported the regeneration of tooth crowns, from cultured tooth bud cells seeded onto biodegradable scaffolds and implanted into rat hosts. The morphology of the developing tissue-engineered tooth crowns closely resembled that of naturally formed teeth. Next, ...

Silica smart bombs deliver knock-out to bacteria

...hoenfisch and his lab of analytical chemists at UNC have created nano-scale scaffolds made of silica and loaded with nitric oxide (NO) an important molecule in ...Sciences. Schoenfisch, Hetrick and their colleagues tested their silica scaffolds head-to-head with small molecules against the bacteria Pseudomonas aerugino...
scaffolds in Medical Technology

Cognition Therapeutics Closes Series A Financing to Advance Drug Candidates for Alzheimer's Disease

...disease model for the critical molecular step that causes memory loss. In addition, the company's proprietary chemistry is based on natural molecular scaffolds which brought us effective drugs like aspirin, lidocaine and taxol. We anticipate new disease-modifying drugs for Alzheimer's disease will result fro...

Applying Clinical Findings to the Practice of Medicine

...e of Medicine for the paper "Osteoinductive Injectable Degradable Polymeric scaffolds for Osseous Defect Repair." This research team studied the field of bone t... cells and make bone. According to Dr. Yaszemski, "The osteoconductive scaffolds and osteoinductive factors are intended to replace bone graft in these proc...

Rib-X Pharmaceuticals Renews Collaborative Agreement with the Medical Research Council

... of work with the MRC, Rib-X has been able to advance the iterative intelligent discovery engine that the Company developed to design novel antibiotic scaffolds which circumvent the mechanisms employed by resistant bacteria," said Erin Duffy, Ph.D, Rib-X's Vice President of Structure-Based Drug Design. "This i...

Researchers Use Magnetism to Target Cells to Animal Arteries

.... The nanoparticles contained iron oxide. Using an external, uniform magnetic field, Levy's team directed the cells into steel stents, small metal scaffolds that had been inserted into the carotid arteries of rats. The uniform magnetic field created "magnetic gradients," local regions of high magnetic forc...

Idenix Pharmaceuticals Provides Update on Hepatitis C Pipeline at JP Morgan Healthcare Conference

...ovel Macrocyclic Protease Inhibitor Program Idenix is evaluating multiple scaffolds in its protease inhibitor discovery program. Compounds from two of these scaffolds have demonstrated potent and selective antiviral activity in in vitro precl...

Data Show SuperGen's Multi-Targeted Tyrosine Kinase Inhibitor Suppresses Critical Double-Stranded DNA Repair Protein, Rad51

...rocess Using CLIMB, researchers created a model of Axl kinase to screen a large virtual library of chemical structures from which five chemical lead scaffolds were selected. Structural modifications improved biochemical and cell-based potency that resulted in compounds that exhibit sensitization to apoptosis...
scaffolds in Medical Products

TruGraft Synthetic Bone Graft Substitute Granules

Features:... a bone void filler First bone void filler containing resorbable polymers Granules can be packed into irregular shaped defects Proprietary scaffolds are 75% porous for effective tissue ingrowth and incorporation...
Company:OsteoBiologics, Inc.

VITOSS Synthetic Cancellous Bone Void Filler

Features:...improved -TCP made possible by fine particle synthesis technology. Particles approximately 100 nm in size, making up highly porous, 3-dimensional -TCP scaffolds (pores ranging from 1 to 1000 m in size). Similar architecture and chemical composition to natural bone mineral. Dissolution at a rate consistent with...
Company:Orthovita
scaffolds in Biological News

Non-wovens as scaffolds for artificial tissue

This release is available in German . When someone's knee hurts with every step it's a sign that the cartilage has been so badly damaged that the bones rub together when walking. Medical scientists are developing a technique to produce cartilage tissue artificially so that patients with ...

Woven scaffolds could improve cartilage repair

Using a unique weaving machine of their design, Duke University Medical Center researchers have created a three-dimensional fabric "scaffold" that could greatly improve the ability of physicians to repair damaged joints with the patient's own stem cells. "If further experiments are successful, th...

Navigating in the ocean of molecules

...similarities: the program assigns smaller 'parent' scaffolds to each scaffold by gradually removing rings from ...Thus, the researchers identify structurally simple scaffolds with promising characteristics as the starting poi... for new active agents: chemists can then vary the scaffolds with different appendages to synthesize the optima...

Medical use for waste television screens

...l sites. Researchers have now found a way of recovering PVA from television screens and transforming it into a substance suitable for use in tissue scaffolds which help parts of the body regenerate. It can also be used in pills and dressings that are designed to deliver drugs to particular parts of the body...

Healing wounds with lasers, vehicles that drive themselves, other cutting-edge optics

...e medicine. Though cells have complicated and intriguing mechanisms to sense and communicate where an injury occurs, the possibility of using photonic scaffolds to stimulate and guide cells' motility to accelerate tissue repair, is now quite promising. Presentation CMMM2; Monday, June 1, 4 4:15 p.m. ...

New center at Georgia Tech aims to improve recovery of soldiers with severe injuries

...tigating whether bone marrow-derived stem cells can be used in the body to heal large defects in bone and cartilage if they are inserted in fiber mesh scaffolds and silk sponges during a surgical procedure. Additional projects in the center include assessing tissue viability, preventing the growth of bone ...

Award for pioneering stem cell research to mend broken bones

...rstand skeletal cell activity, develop appropriate scaffolds and to understand how the environment the cells fi...ll combine their expertise in skeletal stem cells, scaffolds and materials chemistry to identify the key growth...nerative medicine. Our findings of how stem cells, scaffolds and the physical environment can be combined to in...

WPI professor receives Fulbright Scholarship to work on tissue engineering in Ireland

...the $50 million Life Sciences and Bioengineering Center at Gateway Park." During his stay in Ireland, Billiar will study the mechanics of nanoscale scaffolds for tissue engineering with Dr. Abhay Pandit, Director of the Network of Excellence for Functional Biomaterials. Developing a detailed understanding o...

MIT: New tissue scaffold regrows cartilage and bone

...can stimulate mesenchymal stem cells in the bone marrow to produce new bone and cartilage. The technology is currently limited to small defects, using scaffolds roughly 8 mm in diameter. The researchers demonstrated the scaffold's effectiveness in a 16-week study involving goats. In that study, the scaffold...

NIST issues first reference material for tissue engineering

...nt and grow, in time repairing damaged tissue. The scaffolds are meant to be absorbed gradually by the body and...bility and biodegradability, successful 3-D tissue scaffolds have a number of physical requirements. Porosity o... of Health and ASTM Working Group WK6507 Reference scaffolds for Tissue Engineering. ...
scaffolds in Biological Technology

Pepscan Achieves First Milestone in Research Collaboration With Genmab

...ibodies reactive with a range of complex proteins, including GPCRs. About CLIPS(TM) Technology Chemically Linked Immunogenic Peptides on scaffolds (CLIPS(TM)) is a technology to present one or more peptides in a structurally constrained configuration. These molecules behave as functional mimics o...

Bone Biologics Announces UCB-1 (NELL-1) Bone Growth Protein Production Process With Aragen Biosciences

...ted the product in the lab over the previous ten years. This platform technology is the unique UCB-1 (NELL-1) protein formulated with tissue-specific scaffolds to only deliver the intended outcomes. The lead product effort is to promote bone growth in spinal fusion. ...

Progentix Orthobiology and NuVasive Sign Investment Agreement

...osteoinductive-like material products for clinical application in bone regenerative surgery. CuriOs is based on surface structured ceramic biomaterial scaffolds that, in preclinical testing, have shown the ability to attract stem cells after implantation. W: http://www.progentix.com ...

Nomad Bioscience: New Plant Biotechnology Company Founded to Focus on Biomaterials and Biopharmaceuticals

...and biopharmaceuticals that address critical unmet needs. NOMAD is developing a series of high-value products such as nanopatterned materials, protein scaffolds and templates, proteins and enzymes for important markets including biofuels, electric batteries, and biopharmaceuticals. Nomad's plant-based protei...

Peakdale Molecular Launches AssayReady4U(TM) in Collaboration With ChemPrintCo LLC

.... All compounds in the collection are selected for their applicability to GPCR research. Well-recognized ligand features are combined with proprietary scaffolds and monomers to produce a set of screening compounds for GPCR hit discovery. Glenn Killingworth, Director of Business Development at Peakdale said: ...

Mercury Therapeutics Patents Filed

...without any apparent adverse effects. MTI's proprietary integrated AMPK discovery platform technology has been central to identifying novel chemical scaffolds that have resulted in identifying multiple AMPK activators and inhibitors, and it is continuing to produce additional active molecules. MTI will be ...

Genmab and Pepscan to Identify Human Antibodies Against Intractable Targets

...tional antibodies reactive with a range of complex proteins, including GPCRs. About CLIPS(TM) Technology Chemically Linked Immunogenic Peptides on scaffolds (CLIPS(TM)) is a technology to present one or more peptides in a structurally constrained configuration. These molecules behave as functional mimics o...

Organogenesis, Inc. Announces Acquisition of NanoMatrix, Inc.

... Organogenesis and NanoMatrix are highly complementary. Our innovative electrospinning techniques enable researchers to develop the most cell-friendly scaffolds and physiologically-realistic tissues to date, translating into greater clinical benefit for the patient." William C. Fioretti, Ph.D., Chairman of N...

Ten Extraordinary Innovations Line Up For US $100,000 Saatchi & Saatchi Award For World Changing Ideas

...in eradicating cancer. http://www.actuality-systems.com Printing Skin and Bones (UK) Uses inkjet printing technology to fabricate complex tissue scaffolds on which cells can be grown. The later aim is to use inkjet printing to build 3-D structures that contain both the living cells and the scaffold ma...

Progentix Orthobiology B.V. Closes Series A Financing Round

...erial products for clinical application in bone regenerative surgery. Progentix bone graft material is based on surface structured ceramic biomaterial scaffolds that have the ability to attract growth factors and stems cells after implantation, which results in the induction of bone growth. These materials are...
scaffolds in Biological Products

Fragment Library I: Large Volume with mixtures from ActiveSight

Description:...le rigid core decorated with 1-3 short side groups. Average molecular weight of 142 Da; 95% of library members have weights in the range of 90-220 Da. scaffolds include benzenes, pyridines, pyrimidines, indoles, indazoles, benzimidazoles, purines, pyrazoles, pteridines, cyclohexanes, napthalenes, quinolines, i...
Company:ActiveSight
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(Date:8/29/2014)... Researchers at UC Davis have made some surprising ... infection. Studying simian immunodeficiency virus (SIV), the team ... Paneth cells are early responders to viral invasion ... producing a cytokine called interleukin-1 beta (IL-1β). ... IL-1β causes breakdown of the gut epithelium that ...
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