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poxvirus in Medical News

Oklahoma State University researchers make breakthrough against poxviruses

... solved a three-dimensional crystal structure of a poxvirus protein in the act of disarming the IL-18. "We .... "In the future, we can design a drug to stop the poxvirus from blocking the IL-18 protein." As there is c...d international security efforts against potential poxvirus use as bioterrorism. Deng called the finding a...

JCI online early table of contents: April 8, 2008

... immune molecule TLR9 is crucial to prevent lethal poxvirus infection in mice Smallpox is caused by infect...ective immune responses against infection with the poxvirus that causes mousepox ectromelia virus (ECTV). Ind... normal mice. By contrast, the strongly attenuated poxvirus modified vaccinia virus Ankara (MVA) induced both ...

Researchers uncover more about how poxviruses evade the immune system

...its name implies, the protein literally binds to interferon-gamma and immobilizes it, preventing it from marshalling the immune systems defenses. The poxvirus is then able to replicate and cause immense damage. The research describes how interferon-gamma binding protein looks and behaves on the molecular...

How to design a cancer-killing virus

... have described the development of a new virotherapuetic with antitumor effects in both mice and rabbits. After selecting a highly potent strain of poxvirus that was able to traffic to tumors when administered intravenously to mice the authors engineered the virus such that it would target only specific ca...

JCI table of contents: Oct. 25, 2007

... have described the development of a new virotherapuetic with antitumor effects in both mice and rabbits. After selecting a highly potent strain of poxvirus that was able to traffic to tumors when administered intravenously to mice the authors engineered the virus such that it would target only specific ca...

Penn Researchers Throw Light on the Structure Of Smallpox Virus Protein

...percoiled DNA when it binds to specific DNA sequences. The structure of the poxvirus topoisomerase-DNA complex provides some important clues about how this reco...poisomerase-DNA complex will also facilitate the design of agents to combat poxvirus infections. Topoisomerases are some of the most widely targeted proteins by...

Structure of DNA-modifying enzyme In Small Pox Determined

...percoiled DNA when it binds to specific DNA sequences. The structure of the poxvirus topoisomerase-DNA complex provides some important clues about how this reco...poisomerase-DNA complex will also facilitate the design of agents to combat poxvirus infections. Topoisomerases are some of the most widely targeted proteins by...
poxvirus in Medical Technology

Jennerex Completes the Treatment of First Patient Cohort in Phase 1 Trial With Intravenous Delivery of JX-594 Oncolytic Virus

...ation, cancer cell destruction, release and spread is then repeated. Normal cells are not affected by JX-594 resulting in safety and tolerability. The poxvirus strain backbone of JX-594 has been used safely in millions of people as part of a worldwide vaccination program. This strain naturally targets cancer ...

AlphaVax Continues to Expand the Use of Its Vaccine Platform

...l be presented by Dr. Kurt Kamrud, Director of Discovery Research at AlphaVax and the Principal Investigator on both grants, at the XVII International poxvirus and Iridovirus Conference in Grainau, Germany on June 7-12th, 2008. "The work completed under the NIAID grant to date is an excellent demonstration ...

Albemarle Optimizes Smallpox Drug Candidate for SIGA

... the environment, but it is considered a formidable bio-warfare threat. SIGA's ST-246 has shown evidence of safety and high levels of efficacy against poxvirus disease in multiple animal trials, as well as continued success in human safety studies. As a result of success in early trials and in one emergency...

GeoVax Labs, Inc. Comments on Discontinuance of Merck's HIV Vaccine Trial

...ntract into a state called "central memory" from which they rapidly expand to fight the appearance of HIV. Merck's vaccines use adenovirus instead of poxvirus vectors. Adenovirus vectors provide more prolonged AIDS virus antigen exposure than the GeoVax poxvirus vectors. Prolonged antigen exposure affects th...
poxvirus in Medical Dictionary

Molluscum contagiosum

...cience of medicine and surgery related to ... Molluscum contagiosum does not affect ... Molluscum contagiosum is a disease caused by a poxvirus of the Molluscipox virus ... Molluscum contagiosum virus (MCV) can be found worldwide with a higher ... Learn molluscum contagiosum ca...
poxvirus in Biological News

Ugandan monkeys harbor evidence of infection with unknown poxvirus

Researchers report this month that red colobus monkeys in a park in western Uganda have been exposed to an unknown orthopoxvirus, a pathogen related to the viruses that cause smallpox, monkeypox and cowpox. Most of the monkeys screened harbor antibodies to a virus that is similar but not identica...

Cancer drug slows poxvirus in mice

Mice given a relatively new cancer drug can survive an otherwise lethal dose of vaccinia virus, a relative of smallpox virus, report scientists supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. The findings, say the investigat...

Poxvirus potency uncovered in new atomic map

...during the evolution of the poxvirus, it captured an IFN-y gene from its host and incorporated some of the protein structure into its own. As a result poxvirus has a very efficient blocker of the IFN-y antiviral response, Walter said. The new study shows this blocking ability through crystallography, the s...

New molecular clock from LLNL and CDC indicates smallpox evolved earlier than believed

...ion between LLNLs Pathogen Bioinformatics group and the CDCs Sequencing and poxvirus groups took place under a Memorandum of Understanding between the Laborator...aid corresponding author Inger Damon, M.D., Ph.D., acting chief of the CDCs poxvirus and Rabies Branch. It shows the delineation of tantalizing potential connec...

Virus has 'catastrophic' affect on red squirrels, research shows

...red squirrels. The research shows that squirrel poxvirus is threatening to wipe out red squirrels in some o...l numbers of greys that may come in. Squirrel poxvirus is passed to reds by grey squirrels, and probably ...e severity and debilitating nature of the squirrel poxvirus disease on red squirrels. "Given that the gre...

Novel virus entry mechanism could lead to new drugs against poxviruses

...caused a non-fusogenic disruption of the virus outer envelope, allowing the poxvirus to enter the cell. As well as discovering how the double membrane probl... the researchers demonstrated that polyionic compounds can be used to treat poxvirus infections, even days after infection has started. Disrupting the outer mem...

Protein finding could lead to treatment for inflammatory diseases

... A protein that undesirably shields a skin poxvirus from the immune system may become the key ingredient in a new topical treatment for inflammatory diseases, say medical researchers at the University o...

Researchers develop new testing methods for potential monkeypox or smallpox outbreak

...ka. "In a previous study, we predicted that about 50 percent of previously vaccinated people would maintain fully protective immunity against virulent poxvirus infections, and these findings are totally in line with what we expected. What this means is that there are more than 100 million people in the U.S. t...

'EuroVacc 02' HIV Vaccine Trial Begins

...lts from recent pre-clinical studies in non-human primates conducted by EuroVacc suggest that the use of the DNA as prime followed by a boost based on poxvirus (NYVAC in this trial) induces stronger immune responses than either vaccine alone. ...
poxvirus in Biological Technology

Nature Reviews Publishes Article About Jennerex's Multi-Mechanistic Cancer Therapeutic

... cells are left unharmed. The Phase 1 study results were recently published in prestigious journals Lancet Oncology and Molecular Therapy. The poxvirus strain backbone of Jennerex's cancer therapeutics have been used safely in millions of people as part of a worldwide vaccination program against small...

Jennerex Completes $8.3 Million Series B Financing and Appoints Dr. Cal Stiller as Director

...ation, cancer cell destruction, release and spread is then repeated. Normal cells are not affected by JX-594 resulting in safety and tolerability. The poxvirus strain backbone of JX-594 has been used safely in millions of people as part of a worldwide vaccination program. This strain naturally targets cancer ...
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