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Polymerase in Medical News
Biologist finds plant polymerases IV and V are really variants of Polymerase II
It's a little like finding out that Superman is actually Clark Kent. A team of biologists at Washington University in St. Louis has discovered that two vital cellular components, nuclear RNA Polymerases IV and V (Pol IV and V), found only in plants, are actually specialized forms ...New test for safer biomedical research results
...ailable commercial mycoplasma tests. McCT results are reproducible to 99.6 percent. The method is based on multiplication of specific DNA sequences by polymerase chain reaction and subsequent detection of the multiplied DNA regions. A special advantage of the new test is that it can be carried out on a high-thr...Urine Test for Chlamydia Shown Effective in Men
...dia infection is diagnosed by nucleic acid amplification tests, such as the polymerase chain reaction. But these tests are expensive, technically complex and can ... fast and accurate results in women. The new study compared the test to the polymerase chain reaction test using urine samples from more than 1,200 men, ages 16 t...Abbott Reports Strong Second Quarter Results; Confirms Double-Digit Earnings Growth Outlook for 2009
... Abbott's broad-based hepatitis C program includes our partnership with Enanta Pharmaceuticals to develop protease inhibitors, as well as our internal polymerase inhibitor program. Our compounds in development have the potential to shorten treatment duration, improve tolerability and increase cure rates. Abbott...New Report Just Published: World Hepatitis C Virus And Therapeutics Market Report
...r and Boceprevir II-7 Telaprevir and Boceprevir - A Comparison II-8 polymerase Inhibitors (PLIs) - Adding More Teeth to HCV Pipeline II-8 Viral Polymerases II-8 polymerase Inhibitor Drugs in Pipeline by Company, Category, and Development Stage......candidate from two series of purine analogs for the treatment of chronic hepatitis C virus (HCV) infection. PSI-938 is a proprietary nucleotide analog polymerase inhibitor of HCV that is being advanced into studies required for submission of an Investigational New Drug (IND) application with the FDA or equivale...
Polymerase in Medical Technology
Start of trial triggers $10 million milestone payment to Pharmasset
PRINCETON, N.J., April 24 /PRNewswire-FirstCall/ -- Pharmasset, Inc. (Nasdaq: VRUS ) and Roche (Roche SWX: RO, ROG; Pink Sheets: RHHBY) today announced that the first patient has been dosed in a Phase IIb study of R7128, th...
- Roche progresses R1626 into phase IIb study, called POLI 1 - BOSTON, Nov. 2 /PRNewswire/ -- R1626, one of Roche's new investigational drugs for chronic hepatitis C virus (HCV) infection, has shown promising antiviral activity when given in combination with PEGASYS(R) (peginterferon alfa...
REDWOOD CITY, Calif., May 02, 2007 /PRNewswire-FirstCall/ -- Genelabs Technologies, Inc. announced today that a presentation was made today at the 20th International Conference on Antiviral Research being held in Palm Springs, California, on a non-nucleoside hepatitis C virus (HCV) polymerase inhi...
... (HCV). PSI-7851 is a second generation nucleotide polymerase inhibitor of HCV. PSI-7851 Phase 1 Multip...tent than Pharmasset's first generation nucleoside polymerase inhibitor, RG7128 (formerly known as R7128). In v... which act as alternative substrates for the viral polymerase thus inhibiting viral replication. We currently ha...
...hich support the potential for IDX184 to be a best-in-class nucleoside/tide polymerase inhibitor with demonstrated antiviral activity and tolerability, coupled wi...gational new drug applications in the coming months from our non-nucleoside polymerase inhibitor and protease inhibitor programs, we are closer to achieving our u...
...ely licensed by SEQUENOM and known as the AttoSense(TM) HPV assay). Utilizing SEQUENOM's proprietary MassARRAY((R)) system that couples standard polymerase chain reaction (PCR) techniques with mass spectrometry (PCR-MS), study samples were simultaneously screened, genotyped and quantified for each of 13 H...
- Roche progresses R1626 into phase IIb study, called POLI 1 - BOSTON, Nov. 2 /PRNewswire/ -- R1626, one of Roche's new investigational drugs for chronic hepatitis C virus (HCV) infection, has shown promising antiviral activity when given in combination with PEGASYS(R) (peginterferon alfa...
REDWOOD CITY, Calif., May 02, 2007 /PRNewswire-FirstCall/ -- Genelabs Technologies, Inc. announced today that a presentation was made today at the 20th International Conference on Antiviral Research being held in Palm Springs, California, on a non-nucleoside hepatitis C virus (HCV) polymerase inhi...
... (HCV). PSI-7851 is a second generation nucleotide polymerase inhibitor of HCV. PSI-7851 Phase 1 Multip...tent than Pharmasset's first generation nucleoside polymerase inhibitor, RG7128 (formerly known as R7128). In v... which act as alternative substrates for the viral polymerase thus inhibiting viral replication. We currently ha...
...hich support the potential for IDX184 to be a best-in-class nucleoside/tide polymerase inhibitor with demonstrated antiviral activity and tolerability, coupled wi...gational new drug applications in the coming months from our non-nucleoside polymerase inhibitor and protease inhibitor programs, we are closer to achieving our u...
...ely licensed by SEQUENOM and known as the AttoSense(TM) HPV assay). Utilizing SEQUENOM's proprietary MassARRAY((R)) system that couples standard polymerase chain reaction (PCR) techniques with mass spectrometry (PCR-MS), study samples were simultaneously screened, genotyped and quantified for each of 13 H...
Polymerase in Medical Products
Description:... Next-generation real-time polymerase chain reaction (PCR) testing for clinical laboratories.
The COBAS TaqMan 48 Analyzer allows automated real-time amplification and detection of ...
Company:Roche Diagnostics
Description:...amplification. It is based on the principle that only primers whose sequence is completely complementary to a target sequence will be converted by the polymerase into PCR products. In contrast, non-complementary primers produce no amplification product. Using the Biotest SSP Kit Systems, reliable typing results...
Company:Biotest
Description:...amplification. It is based on the principle that only primers whose sequence is completely complementary to a target sequence will be converted by the polymerase into PCR products. In contrast, non-complementary primers produce no amplification product. Using the Biotest SSP Kit Systems, reliable typing results...
Company:Biotest
Company:Roche Molecular Systems, Inc.
Description:... The HSV Non-Typing ASR contains primers and a FAM-labeled probe that is designed to detect a 92 bp region of the HSV Type 1 and Type 2 polymerase gene. This ASR requires an instrument that can detect a FAM reporter dye like the Cepheid SmartCycler System. The Cepheid Analyte Specific Reagent* (...
Company:Cepheid
Company:Applied Biosystems
Company:Roche Diagnostics
Description:...amplification. It is based on the principle that only primers whose sequence is completely complementary to a target sequence will be converted by the polymerase into PCR products. In contrast, non-complementary primers produce no amplification product. Using the Biotest SSP Kit Systems, reliable typing results...
Company:Biotest
Description:...amplification. It is based on the principle that only primers whose sequence is completely complementary to a target sequence will be converted by the polymerase into PCR products. In contrast, non-complementary primers produce no amplification product. Using the Biotest SSP Kit Systems, reliable typing results...
Company:Biotest
TaqScreen West Nile Virus Test
Description:... Roches patented polymerase chain reaction (PCR) technology, the worlds leading nucleic acid amplification technology, is an essential component of Roches blood screening assays ...Company:Roche Molecular Systems, Inc.
Description:... The HSV Non-Typing ASR contains primers and a FAM-labeled probe that is designed to detect a 92 bp region of the HSV Type 1 and Type 2 polymerase gene. This ASR requires an instrument that can detect a FAM reporter dye like the Cepheid SmartCycler System. The Cepheid Analyte Specific Reagent* (...
Company:Cepheid
Applied Biosystems 2720 Thermal Cycler
Description:...nywhere. And because its cooling vents are in the back, you can safely place it in tight spaces to save valuable bench space. Practice of the patented polymerase chain reaction (PCR) process requires a license. The Applied Biosystems 2720 Thermal Cycler is an Authorized Thermal Cycler for PCR and may be used wi...Company:Applied Biosystems
Polymerase in Biological News
New RNA polymerase discovered in plants
Biologists at Washington University in St. Louis have discovered an entirely new cellular "machine" in plants that plays a significant role in plant flowering and DNA methylation, a key chemical process essential for an organism's development. A team headed by Craig Pikaard, Ph, D., Washington U...Faster, more cost-effective DNA test for crime scenes, disease diagnosis
... Scientists in Japan are reporting development of a faster, less expensive version of the fabled polymerase chain reaction (PCR) a DNA test widely used in criminal investigations, disease diagnosis, biological research and other applications. The new method ...Molecular typesetting -- proofreading without a proofreader
...ular machines called RNA polymerases. "The RNA polymerase acts like an old fashioned newsprint typesetter, c...y assembling letters one at a time. Similarly, RNA polymerase constructs RNA by reading the DNA and adding new l... explains Dr Cohen. There's no way for the RNA polymerase to ensure that the correct letter is always incorp...DNA template could explain evolutionary shifts
...g the hydrogen bonds between the A T and G C base pairs. The two separating strands become the replication fork. On one strand, an enzyme called DNA polymerase reads the genetic material in the strand as a template and makes a strand of complementary DNA to pair to it. Again, the code is A to T and C to G. Th...New piece found in the puzzle of epigenetics
...the fine regulation of the cell nucleus enzyme RNA polymerase II. This transcribes the genetic information of th... basis for protein synthesis. At the same time RNA polymerase II is also responsible for the production of other...gues had observed that a certain region of the RNA polymerase II enzyme the carboxy-terminal domain is involve...TRAPping proteins that work together inside living cells
...A polymerase, a well-studied machine in cells. The polymerase is made up of many proteins that cooperate to translate DNA. One of the polymerase proteins has a tail that is known to touch the DNA and some helper proteins just before the polymerase starts translating. No one knew if this tail -- al...Polymerase in Biological Technology
Real-Time Quantification of Genomic DNA Using DyNAzyme II DNA Polymerase and SYBR Green I Dye
Mimi Amutan and David Batey, Ph.D. Abstract Real-time quantification was performed for lambda and human genomic DNA on the DNA Engine Opticon system (MJ Research). DyNAzyme II DNA polymerase* was used for amplification, and SYBR Green I fluoresc...The FastStart Taq DNA Polymerase FastStart Taq DNA Polymerase, a chemically modified version of Taq DNA Polymerase for hot start PCR, was introduced in 2000. Based on the feedback f...
C. therm. Polymerase for Reverse Transcription in Two-Step RT-PCR
Polymerase for two-step RT-PCR amplification of up to 4 kb targets Cat. No. 2 016 311 300 units Description C. therm. Polymerase provided by Roche Applied Science is the recombinant form ...C. therm. Polymerase One-Step RT-PCR System
for one-step RT-PCR amplification of up to 3 kb RNA targets Cat. No. 2 016 338 50 reactions Cat. No. 2 016 346 250 reactions Description The system contains a unique enzyme blend of C. therm....The Use of MasterTaq Polymerase for PCR with Humic Material-Contaminated DNA
Katrin Ravenschlag Max-Planck-Institute for Marine Microbiology, Celsiusstr.1, 28359 Germany Phone: ++49-421-2028-936, Fax: ++49-421-2028-580, email: kravensc@mpi-bremen.de Introduction Direct extracti...Unique Enhanced DNA Polymerase Delivers High Fidelity and Great PCR Performance
Improve reliability of PCR reactions with Herculase enhanced DNA polymerase Michael Borns Holly Hogrefe Stratagene Stratagene recently released Herculase enhanced DNA polymerase,* , a novel enzyme formulation that provides superior performance in both routine and...Polymerase in Biological Products
Description: RNA polymerase sigma 70 Immunogen: Recombinant, full length protein. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Company:ABR-Affinity BioReagents
Company:New England Biolabs
Company:Promega
Company:QIAGEN
Description: Chicken Anti-Human DNA-directed RNA Polymerase II 7.6 Kd Polypeptide (POLR2L Polyclonal AntibodyOther Sub-Family: not assigned-Other Applications: ELISA, Western Blot...
Company:Lifespan Biosciences
Company:Novagen
Company:ABR-Affinity BioReagents
T7 RNA Polymerase from New England Biolabs
Description: Request Info...Company:New England Biolabs
GoTaq Flexi DNA Polymerase from Promega
Description: ...Company:Promega
Taq DNA Polymerase from QIAGEN
Description: ...Company:QIAGEN
Description: Chicken Anti-Human DNA-directed RNA Polymerase II 7.6 Kd Polypeptide (POLR2L Polyclonal AntibodyOther Sub-Family: not assigned-Other Applications: ELISA, Western Blot...
Company:Lifespan Biosciences
NovaTaq DNA Polymerase from Novagen
Description: NovaTaq DNA Polymerase is a premium quality recombinant form of Thermus aquaticus DNA polymerase. This thermostable enzyme is suitable for a wide range of PCR applications. To ensure the highest purity and reproducible performance, each preparation is extensively tested in a variety of quality cont...Company:Novagen
Polymerase in Biological Definition
...eticists at the Australian Museum announced that they had replicated DNA of the Thylacine (Tasmanian Tiger), extinct about 65 years previous, using polymerase chain reaction (PCR) [3] . However, on February 15 2005 the museum announced that it was stopping the project after tests showed the specimens' ...
...n be easily separated by enzymes . Enzymes known as helicases unwind the strands to facilitate the advance of sequence-reading enzymes such as DNA polymerase . The unwinding requires that helicases chemically cleave the phosphate backbone of one of the strands so that it can swivel around the other. The str...
...th the word ending in "-ase". Examples are alcohol dehydrogenase and DNA polymerase . Kinases are enzymes that transfer phosphate groups. The Internationa...imilar compounds Phenylalanine hydroxylase (PAH): Phospholipase polymerase : builds long chains of nucleic acid polymers from their constituents ...
...omparing individual samples of DNA. One of the most modern and widely accepted methods for producing DNA fingerprints in criminal cases, is that of polymerase chain reaction (PCR). PCR involves the amplification of specific regions of DNA that are known to be highly variable from one individual to another. ...
...orking independently. Sanger's lab complete the entire genome of sequence of Bacteriophage Φ-X174; . 1983 Kary Banks Mullis discovers the polymerase chain reaction enabling the easy amplification of DNA 1989 The first human gene is sequenced by Francis Collins and Lap-Chee Tsui , it encodes...
... Kary Banks Mullis (born December 28 , 1944 ) is a biochemist . In the 1980s , he invented the polymerase chain reaction (PCR), a central technique in molecular biology which allows the amplification of specified DNA sequences. He was awarded the No...
...n be easily separated by enzymes . Enzymes known as helicases unwind the strands to facilitate the advance of sequence-reading enzymes such as DNA polymerase . The unwinding requires that helicases chemically cleave the phosphate backbone of one of the strands so that it can swivel around the other. The str...
...th the word ending in "-ase". Examples are alcohol dehydrogenase and DNA polymerase . Kinases are enzymes that transfer phosphate groups. The Internationa...imilar compounds Phenylalanine hydroxylase (PAH): Phospholipase polymerase : builds long chains of nucleic acid polymers from their constituents ...
...omparing individual samples of DNA. One of the most modern and widely accepted methods for producing DNA fingerprints in criminal cases, is that of polymerase chain reaction (PCR). PCR involves the amplification of specific regions of DNA that are known to be highly variable from one individual to another. ...
...orking independently. Sanger's lab complete the entire genome of sequence of Bacteriophage Φ-X174; . 1983 Kary Banks Mullis discovers the polymerase chain reaction enabling the easy amplification of DNA 1989 The first human gene is sequenced by Francis Collins and Lap-Chee Tsui , it encodes...
... Kary Banks Mullis (born December 28 , 1944 ) is a biochemist . In the 1980s , he invented the polymerase chain reaction (PCR), a central technique in molecular biology which allows the amplification of specified DNA sequences. He was awarded the No...
Polymerase in Biological Dictionary
A polymerase is an enzyme whose central function is associated with polymers of nucleic acids such as RNA and DNA. The primary function of a polymerase is the polymerization of new DNA or RNA against an existing DNA or RNA template in the processes of replication and... RNA polymera...
Taq polymerase is a thermostable DNA polymerase named after the thermophilic bacterium Thermus aquaticus from which it was originally isolated by Thomas D. Brock in 1965 . It is often abbreviated to " Taq Pol", and is frequently used in polymerase chain reaction (PCR),... What...
T7 RNA Polymerase is an RNA polymerase that catalyzes the formation of RNA in the 5'→ 3' direction. T7 polymerase is extremely promoter-specific and only transcribes bacteriophage T7 DNA or DNA cloned downstream of a T7 promoter. The T7 polymerase also requires a DNA...
RNA polymerase is an enzyme that produces RNA . In cells, RNAP is needed for constructing RNA chains from DNA genes as templates, a process called transcription. RNA polymerase enzymes are essential to life and are found in... RNA polymerase II is an enzyme found in eukaryotic...
A DNA polymerase is an enzyme that catalyzes the polymerization of deoxyribonucleotides into a DNA strand. DNA polymerases are best-known for their role in DNA replication, in which the polymerase "reads" an intact DNA strand... DNA polymerase lambda, also known as ...
...promoter region with ... The transcription start sites of the human FMR1 gene were determined using 5' ... transcription factors, RNA polymerase II in eukaryotes recognizes the start site ... TATA box and the transcription start site . This spacing is characteristic ... ... initi...
Taq polymerase is a thermostable DNA polymerase named after the thermophilic bacterium Thermus aquaticus from which it was originally isolated by Thomas D. Brock in 1965 . It is often abbreviated to " Taq Pol", and is frequently used in polymerase chain reaction (PCR),... What...
T7 RNA Polymerase is an RNA polymerase that catalyzes the formation of RNA in the 5'→ 3' direction. T7 polymerase is extremely promoter-specific and only transcribes bacteriophage T7 DNA or DNA cloned downstream of a T7 promoter. The T7 polymerase also requires a DNA...
RNA polymerase is an enzyme that produces RNA . In cells, RNAP is needed for constructing RNA chains from DNA genes as templates, a process called transcription. RNA polymerase enzymes are essential to life and are found in... RNA polymerase II is an enzyme found in eukaryotic...
A DNA polymerase is an enzyme that catalyzes the polymerization of deoxyribonucleotides into a DNA strand. DNA polymerases are best-known for their role in DNA replication, in which the polymerase "reads" an intact DNA strand... DNA polymerase lambda, also known as ...
...promoter region with ... The transcription start sites of the human FMR1 gene were determined using 5' ... transcription factors, RNA polymerase II in eukaryotes recognizes the start site ... TATA box and the transcription start site . This spacing is characteristic ... ... initi...
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