PROFILE

Papers of DNA Pioneer and Nobel Laureate Francis Crick Added to National Library of Medicine’s Profiles in Science Web Site

The National Library of Medicine, a part of the National Institutes of Health, is proud to present an extensive selection from the papers of one of the twentieth century’s greatest scientists, Francis Crick, on its Profiles in Science Web site. Don't miss Crick's This la...

Towards precise classification of cancers based on robust gene functional expression profiles

Chemists say they have identified a gene that appears to play a key role in the development of type 1 diabetes, also known as insulin-dependent or juvenile diabetes, a disease that affects about one million people in the U.S. and is on the rise worldwide. They described their findings, which they say could lead to new drug interventions and possibly gene therapy, today at the 229th national meeti...

High-powered gene profiles provide clues to genes involved in common form of lung cancer

Using technology that makes it possible to zoom in on smaller sections of cell chromosomes than ever before, researchers at Dana-Farber Cancer Institute have identified nearly 100 chromosome regions where genes are either over-copied or missing in non-small cell lung cancer. The findings provide new clues about the location of genes potentially involved in the most common type of lung cancer –?an...

Gene expression profile helps predict chemotherapy response in ovarian cancer patients

A newly identified gene expression profile could help predict how patients with advanced ovarian cancer will respond to chemotherapy treatment. Described in a study in the November 1, 2005 issue of The Journal of Clinical Oncology (JCO), the new findings further establish an important role for microarray gene profiling as a predictor of clinical outcome in ovarian cancer, and could eventually pro...

Study offers innovative profile of enzyme that aids tumor growth

"Using a combination of enzyme activity and metabolite profiling, we determined that this protein-whose function was previously unknown-serves as a key regulator of a lipid signaling network that contributes to cancer," said Benjamin F. Cravatt, a Scripps Research professor and a member of its Skaggs Institute for Chemical Biology who led the study. "The heightened expression of KIAA1363 in sever...

PROFILE at Biology Products

BioProfile Chemistry Analyzer from Nova Biomedical

Description:A key to successful cell culture or fermentation is the ability to monitor nutrient composition during the process, and make rapid adjustments in response to changes in the composition. Nova BioProfile Chemistry Analyzers provide immediate analysis of key nutrients, metabolites, and gases in cell culture and fermentation media. BioProfile analyzers are fully automated, multi-test systems designed...
Company:Nova Biomedical

Customized Profile from Novascreen-a Caliper Life Sciences Company

Description:Compound(s) screened through any number of client selected assays. Client also selects number of concentrations and replicates....
Company:Novascreen-a Caliper Life Sciences Company

Neurological Profile from Novascreen-a Caliper Life Sciences Company

Description:Compound(s) tested through a broad panel of 38 ligand binding and enzyme assays targeting the Central Nervous System. Used to determine selectivity and potential Neurological liabilities of compounds....
Company:Novascreen-a Caliper Life Sciences Company

Gastrointestinal Profile from Novascreen-a Caliper Life Sciences Company

Description:Compound(s) tested through a broad panel of 38 ligand binding and enzyme assays targeting the Central Nervous System. Used to determine selectivity and potential GI liabilities of compounds....
Company:Novascreen-a Caliper Life Sciences Company

Cardiovascular/Renal Profile from Novascreen-a Caliper Life Sciences Company

Description:Compound(s) tested through a broad panel of 38 ligand binding and enzyme assays targeting the Central Nervous System. Used to determine selectivity and potential CV/Renal liabilities of compounds....
Company:Novascreen-a Caliper Life Sciences Company

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PROFILE at Biology Technology

Thermal Cycling Profile for Standard PCR

It is very important to denature the template DNA completely. Initial heating of the PCR mixture for 2 minutes at 9495C is enough to completely denature complex genomic DNA so that the primers can anneal to the template as the reaction mix is cooled. If the template DNA is only par...

PCR Polymerases Application Profiles

Taq DNA polymerase is still the most commonly used thermostable polymerase for PCR today. However, Taq polymerase has serious limitations like the lack of an error-correcting activity and can only be used for amplification of rather short sequenc...

Setting up a kinase profiler with IMAP

By Liz Gaudet, Ph.D., Joyce Itatani, Francisco Ramirez and Annegret Boge, Ph.D. Molecular Devices Corporation, 1311 Orleans Dr., Sunnyvale, CA...

RNAlater Preserves Bacterial Gene Expression Profiles for Array Analysis

Tissue Collection: RNA Stabilization Solution is the worldwide standard for the preservation of RNA in intact animal tissues, organs, and cells. RNA eliminates the need to immediately process tissue samples or to freeze samples in liquid nitrogen for later proces...

Successful stabilization of gene expression profiles

RNA in a biological sample becomes extremely unstable upon collection of the sample, leading to changes in the geneexpression profile. For accurate gene expression analysis in applications such as real-time RT-PCR and microarray analysis,it is important to stabilize the RNA immediately. QIAGEN provides products which enable stabilization and purification ofhig...

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PROFILE at Medicine News

Unfavourable Lipid-Lipoprotein profiles in older adults has been linked to abdominal visceral fat

According to investigators from the Department of Human Services at the University of Virginia, in persons over 60 years of age, elevated levels of abdominal visceral fat are associated with unfavourable plasma concentrations of lipids and lipoproteins. Abdominal fat was also found to be a primary determinant in the release of growth hormone in these individuals. The investigators assessed// plas...

Understanding Gene Profiles Could Help Cure A Resistant Form Of Leukemia In Kids

Researchers have uncovered new genes that may help explain why 20 percent of children diagnosed with acute lymphoblastic leukemia // ( ALL ) are resistant to treatment with chemotherapy drugs. According to researchers chemotherapy cures about 80 percent of ALL cases, but the remaining 20 percent have cancer cells that are resistant to chemotherapy drugs. In order to determine genetic pr...

Personality profiles of gamblers and substance abusers are similar

Individuals suffering from problem gambling behavior may share their personality// profiles with substance abusers like drug addicts and alcoholics. Researchers have been able to identify personality traits of problem gambling behavior in people and have found marked semblance with those of substance abusers. Researchers in their research have pointed out that people who seek help for...

Genetic Profile To Predict Ovarian Cancer Prognosis

A new study appearing in the November 1, 2005 issue of The Journal of Clinical Oncology (JCO), says that a new gene profile may help in predicting how patients with advanced ovarian cancer would respond to aggressive chemotherapy. // In many patients with ovarian cancer, at whatever stage, first grade chemotherapy usually shows an effect in combating the cancer. But, "due to the lingerin...

Lung cancer molecular profile discovered by researchers.

According to a team of researchers an expression pattern of certain microRNA’s heve been found that can predict tumour aggressiveness in lunch cancer patients.// The analysis of these findings indicates that miRNAs may represent a new class of diagnostic and prognostic tools for lung cancer. The Ohio State University Comprehensive Cancer Centre, Columbus, Ohio; the Jikei Univer...

PROFILE at Medicine Products

RM full profile cup

Description:For primary and revision cases...
Company:Mathys AG

ThinProfile Design Eyelid Implants

Description:Thinprofile design eyelid implants....
Company:FCI Ophthalmics Inc.

Lorenz 2.0 mm Low Profile Titanium

Description:Lorenz 2.0 mm titanium system for the midface provides an excellent alternative to lower profile systems in areas of the midface where greater fixation is needed....
Company:Lorenz Surgical (A Biomet Company)

Signa Profile 0.2T

Description:Signa Profile is built on the Signa foundation to deliver speed & image quality....
Company:GE Healthcare

Vasoseal Low Profile kit 1

Description:The VasoSeal Low Profile device is designed for smaller sheath angiography procedures. VasoSeal Low Profile. Seal your arterial punctures with confidence....
Company:Datascope Corp.

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PROFILE at Medicine Technology

Cytogen Presents Phase 1 Data Showing Promising Antitumor Activity and Safety Profile of Quadramet at International Myeloma Workshop

PRINCETON, N.J.--(BUSINESS WIRE)--Jun 28, 2007 - CytogenCorporation (NASDAQ: CYTO) reported updated data from a Phase 1dose escalation study evaluating QUADRAMET(R) (samarium Sm-153lexidronam injection) in combination with bortezomib (Velcade(R),Millennium Pharmaceuticals, Inc.) in patients with relapsedmultiple myeloma. Data from 33 patients were presented today in aposter titled, "Phase 1...

Phase IIIb Clinical Data Validate the Overall and Cardiovascular Safety Profile of Cycloset (A Quick Release Formulation of Bromocriptine Mesylate) in Patients with Type 2 Diabetes

Data Also Support Drug's Efficacy at Improving Glycemic Control andReducing Diabetic Cardiovascular Complications CHICAGO, Ill., June 23, 2007 /PRNewswire/ -- VeroScience, LLC,in conjunction with its commercialization partner S2 Therapeutics,Inc., reported today the results of its Phase IIIb clinical trialsupporting the overall and cardiovascular safety of Cycloset(TM) (Aquick release for...

Kosan Presents Phase 1 Data Showing Promising Antitumor Activity and Safety Profile of Epothilone KOS-1584 at ASCO

HAYWARD, Calif., June 04, 2007 /PRNewswire-FirstCall/ -- KosanBiosciences Incorporated presented data from a Phase 1 clinicaltrial showing that KOS-1584/R1645, an epothilone underco-development with Roche, demonstrated promising antitumoractivity and tolerability in patients with solid tumors.KOS-1584/R1645 showed activity in 32% of patients (13 of 41evaluable) including activity in pati...

Antipsychotic Iloperidone Results Show Favorable Akathisia Profile

SAN DIEGO, May 22, 2007 /PRNewswire-FirstCall/ -- According tostudy results presented today at the 2007 American PsychiatricAssociation annual meeting, iloperidone, an investigationalatypical antipsychotic, was shown to have a favorable akathisiaprofile. Akathisia -- a debilitating sensation of restlessness thatmanifests as an inability to sit still -- is a frequent side effectof antipsy...

Efficacy and Safety Profile of Basilea's Alitretinoin for Severe Refractory Chronic Hand Eczema Confirmed by Data Shown at European Dermatology Congress

BASEL, Switzerland, May 21, 2007 - Results from phase IIIclinical trials and further human pharmacology studies werepresented at the 16th Congress of the European Academy ofDermatology and Venereology (EADV). These data highlighted theefficacy and safety profile of alitretinoin as a potential oncedaily oral treatment for patients with severe refractory chronichand eczema. Currentl...

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