Decontamination and inhibition of ribonucleases
It is common knowledge in most laboratories that RNA is more susceptible
to degradation than DNA. Unlike Deoxyribonucleases (DNases), which require
metal ions for activity (and can therefore easily be inactivated with chelating
Alfacell's ONCONASE(R) and R-Amphinase Show Anti-Tumor Activity in Chronic Lymphocytic Leukemia and Acute Myeloblastic Leukemia Cells
...) cells alone as well as in combination with standard chemotherapeutic agents, expanding the spectrum of malignancies for which Alfacell's proprietary ribonucleases
show promising activity.
The abstracts are the result of research conducted by collaborators at the Department of Hematology, Medical Univers...
Americas Third Coast nurtures biotechnology
...iences. The basis of the Evade technology involves ribonucleases
that degrade RNA.
Because intact RNA is essential for life, ribonucleases
can be toxic to cells, especially rapidly prolifer...n natural ribonuclease inhibitors (RI), which bind ribonucleases
to prevent cell destruction.
The Evade technolo...
Cancer treatment advances as trials show no harm to mice
...e many FDA approved chemotherapy treatments, the companys proprietary EVade ribonucleases
are effective at killing cancer cells. But Quintessences therapies seem to ... a supplement for existing treatments.
We definitely anticipate that the ribonucleases
will be [and] can be used with chemotherapy and radiation, Strong said.
UW's Waisman Center seeing strong demand for biomanufacturing facility time
...em is Madison-based Quintessence Biosciences Inc., which is working with the Waisman to scale up the process of manufacturing injectible-grade EVade ribonucleases
- a cancer therapy that doesn't have the side effects normally associated with chemotherapies, said Ralph Kauten, president and CEO of the company.
Quintessence cancer treatment chosen for clinical studies
...tumor-growth inhibition in vivo (inside the body) against human pancreatic, non-small cell lung, prostate, and ovarian tumors.
Of the 30 EVade ribonucleases
that Quintessence has tested, QBI-139 had the broadest efficacy in multiple tumor lines.
QBI-139 is the first of some very exciting compounds iden...
Robust High Throughput RNA Isolation from Blood Samples
...X-96 Blood RNA Isolation Kit uses strong denaturing
lysis conditions and proteases to effectively inactivate
and remove blood proteins.
MagMAX-96 Blood Technology
For RNA purification, Ambions magnetic
Get the miRNA OutPlant Applications
...en is laborious and time consuming. Furthermore,
any accidental thawing will cause the release of endogenous
and subsequent RNA degradation.
To simplify the processing of frozen plant
tissues, we recommend treatment...
PCR Grade Water
Specially purified, double distilled, deionized, auto-claved water
Free of detectable endonucleases, ribonucleases
and nicking activity
Routinely function checked in PCR pH at 20C: 8.3
Instrument and related LightCycler kits. In addition, this water is guaranteed
to be free of detectable endonucleases, ribonucleases
and nicking activity.
The PCR Master Kit cont...
Tritirachium album Proteinase K from USB Corp.
Description:... (1) ; Not inactivated by EGTA, thiol reagents or trypsin/chymotrypsin inhibitors (1) Form: Lyophilized powder Purity: Tested for contaminating ribonucleases
and deoxyribonucleases. Shipping and Storage: Shipped on dry ice. Store dry at 4C. Unit Definition: One unit is the amount of enzyme that libera...
RNaseOUT Recombinant Ribonuclease Inhibitor from Invitrogen
Description:... RNaseOUT Recombinant Ribonuclease Inhibitor is a potent noncompetitive inhibitor of pancreatic-type ribonucleases
such as RNase A. Like other RNase inhibitors RNaseOUT Recombinant Ribonuclease Inhibitor is an acidic protein with a molecular weight ~52 kDa. RNaseOU...
GeneChoice RNA Safe Recombinant Ribonuclease Inhibitor from GeneChoice, Inc.
Description:...r MMLV reverse transcriptases; SP6, T3, and T7 RNA polymerases; Taq DNA polymerase; RNase H; RNase T1; or S1 Nuclease. • Efficient inhibition of ribonucleases
•Protects RNA during cDNA synthesis and in vitro transcription/translation. Applications: First and second strand cDNA synthesis, RT-PCR,...
QIAGEN RNase Inhibitor (7500 U) from QIAGEN
Description:... For potent inhibition of RNase A-type ribonucleases
QIAGEN RNase Inhibitor is a protein of nonhuman origin that binds noncovalently and inactivates a variety of ribonucleases
(e.g., RNase A, B, and C). It does not interfere with RNase T1, T2, H, U1, ...