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reuptake in Medical News

Zogenix and Astellas Enter Exclusive Co-Promotion Agreement in the US for Newly Approved Sumavel(TM) DosePro(TM)

...)agonists and is not generally recommended for use with selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors SNRIs or MAO inhibitors. Sumavel DosePro should be used durin...

Depression Poses Pregnancy Risks

...of birth defects. Other reports have found that babies born to women who are taking a type of antidepressant known as an SSRI (selective serotonin reuptake inhibitor) could have breathing or feeding problems, according to the March of Dimes. The bulletin recommends that treatment with antidepressants b...

World's First Deep Brain Stimulation Device Approved for Treatment of Psychiatric Condition in Europe

...erapy for OCD in Western Europe. Patients with severe OCD, as defined by a Y-BOCS score over 30, and who have tried at least three selective serotonin reuptake inhibitors (SSRIs) without treatment success, may be considered eligible for Reclaim DBS therapy. The neurostimulators used for Reclaim DBS The...

Lilly Resubmits Cymbalta(R) Supplemental New Drug Application for Chronic Pain to U.S. Food and Drug Administration

... be a major cause of work absenteeism, underemployment and unemployment. About Cymbalta Based on preclinical studies, Cymbalta is a potent reuptake inhibitor of serotonin and norepinephrine. Although the exact way that Cymbalta works in people is unknown, it is believed to be related to an increas...

Surveyed Psychiatrists and PCPs Expect to Increase Their First-Line Use of SNRIs Over the Next Two Years for the Treatment of Generalized Anxiety Disorder

... physicians (PCPs) expect to increase their use of serotonin-norepinephrine reuptake inhibitors (SNRIs) over the next two years for the treatment of generalized...Patient-level claims data show that benzodiazepines and selective serotonin reuptake inhibitors (SSRIs) dominate early lines of treatment. However, the frequent...

Celexa May Not Help Kids With Autism

...ic neurologist and director of medical autism research at the Kennedy Krieger Institute in Baltimore. Antidepressants known as selective serotonin reuptake inhibitors, or SSRIs, are a common treatment for autism and given to perhaps 30 percent of children with the condition, said Dr. Bryan King, lead auth...

Depression Treatment Wanes Following FDA Warnings

...alysis finds. Researchers at the University of Colorado say the U.S. Food and Drug Administration's advisories about the use of selective serotonin reuptake inhibitors (SSRIs) appear to be associated with "unintended" and "persistent" changes in the diagnosis and treatment of depression, especially in chil...

Some Antidepressants May Thwart Tamoxifen's Effect on Breast Cancer

...g tamoxifen to reduce their odds for recurrence. But tamoxifen often causes hot flashes, a side effect that can be controlled with selective serotonin reuptake inhibitor (SSRI) antidepressants such as paroxetine (Paxil) or fluoxetine (Prozac). Besides working on the neurotransmitter serotonin, these drugs inh...

Transcept Pharmaceuticals Presents Data from Studies of Two Product Candidates at Annual Meeting of the American Psychiatric Association

...ved 14 patients with a DSM-IV diagnosis of treatment resistant obsessive compulsive disorder (OCD) and under stable treatment with selective serotonin reuptake inhibitors (SSRIs) and neuroleptic augmentation, aimed to evaluate the potential of ondansetron augmentation as an alternative treatment for OCD. ...

Results of phase III study on Labopharm's novel antidepressant published in Psychiatry (Edgemont) Journal

...cally treated with two different types of drug therapy: selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs)). However, some 40 to 50% of patients being treated for ...
reuptake in Medical Technology

Popular Breast Cancer Drug Used with Certain Antidepressants Puts New Jersey Women at Risk

...ol of Medicine released a study revealing that women using tamoxifen to prevent a recurrence of breast cancer who also use certain selective serotonin reuptake inhibitors (SSRI), for example Prozac(R) (fluoxetine), Paxil(R) (paroxetine) and Zoloft(R) (sertraline), have up to twice the chance of having a recur...

New Study: Antidepressants Commonly Prescribed with Tamoxifen Put Women at Much Higher Risk for Recurrent Breast Cancer

...ese drugs impact breast cancer recurrence rates when taken with tamoxifen. The antidepressants at issue are three widely used selective serotonin reuptake inhibitors (SSRIs), Prozac(R) (fluoxetine), Paxil(R) (paroxetine) and Zoloft(R) (sertraline), and are among a group of drugs known as CYP2D6 inhibitor...

March 2009 Mayo Clinic Health Letter Highlights Knee Repair Surgery, Anxiety Disorder and Preventing Blood Clots

... Medications, both antidepressants and anti-anxiety drugs, also can help. Among antidepressants, the first choice often is a selective serotonin reuptake inhibitor (SSRI). This category includes fluoxetine (Prozac), paroxetine (Paxil), sertraline (Zoloft) and citalopram (Celexa). Other antidepressants t...

Intra-Cellular Therapies Announces Successful Outcome of a Phase II Clinical Trial with ITI-007 in Patients with Sleep Maintenance Insomnia

.... At the highest dose tested (10 mg) we expect to have full occupancy of 5HT2A receptors while adding incremental amounts of D2 receptor and serotonin reuptake transporter (SERT) occupancy. This has been confirmed in an ongoing human Positron Emission Tomography (PET) study where we have demonstrated that thi...

Forest Laboratories, Inc. and Cypress Bioscience, Inc. Announce Positive Results of Phase III Study of Milnacipran for the Management of Fibromyalgia

... which occurred at a rate of less than 2%. About Milnacipran Milnacipran is a dual-reuptake inhibitor that preferentially blocks the reuptake of norepinephrine with higher potency than serotonin, two neurotransmitters thought to play a central role in the symptoms of fibromyalgia. Milnacipr...

FDA Approves Tapentadol Immediate-Release Tablets for Relief of Moderate to Severe Acute Pain

...chanisms of action, combining mu-opioid receptor agonism and norepinephrine reuptake inhibition. Tapentadol tablets have been approved in 50 mg, 75 m...y at parts of the brain that control how pain is perceived. Norepinephrine reuptake inhibitors are a type of central nervous system medication that increases t...

American Heart Association Scientific Statement: Heart Patients Should Be Screened, Treated for Depression

...ioral therapy, physical activity, cardiac rehabilitation, antidepressant drugs or combinations of those treatments. -- Selective serotonin reuptake inhibitor (SSRI) treatment soon after a heart attack is considered safe, relatively inexpensive and may be effective for treating depression...

MonoSol Rx Completes Thin Film Escitalopram Oxalate Pilot Product Development

...cal products, today announced the completion of pilot product development for its thin film formulation of escitalopram oxalate, a selective serotonin reuptake inhibitor. Escitalopram oxalate is indicated for depression and generalized anxiety disorders and is marketed under the brand name Lexapro(R). Lexapro...

XTL Biopharmaceuticals Announces Completion of Patient Randomization Into the Bicifadine Phase 2b Clinical Trial for the Treatment of Diabetic Neuropathic Pain

...dy of Bicifadine -- a serotonin and norepinephrine reuptake inhibitor (SNRI) -- for the treatment of diabetic ...nts. Importantly, Bicifadine has a unique ratio of reuptake inhibition of serotonin versus norepinephrine, whi...eloping Bicifadine, a serotonin and norepinephrine reuptake inhibitor, for the treatment of diabetic neuropath...

European CHMP Issues Positive Opinion on Cymbalta for the Treatment of Generalised Anxiety Disorder

... for those suffering from this debilitating condition." Duloxetine, a member of a class of drugs commonly referred to as serotonin and noradrenaline reuptake inhibitors,(13) is already approved to treat major depressive disorder and diabetic peripheral neuropathic pain. Duloxetine gained marketing authorisa...
reuptake in Medical Dictionary

Norepinephrine

...opylamino )tetralin ... Learn about taking duloxetine (Cymbalta) to treat fibromyalgia. ... of medications called serotonin and norepinephrine reuptake inhibitors (SNRIs) ... Read more about the prescription drug NOREPINEPHRINE BITARTRATE... norepinephrine bitartrate-injection Index. Gloss...

Desensitization

...t Desensitization Program, UK ... Separation anxiety is a fairly common anxiety disorder that affects children and ... Selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine (Prozac) and ... Obesity, Obsession, Obsessive-compulsive disorder, Obsessive-compulsive personality disorde...
reuptake in Biological News

Chinese slimming capsules

...r, examination of the formulation has shown that it also contains the active substance sibutramine, which resembles amphetamine and which inhibits the reuptake of serotonin and noradrenaline in the brain. The sibutramine dose in each capsule corresponded to twice the daily maximum dose of the prescription dru...

The genetics of fear: Study suggests specific genetic variations contribute to anxiety disorders

...r the enzyme COMT. Serotonin is a brain chemical involved in mood regulation. The serotonin transporter, which is the target of selective serotonin reuptake inhibitors (SSRI) used to treat anxiety and depression, harbors a common polymorphism in its gene. This polymorphism can come in two different version...

Researchers iron out new role for serotonin

... including alcoholism, depression, autism and obsessive-compulsive disorder. SERT is also a major target for medications like the selective serotonin reuptake inhibitors (SSRI) used for treating depression. Thanks to a serendipitous mix-up in an animal order, Blakely and first author Ana Carnerio, Ph.D., d...

Likely cause of postpartum blues and depression identified

... interleukin-1 beta. If our hypothesis holds true, lowering interleukin-1 beta levels may be a better treatment option." He notes that while serotonin reuptake inhibitors, commonly used for depression, work well in these women, transferring the drug to the baby during nursing can be problematic. But there'...

New treatment mechanisms for schizophrenia

...akthrough in the discovery of a completely novel means of adjunct therapy for schizophrenia that is analogous to the use of SSRIs [selective serotonin reuptake inhibitors] for the treatment of depression." In the second article, Hashimoto and colleagues demonstrated that repeated administration of the N-me...

Insulin's brain impact links drugs and diabetes

...ic Library of Science Biology (PLoS Biology). The psychostimulant drugs amphetamine and cocaine, as well as related medications for ADHD, block the reuptake of the neurotransmitter dopamine by dopamine transporters (DATs) and increase the level of dopamine signaling. Some of these compounds, including amph...

Adolescent but not adult hamsters are more aggressive on low dose of fluoxetine

... are different. Thus, she says, "It is unwise to expect a drug to work the same in juveniles as in adults." Fluoxetine, a selective serotonin reuptake inhibitor (SSRI), is the only medication approved to treat depression in children and adolescents. However, it has carried an FDA "black box" warning...

High dopamine transporter levels not correlated with ADHD

...s attempt to compensate for lower dopamine levels by reducing the number of reuptake proteins. This would explain the positive correlation between transporter levels and inattention: as the number of reuptake proteins rises, the amount of dopamine would decline, leading to a higher l...

Nobelist discovers antidepressant protein in mouse brain

...ate with each other by secreting messengers, such as serotonin, which bind to receptors located on the surface of receiving cells. Serotonin selective reuptake inhibitors (SSRIs), medications commonly prescribed for anxiety and depression, compensate for reduction in serotonin signaling by boosting levels and...

Commonly used antidepressants may also affect human immune system

...nse. They do not know yet, however, whether these SSRI (selective serotonin reuptake inhibitors) drugs "including the brands Prozac, Zoloft, Paxil and others" c...tional way of stimulating a T cell response." Drugs that block serotonin reuptake "likely change some of the parameters of T-cell activation, but we don't kn...
reuptake in Biological Technology

Sumavel(TM) DosePro(TM) (sumatriptan injection) Approved by FDA for Acute Migraine and Cluster Headache: First Product Featuring Novel DosePro Needle-Free Delivery System

...)agonists and is not generally recommended for use with selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors SNRIs or MAO inhibitors. Sumavel DosePro should be used durin...

REMERON(R) Now Approved in Japan for the Treatment of Depression in Adult Patients

...th a mechanism of action that is different from that of selective serotonin reuptake inhibitors (SSRI) and serotonin-noradrenaline reuptake inhibitors (SNRI). Important Safety Information About REMERON in the...

Intra-Cellular Therapies Reports Positive Final Results of a Phase II Clinical Trial with ITI-007 in Patients with Sleep Maintenance Insomnia

...tested. The highest dose tested (10 mg) is thought to fully occupy 5HT2A receptors while adding incremental amounts of dopamine receptor and serotonin reuptake transporter (SERT) occupancy. Together, these data suggest that ITI-007 induces a novel pattern of sleep improvement. Doses of ITI-007 were sa...

Valdoxan(R) Granted Marketing Authorisation for the Treatment of Major Depressive Episodes in Europe

...g almost 6,000 adult patients with depression. The results demonstrate the superior efficacy of Valdoxan as compared with placebo, selective serotonin reuptake inhibitors (SSRIs) and serotonin noradrenaline reuptake inhibitor (SNRI) treatments and also show that: - Valdoxan has proven efficacy whateve...

Northern Antibiotics Presents New Data on Novel Polymyxin Compounds at the Joint ICAAC/IDSA 2008

...ds are excreted into urine to a significant extent. This indicates that the reuptake of the NAB compounds in the proximal tubuli of the kidneys is less intense than that of colistin and polymyxin B. The extensive reuptake is regarded to be the mechanism of the nephrotoxicity of polymyxins. Thus t...

European CHMP Adopts Negative Opinion on Cymbalta for the Treatment of Fibromyalgia

...h serotonin and norepinephrine/noradrenaline mediated nerve signaling in the brain and the spinal cord. Based on pre-clinical studies, duloxetine is a reuptake inhibitor of serotonin and norepinephrine/noradrenaline. Scientists believe its effect on pain perception is due to increasing the activity of seroton...

Extraordinary General Meetings Statement - XTL Notifies NASDAQ of Compliance with Marketplace Rule 4350(d)(2)

.... ("XTL") is engaged in the development of therapeutics for the treatment of diabetic neuropathic pain and HCV. XTL is developing Bicifadine, a triple reuptake inhibitor of serotonin, norepinephrine and dopamine, which is currently in a Phase 2b study for the treatment of diabetic neuropathic pain. XTL has ou...

US Neuropathic Pain Market Value Doubles to $5 Billion by 2018

...-1 (EpiCept/Epitome); two serotonin/norepinephrine reuptake inhibitors desvenlafaxine (Wyeth), and paroxetine ...pha-2 adrenergic receptor antagonist/norepinehrine reuptake inhibitor reboxetine (Pfizer); an opioid receptor agonist/norepinephrine reuptake inhibitor tapentadol (Ortho-McNeil); a dopamine re...

XTL Biopharmaceuticals Receives Notice of Non-Compliance with Nasdaq Marketplace Rule Due to Changes in Board Composition

...n the development of therapeutics for the treatment of diabetic neuropathic pain and HCV. XTL is developing Bicifadine, a serotonin and norepinephrine reuptake inhibitor, for the treatment of diabetic neuropathic pain, which is currently in a Phase 2b study. XTL has out-licensed its novel pre-clinical HCV sma...

AGM / EGM Postponed to July 20, 2008

...n the development of therapeutics for the treatment of diabetic neuropathic pain and HCV. XTL is developing Bicifadine, a serotonin and norepinephrine reuptake inhibitor, for the treatment of diabetic neuropathic pain, which is currently in a Phase 2b study. XTL has out-licensed its novel pre-clinical HCV sma...
reuptake in Biological Definition

Neurotransmitter

...d from the synaptic cleft by a process is called reuptake (or often simply uptake ). Without reuptake, th...geted by drugs. Cocaine , for example, blocks the reuptake of dopamine , leaving these neurotransmitters in ...the synaptic gap longer. Prozac is a serotonin reuptake inhibitor, hence potentiating its effect. AMPT pr...

Selective serotonin reuptake inhibitor

... Selective serotonin reuptake inhibitors ( SSRIs ) are a class of antidepressa...or 5-HT), in the synaptic gap by inhibiting its reuptake . One notable characteristic of SSRIs is that, unl...monoamine transporters in the sending cell (thus reuptake ). Depression has been linked to a lack of sti...
reuptake in Biological Dictionary

Norepinephrine

...rmal and Pulmonary ... Norepinephrine . Epinephrine. A norepinephrine reuptake inhibitor (NRI, NERI) or ... Norepinephrine reuptake Inhibitors: Atomoxetine (Tomoxetine) • Ciclazindol ... NB norepinephrin...
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