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potentiation in Medical News

Generation of a severe memory-deficit mutant mouse by exclusively eliminating the kinase activity of CaMKIIalpha

... alpha, and examined the effects on structural, functional, and behavioral expression of synaptic memory. In the K42R brain, tetanus-induced long-term potentiation (LTP), a proposed cellular mechanism of memory, and sustained postsynaptic spine enlargement, a structural basis for LTP, were both impaired, whereas ...

Cancer-causing virus associated with higher risk of new HIV infection

...uamous cell cancer. This study points to another important means by which HPV infection may be associated with morbidity and mortality, i.e., through potentiation of HIV infection. A direct role for HPV in this process will need to be confirmed in additional studies, and additional studies will be needed to und...

What Moms Learned May Be Passed to Offspring

...rly short period of time unlocks an otherwise dormant biochemical and control mechanism that boosts a cellular process in nerve cells called long-term potentiation (LTP), which is believed to be involved in learning and memory. "This is the first study to demonstrate an inheritance of a change in a signaling p...

Cocaine addiction linked to voluntary drug use and cellular memory, UCSF study shows

...own as the ventral tegmental area (VTA). In rats that self-administered cocaine, the increase in neuronal communication called long-term synaptic potentiation (LTP) was similar to those that had self-administered food or sucrose, but with a critical distinction. The increase in LTP due to cocaine persisted ...

Hebrew University research on octopuses sheds light on memory

...vered that an area in the octopus brain that was known to be important for learning and memory showed a robust, activity-dependent, long-term synaptic potentiation (LTP) a process which is strikingly similar to that discovered in vertebrate brains. This LTP process accelerates the transformation of information...

Combination of 2 novel anti-cancer agents may help fight CML resistant to current therapy

... of Hematology, which appeared online May 27. Further, Grant said that the interaction between these agents may occur at multiple levels, including potentiation of Bcr/Abl inhibition as well as enhanced disruption of aurora kinase and mitosis. In addition, the group demonstrated that vorinostat-mediated up-reg...

Pain receptor in brain may be linked to learning and memory

...es lasting changes in the connections between neurons. These changes in the brain and the related process of neural reorganization known as long-term potentiation are believed to be the cellular basis for memory making. Weve known that TRPV1 receptors are in the brain, but this is some of the first evidence ...

Brain Cells More Powerful Than You Think

...dently," Svoboda said, so that long-term electrical activation ("potentiation") of one synapse didn't directly affect a neighboring synapse. Long-term potentiation is, in essence, the key cellular step in how the brain lays down memory. However, computer models had suggested that activation at one synapse migh...

Southern Research Institute's Neurodegenerative Disease Drug Discovery Program Receives National Institute of Mental Health Funding

...eral indications that the NF-kB signaling system plays a role in neuronal resilience and in the changes induced by cellular learning such as long term potentiation and depression. Several reports have shown that knocking out NF-kB activity in the brain causes sensitization to toxic stimuli, such as beta-amyloid, ...

Memory Loss Linked to Cognitive Disorders

...erlie memory thus linking memory loss to cognitive disorders. Earlier studies have established that a physiological effect known as long-term potentiation (LTP) encodes everyday forms of memory. In neuroscience, LTP is an increase in the strength of a chemical synapse that lasts from minutes to s...
potentiation in Medical Technology

New Data for XL880, XL647 and XL184 to Be Presented at AACR-NCI-EORTC

... #B248) Preclinical Abstracts -- XL820 inhibits mutated forms of KIT associated with drug resistance (Abstract #B237) -- In vitro and in vivo potentiation of cytotoxic therapy by XL844, an orally bioavailable inhibitor of Chk1 and Chk2 (Abstract #B228) -- XL518, a Potent Selective Orally Bioavailabl...
potentiation in Medical Definition

Depolarization-induced suppression of inhibition

...al process mediated by the endocannabinoids, and may contribute to many forms of cortical plasticity and synaptic strengthening, such as in long-term potentiation (Carlson et al. 2002). A note on DSE While working with the cerebellum, Kreitzer's group also discovered that depolarization of Purkinj...

Medical procedure

...ervical conization Chemotherapy Cytoluminescent therapy Insulin potentiation therapy Low-dose chemotherapy Monoclonal antibody therapy Photo...py Monoclonal antibody therapy Oral rehydration therapy Insulin potentiation therapy Surgical Stereotactic surgery Radiosurgery ...
potentiation in Medical Dictionary

Histamine

...east cancer is unclarified. ... Histamine H3-Receptor. A. Distribution and Function. B. H3-Receptor ... V. Other Responses to Histamine . A. potentiation of Responses to N-Methyl-D-Aspartate ... ...
potentiation in Biological News

Neuroscientists discover long-term potentiation in the olfactory bulb

CLEVELAND May 3, 2009 Ben W. Strowbridge, Ph.D, associate professor of Neuroscience and Physiology/Biophysics, and Yuan Gao, a Ph.D. student in the neurosciences program at Case Western Reserve University School of Medicine, are the first to discover a form of synaptic memory in the olfactory bul...

Building memories with actin

... Memories aren't made of actin filaments. But their assembly is crucial for long-term potentiation (LTP), an increase in synapse sensitivity that researchers think helps to lay down memories. In the July 13, 2009 issue of the Journal of Cell Biolog...

Mitochondria could be a target for therapeutic strategy for Alzheimer's disease patients

...atly improved the learning, memory, and synaptic function of an Alzheimer's disease mouse model and alleviated Aβ-mediated reduction of long term potentiation (LTP). Thus, the CypD/Aβ-mediated mitochondrial permeability transition pore directly links to the cellular and synaptic perturbation relevant to...

Astrocytes and synaptic plasticity

...tic transmission to affect processes such as learning and memory, say Bergami et al. The major cellular events of learning and memory are long-term potentiation (LTP) and long-term depression (LTD), both of which affect neurons' ability to communicate with one another. Neurons that have undergone LTP display a...

Paradigm shift in Alzheimers's research: new treatments

...tion in brain and spinal cord23. At six months of age already a 33% CA1 neuron loss in the hippocampus, together with a drastic reduction of long-term potentiation was observed24. CA1 neuron loss in these mice is likely to contribute to the working memory deficits and complete loss of synaptic plasticity (long...

UCI researchers restore memory process in most common form of mental disability

...ory deficits, Lauterborn said. In their study, the researchers reported how the loss of a functional Fmr1 gene impaired a process called long-term potentiation (LTP) in the hippocampus region of the brain where memories are created and stored. LTP describes a chemical process that literally strengthens a syna...

Hearts of male and female rainbow trout are different

...oxygenated and hypoxic conditions. The researchers measured several indices of contractile performance (resting tension, twitch force, post-rest potentiation and other variables. Frozen samples of ventricle tissue were homogenized and assayed for citrate concentration. Ventricle rings were processed, sectio...

New Brandeis research sheds light on memory by erasing it

...d CaMKII as a memory molecule." The research involved electrically stimulating neuronal synapses to strengthen them, a process known as long-term potentiation (LTP). This process has served as a model system for studying memory. CaMKII has been a leading candidate as a memory molecule because it is persisten...

Drug treatment improves learning in mice with Down syndrome symptoms, Stanford/Packard study shows

...general terms, once a threshold of activating signals has been achieved, a neuron becomes permanently more sensitive to excitation. Although long-term potentiation has been shown to be impaired or absent in the brains of Down syndrome mice, postdoctoral scholar Wade Morishita, PhD, who works in the Stanford labor...

A natural chemical found in strawberries boosts memory in healthy mice

...e stored in the brain by strengthening connections between neurons. "We wanted to find out whether we could detect any effects of fisetin on long-term potentiation and the formation of memories in animals," Maher recalls. Since the hippocampus plays an important role in establishing new memories, Maher, and c...
potentiation in Biological Technology

Keryx Biopharmaceuticals Presents Encouraging Preclinical Data at Annual Meeting of the American Association of Cancer Research

...OR signaling pathway. The following abstract was presented yesterday: Abstract 2822: Evidence implicating Bim activation/induction in potentiation of PI3K/Akt inhibitor-mediated apoptosis in human leukemia cells Author(s): Mohamed Rahmani, Anh Anderson, Joseph Reza Habibi, Timothy Ryan Crabt...

GlaxoSmithKline and Mpex Pharmaceuticals Form Alliance to Develop Novel Efflux Pump Inhibitors for Use Against Serious Gram-Negative Infections

...c pipeline. Mpex has a first rate entrepreneurial R&D team with deep experience in antibacterial research and has validated efflux pump inhibition for potentiation of antibacterial activity, as well as expanding the spectrum of bacterial susceptibility. I look forward to having a great synergy in this important a...

JCI table of contents: Dec. 3, 2007

...ther by a drug or continual gentle handling) of 24 hours in mice, long-term potentiation of the synapses between hypocretin/orexin neurons was detected. The authors... University of Wisconsin, Madison, suggest that This increase in [long-term potentiation of the synapses between hypocretin/orexin neurons] may be one of the mechan...

Amarin Announces Publication of Pre-Clinical Memory Data in Journal of Neurochemistry

...d and beta amyloid-induced impairment of Long Term potentiation (LTP). LTP is a phenomenon considered an important... by year-end." About the Role of EPA in Long-Term potentiation (LTP), Age Associated Memory Impairment (AAMI) and...nt on analysis of age-related changes in long-term potentiation (LTP) in the hippocampus. Further, these findings...

Gene-Specific Primers for NMDA Receptor Subunits

...3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as kainate/AMPA receptors (K/AMPAR). The NMDAR assumes a critical role in long-term potentiation (LTP), a putative cellular substrate of memory. 1 This receptor has also been linked to neuronal development and has been implicated in several d...

Antibodies for Studying NMDA Receptor Protein Expression and Synapse-Specific Immunolabeling

...o-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as kainate/AMPA receptors (K/AMPAR). The NMDAR plays a critical role in long-term potentiation (LTP), a putative cellular substrate of memory. 1 This receptor has also been linked to conditions involving injury neurotoxicity and in patholog...
potentiation in Biological Definition

Long-term potentiation

In neuroscience , long-term potentiation ( LTP ) is the strengthening (or potentiation ) of the connection between two nerve cells which lasts for an extended period of time (minutes to hours in vitro and hours to days and months in vivo ). LTP can be induced experimentally by applyin...

Apoptosis

...e worm people" began to publish their celebrated findings. In 1964 Richard A. Lockshin and Carroll Williams published their contribution on "Endocrine potentiation of the breakdown of the intersegmental muscles of silkmoths" in the Journal of insect physiology (10 p. 643), where they used the concept of "progr...

Memory

... specific brain regions. Learning and memory are attributed to changes in neuronal synapses . Related topics Amnesia Long-term potentiation Hebbian learning The Memory-Prediction Framework- An Acclaimed Unifying Theory of Memory Mnemonic Muscle memory or proprioceptio...
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