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postmortem in Medical News

Stress may cause the brain to become disconnected

...maging studies. These studies have the ability to raise important questions about brain structure in a general sense, but we still rely on studies of postmortem human tissue and animal research to determine the specific nature of neural changes," explains Dr. John Krystal, Editor of Biological Psychiatry and a...

Two Scientists Honored with MetLife Foundation Awards for Medical Research in Alzheimer's Disease

...eing honored for his work on the histopathology and protein biochemistry of postmortem human brains with Alzheimer's, which has led to the establishment of cellul...isciplinary approaches, based on histopathology and protein biochemistry of postmortem human brains. He has extended the knowledge derived from the human studies ...

Analysis of alcoholics' brains suggests treatment target

...t target, he said. If it shows up later, it could be from the toxic effects of alcohol. We need to further define its role. The researchers studied postmortem brain tissue samples from 14 male chronic alcoholics and 14 age-matched male individuals with no history of alcohol abuse. The samples were from the s...

Autism's origins: Mother's antibody production may affect fetal brain

... of autism. Mostly anecdotal past evidence of immune system involvement has emerged from unusual antibody levels in some autistic children and from postmortem brain tissue studies showing immune abnormalities in areas of the brain. Antibodies are proteins the body makes in response to viruses and bacteria or...

Chemical signature of manic depression discovered by scientists

...alth in the US, hope that their research will enable a better understanding of the condition and of how it can be treated. The researchers compared postmortem brain tissue samples of people with manic depression with those of age and gender matched controls. The samples were taken from the dorsolateral prefr...

Terriers Join Fight Against a Killer Disease in Humans

...e epidemiological -- studying disease prevalence and gathering a core of dogs and their owners that researchers might follow going forward. Getting postmortem samples of canine lung tissue will also be crucial to a better understanding of the causes of the disease, Corcoran said. But that has its own challe...

Martek Announces Third Quarter 2007 Financial Results

...omposition of the orbitofrontal cortex and found a selective deficit in the level of DHA compared with controls in brain examinations of postmortem patients who had been diagnosed with major depression compared with controls. These findings add to the growing body of evidence showing...

Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinson's symptoms

... of the dopamine." "The dogma in the field is that Parkinson's disease involves a selective loss of dopamine neurons. The truth is, if you look at postmortem Parkinson's disease brains, you will see that both dopamine and norepinephrine neurons are gone," Dr. Weinshenker explains. "We know that norepinephri...

No Avian Flu In West Bengal And Kerala

...uty Director (AH) reached the farm on 07.05.07. The dead birds found at site were buried under the supervision of the team following proper procedure. postmortem revealed Newcastle disease (Ranikhet) with Infectious Bursal Disease (IBD) (Gumboro). Samples were sent to HSADL, Bhopal, which have been tested negat...

Brain Inflammation A Friend for Alzheimer's Patients

...mmation plays a potentially negative role in Alzheimers disease, said OBanion. But much of the evidence comes from experiments with cells in a dish or postmortem human tissue, not from living organisms in which disease progression is closely monitored. People have talked for a long time about a balance ...
postmortem in Medical Technology

Michael J. Fox Foundation Commits up to $6.5 Million in Funding for Critical Challenges in Parkinson's Disease

...logical correlates of Parkinson's disease using extensive clinical data and postmortem tissue from normal control, PD and related disease subjects. Applicants wil...g MJFF grantee that has developed an exceptional bank of well-characterized postmortem tissue and associated clinical data. Understanding LRRK2 Biology ...

Adlyfe Study on the Detection of Misfolded Proteins Published in the Journal Transfusion

...ins in the blood, especially during early disease stages. These challenges have largely restricted diagnostic tests for amyloid diseases to the use of postmortem tissue. Adlyfe's novel technology is based on the synthesis of conformationally sensitive peptides (chains of amino acids that are smaller than prote...
postmortem in Medical Dictionary

Pallor

...m pallere "be pale," related to pallus " ... Pallor is not usually clinically significant unless it is accompanied by a ... Pallor mortis is a postmortem paleness which happens in those with light skin ... Pallor . You don't need to be Editor-In-Chief to add or edit content to WikiDoc. ... Cl...

Autopsy

... in Texas was ... 2 Official findings of the autopsy . 2.1 The gunshot wound in the back ... An authentic detailed narrative account of a routine postmortem examination ( autopsy ) as performed by a pathologist on a patient who has died in hospital. Online Medical Dictionary and glossary with medical d...
postmortem in Biological News

Flow of potassium into cells implicated in schizophrenia

...s potential role in sustaining the type of neuronal firing that supports the higher mental functions disturbed in schizophrenia. Spurred by hints from postmortem studies of genetic variation linked to schizophrenia in the genomic neighborhood of KCNH2, the researchers analyzed the gene's association with the il...

Altered gene can increase risk of schizophrenia

...a dramatic increase in gene expression in one variant over the others. These results echo the increased expression of NOS1AP that has been observed in postmortem brain samples from individuals with schizophrenia. Bonnie Firestein, a professor in Rutgers' Department of Cell Biology and Neuroscience, though no...

Algorithm finds the network -- for genes or the Internet

...een collaborating with scientists in the Washington University School of Medicine and Scripps Institute in La Jolla, California, to study roughly 30 postmortem brain samples of people who died from Alzheimers disease. Im interested in modeling gene expression perturbation in diseased brains, and am looki...

Entomological Society announces 2007 award winners

...s on how photoperiod and light intensity affect development rates of some forensically-important blow flies for increased accuracy when estimating the postmortem interval (PMI). His background is in medical and veterinary entomology, and he is currently a Board Certified Entomology-Intern with medical/veterinar...

Brain inflammation may be friend, not foe, for Alzheimer's patients

...ion plays a potentially negative role in Alzheimer’s disease,” said O’Banion. “But much of the evidence comes from experiments with cells in a dish or postmortem human tissue, not from living organisms in which disease progression is closely monitored. “People have talked for a long time about a balance of...

Brain tissue reveals possible genetic trigger for schizophrenia

... mechanism involved in the development of schizophrenia. In studying the postmortem brain tissue of adults who had been diagnosed with schizophrenia, the resea...As may disconnect, thus allowing protein expression to resume. Using postmortem prefrontal cortical brain tissue of people with schizophrenia and persons w...

Protein 'fingerprint' in spinal fluid could spot Alzheimer's disease

...ophisticated proteomic methods to hone in on a group of cerebrospinal fluid biomarkers that are specific to autopsy-proven Alzheimer's disease. Those postmortem tests confirmed that the panel is over 90 percent sensitive in identifying people with Alzheimer's disease," says Kelvin Lee, the Samuel C. and Nancy ...

How the US drug safety system should be changed

...s needed for nonregulatory tasks that are not within the mission of the FDA. Since many of these tasks are academic in nature ?for example, performing postmortem examinations in the event of drug disasters or developing new pharmacoepidemiological methods ?he suggests that the Agency for Healthcare Research and...

Autistic brain has fewer neurons for processing emotion

...unted and measured neurons in the amygdala of nine postmortem autistic male brains and 10 age-matched male postmortem non-autistic brains. Ages ranged from 10 to 44 years old. Unlike previous postmortem studies, the sample excluded brains of individuals...
postmortem in Biological Technology

Evaluation of RNA isolated from human tissues: quality control for surgical and postmortem samples

James F. Eliason, Ph.D., Asterand plc Introduction The path to identification of new and improved drugs for the treatment of human diseases often begins with the identification of novel gene targets through RNA expression analysis. Most high thro...

Laser dissection of depression

...d Dutch researchers in Amsterdam have collaborated using for the first time a combination of new elegant methodology in Depression research. They used postmortem human brain tissue that was donated to the Netherlands Brain Bank for research purposes and investigated a region in the basal part of the brain, the ...

The Bio-Rad Silver Stain, Rev E

...man breast tumors: optimal migration conditions, Clin Chem 30, 19471949 (1984) 62. Narayan RK, Proteins in normal, irradiated, and postmortem human brain quantitatively compared by using two-dimensional gel electrophoresis, Clin Chem 30, 19891995 (1984) 63. Nee...

Quantitation of GAD67 Gene Expression in Prefrontal Cortex of Schizophrenia Patients Using the iCycler iQ Detection System and Molecular Beacons, Rev A

...sis of results from in vivo imaging and postmortem studies (Lewis et al. 1999) also suggests ...on in dorsolateral prefrontal cortex of postmortem specimens from chronically ill elderly ...ia patients to normal controls matched for age and postmortem interval (PMI). Real-time PCR* was appl...

Delivery of pCMV-S DNA Using the Helios Gene Gun System Is Superior to Intramuscular Injection in Balb/c Mice

...V-S DNA vaccination each at weeks 0 and 2 by either gene gun or intramuscular delivery. Antisera were then obtained at week 4 by postmortem cardiac puncture. In the second experiment, the duration and degree of antibody response generated following two gene gun vaccina...

RNArticles: Keeping RNA Intact Prior to RNA Isolation - RNAlater

...les derived from nasal swabs, postmortem tissue, and finely dissected ... such studies. postmortem Tissue De Paepe ME, Mao Q, Huang C, Zhu D, Jackson CL, Hanson K (2002) postmortem RNA and protein stability in ...
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