Coming Soon: Lung-Cancer Spray?
...y disorders and offers numerous advantages over more invasive modes of delivery."
In the study, researchers used a lentiviral vector derived from a retrovirus
able to infect non-dividing cells, causing lasting genetic changes. The lentiviral vector included a carboxyl-terminal modulator protein (CTMP), which...
Vaporized viral vector shows promise in anti-cancer gene therapy
...ent of non-small cell lung carcinomas were associated with the activation of the Akt signaling pathway. They chose a lentiviral vector, derived from a retrovirus
and known for its ability to infect nondividing cells and effect persistent genetic changes. They transfected the lentiviral vector with a negative re...
A Global Call to Action From HIV Co-Discoverers Robert Gallo and Luc Montagnier
...tional Cancer Institute (NCI). These reports followed the publication by Dr. Montagnier and his co-workers who showed the first existence of this new retrovirus
and subsequently contributed to demonstrate its causative role in AIDS."
Drs. Gallo and Montagnier are participating in a symposium, "25 Years Af...
Exploring the frontiers of retrovirology
... BioMed Central recently announced the launch of "Frontiers of Retrovirology", an international conference that will bring together leading human retrovirus
researchers to review current progress and to chart future challenges.
HIV affects 33 million individuals worldwide. To date, 25 million have died ...
New Roche Dual Target HIV-1 Test Approved for Use in European Union
....5 million people became newly infected, and 2.1 million died of AIDS,
including 330,000 children.
The human immunodeficiency virus (HIV) is a retrovirus
that infects cells
of the human immune system, destroying or impairing their function. In the
early stages of infection, the person has no symptoms. W...
Hopes for AIDS Vaccine Still Alive Despite Setbacks
...eady for when you get exposed to HIV."
But there's yet one more hurdle unique to HIV. Unlike standard flu or cold viruses, HIV -- a more primitive retrovirus
-- actually inserts a piece of its DNA into the genome of the human host cell.
This "integration" begins within hours or days of infection, mainly ...
Recipe for cell reprogramming adds protein
...makes the reprogramming process time-consuming and highly inefficient.
To bypass these obstacles, the Whitehead researchers replaced c-Myc and its retrovirus
with a naturally occurring signaling molecule called Wnt3a. When added to the fluid surrounding the cells being reprogrammed, Wnt3a promotes the conve...
Dr. Anthony Fauci reflects on 25 years of HIV
... On the 25th anniversary of the first scientific article linking a retrovirus
to AIDS, Anthony S. Fauci, M.D., director of the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, ref...
JCI table of contents: Feb. 21, 2008
...ot expressed by healthy cells. The gene responsible for making this protein was part of a region of human chromosome 6 derived from a human endogenous retrovirus
(HERV) type E. The authors therefore suggested that HERV-E is activated in metastatic kidney cancer providing a protein target for the immune system. ...
Scientists Show Stem Cells Don't Cause Cancer
...to treat disease has been the possibility that the retrovirus
used to implant the cells might cause cancer, but ...how that these stem cells can be implanted using a retrovirus
without fear of causing cancer.
"This is a real...
In addition, there has been a fear that using a retrovirus
to implant stem cells results in an increased risk...
Retrovirus in Medical Technology
Indevus Pharmaceuticals Announces PRO 2000 Found to Show Promise in Large HIV Prevention Study
... Results of NIH-sponsored Clinical Trial to be Presented at retrovirus
LEXINGTON, Mass., Feb. 9 /PRNewswire-FirstCall/ -- Indevus Pharmaceuticals, Inc. (Nasdaq: IDEV ) announced today that a National Ins...
GeoVax Labs, Inc. Reports Fourth Quarter and Year-End 2007 Financial Results
... Dr. Harriet Robinson to its staff as Vice President of Research & Development. Dr. Robinson is known worldwide for her outstanding work on retrovirus
biology and development of DNA vaccines with special emphasis on HIV/AIDS. Significant advances by GeoVax's HIV/AIDS vaccine development progr...
Dr. Harriet Robinson Joins GeoVax Team as V.P. of R & D to Accelerate AIDS Vaccine Trials Program
... & Development. Dr. Robinson is
known worldwide for her outstanding work on retrovirus
development of DNA vaccines with special emphasis on HIV/AIDS.
...dvancement of Science) where
she was recognized for her outstanding work on retrovirus
development of DNA vaccines with special emphasis on HIV/AIDS v...
Preclinical Study Finds Protease Inhibitor-Resistant HIV May Have
Reduced Potential to Develop Resistance to Panacos' Bevirimat
...ce Program at the National Cancer Institute, Frederick, MD,
in collaboration with Panacos, was presented at the Cold Spring
Harbor Laboratory's (CSHL) retrovirus
Conference held May 22-27,
2007 in Cold Spring Harbor, NY.
While resistance to bevirimat has not yet been reported in
clinical studies, bevirimat-res...
Fat Kills Cancer: Turning Stem Cells from Fat Tissue into
Personalized, Cancer-Targeted Therapeutics
(5-FU), which can produce toxic side effects in normal cells. They
expanded the number of mesenchymal stem cells in the laboratory and
then used a retrovirus
vector to insert the gene cytosine deaminase
into the cell. This gene can convert a less toxic drug,
5-fluorocytosine (5-FC), to 5-FU inside the stem...
Retrovirus in Medical Products
Features:... Can initiate up to 800 tests per hour
Screens blood for hepatitis, retrovirus
and other analytes...
Retrovirus in Medical Dictionary
(REH-troh-VY-rus) ... The virus that causes AIDS, the human immunodeficiency virus (HIV), is a type of retrovirus
. ... During the life cycle of the retrovirus
, the RNA is converted to DNA by a unique ... HIV is a retrovirus
that begins its infection cycle by recognizing...
...ter a possible exposure should I wait ... If I test HIV negative, does that mean that my sex partner is HIV negative also? ... HIV ( ) n. A retrovirus
that causes AIDS by infecting helper T cells of the immune system. ... as Kaposi's sarcoma also take hold in HIV -infected individuals. ... ...
Acquired Immunodeficiency Syndrome
... the HIV virus. Covers AIDS ... HIV: Human immunodeficiency virus ... acquired immunodeficiency syndrome n AIDS A disease caused by a retrovirus
known as human immunodeficiency virus type 1 (HIV-1) immunodeficiency syndrome n. A syndrome associated with an immunological deficien...
Retrovirus in Biological News
Nanotubes could help study retrovirus transmission between human cells
ALBUQUERQUE, N.M. Recent findings by medical researchers indicate that naturally occurring nanotubes may serve as tunnels that protect retroviruses and bacteria in transit from diseased to healthy cells a fact that may explain why vaccines fare poorly against some invaders.
To better study ...
Ancient retrovirus sheds light on modern pandemic
Human resistance to a retrovirus
that infected chimpanzees and other nonhuman primates 4 million years ago ironically may be at least partially responsible for the susceptibility of humans to HIV infection today.
These findings, reported by a team of researchers at Fred Hutchinson Cancer Researc...
New human retrovirus originated in mice
Howard Hughes Medical Institute researchers and their colleagues have discovered a new retrovirus
in humans that is closely related to a cancer-causing virus found in mice. Their findings describe the first documented cases of human infection with a retrovirus
that is native to rodents.
Two Hutchinson Center researchers named HHMI Early Career Scientists
...that are critical for proper cell division. For example, to explore why humans are susceptible to HIV, Malik and his colleagues resurrected an extinct retrovirus
that infected chimps and gorillas, but not humans, 4 million years ago. Malik's research suggests that we may be vulnerable to HIV infection because o...
Evolutionary biologist will study HIV with grant from AIDS research foundation
...ltrates cells, the virus hijacks its host's genetic machinery to produce proteins and ultimately replicate itself. It has been recently found that the retrovirus
hijacks about 1,000 human genes.
"The big challenge now is to find which of these 1,000 genes and the proteins they encode are critical for HIV inf...
Gene therapy demonstrates benefit in patients with rheumatoid arthritis
... females under the age of 75 with a diagnosis of advanced rheumatoid arthritis. After tissue was removed from the subjects' knuckle joints, a harmless retrovirus
was inserted into the tissue cells, in order to serve as a "vector" to transport the gene into the patients' joints. After being placed in culture to ...
Body's anti-HIV drug explained
...directions for drug development.
APOBEC-3G is present in every human cell. It is capable of stopping HIV at the first step of replication, when the retrovirus
transcribes its RNA into viral DNA.
The study's authors, led by Xiaojiang Chen of the University of Southern California, were able to show the atom...
Yamanaka eliminates viral vector in stem cell reprogramming
..."But, as Shinya has shown, each step forward reveals a new set of challenges."
Dr. Yamanka's team began this series of experiments by replacing the retrovirus
with an adenoviral vector. While transfections with the genes on separate vectors didn't work, they did work when the genes were arranged in a specifi...
UT pathologists believe they have pinpointed Achilles heel of HIV
...ucing the abzymes after decades of the infection. The immune system in some people can cope with HIV after all."
Carl Hanson, Ph.D., who heads the retrovirus
Diagnostic Section of the Viral and Rickettsial Disease Laboratory of the California Department of Public Health, has shown that the abzymes neutraliz...
UC Davis stem researchers demonstrate safety of gene therapy using adult stem cells
... and can give rise to bone, cartilage, fat, and muscle. Genes were inserted into the hematopoietic stem cells using one of two viral vectors either a retrovirus
or a lentivirus before they were transplanted into the mice, along with genetically modified mesenchymal stem cells.
Of the mice used in the long-...
Retrovirus in Biological Technology
Data Presented on Monogram HIV Tropism Tests at Retrovirus Conference sets New Standards of Assay Sensitivity
Company Continues to Lead Tropism Testing Field
SOUTH SAN FRANCISCO, Calif., Feb. 7 /PRNewswire-FirstCall/ -- Monogram
Biosciences, Inc (Nasdaq: MGRM ) today announced that data related to the
company's advanced HIV tropism assay have been presented as multiple
posters during the ...
Safe Production of High-Titer Retrovirus
Produce high-titer retroviral supernatants with safe packaging vectors
Peter Vaillancourt Coleen Miller
We describe a set of vectors that can be used with any MMLV-based
retroviral vector to produce viral supernatants that have titers that are...
New Test from Quest Diagnostics Helps Physicians Choose HIV Antiretroviral Therapy in Patients with History of Drug Resistance
...ersensitivity reaction to abacavir (Ziagen(R)), an antiretroviral therapy.
About HIV and AIDS
HIV, or the human immunodeficiency virus, is a retrovirus
that infects cells of the human immune system, destroying or impairing their function. The two major viruses that cause AIDS are HIV-1 and HIV-2. The ...
GeoVax Labs, Inc. Reports Fourth Quarter and Year-End 2008 Financial Results
..., and in June 2008 Dr. Robinson joined the
Company's Board of Directors. Dr. Robinson is known worldwide for
her outstanding work on retrovirus
biology and a pioneer of DNA
vaccines with special emphasis on HIV/AIDS. Dr. Robinson has
published extensively on HIV/AIDS vaccine ...
GeoVax Labs, Inc. Announces Six Month Financial Results and Provides Operational Update
... Dr. Harriet Robinson to its staff as Vice President of Research & Development. Dr. Robinson is known worldwide for her outstanding work on retrovirus
biology and a pioneer of DNA vaccines with special emphasis on HIV/AIDS. Dr. Robinson has published extensively on HIV/AIDS vaccine research, ...
The Genesis of Gendicine: The Story Behind the First Gene Therapy
FDA,CBER.Guidance for industry: supplemental guidance
on testing for replication competent retrovirus
vector based gene therapy products and during follow-up
of patients in clinical trials using retroviral vectors. 200...
Development of a Multiplex Bead-Based Assay for Antibody Screening of a Nonhuman Primate Colony on the Bio-Plex System
...ur separate enzyme-linked immunosorbent assays (ELISAs)
to screen our primate colony for the viruses of greatest concern: simian
(SRV), simian T-cell leukemia virus (STLV), herpes B, and simian
immunodeficiency virus (SIV). To minimize the labor involved, testing
Enhanced siRNA Delivery and Long-term Gene Silencing
...nserts from either the H1 or U6 promoter were transfected into
packaging cell line in 6 well plates. Three days following
infec.... Retroviral Delivery Used to
Elicit RNAi in Primary Cells. retrovirus
A siRNA or a negative control siRNA (nc) ...
New Mammalian Expression Vectors Employ Stable, High-Level Fluorescence
Humanized Renilla GFP Reporter
...Curr. Biol. 5: 635-642.
5. Gould, SG., et.al.. (1997) J. Cell Biol., 105(6Pt2): 2923-2931.
6. Miller, A. D. (1990) retrovirus
Packaging Cells. In Human
Gene Therapy, pp. 514. Mary Ann Liebert, Inc.,Publishers.
7. Felts, K, Bauer, J., and Vaillancourt, P...
Retrovirus in Biological Definition
is a virus which has a genome consisting of two identical plus sense RNA molecules. It relies on reverse transcriptase to perform a kind of rever...
...es, while the genetic material of their hosts is in the form of DNA. When a retrovirus
infects a host cell, it will introduce its RNA together with some enzymes into the cell. This RNA molecule from the retrovirus
must produce a DNA copy from its RNA molecule before it can be considered p...
Retrovirus in Biological Dictionary
is an RNA virus that is replicated in a host cell via the enzyme reverse transcriptase to produce DNA from its RNA genome. The DNA is then incorporated into the host's genome by an integrase enzyme. The virus... retrovirus
n. , pl. -ruses . Any of a group of viru...
...re. 6 Vector Titration. 6.1 Packaging cells ... While transient transfection is advantageous for fast ... Production of Replication-Defective retrovirus
by Transient Transfection of 293T cells ... transient transfection protocol using 293T cells, a human renal ... Article : Optimizing ...
Tobacco mosaic virus
...) are very closely related. ... How to Identify Tobacco Mosaic Virus and Tomato Mosaic Virus ... virus of tobacco and nightshades: a retrovirus
that causes mosaic disease in ... Tobacco mosaic virus - Wikipedia, the free encyclopedia ... Disintegration of tobacco mosaic virus ...
...o DNA is carried out ... Two species are incompetent for reverse transcription in vivo, while a third ... A full understanding of any single retrovirus
depends on an appreciation of the common properties of retroviruses as a ... of reverse transcription generates, ... II. Protocol for Standard...
...sually double-stranded DNA (dsDNA) but may also be single-stranded DNA (ssDNA). DNA viruses belong to either Group I or Group II of the... A retrovirus
is an RNA virus that is replicated in a host cell via the enzyme reverse transcriptase to produce DNA from its RNA genome. The DNA is t...
...owever, is flanked by two separate IS elements which may or may not be exact replicas. Instead of... A DNA composite transposon . ... the retrovirus
bears a marked similarity to a transposon . ... The most common form of transposon in humans is the Alu sequence. ... File: Composite t...