New Scientific Evidence Suggests Humans Resistant to Phthalate Effect on Lab Rodents

Sharpe et al. Study Finds Dose High Enough to Cause Adverse Effect in Rats and Mice Has No Effect in Male Marmosets ARLINGTON, Va., June 25 /PRNewswire-USNewswire/ -- The American Chemistry Council (ACC) today announced that strong new evidence has emerged that phthalates may not affect the ...

Stress hormone impacts memory, learning in diabetic rodents

Diabetes is known to impair the cognitive health of people, but now scientists have identified one potential mechanism underlying these learning and memory problems. A new National Institutes of Health (NIH) study in diabetic rodents finds that increased levels of a stress hormone produced by the...

Glucose Causes Death of Brain Cells in Rodents Following Hypoglycemic Coma

It was thought that hypoglycemic coma causes brain damage. On the contrary brain damage occurs only when glucose is given to treat the coma//, as discovered by researchers from San Francisco VA Medical Center, during a study on rodents. The study results may have implications on the treatment ...

Longer-Lived Rodents Have Lower Levels of Thyroid Hormone

The thyroid may play an important role in longevity, with longer-lived rodents showing significantly lower levels of a thyroid hormone that speeds metabolism, a new study has found.// The study further strengthens the theory that the faster an animal’s metabolism, the shorter its life, and vic...

Stem Cells Used for 'Biological Pacemaker'

..." cells with properties similar to the heart's conductive tissue from stem cells taken from the brown fat tissue of mice. They then injected them into rodents with reduced heart rates caused by electrical signaling problems known as atrioventricular (AV) block. After a week, the AV block was completely re...

Weight-Loss Enzyme Identified

... alpha-MSH levels stay high and keep appetite in check. When researchers at Yale School of Medicine in New Haven, Conn., blocked PRCP in mice, the rodents lost weight, maintained their energy levels and reduced their risk of developing type 2 diabetes, the team reported in the August issue of the Journa...

A Phase III Alzheimer's Drug Increases Levels of Beta Amyloid in the Brain - But Still Provides Benefits

...ta Amyloid in Alzheimer's Mouse Models Recent evidence suggests that dimebolin (Dimebon((R)), Medivation) may improve cognitive function in aged rodents and in people suffering from mild to moderate Alzheimer's, but how the drug produces these benefits remains unclear. Samuel Gandy, MD, PhD, M...

Reduced diet thwarts aging, disease in monkeys

...s significantly attenuated in several regions of the brain. That's a completely new observation." Since the first studies of caloric restriction in rodents in the1930s, scientists have been intrigued by evidence that reducing calories can effectively extend lifespan. Such studies have been undertaken in a...

'Easter Island' Drug Adds Years to Mice

... that, when administered late in life, can increase life span in a mammal." Previously, researchers have shown that greatly limiting food intake in rodents helps them live longer, but that's not a feasible option for many humans who like to eat. Rapamycin is a compound discovered in the soil on Easter ...

Chromosome Abnormality Tied to Autistic Behavior in Mice

...poor social interaction, behavioral inflexibility, abnormal vocalizations and anxiety, the researchers found. "The link between social behaviors in rodents and social behavior in humans is difficult to establish," the study authors concluded. "Our model mouse will be valuable not only for therapeutic stud...

Rodents in Medical Technology

Orkin Warns of Four Pests to Avoid this Fourth of July

...in, Inc. Founded in 1901, Atlanta-based Orkin, Inc. is an industry leader in essential pest control services and protection against termite damage, rodents and insects in the United States, Canada, Mexico, Central America, the Middle East, the Caribbean and Asia. With more than 400 locations, Orkin's almo...

Isis Highlights New Data on Antisense Drugs to Treat Type 2 Diabetes and Obesity at ADA Scientific Sessions

...on Lowers Body Weight and Adiposity and Improves Insulin Sensitivity in rodents (Oral Presentation) Authors: X.X. Yu, L.M. Watts, P. Manchem, S.L. Boot... Protein (CREB) Expression Lowers Plasma Glucose and Lipids in Diabetic rodents (Oral Presentation) Authors: S.F. Murray, S.L. Booten, L.M. Watts, ...

Update on FDA Advisory Committee Meeting on Liraglutide for the Treatment of Type 2 Diabetes

... majority of Advisory Committee members did not find that Novo Nordisk based on the available data had ruled out that the finding of C-cell tumours in rodents was not relevant to humans, the Advisory Committee was split on the FDA question related to whether the available data on C-cell tumours permitted app...

Astrocytes Help Separate Man From Mouse

...isticated and have more complex processing power," added Nedergaard, who spoke last week at a Gordon Research Conference on glial biology. "Studies in rodents show that non-neuronal cells are part of information processing, and our study suggests that astrocytes are part of the higher cognitive functioning t...

Study Shows Leconotide, an Investigative Calcium Channel Blocker, Has Potential as a Selective, Efficacious, Non-Opioid Pain Treatment

...leconotide, researchers at Monash Institute of Medical Research studied 322 rodents in a model of induced diabetic neuropathy and hyperalgesia, or extreme sensitivity to pain. Roughly one-third of the rodents were given injections of two calcium channel blockers (leconotide or zicono...

'Hibernation-On-Demand' Drug Hydrogen Sulfide Significantly Improves Survival After Extreme Blood Loss

...nd behavioral testing among the long-term survivors (those that lived more than two weeks after hemorrhage) showed no observable defects. In fact, the rodents that were bred produced normal-sized litters of healthy pups. How does hydrogen-sulfide treatment prevent death from profound and sustained blood lo...

AlphaVax Continues to Expand the Use of Its Vaccine Platform

...cond grant to continue development of a smallpox vaccine based on AlphaVax's proprietary vector platform. The grant will support additional studies in rodents and non- human primates to further characterize the high-level protection observed previously in these species. Work completed during the first gran...

Nobel Prize-Winning Discovery

...o prevent heart disease? Now an animal model can be engineered to contain the DNA that codes for an anxiety disorder, or heart disease. These research rodents are called "knock-in mice." Literally, the disorder is turned "on." These discoveries open up a new frontier of possibility, destroying flat-world...

XTL Biopharmaceuticals Presents Data Regarding its Hepatitis C Virus Small Molecule Program at Hep Dart 2007 - an International Scientific Conference on Viral Hepatitis

...ology studies showed that the activity of these molecules was selective for HCV, with no apparent adverse effects on a range of human cell types or on rodents exposed to repeated high doses. The small molecules being presented by the Company at the conference emerged from the Company's DOS program, aimed a...

Calando Pharmaceuticals Announces Preclinical Efficacy and Safety Data of Targeted, Systemic Delivery of siRNA at AACR Annual Meeting

...d monkeys." Calando's presentation details the results of a pilot safety study of Calando's lead siRNA-containing nanoparticle formulation CALAA-01 in rodents and monkeys. Additionally, data from a multi-dose efficacy study in mice using systemically-administered siRNA nanoparticles showed significant anti-t...

Rodents in Medical Products

Ghrelin, Total ELISA Test

Description:...werful growth hormone independent effects (2). Administration of Ghrelin peripherally or centrally into the cerebral ventricles induces weight gain in rodents (3) and in humans, Ghrelin levels peak prior to each meal and then fall to lower levels immediately upon feeding. In humans, circulating Ghrelin le...
Company:Diagnostic Systems Laboratories, Inc.

Rodents in Medical Dictionary

Propane

...il, propane , gasoline and diesel delivery. In addition, we install energy ... 1,3- Propane sultone is used as a chemical intermediate. ... In rodents exposed to 1,3- propane sultone via gavage (experimentally placing the ... thousand gallon tank holding gaseous propane would provide a ... Whe...

Prion

...omain is also ... Covalent prion modifications. Structural studies of the scrapie prion protein using ... Prion proteins from humans and rodents contain two consensus sites for ... Scientists have now identified kuru as a prion disease. ... All known prion diseases are fatal. ... most c...

Polycystic Kidney

... Polycystic kidney disease (PKD) is a genetic. disorder characterized by the growth of ... 6 Polycystic Kidney Disease. Researchers have bred rodents with a ... Overview of the inherited disorder that causes cysts to enlarge the kidneys and interfere with their function. ... polycystic ...

Plague

... Plague is a deadly infectious disease caused by the enterobacteria Yersinia pestis . Plague is a zoonotic, primarily carried by rodents and spread to humans via fleas. Plague is notorious throughout history, due to the... The Black Death was one of the deadliest pandemics in huma...

Moles

...mprehensive overview covers causes, treatment, including how to get rid of skin moles . ... Large moles present at birth. ... Moles are not rodents but belong to the mammalian Order Insectivora. Insectivora means insect eater, and this group includes moles , shrews, and hedgehogs. ... The med...

Hantavirus

...s . The hantavirus that causes HPS is carried by rodents found throughout North America. ... Hantaviru...antavirus n. Any of a group of viruses carried by rodents that cause epidemic hemorrhagic fever and se... about the hantavirus - the disease carried by rodents (rats and mice), particularly their droppings! ......

Adenovirus

...ene delivery system. ... The entire adenovirus genome is a linear, double-stranded DNA of ... Despite evidence for adenovirus oncogenicity in rodents and in tissue culture ... There are 42 adenovirus serotypes with five new types awaiting classification. ... ...

Adenoviruses

...... Adenoviruses are a frequent cause of acute upper respiratory tract (URT) ... In 1962, some Adenoviruses were shown to cause tumours in rodents - this caused ... Adenoviruses cause acute respiratory disease (usually), pneumonia (occasionally) ... The adenoviruses are common pat...

Rodents in Biological News

Novel anti-cancer mechanism found in long-lived rodents

Biologists at the University of Rochester have found that small-bodied rodents with long lifespans have evolved a previously unknown anti-cancer mechanism that appears to be different from any anticancer mechanisms employed by humans or other large mammals. The findings are published in today's is...

Longer-lived rodents have lower levels of thyroid hormone

The thyroid may play an important role in longevity, with longer-lived rodents showing significantly lower levels of a thyroid hormone that speeds metabolism, a new study has found. The study further strengthens the theory that the faster an animal's metabolism, the shorter its life, and vice ver...

A new view on Lyme disease: Rodents hold the key to annual risk

In the United States, Lyme disease incidence has skyrocketed from 497 cases reported in 1982 (the first year national statistics were collected) to a record 23,763 in 2002. Lyme disease, like other zoonoses, is transmitted by a vector that picks up the pathogen during a blood meal from a verte...

Climate-caused biodiversity booms and busts in ancient plants and mammals

...mperatures were at their highest, that area was a tropical rainforest teeming with lemur-like primates, small dawn horses and a number of small forest rodents and other mammals. In fact, there were more species of mammals living in the western part of North America at that time than at any other time." W...

Rodent size linked to human population and climate change

... noticed -- but the head shape and overall size of rodents has been changing over the past century. A Univers...atomic changes between two geographically isolated rodents -- Channel Island deer mice from coastal Californi...f the causes may be." Pergams examined specimen rodents from museums around the world, including the big c...

Short stressful events may improve working memory

... University at Buffalo have shown, in trials using rodents as an animal model, that acute stress can produce ...e it correctly 60-70 percent of the time. When the rodents reached this level of accuracy for two consecutive...cute stress, and that estrogen receptors in female rodents make them more resilient to chronic stress than ma...

Scientists find a biological 'fountain of youth' in new world bat caves

...Weissmann, M.D., Editor-in-Chief of The FASEB Journal . "As it turns out, one of these bat species lives out its long life in Florida. Since bats are rodents with wings, this chemical clue as to why bats beat out mice in the aging game should point scientists to the source of this elusive fountain." ...

Natural-born divers and the molecular traces of evolution

...bly shorter periods of time, to see if they could also find evidence for the same trend. Indeed, the net charge of the myoglobin molecule in aquatic rodents was twice as high compared to their strictly terrestrial relatives, and the trend was also verified for some semi-aquatic species of insectivores. G...

Improved method developed to test carcinogen risk

...t in large numbers at very low cost, about 5 percent of what a rodent study would cost," Bailey said. "For most studies of carcinogens, exposing 2,000 rodents would be a huge project. For us, working with 2,000 trout is a pilot study." The OSU scientists recently completed the largest study ever done with...

UBC researchers develop new method to study gambling addictions

...be successful gamblers, selecting the option with the optimum level of risk and reward to maximize their sugar pellet profits. The study found that rodents treated with drugs that reduced their levels of serotonin levels associated with impulse control in humans dramatically reduced their ability to play...

Rodents in Biological Technology

Nanogenerators produce electricity from running rodents and tapping fingers

Could hamsters help solve the world's energy crisis? Probably not, but a hamster wearing a power-generating jacket is doing its own small part to provide a new and renewable source of electricity. And using the same nanotechnology, Georgia Institute of Technology researchers have also generate...

Of mice and men: new male contraceptives successful in rodents and humans

Pills, sponges, IUDs, diaphragms-- women have many options for planning their fertility, none of them quite perfect. But what if men want to help out? They have only two options -- vasectomy, which is usually permanent, and condoms, which are crucial for dating but get old in long-term relationsh...

SemBioSys receives US$2.5 million from option agreement with MannKind for plant-produced insulin

...d functionally indistinguishable from pharmaceutical-grade human insulin through analytical testing and pre-clinical sub-chronic toxicology studies in rodents and primates. SemBioSys is currently conducting a Phase I/II clinical trial of its plant-produced insulin. The three-arm study, of up to 30 healthy vo...

Proteolix Presents Preclinical Data for Oral Proteasome Inhibitor PR-047 at the 50th Annual Meeting of the American Society of Hematology

...arget the chymotrypsin-like activity of the proteasome and induce tumor cell death across multiple human cell lines. Oral administration of PR-047 in rodents and monkeys resulted in rapid and prolonged dose-dependent inhibition of the proteasome. Furthermore, significant proteasome inhibition was achieved ...

SemBioSys begins phase I/II trial of insulin produced in plant seeds

...d functionally indistinguishable from pharmaceutical-grade human insulin through analytical testing and pre-clinical sub-chronic toxicology studies in rodents and primates. About SemBioSys Genetics Inc. Calgary, Alberta-based SemBioSys Genetics Inc. is a biotechnology company developing pro...

SenesTech, Inc. Commences Product Registration Process With Australian Government

...traPest(R) works through disruption of the reproductive potential of female rodents by selectively eliminating the female's supply of egg cells. The direct eff...oach to pest population control is the reduced potential for disease, since rodents and their carcasses are vectors for many human illnesses, some life-threate...

Data to Be Presented at 58th Annual Meeting of The American Society of Human Genetics

...cer Emil Kakkis, M.D., Ph.D. The following posters will be featured: 590/W - "Implications of absence of clinical phenotype on Morquio A mice: Why rodents do not require skeleton keratan sulfate?" 752/W - "Intrathecal (IT) enzyme replacement therapy (ERT) for symptomatic spinal cord compression (SCC) i...

Use it or lose it? Researchers investigate the dispensability of our DNA

...ithin the other 98% of the genome are stretches of sequences, known as ultraconserved elements, which are identical between humans and animals such as rodents and chickens, even though hundreds of millions of years of independent evolution separates them. Other evidence has suggested that ultraconserved s...

UTSA/UTHSCSA publish results on bio-threat agent

... life-threatening bioterrorism agent by the Centers for Disease Control. Tularemia is an illness caused primarily by bites or scratches from rabbits, rodents and hares. In most cases, the bacterium causes relatively benign fever, chills and headaches that can be treated with antibiotics. However, when spre...

UTSA/UTHSCSA publish results on bio-threat agent

... life-threatening bioterrorism agent by the Centers for Disease Control. Tularemia is an illness caused primarily by bites or scratches from rabbits, rodents and hares. In most cases, the bacterium causes relatively benign fever, chills and headaches that can be treated with antibiotics. However, when spre...

Rodents in Biological Definition

Charles Darwin

..., an up and coming anatomist who agreed to work on the fossil bones at his Royal College of Surgeons . Owen's surprising revelations of extinct giant rodents and sloths confirmed Darwin's place in the scientific establishment. With Lyell's enthusiastic backing Darwin read his first paper to the Geological ...

Herbivore

... Bovids Horses (including all members of the horse family such as domestic horses , donkeys , and zebras ) Deer Elephants Some rodents such as guinea pigs , porcupines , beavers , and capybaras Rabbits Grasshoppers Snails and slugs For a complete further list o...

Malaria

...alciparum . Complications of malaria include coma and death if untreated—young children are especially vulnerable. Other mammals ( bats , rodents , non-human primates ) as well as birds and reptiles also suffer from malaria. Contents showTocToggle("show","hide") 1 Mechanism...

Rodents in Biological Dictionary

Transgenic

...c humans, green or otherwise. ... This is a brief outline of the steps necessary to obtain transgenic mice or rats. ... Potentially transgenic rodents are born. ... Breekveldt, J. and Jongerden, J., ' Transgenic Animals in Pharmaceutical Production.' The production of pharmaceutical human prot...

Placental mammals

... distinguished from non-eutherians by various... Placental mammals (subclass Eutheria). A sampling of placental mammals . ... There are more rodents and bats than other types of placental mammals . ... Eutheria ( Placental . Mammals ) J David Archibald, ... interordinal relationships of pla...