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sPLA2 in Medical News

Experimental Drug May Prevent Plaque Buildup

...atherosclerosis are produced when enzymes known as spla2 break down particular molecules in the blood and a...e of The Lancet . "Our study demonstrates that spla2 inhibition produces favorable changes in plasma li...rther study is needed to determine "the effects of spla2 inhibition on reducing atherosclerosis progression...
sPLA2 in Medical Technology

Anthera's Varespladib Meets Primary Endpoint in Phase 2 FRANCIS Trial for the Treatment of Acute Coronary Syndrome

...-HDL cholesterol - Varespladib's immediate and selective inhibition of spla2 effectively suppressed inflammation following the index event and was furth...nt markers of cardiovascular risk including, a near complete suppression of spla2 activity and mass, clinically meaningful and statistically significant redu...

Following Encouraging Results Anthera to Continue IMPACTS Trial for the Prevention of Acute Chest Syndrome in Patients With Sickle Cell Disease

...d Chief Medical Officer of Anthera Pharmaceuticals, Inc. "We believe a drug that is deemed to be safe and able to suppress inflammation by inhibiting spla2 provides an opportunity for early intervention for patients where current treatment options are limited." "Today's announcement marks an exciting...

Anthera Announces Preliminary Positive Results From Once-Daily A-002 Phase II Cardiovascular Trial

... Phase IIb clinical trial of A-002, for the treatment of cardiovascular disease. In this second study, administration of once-daily A-002 lowered both spla2 and LDL-C levels confirming the positive effects of A-002 treatment seen in the twice-daily PLASMA study (Phospholipase Levels And Serological Markers...

Anthera's A-001 Receives Orphan Drug Status for the Prevention of Acute Chest Syndrome in Patients With Sickle Cell Disease

...rvention for a serious inflammatory lung disease with a potent inhibitor of spla2 such as A-001. Worldwide, nearly 200,000 suffer from some form of sickle ce...even the common complications of sickle cell disease. As such, discovery of spla2 as a potential therapeutic target for patients at risk for acute chest synd...

Anthera Announces Completion of Enrollment and Dosing in Phase II Trial of A-002 for the Treatment of Cardiovascular Disease

...g of A-002, suggests that a single daily dose may be sufficient to suppress spla2 for up to 24 hours. We look forward to further exploring this opportunity t...irst half of 2008. Further information about Anthera's clinical trials and spla2 can be found at http://www.PLASMAtrial.com or http://www.anthera.com . ...
sPLA2 in Biological Technology

Anthera Presents Data on Varespladib at ATVB Meeting

...ow-Density Lipoproteins in CHD Patients with Diabetes. -- The Synergistic Inhibition of Atherogenesis in ApoE-/- Mice Between Pravastatin and the spla2 Inhibitor Varespladib (A-002). "We are pleased to see the synergistic effect of Varespladib with statins on plaque reduction, composition and stabil...
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