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reductase in Medical News

Unique Glutathione Reductase Enzyme Introduced by Bio-Research Products

NORTH LIBERTY, Iowa, Feb. 3 /PRNewswire/ -- Bio-Research Products announced today that it will offer a high specific activity lyophilized grade of the enzyme Glutathione Reductase (GR). Dr. Bryce Cunningham, President and Chief Technology Officer of Bio-Research, reports that this is the first...

FDA Approves LIVALO(R) for Primary Hypercholesterolemia and Combined Dyslipidemia

...inistration (FDA) has approved LIVALO (R) (pitavastatin), a potent HMG-CoA reductase inhibitor (statin), for the primary treatment of hypercholesterolemia and c...cyclopropyl group contributes to a more effective inhibition of the HMG-CoA reductase enzyme to inhibit cholesterol production, and potentially affords greater l...

Statins don't lower risk of pneumonia in elderly

...cholesterol and risk of heart disease and stroke in people who've had either disease or are at risk for them," said Dublin. Statins are HMG coenzyme A reductase inhibitors, which also include Zocor (simvastatin) and Mevacor (lovastatin). This class of medications lessens inflammation, which plays a role in inf...

Two Studies at AACE 2009 Annual Meeting Highlight Effects of Welchol(R) (colesevelam HCl) on Blood Glucose and LDL-C in Patients with Type 2 Diabetes

...C) in patients with primary hyperlipidemia (Fredrickson Type IIa) as monotherapy or in combination with an hydroxymethyl-glutaryl-coenzyme A (HMG CoA) reductase inhibitor. - improve glycemic control in adults with type 2 diabetes mellitus. Important Limitations of Use - Welchol should not be used fo...

Research Findings on Nine GlaxoSmithKline Cancer Compounds to be Presented at ASCO 2009

... (R) (dutasteride) Dutasteride inhibits both type 1 and type 2 5-alpha reductase isoenzymes, which are responsible for converting testosterone to dihydrotes...significance of the in vitro dual inhibition of type 1 and type 2 5-alpha reductase isoenzymes has not been established. Dutasteride is indicated for the ...

Video: CRESTOR(R) Reduced Risk of Blood Clots in the Veins

...nd in nursing mothers. Cases of myopathy and rhabdomyolysis with acute renal failure secondary to myoglobinuria have been reported with HMG-CoA reductase inhibitors, including CRESTOR. These risks can occur at any dose level, but are increased at the highest dose (40 mg). CRESTOR should be prescr...

Researchers Report Combined Molecules in Red Wine by Far Exceed the Biological Activity of Plain Resveratrol, Consistent With the Composition of Longevinex(R)

...earch. For more information about Longevinex(R), please visit www.longevinex.com Reference: Red wine triggers cell death and thioredoxin reductase inhibition: effects beyond resveratrol and SIRT1. Experimental Cell Research 2009 Mar 4. [Epub ahead of print] ...

Statins lower stroke severity, improve recovery

... improved outcomes in general, so we focused on the patients who had optimal LDL levels and found it still had quite significant value." Statins or reductase inhibitors are enzymes that are widely used to improve cardiovascular health and, more recently, for certain vascular conditions in the brain. One use...

New ASCO/AUA guideline recommends men and their doctors discuss using 5-ARIs to reduce prostate cancer risk

...that healthy men who are screened regularly for prostate cancer and show no symptoms of the disease should talk to their doctors about using a 5-alpha reductase inhibitor (5-ARI) to prevent the disease. 5-ARIs lower the level of the hormone dihydrotestosterone (DHT), which can contribute to the growth of prost...

Drugs May Help Healthy Men Lower Prostate Cancer Risk

...al Oncology and the American Urological Association have issued new guidelines recommending that these men talk to their doctors about using a 5-alpha reductase inhibitors (5-ARI). These drugs -- which include finasteride (Propecia), used to treat male pattern baldness -- can reduce levels of dihydrotestostero...
reductase in Medical Technology

Study Demonstrates Efficacy of Pitavastatin in Elderly Patients

... of 2 mg of pitavastatin once daily." About pitavastatin Pitavastatin (a statin) is a fully synthetic and highly potent inhibitor of HMG-CoA reductase used for primary hypercholesterolemia and combined dyslipidemia. Pitavastatin has a unique cyclopropyl group on the base structure common to the stati...

Generic Substitutes Less Effective/Safe Than Branded Medications in Treating Lower Urinary Tract Symptoms

...dy at the 104th Annual Scientific Meeting of the American Urological Association (AUA) showing that generic substitutes for alpha blockers and 5-alpha reductase inhibitors (5-ARIs), two classes of medications used to treat lower urinary tract symptoms (LUTS) in men, are less effective than their branded counte...

CRESTOR(R) Reduced CV Risk in Patients Achieving Low LDL and hsCRP Targets in New JUPITER Analysis

...nd in nursing mothers. Cases of myopathy and rhabdomyolysis with acute renal failure secondary to myoglobinuria have been reported with HMG-CoA reductase inhibitors, including CRESTOR. These risks can occur at any dose level, but are increased at the highest dose (40 mg). CRESTOR should be prescr...

CRESTOR(R) Reduced Risk of Blood Clots in the Veins

...nd in nursing mothers. Cases of myopathy and rhabdomyolysis with acute renal failure secondary to myoglobinuria have been reported with HMG-CoA reductase inhibitors, including CRESTOR. These risks can occur at any dose level, but are increased at the highest dose (40 mg). CRESTOR should be prescr...

Statins Lower Stroke Severity, Improve Recovery

...mproved outcomes in general, so we focused on the patients who had optimal LDL levels and found it still had quite significant value." Statins or reductase inhibitors are enzymes that are widely used to improve cardiovascular health and, more recently, for certain vascular conditions in the brain. One use...

Arpida Comments on FDA's Anti-infective Drugs Advisory Committee Outcome

...signed to meet a growing medical need for additional treatment options to combat resistant infections and is the first antibiotic in the dihydrofolate reductase (DHFR) selective inhibitor class to demonstrate efficacy against cSSSIs caused by MRSA. The DHFR class has been proven safe and effective in more than...

Colesevelam HCl Lowered LDL Cholesterol in Pediatric Patients With Heterozygous Familial Hypercholesterolemia

...terol in adults with primary hyperlipidemia (Fredrickson Type IIa) as monotherapy or in combination with a hydroxymethyl-glutaryl-coenzyme A (HMG CoA) reductase inhibitor (a statin). Welchol should not be used for the treatment of type 1 diabetes or diabetic ketoacidosis. Welchol has not been studied in type 2...

CRESTOR Demonstrates Dramatic CV Risk Reduction in a Large Statin Outcomes Study

...nt, and in nursing mothers. Cases of myopathy and rhabdomyolysis with acute renal failure secondary to myoglobinuria have been reported with HMG-CoA reductase inhibitors, including CRESTOR. These risks can occur at any dose level, but are increased at the highest dose (40 mg). CRESTOR should be prescribed ...

N30 Pharma Announces Completion of Phase 1 Clinical Studies With N30-201

...tone. N30's drug development strategy focuses on administration of GSNO to the human airway, and the development of inhibitors of GSNO reductase. GSNO reductase is the key enzyme in the body that breaks down GSNO. These approaches allow N30 to deliver targeted, long lasting, physiologically relevant doses of s...

N30 Pharma Announces Successful Initiation of Human Studies With N30-201

...y diseases. N30's strategy focuses on administration of GSNO to the human airway, and development of small molecule inhibitors of GSNO reductase. GSNO reductase is the key enzyme in the body that breaks down GSNO. These approaches allow N30 to deliver long lasting, physiologically relevant doses of s-nitrosoth...
reductase in Medical Products

Methylenetetrahydrofolate Reductase Mutation Detection, Fetal

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Methylenetetrahydrofolate Reductase Mutation Detection (Thermolabile Form) (C677T & A1298C)

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories
reductase in Medical Dictionary

Testes

... have ... Testes were collected from 1–24 d of age, and testicular development was ... The porcine testes is known to be a rich source of both reductase and cytochrome ... Learn the casues of testicular pain such as trauma, testicular torsion (a medical emergency), infection, hernia, inflammati...
reductase in Biological News

SNPs affect folate metabolism in study of Puerto-Rican adults

... involved in folate metabolism previously associated with altered blood folate and homocysteine concentrations were studied: methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MTR). SNPs are variations in the sequence of nucleotides, or building blocks, that make up genes. Humans possess ...

Phase III data show efficacy/safety of iclaprim in patients with complicated skin infections

...od and Drug Administration Anti-Infective Drugs Advisory Committee on 20 November 2008. Iclaprim, a novel antibiotic from the trusted dihydrofolate reductase (DHFR) selective inhibitor class of antibiotics, was specifically designed to address the growing need for additional treatment options to combat resi...

Infection blocks lung's protective response against tobacco smoke

...acts and neutralizes reactive species in the lungs, it becomes oxidized. Under normal conditions mice and humans produce an enzyme, called glutathione reductase (GR), which recycles the oxidized glutathione into its protective, reduced state. The researchers found that mice exposed to tobacco smoke and Mp ...

Powerful integration of lipid metabolic profiling with gene expression analysis

... analysis methods of Genomatix Software GmbH. The study elucidated the effects on Mouse lipid metabolism by the disruption of hepatic Cytochrome P450 reductase (POR) in a POR deficient knock-out mouse model. It clearly could demonstrate that though gene expression and lipid metabolism in extrahepatic tissues ...

Hair-growth drug artificially lowers PSA levels in prostate cancer screening, study finds

...ctase. DHT activates the genes responsible for the development of male-pattern hair loss. Finasteride interferes with this process by blocking 5-alpha reductase and preventing the conversion of testosterone to DHT. The data in The Lancet study were collected by Dr. Roehrborn from 1998 to 2000 in...

Researchers identify new weapon to fight deadly bacterial sepsis

...ng the activity of a single enzyme known as aldose reductase can short-circuit sepsis, protecting heart functio...e in diabetics, it's possible that such an "aldose reductase inhibitor" could be used by physicians relatively ...les. But when they treated the mice with an aldose reductase inhibitor, they found that blocking the enzyme's a...

Novel protein complex enables survival in hostile environment

... same organism after all, and, in the course of time, a loss of the sulfite reductase gene gave rise to a sulfite-sensitive methanogen. Similarly the loss of cer...ity on anaerobic microorganisms, commented: "The finding of a novel sulfite reductase in a methanogenic archaeon is an important discovery. It may prove to be di...

NC State researchers redesign life for Mars and beyond

...stitute forAdvanced Concepts, entails extracting a gene - called superoxide reductase - from P. furiosus and expressing it in plants. That gene, one of nature's ...ed quickly, the toxic superoxide will kill plant cells.Since the superoxide reductase gene is not found in plants, Boss, an expert in plant metabolism and plant ...

Genetic variation alters response to common anti-clotting drug

...redict dose, you need to know more about the genes that control variability," explained Rieder. The team focused on another gene: vitamin K epoxide reductase (VKORC1), which makes a protein that helps control clotting and is the key target of warfarin. The researchers analyzed the VKORC1 gene's DNA sequence...

USC researchers determine mechanism of action of chemotherapy drug

...oredoxin reductase-that is an important component in the cell's antioxidant system, as well as important in DNA synthesis. In other words, thioredoxin reductase is key to the replication and survival of cells, and its inhibition ultimately leads to cell death. "Our studies showed that MGd induces oxidative ...
reductase in Biological Technology

Canadian researchers discover gene related to the appearance of aging

...the gene responsible for CL2 in these patients, citing an interruption of the metabolism of the amino acid, proline. The gene, pyrroline-5-carboxylate reductase 1, carries out the final step of proline synthesis. Proline is a major component of connective tissue and skin proteins, collagen and elastin. It ca...

Kowa Company, Ltd. Acquires ProEthic Pharmaceuticals, Inc.

... the company to ensure its future success." The first pharmaceutical product to be launched by the new company will be pitavastatin, a novel HMG CoA reductase inhibitor for the treatment of hyperlipidemia. Pitavastatin is sold in Japan, Korea and Thailand under the brand Livalo(R). Pitavastatin has recently ...

Three PDX (Pralatrexate) Studies Presented at the 2007 AACR-NCI-EORTC Conference

...ed uptake of PDX into the tumor cell and/or greater intracellular accumulation and polyglutamylation, resulting in greater inhibition of dihydrofolate reductase (DHFR). In addition, PDX induced greater tumor regression compared to MTX or Alimta in two human NSCLC xenograft models, including the highly aggressi...

Spectrum Pharmaceuticals Initiates Second Registrational Phase 3 Clinical Trial for EOquin(R) in Patients With Non-Invasive Bladder Cancer

...t of non-invasive bladder cancer, which is a cancer that has invaded the lining of the bladder. EOquin, an anti-cancer agent that becomes activated by reductase enzymes found in cancer cells, is formulated for administration directly into the urinary bladder. In a Phase 2 pilot study which was completed earlie...

Electroporation of Primary Bone Marrow Cells

...Pulser apparatus to electro-transfect either a murine MHC class II gene, A B b , or a plasmid encoding a mutant dihydrofolate reductase enzyme (dhfr) into murine bone marrow cells. 1 In these studies, we determined which parameters worked best for transient expre...

Translate High Yields of Biologically Active Proteins

... according to protocol. The proteins analyzed were dihydrofolate reductase (DHFR), adenylate kinase 1 (AK1), carbonic anhydrase 2 (CA2), ca...kits were compared to that from the ActivePro Kit. Dihydrofolate reductase (DHFR): Activity was measured with a standard DHFR assay, which ...

Transfection Reagent Selector Kit Handbook

...) or hygromycin B phosphotransferase (HPH). Other selectable markers are the genes encoding adenosine deaminase (ADA), dihydrofolate reductase (DHFR), thymidine kinase (TK) or xanthine-guanine phosphoribosyl tranferase (XGPRT; gpt gene). ...

Detect Single Nucleotide Sequence Changes with Mx4000 Molecular Beacon Allelic Discrimination Kits

... 1). The MTHFR (C677T) allelic discrimination kit is used to detect a common point mutation in the human methylenetetrahydrofolate reductase gene. This mutation has been shown to be an important genetic risk factor for vascular disease and coronary heart disease ( Tabl...
reductase in Biological Products

NADPH-cytochrome c reductase Colorimetric Assay Kit from Sigma-Aldrich

Description: Analysis Note: The kit contains all the reagents required for a fast and convenient determination of NADPH-cytochrome c reductase activity in cell and tissue extracts and in purified microsomes [endoplastic reticulum (ER)]. It has been tested on samples prepared from mammalian tissues such as liver...
Company:Sigma-Aldrich

Origami(DE3) Glycerol Stock from Novagen

Description:...st strains are K-12 derivatives that have mutations in both the thioredoxin reductase (trxB) and glutathione reductase (gor) genes, which greatly enhances disulfide bond formation in the cytopla...
Company:Novagen

Origami(DE3)pLysS Glycerol Stock from Novagen

Description:...st strains are K-12 derivatives that have mutations in both the thioredoxin reductase (trxB) and glutathione reductase (gor) genes, which greatly enhances disulfide bond formation in the cytopla...
Company:Novagen
reductase in Biological Definition

Coenzyme A

...etaldehyde , then attached to coenzyme A while NAD + is subsequently reduced to NADH and H + . See also Citric acid cycle HMG-CoA reductase pathway ...

Cancer

...etinoic acid also has been shown to reduce risk of second primary tumors among patients with primary head and neck cancer . Finasteride , a 5-alpha reductase inhibitor , has been shown to lower the risk of prostate cancer. Other examples of drugs that show promise for chemoprevention include COX-2 inhibito...

Electron transfer chain

...o called NADH coenzyme Q reductase. Complex II - Succinate - coenzyme Q reductase . Complex III - Coenzyme Q - cytochrome c reductase . Complex IV - Cytochrome c oxidase . Complex V - ATP synthase , al...

Enzyme

...curdle Chymotrypsin : can digest proteins Coenzyme Q - cytochrome c reductase : participates in the electron transfer chain by reducing cytochrome c ...al of iodine Diastase : break starch into glucose Dihydrofolate reductase : reduces dihydrofolic acid to tetrahydrofolic acid DNA gyrase : cat...

Light-dependent reaction

...Arif Rashid electrons are transferred to the primary acceptor protein, but this time are passed on to ferredoxin, and then to an enzyme called NADP + reductase which uses them to drive the reaction NADP + + H + + 2e - → NADPH This consumes the H + ions produced by the splitting of water, lea...

Metabolism

...hat create building blocks and compounds from simple precursors: Glycogenesis Gluconeogenesis Porphyrin synthesis pathway HMG-CoA reductase pathway , leading to cholesterol and isoprenoids . Secondary metabolism , metabolic pathways that are not essential for growth, development or ...

Mitochondrion

...en (O 2 ) in several steps involving the electron transfer chain. The protein complexes in the inner membrane ( NADH dehydrogenase , cytochrome c reductase , cytochrome c oxidase ) that perform the transfer use the released energy to pump protons (H + ) against a gradient (the concentration of proton...

Mitochondrion

...en (O 2 ) in several steps involving the electron transfer chain. The protein complexes in the inner membrane ( NADH dehydrogenase , cytochrome c reductase , cytochrome c oxidase ) that perform the transfer use the released energy to pump protons (H + ) against a gradient (the concentration of proton...

Oxidative phosphorylation

... citric acid cycle, are used in an intricate mechanism (involving NADH-Q reductase , cytochrome c oxidase , and cytochrome reductase ) to pump H + across the membrane against a proton gradient . A l...

Light-dependent reaction

...Arif Rashid electrons are transferred to the primary acceptor protein, but this time are passed on to ferredoxin, and then to an enzyme called NADP + reductase which uses them to drive the reaction NADP + + H + + 2e - → NADPH This consumes the H + ions produced by the splitting of water, lea...
reductase in Biological Dictionary

Polymorphisms

... - SNPs - SNP genotyping information and resources available for pharmacogenomics - Building on the Human Genome Project Methylenetetrahydrofolate reductase (MTHFR) is 'a critical enzyme in both folate and homocysteine metabolism,' according to Ueland (LOCUS for Homocysteine and ... ...

NADPH

... Information on EC 1.6.2.4 - NADPH -hemoprotein reductase ... NADPH cytochrome P450 reductase. Homo sapien...rmation on EC 1.1.1.34 - hydroxymethylglutaryl-CoA reductase ( NADPH ) ... (R)-mevalonate + CoA + 2 NADP+ = (S)...Bioinformatics Institute ... NADPH -dependent FMN reductase (EC: ... NADPH -dependent ,FMN reductase, SsuE. E...

Electron transport chain

...ron transport chain is a highly. organized group of proteins and associated ... The Electron Transport Chain . 2e- Complex III. cytochrome reductase ... The mitochondiral electron transport chain consists of a series of ... Energetics of the Mitochondrial Electron Transport Chain ......

Collecting tubules

...onary.com a free ... Link To collecting tubule . Tubal Reversal Surgery. Want more information We have it. ... See under tubule . ... of Aldose reductase to the Collecting Tubules Restores Maturation of the Urine ... collecting tubule - A channel through which fluids ... ... is a cystic dilat...
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