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Ras in Medical News

Yet Another Use For Cell Phone Cameras

Researchers say there might be another use for cell phones that come complete with cameras: diagnosing chronic leg ulcerations.// Swiss researchers who used the phone cameras to send pictures of wounds to specialists in remote locations say doctors felt fairly comfortable diagnosing the wounds from...

Addario Lung Cancer Medical Institute Announces Diagnostic Screening and Clinical Research Collaborations With Response Genetics, Inc.

... (Logo: http://www.newscom.com/cgi-bin/prnh/20090731/DC55399LOGO ) Specific molecular features of tumors, including EGFR mutations, ras mutations, ERCC1, RRM1 or TS overexpression, have been shown in multiple studies to have prognostic importance and/or be associated with benefit from ...

New Gene May Signal Aggressive Breast Cancer

... metastasis. According to the study, RCP overexpression also impacts the ras protein, which previous research has implicated in tumor growth. Researchers said RCP may promote breast cancer by activating the ras signaling pathway. Developing treatments that target RCP may represent a ne...

New drug candidate prolongs the lives of pancreatic cancer patients

...ast cancers as well as diabetes. Blocking the ras protein Salirasib works by inhibiting a protei...ancers. In cancer of the pancreas, mutant forms of ras are found in up to 90% of all tumors. Salirasib's ..., works to block the formation of cancer-promoting ras nanoclusters, thus blocking a cascade of biochemic...

Cell Protein Could Help Spur Malignancy

... be highly specific for cancer cells." Levy and his team made the discovery about the mitochondrial role of STAT3 by analyzing tumors caused by the ras oncogene, which has been determined to be involved in many human cancers. A report on the findings appears in the June 26 issue of Science . "F...

Are angiotensins involved in the hemodynamic changes of cirrhosis patients?

...terized by marked changes in the precursors of the ras cascade (renin and Ang 1 with repercussions on the 2 main ras components, Ang 2 and Ang-(1-7), in the splanchnic...circulation. Therefore, the circulating profile of ras components at different stages of liver cirrhosis ...

Quest Diagnostics Introduces First Comprehensive Laboratory Test To Analyze KRAS, NRAS, and BRAF Gene Mutations in Reflex Testing Service

...lable from a single test offering for identifying ras and BRAF gene mutations in patients with mCRC w...colon cancer samples that found that 11 percent of ras mutations would have been missed if only codons 12...ed (as recommended by ASCO's PCO), and recommended ras mutation testing include KRAS and NRAS encompassin...

Cancer cells need normal, nonmutated genes to survive

...ery way except for onethe presence or absence of a ras oncogene. ras mutations are prevalent in many deadly cancers, an...evels of a particular protein while cells with the ras mutation perished. Luo validated 50 of these hits ...

The vulnerable cancer cell

... "Efforts to develop drugs that inhibit oncogenic ras proteins have been largely unsuccessful, despite the fact that ras gene family members are mutated in about 30 percen...nted in Cell shows that STK33 is not a part of the ras signaling pathway, nor is it mutated in human canc...

American Cancer Society awards 143 research grants to investigators at 83 institutions nationwide

...s interest is in how growth factors initiate the process of cell movement. This work could supply a critical new understanding of why mutations called ras mutations are so common in so many different cancers. Preclinical and Translational Cancer Research Kimberly Stegmaier, M.D., Dana-Far...

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Ras in Medical Technology

Ongoing Landmark ROADMAP Study Demonstrates Significant Improvement in Blood Pressure Control at One Year, According to Blinded Results

...l patient population, which includes patients randomized either to olmesartan or placebo in addition to standard antihypertensive treatment (excluding ras inhibition). After one year of treatment, 61 percent of patients in ROADMAP achieved the recommended BP goal of <130/80 mm Hg, a significant increa...

Millennium Presents New Data on Investigational Drugs for Novel Cancer Targets at EORTC-NCI-AACR Symposium

...ity, favorable pharmacokinetics and tumor distribution, efficacy in EGFR- and HER2-expressing xenograft models, activity in tumors harboring activated ras or inactivated LKB1 mutations and activation of AMPK pathways in cardiac cells. -- Tyrosine kinase inhibitors, such as TAK-285, GW572016 or SU1124...

Lotrel, a Single-Pill Combination for Treating High Blood Pressure, Reduced Cardiovascular Events by 20% in High-Risk Patients

... two single-pill combinations of commonly used high blood pressure medicines in reduction of cardiovascular events - ras inhibition with an ACEI was the foundation of the combination therapies in this study and exceptional blood pressure control rates were ...

Use of PressureWire(R) Yields a More Accurate Assessment of Translesion Pressure Gradients in Peripheral Vasculature, Two New Studies Report

...sessment of renal artery stenosis: side-by-side comparison of angiography and duplex ultrasound with pressure gradient measurements," this study of 56 ras patients reports that diagnoses based on renal angiography and color duplex ultrasound overestimated the severity of RAS by 38 percent and 55 percent ...

Prolexys Pharmaceuticals Initiates Phase 1 Study

...erived from tumors with dissimilar causative mutations, indicating potent and selective activity against a wide variety of tumors, many with activated ras pathway. The compound showed robust tumor regression in a range of human tumor xenografts grown in immuno-compromised mice, including models of pancre...

New Data Highlights Potential of SPP100 (Tekturna) as Gold Standard Therapy in Treatment of Hypertension

...years of research on renin. Renin is the key enzyme at the top of the Renin Angiotensin System (RAS), one of the key regulators of blood pressure. The ras is a cascade, starting with renin, leading to angiotensin I and finally to angiotensin II. Angiotensin-converting enzyme inhibitors (ACE-Is) and angio...

Thallion Announces Publication of ECO-4601 Phase I/II Clinical Data at ASCO

...l, McGill University in Montreal in conjunction with Thallion Pharmaceuticals Inc. The abstract is titled: “Phase I study of ECO-4601, a novel ras pathway inhibitor.” Abstract No. 14128 by P. Kavan, D. Melnychuk, A. Langleben, S. D. Baker, A. Bangash, C. Gauthier, M. Ranger, H. Gourdeau, M....

Pharmexa A/S (DK) - Long lasting immune response and survival to RAS vaccine

... Summary: Follow-up ras data presented at ASCO HORSOLM, Denmark, June 4,... with two different peptide vaccines targeting the ras mutation found in most instances of pancreatic can...em in three of these patients still remembered the ras vaccination. The...

Prolexys Pharmaceuticals and Columbia University Researchers Publish Study on Anti-Tumor Properties of a Selective Small Molecule Anti-Tumor Agent With Novel Mechanism of Action

.... This process has a degree of selectivity for cells with aberrantly active ras pathway. In normal cells, ras pathway is involved in growth and differentiation of cells; however the abe...

Hypertension Vaccine CYT006-AngQb Achieves Strong Blood Pressure Reduction During Important Early Morning Period When Most Adverse Cardiovascular Events Occur

...eceptors and subsequent narrowing of blood vessels should be decreased. The ras has already been successfully targeted by three major classes of antihypert...atory blood pressure monitoring devices. Angiotensin II: a molecule of the ras inducing vasoconstriction of blood vessels and other effects to raise blood...

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Ras in Biological News

Yale Scientists Find MicroRNA Regulates Ras Cancer Gene

Research in the laboratory of Assistant Professor Frank J. Slack at Yale University has identified a new way that a familiar gene is regulated in lung cancer, presenting new possibilities for diagnosis and treatment. The work is reported in March issues of the journals Cell and Developmental Cell. ...

Cancer-causing protein can also help fight the tumors it causes

...rsity's Department of Neurobiology have found that ras has the ability to transfer from cancer cells into...th the immune and original cells alike." "When ras transfers from one cell to another, it strengthens...e system. The immune cell that adopts the mutated ras gets activated and reacts against the cancerous ce...

Zebrafish provide a model for cancerous melanoma in humans

...nown to lead to cancer. In some cases, the type of ras mutation is a predictor of a patient's response to...erland generated several zebrafish with changes in ras or other RAS-regulated proteins to create a useful... to identify a pathway that reduced the effects of ras mutations on melanoma progression in zebrafish. ...

New drug agent knocks out multiple enzymes in cancer pathway

...hways in tumor cells, focusing on a protein called ras since nearly a third of all human cancers involve a mutation in the ras gene that causes cell signaling to go awry. These ...ymes, called FPPS and GGPPS, which are upstream of ras in the cell survival pathway. Inhibiting these enz...

Damon Runyon Cancer Research Foundation awards prestigious fellowships to 13 top young investigators

...fenburger, PhD, at Massachusetts General Hospital, Boston, Massachusetts, is working to identify new protein networks that interact with the oncogenic ras signaling pathway, which is rewired in over half of colorectal cancer cases. Targeting these new interactions in combinatorial therapy may become an ...

JCI online early table of contents: Jan. 19, 2009

...are associated with excessive activation of either ras or PI3K signaling pathways, and many therapies aim...of breast cancer caused by excessive activation of ras and PI3K. Further, silencing the FAK gene arrested...t cancer cells with excessive activation of either ras or PI3K signaling pathways. The authors therefore ...

Mayo researchers identify dangerous 'two-faced' protein crucial to breast cancer spread and growth

... aggressive, able to grow in conditions that other cancer cells can't. They specifically found that p120 activates a family of molecules that includes ras and Rho, which promote cell growth and movement. "What is really interesting here is that p120 is acting like a tumor suppressor when it is bound t...

Gene's newly explained effect on height may change tumor disorder treatment

...uch research focused on neurofibromin's effects on ras protein activity, which is linked to cell growth, ...roliferation and cancer. Normally, NF1 deactivates ras proteins. In its absence, scientists believe unchecked ras can promote cancer development. To learn more,...

Emissions irrelevant to future climate change?

...Mokhov and Alexey Eliseev from the A.M. Obukhov Institute of Atmospheric Physics RAS, in Moscow, Russia. The authors used a climate model known as IAP ras CM to study how feedback between our climate and the carbon cycle changes over time. In their simulations, the authors assumed that fossil fuel emissi...

Fox Chase researchers discover a method for clamping down on a cancer-promoting enzyme

...enzyme becomes active. Previous studies have linked PAK1 activity with breast cancer and have shown the enzyme is important in pathways involving the ras oncogene, which is thought to cause up to 30 percent of all cancers. In the April 24 issue of the journal Chemistry & Biology, the researchers deta...

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Ras in Biological Technology

/R E P E A T -- Oncolytics Biotech Inc. Announces U.S. Phase 2 Combination Clinical Trial for Non-Small Cell Lung Cancer Patients with K-RAS or EGFR-Activated Tumours/

... replicates in cancer cells that have an activated ras pathway. Approximately two thirds of all cancers have an activated ras pathway, including most metastatic disease. A larg...cluding mutations in EGFR, Her2 or K-RAS along the ras pathway lead to...

Oncolytics Biotech Inc. Announces U.S. Phase 2 Combination Clinical Trial for Non-Small Cell Lung Cancer Patients with K-RAS or EGFR-Activated Tumours

... replicates in cancer cells that have an activated ras pathway. Approximately two thirds of all cancers have an activated ras pathway, including most metastatic disease. A larg...cluding mutations in EGFR, Her2 or K-RAS along the ras pathway lead to...

SGX - Lilly Merger Offer Receives Positive Opinions From Proxy Advisory Firms

...covery activities are focused on a portfolio of other protein and enzyme targets that have been implicated in human cancers, including JAK2, RON, ALK, ras and IKKe. More information on the pipeline and drug discovery platform can be found at http://www.sgxpharma.com and in the Company's various filings...

SGX Pharmaceuticals Announces Financial Results for the Three and Six Months Ended June 30, 2008

...covery activities are focused on a portfolio of other protein and enzyme targets that have been implicated in human cancers, including JAK2, RON, ALK, ras and IKKe. More information on the pipeline and drug discovery platform can be found at http://www.sgxpharma.com and in the Company's various filings...

Lilly to Acquire SGX Pharmaceuticals

...covery activities are focused on a portfolio of other protein and enzyme targets that have been implicated in human cancers, including JAK2, RON, ALK, ras and IKKe. More information on the pipeline and drug discovery platform can be found at http://www.sgxpharma.com and in SGX's various filings with th...

SGX Pharmaceuticals Submits Investigational New Drug Application for SGX393

...covery activities are focused on a portfolio of other protein and enzyme targets that have been implicated in human cancers, including JAK2, RON, ALK, ras and IKKe. More information on the pipeline and drug discovery platform can be found at http://www.sgxpharma.com and in the Company's various filings...

SGX Pharmaceuticals Announces First Quarter Financial Results and Gives Pipeline Update

... other than SGX393. Oncology Drug Discovery In addition to the JAK2 and ras programs described previously, the Company's drug discovery portfolio inclu...rgets that have been implicated in human cancers, including JAK2, RON, ALK, ras and IKKe. More information on the pipeline and drug discovery platform can ...

Pharsight Achieves $7.6 Million In Quarterly Revenue

...ments during the quarter," said Mr. O'Connor. "Our ras offering, now staffed with 12 people, generated 86...ution for regulatory studies. -- Expanded the ras team in response to global demand for the group's ...als. -- Achieved continued strong revenue growth; ras revenue up 86% quarter over quarter. Additio...

SGX Pharmaceuticals Schedules Teleconference and Webcast to Discuss First Quarter 2008 Results and Provide Pipeline Update

...scovery activities are focused on a portfolio of other protein and enzyme targets that have been implicated in human cancers including JAK2, RON, ALK, ras and IKK. More information on the pipeline and drug discovery platform can be found at http://www.sgxpharma.com and in the Company's various filings ...

Oncolytics Biotech Inc. Announces 2008 First Quarter Results

...at have not been successfully treated with conventional therapeutics. The product being developed by the Company may represent a novel treatment for ras mediated cancers which can be used as an alternative to existing cytotoxic or cytostatic therapies, as an adjuvant therapy to conventional chemother...

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Ras in Biological Definition

Oncogene

...ytoplasmic tyrosine kinases like the Src-family, Syk-ZAP-70 family and BTK family of tyrosine kinases. Regulatory GTPases , for example, the ras protein . Cytoplasmic Serine / Threonine kinases and their regulatory subunits , for example, the Raf kinase , and cyclin-dependent kinases (t...
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