Nano-Probes Allow an Inside Look at Cell Nuclei
Nanotechnology may be in its infancy, but biologists may soon use it to watch the inner workings of a living cell like never before. Scientists at the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) and Lawrence Livermore National Laboratory have developed a way to sneak nano-sized probes inside cell nuclei where they can track life's fundamental processes, such a...Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin
Nano-sized particles embedded with bright, light-emitting molecules have enabled researchers to visualize a tumor more than one centimeter below the skin surface using only infrared light. A team of chemists, bioengineers and medical researchers based at the University of Pennsylvania and the University of Minnesota has lodged fluorescent materials called porphyrins within the surface of a polyme...Products containing specific probes for detecting alternative splice forms protected
ExonHit Therapeutics, today announced the grant of a major patent, US # 6,881,571, by the United States Patent and Trademark Office on microarray products allowing the specific detection of mRNAs produced by alternative splicing, covering microarrays optimised for the discovery of alternative RNA splicing events. The patent protects the probe configuration of a unique set of five oligonucleotides...'Smart' nanoprobes light up disease
Researchers from Rice University's Center for Biological and Environmental Nanotechnology (CBEN) have developed a "smart" beacon hundreds of times smaller than a human cell that is programmed to light up only when activated by specific proteases. Altered expression of particular proteases is a common hallmark of cancer, atherosclerosis, and many other diseases. In the September issue of th...UC Davis researchers use heated nanoprobes to destroy breast cancer cells in mice
In experiments with laboratory mice that bear aggressive human breast cancers, UC Davis researchers have used hot nanoprobes to slow the growth of tumors -- without damage to surrounding healthy tissue. The researchers describe their work in the March issue of the Journal of Nuclear Medicine. "We have demonstrated that the system is feasible in laboratory mice. The next step will be clinic...SYBR Green II RNA gel stain*10,000X concentrate in DMSO* from Molecular Probes (Invitrogen)
Description:is a sensitive nucleic acid gel stain that has bright fluorescence when bound to RNA and low background in gels, making it ideal for use with either formaldehyde/agarose or polyacrylamide gels using laser scanners or standard UV transilluminators. One mL stains 100 minigels. A 500 µL unit size (S-7564) and a special packaging (S-7586) are available....SYBR Green II RNA gel stain*10,000X concentrate in DMSO* from Molecular Probes (Invitrogen)
Description:is a sensitive nucleic acid gel stain that has bright fluorescence when bound to RNA and low background in gels, making it ideal for use with either formaldehyde/agarose or polyacrylamide gels using laser scanners or standard UV transilluminators. 500 µL stains 50 minigels. A 1 mL unit size (S-7568) and a special packaging (S-7586) are available....adenosine 5'-O-(3-thiotriphosphate), BODIPY FL conjugated/tagged from Molecular Probes (Invitrogen)
Description:BODIPY FL ATP-Gamma-S binds to ATP-binding proteins. To create this fluorescent nucleotide the BODIPY FL fluorophore was linked through the Gamma-thiol of ATP-Gamma-S. In addition to its potential use for binding studies the BODIPY FL ATP-Gamma-S thioether is an important new substrate for Fhit a member of the histidine triad superfamily of nucleotide-binding proteins....SlowFade Antifade Kit from Molecular Probes (Invitrogen)
Description:The active ingredient in Molecular Probes. SlowFadeAntifade Kits is 1,4-diazabicyclo[2.2.2]octane (DABCO), which appears to act as a free radical scavenger that extends useful fluorescence emission. Our original SlowFade formulation (S-2828) was designed to reduce the fading rate of fluorescein to almost zero (Figure 1); it does, however, decrease fluorescein.s fluorescence intensity. Because it...New Microarray Labeling Kit for Preparing cDNA Probes
A more reliable and reproducible way to create fluorescently orradioactively labeled cDNA David T. Wong Heidi Davis Darryl Garrison TerryPayette Matt Lundy Kim Kuplent Mary A. Buchanan Joseph A. Sorge Rebecca L. Mullinax Stratagene Phenogenex Nucleic acid micro...RNase Protection Assay (RPA) Using DIG-Labeled RNA Probes
The ribonuclease protection assay (RPA) is a highly sensitiveand specific method for the detection and quantitationof mRNA species. The assay was made possibleby the discovery and characterization of bacteriophageencodedDNA-dependent RNA polymerases (SP6, T7,and T3)....Detection of mRNAs on Cryosections of the Cardiovascular System Using DIG-Labeled RNA Probes
The following protocol was optimized from a protocolusing 35S-labeled RNA probes [1, 2]. In research studies,it enables detection of the expression of rare mRNAs inthe cardiovascular system (e.g., of the proinflammatorycytokine granulocyte macrophage colony stimulating...Prepare siRNA and miRNA Probes in Just 1 Hour
Prepare your probe in less than 1 hour Synthesize high specific activity RNA probes for RPA, Northern, Southern, or in situ hybrid...Rapidly Prepare Probes and Markers for Small RNA Analysis
Ideal for analyzing miRNA, siRNA, and other small RNAs Prepare high specific activity RNA or DNA probes Contains reagents to prepare Decade Markers and single-base </B...New scalpel probes into cancer
A smart scalpel which is able to detect the presence of cancer cells beneath layers skin, blood and muscle have been developed by US researchers. The bottle-top sized microcavity laser developed by the US department of Energy will enable surgeons to operate more accurately on tumours without cutting large amounts of tissue.// This device could detect which cells were cancerou...Obesity And Environmental Chemicals: Research Probes Potential Link
A team of researchers is investigating whether the increasing ubiquity of chemical flame-retardants might be related to the climbing rate of obesity// in the United States. “Environmental chemicals are a possible third component to the obesity epidemic, along with diet and exercise,” says Gale Carey, professor of nutrition and a leader of the research project, along with professor of...Endophotocoagulation Probes Disposable, Single Use
Description:Endoscopic CycloPhotocoagulation (ECP) is a surgical approach to glaucoma management that employs light, endoscopy and visualized laser application. The ciliary body (which produces aqueous humour) is viewed by the surgeon, from the anterior or posterior segment, through the endoscope in real time. The target tissues are easily and accurately identified utilizing endoscopy. This allows discrete t...COAG Bipolar Laparoscopy Probes
Description:ACMI COAG Bipolar Laparoscopy Probes provide 360 of hemostatis, bipolar safety, blunt dissection, irrigation, and suction in one instrument....Corson® Suction-Irrigation Probes
Description:Corson Suction-Irrigation Probes are designed to provide flexibility and reliability in a disposable probe....Diamond Reusable Suction-Irrigation Probes
Description:Diamond Reusable Probed work with all ACMI instrument inserts. Dual trumpet valves provide smooth, effective fingertip control over suction and irrigation....Vaginal Pathogens DNA Direct Probes
Description:ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' clients include more than half of the nation's university teaching hospitals and children's hospitals, maj...