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Bound for destruction: Ubiquitination protects against improper Notch signaling

The is an important molecular signaling mechanism whose existence has beenknown, or at least hinted at, for nearly a century since theidentification of a mutant strain of Drosophila fruit flies with“notched?wings in Thomas Hunt Morgan’s lab in 1910. Later studiesrevealed that the Notch gene encodes a receptor protein tha...

University of Nevada, Reno research team discovers hormone that causes malaria mosquito to urinate

Discovery has implications for control of mosquitoes, malaria and West Nile Virus Methoprene, which has the same effect as an insect hormone called juvenile hormone, also sto...

Fighting malaria by manipulating mosquitoes' sense of smell

Combating the spread of malaria by manipulating the mosquitoes' sense of smell is the object of an ambitious research project, led by Vanderbilt University, that has been selected to receive $8.5 million as part of the Grand Challenges to Global Health. The initiative, which was launched by the Bill and Melinda Gates Foundation, has just announced the selection of 43 "groundbreaking" resea...

Mosquito study shows new, faster way West Nile can spread

Researchers at the University of Texas Medical Branch at Galveston (UTMB) have discovered a quick new way that mosquitoes can pass West Nile virus to each other. The new study challenges fundamental assumptions about the virus' transmission cycle and may help explain why it spread so rapidly across North America despite experts' predictions that it would progress more slowly or even die out....

Mosquitoes are more attracted to individuals infected with malaria

Malaria remains a devastating problem in Africa and understanding the factors affecting its transmission remains a crucial part of the effort to combat the disease. A new study published in the premier open access journal PLoS Biology conducted in Western Kenya by Jacob Koella and colleagues now reveals that mosquitoes are more attracted to children with the infectious stages of malaria than to t...

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Ubiquitin/Proteasome Fraction II Extract from GeneTex

Description:Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs...
Company:GeneTex

Ubiquitin Fraction I from ABR-Affinity BioReagents

Description:Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstruct...
Company:ABR-Affinity BioReagents

Ubiquitin Fraction I Extract from GeneTex

Description:Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs...
Company:GeneTex

Mouse Anti-Ubiquitin, Multi Monoclonal Antibody, Unconjugated, Clone FK2 from Assay Designs/Stressgen Bioreagents

Description:This antibody detects ubiquitinated proteins on SDS-PAGE immunoblots. It does not detect free ubiquitin....
Company:Assay Designs/Stressgen Bioreagents

Newborn Calf serum from Equitech-Bio

Description:A cost-effective serum for general cell growth requirements. All serum is collected from calves aged 10 days old or less....
Company:Equitech-Bio

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Of private equity, research, and drug development

, for $29 billion. The New York Times <a href="http://www.nytimes.com/2007/04/03/business/03data.web.html?_r=...

Reader predictions would make 2007 quite a year

From Virtual worlds get r...

Boston equity firm becomes majority owner of Cedarburg-based Mortgagebot

Following...

Whats in a name? Quite a bit, when youre competing in biotech

SAN FRANCISCO The sign hanging over the Badger state pavilion at the annual BIO convention proclaimed, Wisconsin Room to Breathe. But you had to visit the New York State exhibit to breathe gardenia-scented oxygen at that states oxygen bar. In a business that has grown to be as competitive as biotechnology, most states, provinces and even nations are eager to distinguish themselves from...

How to Quit Your Midwest Technology Job

CHICAGO Can it be that things are looking up in our Midwest tech economy? Headhunters are a little more optimistic this fall. Monster.com and HotJobs are a little more interesting. Hiring managers are still deluged with inquiries from job seekers but working harder to fill some of their positions, too. What if one of your irons in the fire gets hot and ignites? Its a wonderful feeling...

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Ubiquitin

proteas...

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Vaccine to quit smoking?

Well, there is aren’t too many approaches which have not been taken in trying to prevent smoking, but a new vaccine developed by Nabi,// a pharmaceutical company, promises new hope in preventing people from relapsing. The vaccine (NicVAX) binds nicotine and prevents it from reaching the brain, where it causes its stimulatory effects. In animal control experiments, the vaccine was effectiv...

New hope on the Horizon for People Wishing to Quit Smoking

Smoking is one of the most difficult addiction to give up. In an exciting research done at the University of Toronto in Canada it was found that medication called methoxsalen ( this is currently used to treat skin disorders) may help addicts who wish to give up smoking. Nicotine replacement, in the form of a patch or gum, to keep the level of nicotine in blood up witho...

Glaxo launches pills to help smokers quit in 7-12 weeks

GLAXO SmithKline India has launched an oral treatment for smoking, called Zyban. The pill (generic - Bupropion Hydrochloride) is reportedly the first product aimed at stopping smoking and is available at Rs. 40 per tablet. Speaking to newspersons, Mr. Kalyanasundaram, Director (Pharmaceuticals), Glaxo India Ltd, said the complete treatment osts about Rs. 5000 and takes about 7-12 weeks....

A boost to quit smoking

Smoking is injurious to health, especially to the heart.Improvements in heart disease risk factors are measurable within weeks of quitting smoking. It's known that smoking increases the risk of heart disease. The main culprit is carbon monoxide in cigarette smoke,// which raises cholesterol levels, white blood cell counts and creates other heart disease risk factors. Each 1% increase in c...

Quitting smoking stops lung decline

Quitting smoking for a year at a time can keep lungs from deteriorating and reduce the risk of death, according to American researchers. At the University of Ohahio, Dr.Margit Pelkon and collegues investigated the effects of quitting smoking. They studied more than 1,000 Finnish participants in four groups:// those who had never smoked, those who had quit permanently, those who had qui...

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Halstead Straight Haemostatic Mosquito Forceps

Description:Straight 22 mm serrated jaws. Ring handle with ratchet lock and dull finish. Overall length 4.9 inches...
Company:Bausch & Lomb Storz

Halstead Curved Haemostatic Mosquito Forceps - Non-Magnetic

Description:Curved 21 mm serrated jaws. Ring handle with ratchet lock. Non-magnetic and dull finish. Overall length 4.7 inches....
Company:Bausch & Lomb Storz

Halstead Straight Haemostatic Mosquito Forceps - Non-Magnetic

Description:Straight 21 mm serrated jaws. Ring handle with ratchet lock. Non-magnetic and dull finish. Overall length 4.8 inches....
Company:Bausch & Lomb Storz

Halstead Curved Haemostatic Mosquito Forceps

Description:Curved 21 mm serrated jaws. Ring handle with ratchet lock and dull finish. Most popular size or model. Overall length 4.7 inches...
Company:Bausch & Lomb Storz

Hartman Curved Haemostatic Mosquito Forceps

Description:Curved 20 mm serrated jaws. Ring handle with ratchet lock and dull finish. Most popular size or model. Overall length 3.9 inches...
Company:Bausch & Lomb Storz

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Metabasis to Present at C.E. Unterberg, Towbin Emerging Growth Conference and Attend Pacific Growth Equities Conference

SAN DIEGO--(BUSINESS WIRE)--Jul 2, 2007 - Metabasis Therapeutics(NASDAQ:MBRX), a biopharmaceutical company focused on thediscovery, development and commercialization of novel drugs for thetreatment of metabolic and liver diseases by targeting the liverand liver pathways, announced today that John Beck, senior vicepresident of finance and chief financial officer of Metabasis willpresent at t...

Ulcerative Colitis (UC) Sufferers Find UC Quite Disruptive to Many Aspects of Daily Life

UC's Overall Psychological Toll Is Greater Than for Asthma,Rheumatoid Arthritis and Migraines WAYNE, Pa., May 17, 2007 /PRNewswire/ -- Nearly three out offour ulcerative colitis (UC) sufferers (73 percent) responding to anew nationwide survey say not feeling well has become a normal partof life. Furthermore, they describe UC as disruptive when it comesto their relationship with a spouse (...

Rigel Ubiquitin Ligase Program Identifies Molecules With Anti-HIV Activity

Rigel Program to be Presented at Keystone Scientific Meeting SOUTH SAN FRANCISCO, Calif., March 27, 2007/PRNewswire-FirstCall/ -- Rigel today announced that YonchuJenkins, Ph.D., Associate Director of Virology, will be presentingon the company's efforts to develop a small molecule therapeutic totreat patients with the Human Immunodeficiency Virus (HIV)infection at the Keystone Symposium i...

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