Protease

HIV Patients May Be at Risk of Heart Problems When Taking Protease Inhibitor Drugs

A widely-used class of drugs that keep the HIV-virus infection from progressing to AIDS may cause serious and potentially lethal heart rhythm disturbances in some patients. The finding of a Mayo Clinic-led investigation appears in the current edition of The Lancet. In collaboration with colleagues from the HIV Program of Hennepin County Medical Center, Minneapolis; the University of Minn...

Protease inhibitors reach beyond HIV

The immunodeficiency that arises in HIV may be due to excessive programmed cell death of immune CD4 T cells. HIV protease inhibitors (PI) can block programmed cell death in virus-infected T cells in vitro, but have also been shown to induce programmed cell death at higher concentrations. The mechanisms for these paradoxical data are unclear, as is whether PI therapy would aid CD4 T cell reconstit...

Protease at Biology Products

Factor Xa Protease from QIAGEN

Description:Efficient 6xHis tag cleavage (greater than 90%)...
Company:QIAGEN

HRV 3C Protease from Novagen

Description:Recombinant type 14 3C protease from human rhinovirus (HRV 3C) is the newest addition to the Novagen brand line of restriction grade proteases. The recombinant protease is a highly purified recombinant 6XHis-fusion protein, which recognizes the same cleavage site as the native enzyme: LeuGluValLeuPheGln/GlyPro. The small, 22 KDa size of the protease, optimal activity at 4° C, high specificity...
Company:Novagen

AcTEV Protease from Invitrogen

Description:AcTEV Protease is an enhanced form of Tobacco Etch Virus (TEV) protease that is highly site-specific, highly active, and significantly more stable than native TEV protease, resulting in long-term activity. AcTEV Protease specifically recognizes a seven amino acid (Glu-Asn-Leu-Tyr-Phe-Gln-Gly, cleaving between Gln and Gly), making it useful for removing affinity tags from fusion proteins (1,2). Fo...
Company:Invitrogen

Protease Inhibitor Cocktail Set I from Calbiochem

Description:...
Company:Calbiochem

Protease at Biology Technology

Fluorometric Protease Assays in the SpectraMax Gemini Microplate Spectrofluorometer: Example Using Caspase3 (MaxLine Application Note #35)

Evelyn McGown, Ph.D. and Anna Lam, B.S. Molecular Devices Corporation, 8/99 Modern assays for proteolytic activity typically use synthetic chromogenic or flu-orogenic peptide substrates. Enzyme selectivity is obtained by choosing a peptide sequence uniquely recognized by the catalytic site of a particular enzy...

A simple and rapid LC-MS/MS method for the simultaneous determination of nine antiretroviral drugs commonly used in Europe (protease Inhibitors and non-nucleoside reverse transcriptase inhibitors)

In clinical research, the monitoring of protease inhibitor (PI) and non-nucleoside reverse transcriptase inhibitor (NNRTI) antiretroviral drugs is of significant interest due to the importance of assessing inter-individual and intra-individual metabolism variability. To be of practical use, it is essential that the analytical method used to mon...

Fluorescence assay for determination of protease activity

VICTOR is a new multitechnology and multilabel counter from Wallac that can me...

Protease at Medicine News

Reducing the Risk of Protease Inhibitor-Related Atherosclerosis

Physiologists may have found a way to decrease the risk of hardening of the arteries that accompanies the long-term use of protease inhibitors//, a class of drugs that has emerged as the most effective treatment against HIV and AIDS. Writing in the American Journal of Physiology–Cell Physiology, researchers from the University of Kentucky found that when mice were given a nucleoside re...

Protease at Medicine Products

ADAMTS13 Activity & Inhibitor (VWF Cleaving Protease)

Description:ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' clients include more than half of the nation's university teaching hospitals and children's hospitals, maj...
Company:ARUP Laboratories

Serine Protease 3 Antibody

Description:ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' clients include more than half of the nation's university teaching hospitals and children's hospitals, maj...
Company:ARUP Laboratories

Protease at Medicine Technology

Preclinical Study Finds Protease Inhibitor-Resistant HIV May Have Reduced Potential to Develop Resistance to Panacos' Bevirimat

WATERTOWN, Mass.--(BUSINESS WIRE)--May 29, 2007 - PanacosPharmaceuticals, Inc. (NASDAQ:PANC), a biotechnology companydedicated to developing the next generation of antiviraltherapeutic products, today announced the results of a new studyindicating that HIV resistant to Protease Inhibitors (PI) may havereduced potential for the development of resistance to the HIVmaturation inhibitor bevirim...

Vertex Pharmaceuticals Announces New Data for Investigational HCV Protease Inhibitor Telaprevir to be Presented at 42nd Annual Meeting of the European Association for the Study of the Liver (EASL)

BARCELONA, Spain--(BUSINESS WIRE)--Apr 11, 2007 - New datasupporting the clinical development of telaprevir (VX-950), one ofthe most advanced investigational oral protease inhibitors for thetreatment of hepatitis C virus (HCV) infection, will be presentedat the 42nd Annual Meeting of the European Association for theStudy of the Liver (EASL) in Barcelona this week. In total, nineabstracts re...