SOX9 renders melanomas sensitive to retinoic acid and stops tumor growth
Melanomas are often resistant to standard cancer therapies such as radiotherapy, chemotherapy, and retinoic
acid (RA). Given the lack of available treatments for melanoma, the prognosis for patients is often poor. However, Vincent Hearing and colleagues at the National Cancer Institute at the Nati...
Dermatologists Shed Light on Common Pigmentation Problems and Solutions in Skin of Color
...l dark spots, a prescription topical medication consisting of hydroquinone, retinoic
acid and mild hydrocortisone can be effective in fading skin discoloration....
For superficial melasma, the triple cream combination of hydroquinone, retinoic
acid and mild hydrocortisone with regular sunscreen use can be effective, w...
Biomarker associated with poor outcome in aggressive childhood cancer
... involved in the progression of this often devastating pediatric cancer.
acid (RA) is a metabolite of Vitamin A that has important influences over t...growth and differentiation. RA mediates gene expression by interacting with retinoic
acid receptors (RARs) that, in the presence of RA, switch from repressing t...
JCI online early table of contents: March 9, 2009
...EDITOR'S PICK: SOX9 renders melanomas sensitive to retinoic
acid and stops tumor growth
Melanomas are ofte... therapies such as radiotherapy, chemotherapy, and retinoic
acid (RA). Given the lack of available treatments ...d mouse melanoma and restores their sensitivity to retinoic
Vincent J. Hearing
Vitamin A signals offer clues to treating autoimmunity
...tions, turned on genes involved in converting vitamin A to its active form, retinoic
"Others have seen that these genes are turned on constitutively i...ulendran says.
Manicassamy and colleagues found that dendritic cells use retinoic
acid along with other chemical messengers to steer white blood cells into a...
Genetic disease treatments and pharmacogenetics: From scientific discovery to medical delivery
...or PPARd have been developed and are currently being studied in clinical trials in humans; and 2) PPARd mediates pro-survival signaling in response to retinoic
acid, a compound that has been used for years to treat human patients with leukemia and brain tumors.
"My colleagues and I are very excited about t...
Why some treatments rescue aging skin
...udies since the early 1990s, conducted primarily by U-M dermatologists, to explain why three types of available skin treatments are effective: topical retinoic
acid, carbon dioxide laser resurfacing and injections of cross-linked hyaluronic acid.
These treatments all improve the skins appearance and its ...
Celebrex shows benefit in first-of-its-kind lung cancer chemoprevention trial
...en Hong was the first to demonstrate that retinoids can reverse oral leukoplakia, a premalignant condition that often leads to cancer, and that 13-cis retinoic
acid can prevent secondary primary tumors among patients with head and neck cancers.
"Lung cancer remains a lethal and stubborn disease with tobacc...
Skinvisible Signs Licensing Agreement for Two Acne Formulations
... New retinoic
Acid and Clindamycin Products Developed with Invisicare(R)
LAS VEGAS, May...ulated and licensed three key acne products;
Adapalene, Clindamycin HCL and retinoic
Acid," said Mr. Terry Howlett,
President / CEO of Skinvisible. "This new ag...
First do no harm? UH prof taking opposite approach to treat asthma
...ckers are not the only example of paradoxical pharmacology. Hyperactive children are treated with the amphetamine-like Ritalin, and the skin irritant retinoic
acid is used to treat acne. Additionally, there has been research into using antipsychotic drugs traditionally used for schizophrenic patients to dec...
retinoic in Medical Technology
Phosphagenics Initiates U.S. Clinical Trials for Its Topical Retinoic Acid
MELBOURNE, Australia, Feb. 19 /PRNewswire-FirstCall/ -- Phosphagenics
Limited ("Phosphagenics") (ASX: POH; AIM: PSG; OTCQX: PPGNY) today
announced the initiation of a human clinical trial for its lead
dermatological product, retinoic
acid, a form of vitamin A. This trial
represents the Company...
Research Supported by Samuel Waxman Cancer Research Foundation
Discovers Mode of Action of Arsenic-Based Drugs in Destroying
...enic and its derivatives are now part of the standard
treatment for APL. Recent information indicates that the
combination of the vitamin A derivative retinoic
acid, arsenic and
chemotherapy may cure over 90% of APL patients, which may result in
extending the lives of an estimated 50,000 people a year.
Efficacy and Safety Profile of Basilea's Alitretinoin for Severe
Refractory Chronic Hand Eczema Confirmed by Data Shown at European
P280 / Re-treatment study of alitretinoin (9-cis retinoic
in severe chronic hand eczema refractory to ... M, Brown T.
P286 / Alitretinoin (BAL4079; 9-cis retinoic
Pharmacokinetic interactions between aitret...E, Maares J.
P287 / Alitretinoin (BAL4079; 9-cis retinoic
Pharmacokinetics after single and repeated ...
Barrier Therapeutics Announces Liarozole Phase 2/3 Study Results in
... the potential efficacy and safety of
the class of retinoic
acid metabolizing blocking agents (RAMBAs),
which inhibit the body from breaking down its own retinoic
the active form of vitamin A, a key nutrient...ound that belongs to a new class of
drugs known as retinoic
acid metabolism blocking agents, or RAMBAs.
Phosphagenics Announces Positive Proof of Concept Results from
Studies Utilizing Company's Dermal Drug Delivery Technology
...02 dermal drug delivery
technology formulated with retinoic
acid, a leading topical
treatment for severe acne ...dies showed a three-fold increase in the
amount of retinoic
acid delivered into the skin when formulated
with ...o a control formulation. Importantly, there
was no retinoic
acid detected in the bloodstream. TPM-02's ability...
retinoic in Medical Dictionary
... Sertoli cells, which support and nourish the developing germ cells within the ... Culture of the Sertoli cells in the presence of all-trans retinoic
acid also ... Sertoli cells produce estrogen, support germ cells, and form seminiferous tubule ... Sertoli cell tumors tend to grow in e...
retinoic in Biological News
Study shows how retinoic acid enters a cell's nucleus
Cornell University researchers have revealed a process that has stumped scientists for many years: exactly how an acid derived from vitamin A enters a cell's nucleus, where it has strong anti-carcinogenic effects.
Discovery of this basic transport mechanism opens a new door for future research o...
Embryology study offers clues to birth defects
...h.D., and colleagues, have clarified the role that retinoic
acid plays in limb development. The study showed that retinoic
acid controls the development (or budding) of forelimbs, but not hindlimbs, and that retinoic
acid is not responsible for patterning (or differe...
Frogs reveal clues about the effects of alcohol during development
...normal development by inhibiting the production of retinoic
acid. Under normal conditions, the levels of retinoic
acid made in different areas of the embryo provide...w that alcohol steals away the molecules that make retinoic
acid and use them for its own process of detoxific...
Research links evolution of fins and limbs with that of gills
...rks that has gill rays) responds to treatment with the vitamin A derivative retinoic
acid in the same way a limb or fin skeleton does: by making a mirror image ...to paired appendages, suggest that the signaling network that is induced by retinoic
acid had a patterning function in gills before the origin of vertebrate app...
Gladstone scientists reveal that fat synthesizing enzyme is key to healthy skin and hair
...ce, they found that lack of DGAT1 caused levels of retinoic
acid (RA) to be greatly increased in skin and resu... that one of these enzymes is a major regulator of retinoic
acid actions in the skin."
RA, which comes from v...at DGAT1 is an important component for controlling retinoic
acid levels in the skin of mice," said Michelle Sh...
Dartmouth researchers show effects of low dose arsenic on development
This study set out to see whether arsenic can also disrupt the activity of two hormone receptors that are involved in normal development - the retinoic
acid receptor and the thyroid hormone receptor, two important members of the larger nuclear hormone receptor family. While the researchers studied the...
Male contraception breakthroughs to be presented, Seattle Sept. 27-28
... free of charge.
Here is a sample of the news to be announced at the conference:
a new compound that can be taken orally (Columbia University, retinoic
acid alpha receptor inhibitor)
3-month and 6-month results in men for the Intra Vas Device, a vasectomy alternative (Shepherd Medical Company)
Effect on breast tumors of DNA alternations in 3 genes described
... DNA may also contribute to the development of cancer."
The researchers analyzed methylation status in three genes, known as E-cadherin, p16 and retinoic
acid B2 receptor (RAR-B2), using tissue samples from 887 breast cancers. The samples were taken from women 35-79 years old who participated in the Wes...
One big biology question solved
...rth and the result is sperm."
Professor Koopman and his team found that retinoic
acid, a derivative of Vitamin A, causes germ cells in female embryos to beg....
They also discovered an enzyme present in male embryos that wipes out retinoic
acid and so suppresses meiosis until after birth, resulting in sperm produc...
Vitamin A's paradoxical role in influencing symmetry during embryonic development revealed
...monte and his Salk Institute colleagues found that retinoic
acid (vitamin A) is the signal that buffers the in...lls to develop symmetrically.
In the absence of retinoic
acid, the exterior of our bodies would develop asy...r and left-right axes is coordinated by vitamin A. retinoic
acid exerts its influence at the stage when the em...
retinoic in Biological Technology
retinoic in Biological Products
retinoic in Biological Dictionary
...irect repeats as selective response elements for the thyroid hormone, retinoic
... nucleotide, and the resulting retinoic
acid response element is no longer a TRE. ... ... Response Elemen...
...mutations of homeotic genes cause dramatic changes in body appearance ... In one example of homeotic mutation in mice (Fig. 5), the addition of retinoic
... Another example of a homeotic gene mutation discovered by Lewis is the ... This means that homeotic mutations can be an effective mea...