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retinoic in Medical News

SOX9 renders melanomas sensitive to retinoic acid and stops tumor growth

Melanomas are often resistant to standard cancer therapies such as radiotherapy, chemotherapy, and retinoic acid (RA). Given the lack of available treatments for melanoma, the prognosis for patients is often poor. However, Vincent Hearing and colleagues at the National Cancer Institute at the Nati...

Dermatologists Shed Light on Common Pigmentation Problems and Solutions in Skin of Color

...l dark spots, a prescription topical medication consisting of hydroquinone, retinoic acid and mild hydrocortisone can be effective in fading skin discoloration.... For superficial melasma, the triple cream combination of hydroquinone, retinoic acid and mild hydrocortisone with regular sunscreen use can be effective, w...

Biomarker associated with poor outcome in aggressive childhood cancer

... involved in the progression of this often devastating pediatric cancer. retinoic acid (RA) is a metabolite of Vitamin A that has important influences over t...growth and differentiation. RA mediates gene expression by interacting with retinoic acid receptors (RARs) that, in the presence of RA, switch from repressing t...

JCI online early table of contents: March 9, 2009

...EDITOR'S PICK: SOX9 renders melanomas sensitive to retinoic acid and stops tumor growth Melanomas are ofte... therapies such as radiotherapy, chemotherapy, and retinoic acid (RA). Given the lack of available treatments ...d mouse melanoma and restores their sensitivity to retinoic acid AUTHOR CONTACT: Vincent J. Hearing Nat...

Vitamin A signals offer clues to treating autoimmunity

...tions, turned on genes involved in converting vitamin A to its active form, retinoic acid. "Others have seen that these genes are turned on constitutively i...ulendran says. Manicassamy and colleagues found that dendritic cells use retinoic acid along with other chemical messengers to steer white blood cells into a...

Genetic disease treatments and pharmacogenetics: From scientific discovery to medical delivery

...or PPARd have been developed and are currently being studied in clinical trials in humans; and 2) PPARd mediates pro-survival signaling in response to retinoic acid, a compound that has been used for years to treat human patients with leukemia and brain tumors. "My colleagues and I are very excited about t...

Why some treatments rescue aging skin

...udies since the early 1990s, conducted primarily by U-M dermatologists, to explain why three types of available skin treatments are effective: topical retinoic acid, carbon dioxide laser resurfacing and injections of cross-linked hyaluronic acid. These treatments all improve the skins appearance and its ...

Celebrex shows benefit in first-of-its-kind lung cancer chemoprevention trial

...en Hong was the first to demonstrate that retinoids can reverse oral leukoplakia, a premalignant condition that often leads to cancer, and that 13-cis retinoic acid can prevent secondary primary tumors among patients with head and neck cancers. "Lung cancer remains a lethal and stubborn disease with tobacc...

Skinvisible Signs Licensing Agreement for Two Acne Formulations

... New retinoic Acid and Clindamycin Products Developed with Invisicare(R) LAS VEGAS, May...ulated and licensed three key acne products; Adapalene, Clindamycin HCL and retinoic Acid," said Mr. Terry Howlett, President / CEO of Skinvisible. "This new ag...

First do no harm? UH prof taking opposite approach to treat asthma

...ckers are not the only example of paradoxical pharmacology. Hyperactive children are treated with the amphetamine-like Ritalin, and the skin irritant retinoic acid is used to treat acne. Additionally, there has been research into using antipsychotic drugs traditionally used for schizophrenic patients to dec...
retinoic in Medical Technology

Phosphagenics Initiates U.S. Clinical Trials for Its Topical Retinoic Acid

MELBOURNE, Australia, Feb. 19 /PRNewswire-FirstCall/ -- Phosphagenics Limited ("Phosphagenics") (ASX: POH; AIM: PSG; OTCQX: PPGNY) today announced the initiation of a human clinical trial for its lead dermatological product, retinoic acid, a form of vitamin A. This trial represents the Company...

Research Supported by Samuel Waxman Cancer Research Foundation Discovers Mode of Action of Arsenic-Based Drugs in Destroying Cancer Cells

...enic and its derivatives are now part of the standard treatment for APL. Recent information indicates that the combination of the vitamin A derivative retinoic acid, arsenic and chemotherapy may cure over 90% of APL patients, which may result in extending the lives of an estimated 50,000 people a year. Abou...

Efficacy and Safety Profile of Basilea's Alitretinoin for Severe Refractory Chronic Hand Eczema Confirmed by Data Shown at European Dermatology Congress

... P280 / Re-treatment study of alitretinoin (9-cis retinoic acid) in severe chronic hand eczema refractory to ... M, Brown T. P286 / Alitretinoin (BAL4079; 9-cis retinoic acid): Pharmacokinetic interactions between aitret...E, Maares J. P287 / Alitretinoin (BAL4079; 9-cis retinoic acid): Pharmacokinetics after single and repeated ...

Barrier Therapeutics Announces Liarozole Phase 2/3 Study Results in Lamellar Ichthyosis

... the potential efficacy and safety of the class of retinoic acid metabolizing blocking agents (RAMBAs), which inhibit the body from breaking down its own retinoic acid, the active form of vitamin A, a key nutrient...ound that belongs to a new class of drugs known as retinoic acid metabolism blocking agents, or RAMBAs. Retino...

Phosphagenics Announces Positive Proof of Concept Results from Studies Utilizing Company's Dermal Drug Delivery Technology

...02 dermal drug delivery technology formulated with retinoic acid, a leading topical treatment for severe acne ...dies showed a three-fold increase in the amount of retinoic acid delivered into the skin when formulated with ...o a control formulation. Importantly, there was no retinoic acid detected in the bloodstream. TPM-02's ability...
retinoic in Medical Dictionary

Sertoli

... Sertoli cells, which support and nourish the developing germ cells within the ... Culture of the Sertoli cells in the presence of all-trans retinoic acid also ... Sertoli cells produce estrogen, support germ cells, and form seminiferous tubule ... Sertoli cell tumors tend to grow in e...
retinoic in Biological News

Study shows how retinoic acid enters a cell's nucleus

Cornell University researchers have revealed a process that has stumped scientists for many years: exactly how an acid derived from vitamin A enters a cell's nucleus, where it has strong anti-carcinogenic effects. Discovery of this basic transport mechanism opens a new door for future research o...

Embryology study offers clues to birth defects

...h.D., and colleagues, have clarified the role that retinoic acid plays in limb development. The study showed that retinoic acid controls the development (or budding) of forelimbs, but not hindlimbs, and that retinoic acid is not responsible for patterning (or differe...

Frogs reveal clues about the effects of alcohol during development

...normal development by inhibiting the production of retinoic acid. Under normal conditions, the levels of retinoic acid made in different areas of the embryo provide...w that alcohol steals away the molecules that make retinoic acid and use them for its own process of detoxific...

Research links evolution of fins and limbs with that of gills

...rks that has gill rays) responds to treatment with the vitamin A derivative retinoic acid in the same way a limb or fin skeleton does: by making a mirror image ...to paired appendages, suggest that the signaling network that is induced by retinoic acid had a patterning function in gills before the origin of vertebrate app...

Gladstone scientists reveal that fat synthesizing enzyme is key to healthy skin and hair

...ce, they found that lack of DGAT1 caused levels of retinoic acid (RA) to be greatly increased in skin and resu... that one of these enzymes is a major regulator of retinoic acid actions in the skin." RA, which comes from v...at DGAT1 is an important component for controlling retinoic acid levels in the skin of mice," said Michelle Sh...

Dartmouth researchers show effects of low dose arsenic on development

...ter. This study set out to see whether arsenic can also disrupt the activity of two hormone receptors that are involved in normal development - the retinoic acid receptor and the thyroid hormone receptor, two important members of the larger nuclear hormone receptor family. While the researchers studied the...

Male contraception breakthroughs to be presented, Seattle Sept. 27-28

... free of charge. Here is a sample of the news to be announced at the conference: a new compound that can be taken orally (Columbia University, retinoic acid alpha receptor inhibitor) 3-month and 6-month results in men for the Intra Vas Device, a vasectomy alternative (Shepherd Medical Company) ...

Effect on breast tumors of DNA alternations in 3 genes described

... DNA may also contribute to the development of cancer." The researchers analyzed methylation status in three genes, known as E-cadherin, p16 and retinoic acid B2 receptor (RAR-B2), using tissue samples from 887 breast cancers. The samples were taken from women 35-79 years old who participated in the Wes...

One big biology question solved

...rth and the result is sperm." Professor Koopman and his team found that retinoic acid, a derivative of Vitamin A, causes germ cells in female embryos to beg.... They also discovered an enzyme present in male embryos that wipes out retinoic acid and so suppresses meiosis until after birth, resulting in sperm produc...

Vitamin A's paradoxical role in influencing symmetry during embryonic development revealed

...monte and his Salk Institute colleagues found that retinoic acid (vitamin A) is the signal that buffers the in...lls to develop symmetrically. In the absence of retinoic acid, the exterior of our bodies would develop asy...r and left-right axes is coordinated by vitamin A. retinoic acid exerts its influence at the stage when the em...
retinoic in Biological Technology

New label-free method tracks molecules and drugs in live cells

...se of SRS microscopy to analyze skin tissue could also open new frontiers in drug development. Xie and colleagues used SRS microscopy to view how well retinoic acid, a topical acne medication, is absorbed into skin cells. They also used the technique to capture deep-skin penetration by dimethyl sulfoxide (DMS...

Many paths, few destinations: How stem cells decide what they'll be

...t path through the landscape, yet end up in the same valley. He and his colleagues exposed precursor cells to two completely different drugs (DMSO and retinoic acid) and closely monitored the cells gene expression. Both groups of cells eventually differentiated to become neutrophils (a type of white blood cel...

Method to deliver molecules within embryonic stem cells improves differentiation

...ls mixed with empty microspheres, cells mixed with retinoic acid-loaded microspheres, and cells treated with soluble retinoic acid. retinoic acid was chosen initially because it is a potent i...

Neurite outgrowth cell-by-cell analysis using the IN Cell Developer Toolbox

...

Assay procedure retinoic acid-induced neurite outgrowth was measured by qua... > Results Images from retinoic acid-induced neurite outgrowth were acquired with ...er Toolbox and IN Cell Analyzer 3000 software. The retinoic acid dose-response neurite outgrowth experiment in...

Quantitation of the Protein MIA as a Marker for Chondrocytes in Research Samples

...cytes is dependent on the differentiation status of the cells it was also designated CD-RAP (cartilage-derived retinoic acid sensitive protein). retinoic acid is known as a regulator of chondrocytic cell differentiation in vitro. Recent results indicate an important ...

hNT BlueNeurons Express b-Galactosidase at High Levels

...rom a human teratocarcinoma, exhibits properties indicative of a committed neuronal precursor stage. NT2 cells can be induced by retinoic acid (RA) to differentiate in vitro into postmitotic central nervous system (CNS) neurons, hNT neurons* ( figure 1 ). In the cou...
retinoic in Biological Products

Rabbit Anti-Human Retinoic Acid-Induced 3 (RAI3 / RAIG1) Polyclonal Antibody, Unconjugated from IMGENEX

Description: Peptide-affinity Purified Polyclonal Antibody to Retinoic Acid-Induced 3 (RAI3/RAIG1)...
Company:IMGENEX

Rabbit Anti-Retinoic Acid Receptor beta 2 Polyclonal Antibody, Unconjugated from Abcam

Description:... Rabbit polyclonal to retinoic Acid Receptor beta 2 ( Abpromise for all tested applications). entrezGeneID: 5915...
Company:Abcam

PPARGamma-Competitor Assay Kit Green from Invitrogen

Description:...oliferator-Activated Receptor-gamma (PPAR) is a member of a nuclear receptor family of ligand-activated transcription factors that heterodimerize with retinoic acid-like receptor (RXR). It is involved in the regulation of glucose and lipid metabolism. Agonists include the (TZD) class of anti-diabetic agents c...
Company:Invitrogen

Human and Mouse RAR Neutralizing Peptide from ABR-Affinity BioReagents

Description:... PEP-005 is a synthetic peptide whose sequence is from the C-terminal end of the mouse retinoic acid receptor beta (RAR*). The 21 amino acid sequence extends from amino acids 429 to 448 of RAR*. The sequence of PEP-005 is (amino to carboxy term...
Company:ABR-Affinity BioReagents

NeuroCyte - Rat Neural Stem Cell Kit from Orion BioSolutions, Inc.

Description:...l medium for multi-lineage commitment, through growth factor withdrawal and retinoic acid supplementation, perfect for experiments which examine the effects of ... are switched into the commitment base medium, growth factor withdrawal and retinoic acid induced differentiation proceeds (far right). With Neuro Cyte-NSC int...
Company:Orion BioSolutions, Inc.
retinoic in Biological Dictionary

Response element

...irect repeats as selective response elements for the thyroid hormone, retinoic ... nucleotide, and the resulting retinoic acid response element is no longer a TRE. ... ... Response Elemen...

Homeotic mutation

...mutations of homeotic genes cause dramatic changes in body appearance ... In one example of homeotic mutation in mice (Fig. 5), the addition of retinoic ... Another example of a homeotic gene mutation discovered by Lewis is the ... This means that homeotic mutations can be an effective mea...
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