Prion

Fibril Shape Is The Basis Of Prion Strains And Cross-species Prion Infection

New research on prions, the infectious proteins behind "mad cow" disease and Creutzfeld-Jakob disease in humans, suggests that the ability of prions in one species to infect other species depends on the shape of the toxic threadlike fibers produced by the prion. Two studies on the topic appear in the 8 April issue of the journal Cell. Although research suggests that prions from one specie...

Strongest proof yet found for prion hypothesis

UTMB scientists offer strongest evidence yet that infectious misformed proteins cause mad cow disease and other mysterious brain disorders Researchers at the University of Texas Medical Branch at Galveston (UTMB) have produced the strongest proof yet that the mysterious and devastating brain diseases known as "transmissible spongiform encephalopathies" (TSEs) are transmitted by an infecti...

First technology to remove prions that cause vCJD from blood launched

The risk of receiving blood contaminated with variant Creutzfeldt-Jakob (vCJD) prions may no longer be a concern for the thousands of people who require a transfusion. Pall Corporation (NYSE: PLL) announced today the Council of Europe (CE) marking of its Leukotrap® Affinity Prion Reduction Filter System. It is the first and only technology that removes infectious prions that may be the causative...

Research into how prions act in the brain could hold the key to defeating diseases

Scientists at the University of Southampton are continuing their pioneering research into diseases such as Creutzfeld-Jakob Disease (CJD) and related conditions caused by tiny particles known as prions, thanks to a £300,000 grant from the Medical Research Council. So far, there have been 148 deaths from confirmed or probable variant CJD (vCJD) in the UK. This is the human disease thought...

Active Vaccine Prevents Mice From Developing Prion Disease

NYU School of Medicine scientists have created the first active vaccine that can significantly delay and possibly prevent the onset of a brain disease in mice that is similar to mad cow disease. The new findings, published online this week in the journal Neuroscience, could provide a platform for the development of a vaccine to prevent a group of fatal brain diseases caused by unusual infectious...

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Researchers to study fate of prions in wastewater

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Prion

structures. Though their exact mechanisms of action and reproduction are still unknown, it is now co...

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Prion Disease Agent Causes Heart Damage

These findings raise the possibility that heart infection could be a new aspect of prion diseases, including those that affect humans and livestock //, and that these diseases could travel through the blood. The paper is being published on Friday, July 7 in an advanced, online edition of the journal Science. Prion diseases-also known as transmissible spongiform encephalopa...

Role of Hsp 104 in the Spread of Prion Diseases

Protein’s role in the spread of the lethal Prion diseases has been brought to light by researchers from Brown University//. This was published in an online edition of PLoS Biology. Researchers under Tricia Serio have revealed that the protein Hsp 104 is responsible for the spread and multiplication of Prion diseases. This protein breaks up groups of such infectious proteins leading to...

Single Protein Plays A Major Role In Prion Diseases

A single protein plays a major role in deadly prion diseases by smashing up clusters of these infectious proteins,// creating the "seeds" that allow fatal brain illnesses to quickly spread, new Brown University research shows. The findings are exciting, researchers say, because they might reveal a way to control the spread of prions through drug intervention. If a drug could be made th...

Study Finds Prion Proteins in Milk

A study has identified the presence of normal prion proteins in milk from humans, cows, sheep//, and goats. "Prion Protein in Milk" appeared in the December issue of PLoS One, an online journal from the Public Library of Science, available at www.plosone.org. Infectious prion proteins cause transmissible spongiform encephalopathies in many species, including scrapie in sheep....

Vaccine Prevents Prion Disease in Mice

An oral vaccine can prevent mice from developing a brain disease similar to mad cow disease, according to research that will be presented at the American// Academy of Neurology's 59th Annual Meeting in Boston, April 28 – May 5, 2007. Prion diseases, which include scrapie, mad cow disease, and chronic wasting disease, are fatal and there is no treatment or cure. The disease spreads whe...

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