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retroviruses in Medical News

The vulnerable cancer cell

...o survive?" said Elledge. Elledge's team generated about 75,000 bits of short hairpin RNAs that can be inserted into retroviruses. When the altered retroviruses infected either normal cells or cells that differed by only a single mutation in KRAS, the shRNA bound to corresponding stretches of RNA in the cells,...

A Global Call to Action From HIV Co-Discoverers Robert Gallo and Luc Montagnier

... of Medicine and the National Cancer Institute. The symposium, which will be held May 9-11, 2009, will look back at the origins of research on human retroviruses and the 25 years since proving HIV as the cause of AIDS, summarize the accomplishments of a successful research enterprise, and look forward to overco...

UCSF Team Closer to Creating Safe Embryonic-Like Stem Cells

...yonic stem cells , they have the capacity to become any cell type in the body. The findings suggest that scientists will soon be able to replace retroviruses and even genes currently used in laboratory experiments to induce pluripotency in adult cells. This would make potential stem cell-based therapies saf...

UCSF team closer to creating safe embryonic-like stem cells

...mbryonic stem cells, they have the capacity to become any cell type in the body. The findings suggest that scientists will soon be able to replace retroviruses and even genes currently used in laboratory experiments to induce pluripotency in adult cells. This would make potential stem cell-based therapies saf...

Stem Cells Spur New Eggs in Ovaries of Adult Mice

...to embryonic cells. These new embryonic cells are, like stem cells, capable of transforming into multiple different types of tissue. Currently, retroviruses and genes are used to complete this transformation, but this carries the risk of cancer and other problems. Using microRNAs, which regulate gene expre...

More compelling evidence on why earlier HIV treatment lengthens survival

...as below 350 had an increase of 69% in the risk of death. Results from the second analysis were announced Feb 2009 at the 16th Annual Conference on retroviruses and Opportunistic Infections in Montreal, Canada. Among the 9,155 patients with a CD4+ count above 500, those who deferred antiretroviral therapy unti...

Clinical trial finds microbicide promising as HIV prevention method for women

...or the first time the promise of a vaginal microbicide gel for preventing HIV infection in women. According to findings presented at the Conference on retroviruses and Opportunistic Infections (CROI), one 0.5 % dose of a microbicide designed to prevent HIV from attaching to cells in the genital tract, was 30% eff...

Penn Medicine presents HIV gene therapy trial data at CROI 2009

...A Researchers from Penn Medicine announced today the results from an ongoing Phase I/II open label clinical trial of VRX496 at the 16th Conference on retroviruses and Opportunistic Infections (CROI) in Montreal. VRX496 is a gene therapy product being investigated for the treatment of HIV infection. During the ...

Anti-HIV gel shows promise in large-scale study in women

...ncluded study, funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the NIH, were presented today at the Conference on retroviruses and Opportunistic Infections in Montreal. The study investigators found the microbicide gelknown as PRO 2000 (Indevus Pharmaceuticals, Inc., Lexin...

Tibotec Submits Application to U.S. Food and Drug Administration Seeking Traditional Approval for INTELENCE(TM) (etravirine)

...r-selected antiretroviral drugs (N(t)RTIs with or without enfuvirtide). Forty-eight-week data from this study were presented at the 15th Conference on retroviruses and Opportunistic Infections in Boston on February 7, 2008. Important Safety Information INTELENCE does not cure HIV infection or AIDS, and...
retroviruses in Medical Technology

Genetic Immunity Presents Clinical Data on DermaVir Patch Immune Therapy at 15th Annual Conference on Retroviruses and Opportunistic Infections

Data Shows Excellent Safety Profile and Long Lasting Immunity MCLEAN, Va., and BUDAPEST, Hungary, Feb. 11 /PRNewswire/ -- Genetic Immunity, a US/Hungarian clinical-stage biopharmaceutical company focusing on the development of its patented immunotherapeutic platform technology, announced ...

Data Suggests New Antigen-Antibody Combo Test Useful for High Volume Public Health Screening

...itional HIV antibody tests, according to research presented by Johns Hopkins University , Abbott ( NYSE: ABT ) and others at the 16th Conference on retroviruses and Opportunistic Infections (CROI). "Those with recent HIV infections who have not yet developed an HIV antibody response are a major driver o...

Sequoia Pharmaceuticals Presents Proof of Clinical Concept of SPI-452, a Novel Pharmacokinetic Enhancer

... who would benefit from a PKE given as a stand-alone agent or as part of a fixed-dose combination. These data were presented at the 16th Conference on retroviruses and Opportunistic Infections on Monday, February 9, 2009, in Montreal, Canada. Pharmacokinetic data from a 2-week, repeat-dose, proof-of-clinic...

Indevus Pharmaceuticals Announces PRO 2000 Found to Show Promise in Large HIV Prevention Study

...ansmission of HIV although the beneficial effect did not reach statistical significance. The results will be presented today at the 16th Conference on retroviruses and Opportunistic Infections in Montreal. "We are extremely excited with the results of this trial," stated Glenn L. Cooper, M.D., chairman and c...

Analysis of Long-Term Vicriviroc Data Provides Evidence of Sustained Viral Suppression, Increased CD4 Cell Counts and Tolerability in Treatment-Experienced HIV-Infected Patients

...antagonist, exhibits potent, sustained suppression of viral replication in treatment-experienced adults: VICTOR-E1 48-week results. 15th Conference on retroviruses and Opportunistic Infections (CROI); Feb. 3-6, 2008; Boston, MA, USA; Abstract 39LB. (4) Gulick RM, Su Z, Flexner C, et al. Phase 2 Study of the saf...

VIRxSYS to Host a Web Conference to Announce Clinical Trial Update

... large presence of such T cells in GALT." VIRxSYS presented data at the following four conferences in the first half of 2008: Annual Conference on retroviruses and Opportunistic Infections (Boston, MA, USA) February 2008 Results demonstrating the slowing and possible halting of HIV replication in humans wer...

Ardea Biosciences Appoints John W. Beck Chief Financial Officer, Announces Clinical Development Progress and Reports First Quarter 2008 Financial Results

...tent activity and favorable resistance profiles for our next generation NNRTI family of compounds against HIV at the 15th Annual Conference on retroviruses and Opportunistic Infections (CROI) and the 21st International Conference on Antiviral Research (ICAR); -- Presented preclinical data demonst...

Genetic Immunity Announces Data Related to the DermaVir Nanomedicine Patch in the Journal of Immunology

...er validate and support results from a clinical study of Genetic Immunity's DermaVir Patch presented in February 2008 at the 15th Annual Conference on retroviruses and Opportunistic Infections (CROI). The study demonstrated that the DermaVir Patch induced a significant increase of PHPC counts in all 9 HIV-1-infec...

Schering-Plough Initiates Phase II Study With Vicriviroc in Treatment-Naive HIV-Infected Patients

...bits potent, sustained suppression of viral replication in treatment-experienced adults: VICTOR-E1 48-week results (39LB); 15th Conference on retroviruses and Opportunistic Infections (CROI); February 2008; Boston. 5 ACTG 5211: Phase II study of the safety and efficacy of vicriviroc (VCV) in HIV-infe...

New 48-Week Efficacy and Safety Data Presented for INTELENCE(TM) (etravirine) as Part of HIV Combination Therapy

...se findings from two ongoing double-blind, placebo-controlled, randomized Phase 3 studies (DUET-1 and DUET-2) were presented at the 15th Conference on retroviruses and Opportunistic Infections in Boston. In the DUET-1 and -2 studies, 60 percent and 61 percent of patients in the INTELENCE arms had a confirmed un...
retroviruses in Medical Dictionary

Retrovirus

...virus - Wikipedia, the free encyclopedia ... retroviruses are a sub-category of oncoviruses that include th...... Brief and Straightforward Guide: What are retroviruses ? ... The genetic material of retroviruses consists of ribonucleic acid (RNA), instead ......
retroviruses in Biological News

Prions and retroviruses -- an unholy alliance?

In the Institute of Molecular Virology of the GSF National Research Center for Environment and Health in Neuherberg/Munich (Helmholtz Association of German Research Centres) the group is continuing to search for cellular components whose make-up is changed as a result of a prion infection. In col...

Researchers discover that sheep need retroviruses for reproduction

A team of scientists from Texas A&M University and The University of Glasgow Veterinary School in Scotland has discovered that naturally occurring endogenous retroviruses are required for pregnancy in sheep. In particular, a class of endogenous retroviruses, known as endogenous retroviruses...

Scientists reveal the shape of a protein that helps retroviruses break into cells

The biggest mass extinction in Earth history some 251 million years ago was preceded by elevated extinction rates before the main event and was followed by a delayed recovery that lasted for millions of years. New research by two University of Washington scientists suggests that a sharp decline in ...

Methods for gene transfer in stem cells featured in Cold Spring Harbor Protocols

... COLD SPRING HARBOR, N.Y. (Wed., Aug. 5, 2009) Vectors derived from retroviruses are useful tools for long-term gene transfer because they allow stable integration of transgenes and propagation into daughter cells. Lentiviral vect...

Cutting-edge amfAR grants fight HIV/AIDS in the lab and on the phone

...ant for promoting the HIV life cycle down to a useful group for further study. She argues that mutations in cell proteins that decrease the ability of retroviruses like HIV to grow will be favored over time. She will study the evolutionary history of these HIV cofactors to determine which appear to play the most ...

Evolutionary biologist will study HIV with grant from AIDS research foundation

... in blocking the retrovirus, and could point to new targets for HIV drug development. "Mutations in host cell proteins that decrease the ability of retroviruses like HIV to multiply will be favored over time," says Sawyer. "If we can identify which of these proteins have played the most important role in host ...

New research shows how gene function drives natural selection in important class of genetic elements

...e future be of interest to those studying retroviruses, which evolved from retrotransposons. There are a number of animal and human diseases caused by retroviruses including HIV/AIDS, avian leukosis and feline leukemia. "Because LTR retrotransposons are abundant and impact host genomes, we wanted to determine...

ASU researchers receive NIH awards for studies of malaria and emergent disease

...y of California at Davis and the Fred Hutchinson Cancer Center in Seattle, will examine the evolution, recombination, emergence and exchange of simian retroviruses between human and nonhuman primates. Escalante will also explore the dynamics of nonhuman malarial parasites as part of his vivax-macaque malaria proj...

Global Viral Forecasting Initiative receives $11M to implement pandemic early warning system

...warning system has already allowed the GVFI team and their collaborators to discover a range of novel viruses and has provided the first evidence that retroviruses continue to cross from animals to humans. "Nothing is more important to me than stimulating and sustaining deep innovation, especially for early c...

Salk researchers reprogram adult stem cells in their natural environment

...brain niche." To test whether stem cells in their adult brain environment can still veer off the beaten path and change their fate, Jessberger used retroviruses to genetically manipulate neural stem cells and their progeny in the dentate gyrus of laboratory mice. Under normal conditions, the majority of newbor...
retroviruses in Biological Technology

ImQuest Presents IND-Enabling Safety Pharmacology and Pharmacokinetic Data for the Therapeutic HIV Compound IQP-0410 at Conference on Retroviruses and Opportunistic Infections

FREDERICK, Md., Feb. 9 /PRNewswire/ -- ImQuest Life Sciences today presented important new results on the continued development of their small molecule inhibitor of HIV-1 at the 16th CROI meeting held this week in Montreal. The presentation highlighted the advanced development of ImQuest's lead HI...

Ardea Biosciences to Present Preclinical Data on Three HIV Non-Nucleoside Reverse Transcriptase Inhibitors During 15th Annual Conference on Retroviruses and Opportunistic Infections

- Activity data on lead NNRTI, RDEA806, and next generation compounds to be discussed - CARLSBAD, Calif., Jan. 29 /PRNewswire-FirstCall/ -- Ardea Biosciences, Inc. (Nasdaq: RDEA ) today announced that preclinical data on the Company's non-nucleoside reverse transcri...

ImQuest Presentations at CROI Report Significant Advances in Therapeutic and Microbicide Product Development Programs

...ces presented important new results on the continued development of their small molecule pyrimidinedione inhibitors of HIV-1 at the 16th Conference on retroviruses and Opportunistic Infections held last week in Montreal. Presentations focused on the results of IND-directed development of the HIV therapeutic IQP-0...

Mymetics Corporation Information to be Available Through Standard & Poor's Market Access Program

... process." About Mymetics Corporation Mymetics' primary objective is to develop vaccines and therapies to prevent and treat the effects of certain retroviruses and other infectious diseases, including the human immunodeficiency virus, or HIV, the virus that leads to acquired immunodeficiency syndrome, or AIDS...

Mymetics Corporation Important Shareholders Information Conference Call

...6 PIN 815 726. Corporate description: Mymetics' primary objective is to develop vaccines and therapies to prevent and treat the effects of certain retroviruses and other infectious diseases, including the human immunodeficiency virus, or HIV, the virus that leads to acquired immunodeficiency syndrome, or AIDS...

Strong Double-Digit Net Sales Growth and Solid Earnings Growth Highlight First Quarter for Bristol-Myers Squibb Company

...n Commission in April. The first data comparing boosted REYATAZ(R) (REYATAZ plus ritonavir) and lopinavir/ritonavir was presented at the Congress on retroviruses and Opportunistic Infections in February. The CASTLE study showed similar efficacy between once-daily REYATAZ (atazanavir sulfate)/ritonavir and twice...

Nasal Vaccine for Smallpox Confers High Levels of Immunity Without Safety Risks

...uses and bacteria, including influenza, hepatitis B, RSV, anthrax and HIV. A study to be published this month in the journal AIDS Research and Human retroviruses demonstrates that their HIV vaccine produces both mucosal immunity as well as systemic immunity -- the immune system's long-term memory that enables i...

Data Presented on Monogram HIV Tropism Tests at Retrovirus Conference sets New Standards of Assay Sensitivity

... ) today announced that data related to the company's advanced HIV tropism assay have been presented as multiple posters during the 15th Conference on retroviruses and Opportunistic Infections (CROI) this week in Boston, MA. Highlights from the meeting include data on an enhanced version of the Trofile(TM) Assay'...

Team demos safety of RNA therapy

...ng paper, to perform the RNA interference. In many RNAi studies, including the one that the MIT/Alnylam team was following up on, researchers use retroviruses to deliver genes that code for short hairpin RNA, which is a precursor to siRNA. Once the gene is incorporated into the cell's DNA, short hairpin RNA ...

Enhanced siRNA Delivery and Long-term Gene Silencing

...nsfection. In addition, since retroviruses typically integrate into the ... (see sidebar, Production of retroviruses as a Research Tool ). The p Silencer ...t to transfectNHDF-neo cells. retroviruses expressing either a negative ...
retroviruses in Biological Definition

Cancer

...ncer and ovarian cancer . Some types of viruses can cause mutations. They play a role in about 15% of all cancers. Tumor viruses , such as some retroviruses , herpesviruses and papillomaviruses , usually carry some oncogene or tumor suppressor inactivating gene in their genome . It is impossible to t...

Enzyme

...no acid residue of a protein Restriction enzymes : those enzymes which cut DNA or RNA at specific locations Reverse transcriptase : used by retroviruses to transcribe information from RNA into DNA Ribulose bisphosphate carboxylase : fixes carbon in green plants. RNAse : those enzymes which c...

Gene

...and without the delay in waiting for transcription. On the other hand, RNA retroviruses , such as AIDS , require the reverse transcription of their genome from ...as since been shown to have exceptions, such as reverse transcription in retroviruses . See also Genetics , Gene expression , Gene therapy , Homeobox...

Gene therapy

... vivo 3 Vectors in gene therapy 3.1 retroviruses 3.2 Adenoviruses 3.3 Adeno-associated viruse...o classes of viruses which look promising — retroviruses and adenoviruses . retroviruses are small RNA based viruses. Because they reprod...

Lytic cycle

...e virus. In the case of DNA viruses, the DNA transcribes itself into messenger RNA (mRNA) molecules that are then used to direct the ribosome. In retroviruses , or RNA viruses, a unique enzyme called reverse transcriptase transcribes the viral RNA into DNA, which is then transcribed again into mRNA. R...

Phage

...enter a relatively harmless state, either integrating their genetic material into the chromosomal DNA of the host bacterium (much like endogenous retroviruses in animals) or establishing themselves as plasmids . These endogenous phages, referred to as prophages , are then copied with every cell division...

Retrovirus

...iology . Reverse transcriptase activity outside of retroviruses has been found in almost all eukaryotes, enabling ...oviral coat proteins. Four identified human retroviruses ( HTLV 1&2, HIV 1&2) attack CD4 cells . Another feature common to all retroviruses is a lipid coating surrounding their capsid . ...

RNA

...bably the only, form of life. This hypothesis is inspired by the fact that retroviruses use RNA as their sole genetic material, while peptide bond formation in ...bosome is carried out by an RNA-derived ribozyme . From this perspective, retroviruses and ribozymes are remnants, or molecular fossils, left over from that RNA w...

RNA virus

...tation rates because they lack DNA polymerases which can find and edit out mistakes. DNA viruses have considerably lower mutation rates. See also retroviruses . Although RNA usually mutates rapidly, recent work found that the SARS virus and related RNA viruses contain a gene that mutates very slowly. T...

Virus

...enzyme then uses that RNA copy as a template to make hundreds of duplicates of the original RNA. A second group of RNA-containing viruses, called the retroviruses , uses the enzyme reverse transcriptase to synthesize a complementary strand of DNA so that the virus's genetic information is contained in a molecu...
retroviruses in Biological Dictionary

Transcriptase

...activity of reverse transcriptase , a viral DNA polymerase enzyme that retroviruses need to reproduce. Information about transcriptase in the free online ...scriptase is a common name for an enzyme that functions as a RNA ... All retroviruses have a reverse transcriptase , but the enzymes that are ... Moloney M...

Reverse transcription

... transcription in vivo, while a third ... A full understanding of any single retrovirus depends on an appreciation of the common properties of retroviruses as a ... of reverse transcription generates, ... II. Protocol for Standard Reverse Transcription Reaction (1µg of RNA) ... Reverse Trans...

Reverse transcriptase

...scriptase , a viral DNA polymerase enzyme that retroviruses need to reproduce. Moloney Murine Leukemia Viru...he enzyme reverse transcriptase is needed by retroviruses to transform single ... HIV-1 reverse transcrip... enzyme reverse transcriptase (RT) is used by retroviruses to transcribe ... reverse transcriptase inh...

Retrovirus

...Article on Retrovirus Mutation Rates) ... Human retroviruses in the second decade: a personal perspective. ......f ... Popular description of the life cycle of retroviruses . ... HIV-2, the agents that cause AIDS, are retroviruses . ... A typical, "minimal" retrovirus consists o...

Retrotransposons

...ass of transposon. They are particularly abundant in plants, where they are often a principal component... 1.1 Class I: Retrotransposons . 1.1.1 retroviruses as transposable elements ... Initially retrotransposons copy themselves to RNA (transcription) but, in ... Dan Voytas Lab at the University o...

Pseudoknot

...functions of a pseudoknot are directly related to the ... ... looped strand of RNA that forms what is called a " pseudoknot ," was revealed ... retroviruses by binding to the pseudoknot at this site and blocking these ... ... Rfam alignment (UPSK RNA) with a pseudoknot in Stockholm format is shown...

Insertion mutations

...ons where DNA is inserted into the genetic ... A naturally occurring variation in an essential gene can suppress genetic mutations caused by retroviruses in mice, according to a new discovery by researchers at ... Genotypes of insert-containing isolates and patterns of insertion mutations . ... Th...

Gene insertion

... the insertion of normal ... Currently, such gene insertion therapy is most likely to be effective in the ... LINEs are essentially defective retroviruses that retain a functional rt gene . ... However, an Alu insertion in the NF-1 gene is responsible for neurofibromatosis ... Researchers Identif...
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