Bortezomib for salvage therapy against progressive myeloma
Despite the initial efficacy of these therapies against multiple myeloma (MM), relapse is invariably the rule. Bortezomib (Velcade, formerly PS-341, Millennium, USA) is a novel first-class agent that inhibits the proteasome, a // multicatalytic cellular enzyme whose activity entails several molecu...
Penile Prosthesis Surgery Infection Rates Reduced With The No-Touch Technique By Dr. J. Francois Eid of Advanced Urological Care
...e to skin, rather than the complete elimination of bacteria from the procedure, that accounts for the success of penile prosthesis implantation." salvage
procedures, where an infected implant is removed and a new device immediately inserted, have been successful in the past even though the new implant i...
Cell transplantation and cardiac repair
...eduled for major amputations; their long-term limb salvage
rate was 53 percent.
"Our results suggest that a...-Vascular Center. "Among the patients in whom limb salvage
was successful and amputation avoided, the leg was...le."
Dr. Amann noted that the patients with limb salvage
had better baseline perfusion than the eventually ...
BioCryst Pharmaceuticals Announces Presentation of Forodesine Data at the 45th Annual Meeting of the American Society of Clinical Oncology
...ing held in Orlando, Florida from May 29-June 2. Forodesine is a transition-state analog inhibitor of purine nucleoside phosphorylase (PNP), a purine salvage
pathway enzyme that is essential for the proliferation of T-cells and B-cells.
The poster entitled "Long-Term Treatment of CTCL with the Oral PNP...
Victory! Colombian Government Cuts Price of Abbott's Lifesaving AIDS Drug Kaletra 55%, Says AHF
...letra, which can be a key component of lifesaving AIDS drug treatment regimens, particularly as part of what are known as 'second-line' treatments and salvage
therapy. The advocates vowed to seek compulsory licenses in Mexico if Abbott did not reduce prices for the drug and have officially requested a compul...
ULURU Inc. Announces Altrazeal(TM) Clinical Experience Published in the International Wound Journal
...ew publication detailing clinical experience using Altrazeal(TM), was authored by a team of clinicians and scientists working at Southern Arizona Limb salvage
Alliance ("SALSA") at the University of Arizona College of Medicine, located in Tucson, Arizona.
The article is titled, "Use of a Nanoflex(TM...
Agent Orange Exposure Tied to Prostate Cancer Return
...treating prostate cancer patients who've been exposed to Agent Orange need to be aware that these patients may require closer monitoring and so-called salvage
therapy quickly if their prostate cancer returns.
"Not only are their recurrence rates higher, but their cancers are coming back and growing much f...
Human stem cells promote healing of diabetic ulcers
...researchers discovered that a particular type of stem cell CD133+ cells (derived from human foetal aorta) promoted blood vessel formation in order to salvage
the diabetic limb. Three days following the graft consisting of collagen plus CD133+ cells, hardly any CD133+ cells were detected in the ischaemic di...
How to increase the efficacy of local excision of rectal cancer
...lications, and is suitable for stages Tis and T1 rectal cancers. Prevention of local recurrence, active postoperative follow-up, and administration of salvage
therapy are effective methods of increasing the efficacy of local excision.
Celator(R) Pharmaceuticals Enrolls First Patient in Its Phase 2 Study of CPX-351 in Acute Myeloid Leukemia in First Relapse
...al of CPX-351 (Cytarabine:Daunorubicin) Liposome Injection versus intensive salvage
therapy in adult patients (up to 60 years old) with acute myeloid leukemia ...; "MEC," the mitoxantrone/etoposide/cytarabine regimen; and other published salvage
regimens. Patients will be monitored for all clinical adverse events as we...
salvage in Medical Technology
Pixantrone Produces High Rates of Complete and Partial Remissions Even Among Aggressive NHL Patients With Extensive Prior Doxorubicin Treatment or Prior Rituximab Treatment
... of these patients, most of whom had received an anthracycline as part of a salvage
regimen, was 386 mg/m2 (with a range of 306 mg/m2 to 778 mg/m2). Following...oxorubicin, but even in patients who received an anthracycline as part of a salvage
regimen. Resistance to rituximab was not associated with resistance to pix...
Video: ev3 Inc. Announces First Patient Enrollments in DEFINITIVE LE Post-Market Study
...cal sites throughout the United States and Europe. The study will evaluate one-year patency in patients with leg pain (claudication) and one-year limb salvage
in patients with critical leg ischemia (CLI) and include third party review of results by independent core-labs.
"As one of the most robust plaq...
AUA Guideline: Full Kidney Removal Not Necessary for All Kidney Tumors
...the increased risk of local recurrence when compared to surgical excision, the potential need for reintervention, the potential for difficult surgical salvage
if tumor progression is found and the substantial limitations of the current thermal ablation literature.
Active Surveillance: Active surveill...
ULURU Inc. to Present Altrazeal(TM) Clinical Evidence and Advanced Therapeutic Research at the Diabetic Foot Global Conference (DFCon) 2009
...mmenting on the work, DFCon organizer and one of the study's co-authors, Dr. David Armstrong, Professor of Surgery and Director, Southern Arizona Limb salvage
Alliance (SALSA) University of Arizona College of Medicine stated, "We have been provisionally impressed with this modality. We believe that marryi...
Hana Biosciences Announces Successful Planned Independent Safety Analysis Supports Ability to Complete Pivotal rALLy Clinical Trial of Marqibo, Its Lead Novel Anti-Cancer Compound
...n, and rALLy study lead
investigator, said, "Clinical results from rALLy, as well as in previous ALL
trials, suggest that Marqibo could offer a unique salvage
therapy for relapsed
ALL and therapeutic advantage over standard vincristine-containing chemotherapy
in patients with lymphoid malignancies."
Cell Therapeutics and IDIS Announce Agreement for a European Named Patient/Compassionate Use Program for Pixantrone
...the good tolerance and efficacy of pixantrone since the first clinical trial we had with this drug in our department. We obtained excellent results in salvage
therapy of non-Hodgkin's lymphoma in heavily pretreated patients and several years later some of our patients are still in complete response. These po...
The Leukemia & Lymphoma Society and Celator Pharmaceuticals Announce Partnership to Accelerate Development of CPX-351 for AML
...ugh the partnership, LLS will provide $3.7 million to support Celator's Phase 2B multicenter, randomized, open-label trial of CPX-351 versus intensive salvage
therapy in adult patients less than or equal to 60 years of age with AML in first relapse. Celator expects to start patient enrollment in this study i...
ImQuest Submits Investigational New Product Application to the Food and Drug Administration to Initiate HIV Therapeutic Clinical Trials with IQP-0410
... therapy with currently approved RT and protease inhibitors. The compound is well suited for use as a component of primary HAART regimens as well as a salvage
therapy option. Preclinical studies have also demonstrated the ability of the compound to be used in combination with all other approved HIV drugs.
Arzerra(TM) (ofatumumab) Demonstrates High Response Rates in Patients With Fludarabine Refractory Chronic Lymphocytic Leukemia (CLL)
...nce poorer outcomes. Only about 20 percent of patients respond to available salvage
therapies.(3) Currently there is no approved drug for the treatment of this...
Bulky tumors - when individual tumor masses are >5cm in diameter
therapy - a final treatment for people who are non-responsive to or cannot ...
Novel Therapeutic Approaches May Transform Treatment and Improve Patient Outcomes in Several Platelet Disorders
... of therapy up to the end of six months received a salvage
(rescue) treatment of rituximab plus dexamethasone...0^9/L after 30 days of treatment), activity of the salvage
therapy (dexamethasone/rituximab) in patients not ...sponse in the dexamethasone-alone arm received the salvage
treatment. In this group, ITT and PP sustained res...
salvage in Medical Products
GUARDIAN® Limb Salvage System
Description: The GUARDIAN® Limb Salvage
System offers five different products for limb salvage
surgery. The materials used to make these components are cobalt-chrome, ultra high molecular weight polyethylene, and titanium. All GUARDIAN products are extensions of Wright Medical Technologys hip and ADVANCE kn...
Company:Wright Medical Technology, Inc.
MOST Options™ Limb Salvage Surgery System
Description: The MOST Options System is designed to enable patients facing severe bone loss of the knee or hip to regain use of their limbs and provides the potential for restoration of function.
The system goes beyond the requirements of a rotating hinge and provides the surgeon intraoperative flexibility t...
Orthopaedic Salvage System
Description: The Orthopaedic Salvage
System (OSS) from Biomet Inc. offers the most comprehensive joint reconstruction prostheses designed specifically for orthopaedic surgeons and oncologists who discover the following indications in their patients: significant bone loss, ligamentous deficiencies, bone tumors, ...
Company:Biomet Orthopedics, Inc
Cell Saver® 5 System
Description:... Haemonetics invented surgical blood salvage
nearly thirty years ago and has been an innovator in the field ever since. The Cell Saver autologous blood recovery systems are used in operating room...
The Sabet Lenticular Safety Net
Description:...inue. Can Support Multiple Fragments Simultaneously.
Provides The Length Of A Cyclodialysis Spatula To Reach Into The Vitreous Cavity To salvage
Lens Fragments With One Instrument.
A 23g Tube Fits Through A 1mm Paracentesis Or Pars Plana Incision, And When Opened Inside The Eye, Provide...
Company:Rhein Medical, Inc.
Biomet® Arthrodesis Nail
Failed external fixation
Aseptic failed total knee arthroplasty
Periarticular fractures where repair is not possible
in tumor treatment ...
Company:Biomet Orthopedics, Inc
Description:... Like other blood salvage
devices, the Haemonetics OrthoPAT system collects and cleanses red blood ce...and process red blood cells.
For orthopedic patients, surgical blood salvage
with the OrthoPAT system means a reduced need for donor blood and a lowered...
salvage in Medical Dictionary
...bout C-Port ... From Hawaii to Virginia and along the gulf coast C-Port ... C-PORT is the national trade association for the marine assistance and salvage
industry. ... C-PORT Chairman writes an article for USCG's On Scene Magazine ... Port Columbus International Airport, USA, serves the travel nee...
Diabetic foot care
...betic Foot care amputation prevention, wound care , cutting edge research ... Advancing Care of the Diabetic Foot . Southern Arizona Limb salvage
Alliance ... Information from ePodiatry on the diabetic foot , diabetic foot care for those with diabetes and a diabetic foot ulce...
salvage in Biological News
Biologists rediscover endangered frog population
...many pools drying up, including one where frogs had been living. Concerned about losing the tadpoles, she called the Fish and Wildlife Service and the salvage
effort started the next day. A USGS team led by Dr. Robert Fisher rescued 82 tadpoles, which were taken to the San Diego Zoo's Institute for Conservat...
Forest fire prevention efforts will lessen carbon sequestration, add to greenhouse warming
... already very long, and the additional levels of fuel accumulation have not been that unusual;
A wide range of fire reduction approaches, such as salvage
logging, understory removal, prescribed fire and other techniques, can effectively reduce fire severity if used properly;
Such fuel removal almost...
Fossil teeth of browsing horse found in Panama Canal earthworks
... Rushing to salvage
fossils from the Panama Canal earthworks, Aldo Rincon, paleontology intern at the Smithsonian Tropical Research Institute, unearthed a set of fossil t...
New tool isolates RNA within specific cells
...by the National Institutes of Health and HHMI.
Cleary's group built its tool with the enzyme uracil phosphoribosyltransferase (UPRT), a nucleotide salvage
enzyme that prepares nucleotides for incorporation into newly synthesized RNA. By altering the nucleotide analog 4-thiouracil, the UPRT enzyme caused ...
Agent Orange exposure increases veterans' risk of aggressive recurrence of prostate cancer
...ts her colleagues following prostate cancer patients with Agent Orange exposure to know those patients may need more meticulous scrutiny and so-called salvage
therapy quickly if their prostate cancer returns. "Not only are their recurrence rates higher but their cancers are coming back and growing much faste...
Research synthesis shines light on several management options after fires in diverse ecosystems
...ds and other animals that live in cavities are impacted by the harvesting of large standing dead trees.
"There has been a lot of controversy about salvage
logging over the past decade," says Peterson. "We want to ensure that the most recent scientific information is available for making decisions and det...
Rong Li Lab offers insight into adaptive ability of cells
"The ability of cellular systems to evolve is linked to their component and network complexity, which allows the cell to develop 'workarounds' to salvage
normal functions, even in times of crisis," said Giulia Rancati, Ph.D., Postdoctoral Research Associate and co-equal lead author on the paper. "Surpri...
Herbicide-resistant grape could revitalize Midwest wine industry
... the original Chancellor plants as a control.
"It was quite an accomplishment to get the gene into the plant," said Skirvin. "This grape could help salvage
the wine and grape industry in theMidwest." If all goes well, Skirvin hopes that in about five years they'll be able to work with a grape grower to p...
Combining advanced medical and information technologies offers pathway to lower health care costs
...rscored by Dr. David G. Armstrong, DPM, PhD, Professor of Surgery, University of Arizona College of Medicine and Director of the Southern Arizona Limb salvage
Alliance (SALSA), a noted expert on diabetes care, who said that the current expenditures for caring for the feet of people with diabetes exceeded th...
UCLA researchers develop new PET scanning probe that will allowing monitoring of the immune system
...l so the cells that take in the probe can be seen during PET scanning.
The probe is based on a fundamental cell biochemical pathway called the DNA salvage
Pathway, which acts as a sort of recycling mechanism that helps with DNA replication and repair. All cells use this biochemical pathway to different d...
salvage in Biological Technology
Global Blood Resources' On-Line Calculator Reveals Wasted Blood Costs by Blood Salvage Machines During Heart Surgery to be in the Billions
The Hemobag(R) prevents wastage by saving the patient's own whole blood
SOMERS, Conn., May 6 /PRNewswire/ -- A recent paper in a journal for
perfusionists, the health professionals who manage patients on heart and
lung bypass machines during open heart surgery, reports how Global Blood
UW working to salvage multi-million HR software project
Madison, Wis. -- A report is due this fall that will help University of Wisconsin System officials determine whether and how to proceed with an IT project that was put on hold after approximately $25 million was spent working to implement it over a five-year period. The project was determined to...
Harvest Technologies Announces Completion of Patient Enrollment in its 60 Patient Clinical Trial in India Using Autologous Adult Stem Cells to Treat Patients With Non-Reconstructable Critical Limb Ischemia
...treated with at least twelve weeks follow up at the Cardiovascular Research Foundation meeting on January 15, 2009 in New York City. He showed a limb salvage
rate of 87.5% and significant improvement in reduction of pain, improvement in perfusion measures and in quality of life. Results on the total study ...
Phase II Trial Demonstrates Elacytarabine May Increase Survival Threefold in Patients With Late-Stage Leukaemia
... compared with a detailed
historical outcome analysis of 594 similar second salvage
AML patients, who
were treated at the MD Anderson Cancer Center (Houston, T...late stage AML who had received two prior treatments with
chemotherapy (2nd salvage
treatment). A dose of 2000 mg/m2/day was given as
continuous infusion for f...
Pixantrone Significantly Increases Complete Remissions, Overall Response Rates, Frequency of Durable Remissions and Progression Free Survival in Patients with Relapsed and Refractory Aggressive Non-Hodgkin's Lymphoma
...ity of London, the lead investigator for the PIX 301 EXTEND trial who presented the study at ASCO.
"Anthracycline-related drugs can be effective salvage
agents in aggressive NHL, but our use of them is limited by the significant increase in risk of cardiac failure associated with high cumulative doses ...
ULURU to Present Clinical Evidence and Advanced Research on Altrazeal at the Society for Advance Wound Care Conference for 2009
...e free mesh skin graft protection. Commenting on the new surgical technique, Dr. James Gleaves, FACS of Rush Hospital Wound Care, Hyperbaric and Limb salvage
Center, Meridian, Mississippi and co-author of two posters on the surgical procedure stated, "The development of a technique to cover and protect a me...
The University of Arizona College of Medicine and OmegaGenesis Announce Collaboration Agreement to Address Diabetic Foot Ulcers
...director of the University's Southern Arizona Limb salvage
Alliance (SALSA). "The problem is especially chal... The University of Arizona's Southern Arizona Limb salvage
Alliance," said Oostur Raza, CEO, OmegaGenesis. "... Medicine and SALSA
The Southern Arizona Limb salvage
Alliance (SALSA) at the University of Arizona Co...
Endocare Reports Financial Results for Third Quarter 2008
...d by the American Urological Association (AUA) release
of the official 'best practice' document on cryoablation for prostate
cancer, covering primary, salvage
and focal cryoablation. The AUA release
of these clinical guidelines is an acknowledgement of the important
advances made in the technology of cryoabl...
Best Practices Document on Cryoablation Posted on Website of American Urological Association
...s for the first time posted on its website the organization's official
"best practice" document on cryoablation for prostate cancer, covering
and focal cryoablation, also called cryosurgery. The AUA
posting of these clinical guidelines is an acknowledgement of the important
advances made in ...
Positive SPA Reply From the FDA for TopoTarget's Pivotal Trial With Belinostat in PTCL
...mber of chemotherapy regimens are used for salvage
therapy. However, there is currently no consensus regarding the optimal
treatment approach for PTCL salvage
Belinostat is a promising small molecule HDAC inhibitor being
investigated for its role in the treatment of a wide range...
salvage in Biological Dictionary
...ne. ... in the pyrimidine biosynthesis. ... Pyrimidine biosynthesis. v • d • e ... Nucleotide metabolism: Purine metabolism · Nucleotide salvage
· Pyrimidine metabolism ... Pyrimidine Catabolism. De novo Synthesis of Purine Nucleotides ... The purine and pyrimidine bases releas...
...as examined in two APRT pseudorevertant cell lines, their two APRT homozygous ... growth medium of the pseudorevertant lines induced adenine salvage
to ... The SUX1 pseudorevertant strain was found to carry a single nucleotide ... The MTF1 gene in the SUX3 pseudorevertant , compared wit...