Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer
Deficiencies in the ability of cells to repair damaged DNA are associated with an increased risk of breast cancer, according to a new study in the January 19 issue of the Journal of the National Cancer Institute. is the system of defenses designed to protect the integrity of the genome. Studies have suggested that deficiency...DNA Recombination and Repair—A New Twist to RecA Function
Molecular motors harness the energy of ATP (or GTP, a related energy currency) and transform it into mechanical force. Well-known examples of motors include myosin and dynein, proteins that use ATP to ferry intracellular cargo along fibers made of actin or tubulin proteins. The ATP-dependent assembly of actin or tubulin fibers itself can work as a motor: for instance, the march of white blood cel...Nano-bumps could help repair clogged blood vessels
Biomedical engineers at Purdue University have shown that "vascular stents" used to repair arteries might perform better if their surfaces contained "nano-bumps" that mimic tiny features found in living tissues. The researchers already have shown in a series of experiments that bone and cartilage cells in petri dishes attach better to materials that possess smaller surface bumps than are f...New understanding of DNA repair may pave way to cancer treatments
A Burnham Institute study has found that a protein known for its role in gene regulation has another important function, that of initiating DNA repair. The study, published in the May 27th edition of Molecular Cell, points to new targets for treatment of cancer. Ze'ev Ronai, Ph.D., Director of the Institute's Signal Transduction Program, and his colleagues found that the protein ATF2 ("Ac...DNA Repair Sampler Kit from BD Biosciences Pharmingen
Description:DNA Repair Sampler Kit 10g each...RT-PCR Primer Sets for Human and Mouse Mismatch Repair Genes
Stratagene Cloning Systems from the cDNAsequences of mismatch repair genes. These genes code for specialized proteinsthat participate in correcting areas of base mispairing in DNA. We have...DNA Damage and Repair - Quantification of Sub-Cellular Events Using Automated Confocal Imaging
Oxidative stress, radiation and other external insults have been shown to damage DNA molecules in cells derived from organisms as diverse as bacteria, yeast, drosophila, rodents and man (Friedberg et al. 2005). The presence of DNA damage may lead to cell cycle checkpoint arrest to allow time for DNA repair...Clotting Protein plays a role in nerve repair
According to a new study, fibrin, a protein that helps form blood clots, may also be involved in regulating the repair of nerve damage. The discovery could lead to new strategies for repairing diseases of the nervous system, such as multiple sclerosis, although the research is still on the basic science level.// In multiple sclerosis, the slow destruction of myelin--the thin, protecti...Heart may pull Cells from Body to Self-repair
According to researchers, after analysis of cells in men with transplanted hearts from female donors, the proof is the piling up that the heart may be able toregenerate itself at least somewhat by recruiting cells from elsewhere in the body.// Traditionally, it was thought that once cells were damaged or dead, they could not be replaced or repaired by the heart. By looking at the Y chr...Bone marrow stem cells may help repair cardiac tissues
Two new studies, though small, have boosted confidence in a method used to repair cardiac tissues damaged by a heart attack. Researchers have found that stem cells derived from bone marrow which is much less controversial than embryo cells// helps patients who have had a heart attack and had undergone conventional bypass therapy. Doctors in eastern Germany found that when patients who...Bones repair themselves with bone marrow cells
A research project carried out by Juliette van den Dolder at the University of Nijmegen has shown that new bone cells can be grown into bone fractures with the help of specially prepared titanium mesh and bone marrow cells. Researchers inserted a titanium mesh scaffold into a bone fracture in a rat. They allowed bone marrow cells to grow on this. This resulted in new bone growth being sti...Melanoma caused by low DNA repair capacity
Melanoma is the deadliest form of skin cancer and it has been shown through previous research studies that the risk is increased by exposure to sunlight, whose UV rays cause damage to DNA that triggers cancer. However, it has not been clear why some people are more prone than others to melanoma. Researchers have now found out through a study involving a group of 312 people with melanoma t...Meniscal Repair/Suture Instruments
Description:For universal arthroscopic meniscal repair/suture. Uses double-armed, single-throw sutures....Zone Specific® II Meniscal Repair System
Description:A complete system of cannulas, needles and rasps specifically designed for inside-out meniscal repair procedures....RapidLoc Meniscal Repair System
Description:The RapidLoc Meniscal Repair System is a second-generation "all-inside" system that offers several advantages over current systems including "inside-out" suture repair techniques and current "all-inside" rigid implants. This system is quick, simple, reproducible, reliable, and flexible in many ways, all while decreasing iatrogenic morbidity....Super Revo® Rotator Cuff Repair System
Description:The Linvatec 5mm Super Revo Suture Anchor offers a simple and reproducible technique for arthroscopic or a mini-open rotator cuff repair. The cutting tip requires no pre-drilling and the anchor is pre-threaded with two #2 strands of braided polyester suture. The potential pitfalls of suture management are avoided with the Independent Suture Sliding (I.S.S.™) Eyelet design. The sutures slide...Revo® Rotator Cuff Repair System
Description:The 4mm diameter Revo suture anchor is designed primarily for arthroscopic and open rotator cuff repair. Additional applications include other shoulder repair procedures, as well as use in knees and small joints....