Vaccine shows therapeutic promise against advanced melanoma
...nses. "This vaccine activates the body's cytotoxic T cells to recognize antigens on the surface of the tumor. The T cells then secrete enzymes that poke holes in the tumor cell's membrane, causing it to disintegrate," explained Hwu. After an NCI-led Phase II study combining the vaccine with Interle...Experts Optimistic About Melanoma Vaccine
...is vaccine activates the body's cytotoxic T-cells to recognize antigens on the surface of the tumor," Hwu said. "The T-cells then secrete enzymes that poke holes in the tumor cell's membrane, causing it to disintegrate." More information The Skin Cancer Foundation has more about melanoma . ...MSU researcher links cholesterol crystals to cardiovascular attacks
...lesterol, it will expand, causing the 'cap' of the deposit to tear off in the arterial wall. Or the crystals, which are sharp, needle-like structures, poke their way through the cap covering the cholesterol deposit, like nails through wood." The crystals then work their way into the bloodstream. It is ...Robots May Come to Aging Boomers' Rescue
...e can also bring a faraway loved one into an aging person's home via video Internet hook-up. "So, if I'm at work, and it's lunch hour and I want to poke in on Dad, I can get on the Internet and basically 'step inside' the robot," said uBOT-5 co-inventor Rod Grupen, who directs the Laboratory for Perpet...Aggression as rewarding as sex, food and drugs
...the home male mouse. Aggressive behavior included tail rattle, an aggressive sideways stance, boxing and biting. The home mouse was then trained to poke a target with its nose to get the intruder to return, at which point it again behaved aggressively toward it. The home mouse consistently poked the tr...Combination vaccines okay for infants, study shows
...when clinicians administer a new combination vaccine that streamlines the process in effect, tripling up three of the recommended shots to reduce the poke total from five to three, at each of three bimonthly, well-child checkups. Only more immunizations will enter the schedule, said Michael Pichichero...Decoding Protein Structures Helps Illuminate Cause of Diabetes
...d polypeptide), which is normally produced by the same cells that make insulin. An unknown trigger prompts the protein to fold into sharp fibers that poke holes in pancreatic cells, killing them. Though scientists already have a good idea of the healthy 'before' and dangerous 'after' hIAPP struct...New Analytical Tool to Unravel the Cause of Diabetes
...ptide), which is normally produced by the same cells that make insulin. An unknown trigger prompts the protein to fold into sharp fibers that poke holes in pancreatic cells, killing them. Though scientists already have a good idea of the healthy "before" and dangerous "after" hIAPP struc...Weinstein Corneal MicroAesthesiometer™
Features:... Patented air-based esthesiometer. Doesn't poke holes in the epithelium or alter sensation as its tests (vs Cochet-Bonnet). Tests nonpainfully even in normals (vs. Draeger's device)....New book presents methods to poke and prod individual molecules
COLD SPRING HARBOR, N.Y. Single-molecule biologythe revolutionary field that deals with the study of individual macromoleculesis undergoing rapid growth. Tremendous technical advances have made it possible to probe molecules one by one, and to produce dynamic images as they twist, twirl, wobbl...Reading the brain without poking it
...mputees control bionic limbs. But existing devices use tiny electrodes that poke into the brain. Now, a University of Utah study shows that brain signals co... ECoG and microECoG represent an intermediate step between electrodes the poke into the brain and EEG (electroencephalography), in which electrodes are pl...MIT: Stripes key to nanoparticle drug delivery
...go to the cytosol, and do so without killing the cell. Irvine compares the feat to a phenomenon kids can discover. "If you have a soap film and you poke it with a bubble wand, you'll pop it," he said. "But if you coat the bubble wand with soap before poking the film, it will pass through the film witho...Social standing influences elephant movement
...years, they carefully observed elephant interaction, taking note of the telltale behavior of social dominance, such as the flaring of the ears, a tusk poke here or a trunk slap there, to determine rank. Three of the GPS-collared elephants were from very dominant families, two were in the middle, and tw...Decoding protein structures helps illuminate cause of diabetes
...d polypeptide), which is normally produced by the same cells that make insulin. An unknown trigger prompts the protein to fold into sharp fibers that poke holes in pancreatic cells, killing them. Though scientists already have a good idea of the healthy "before" and dangerous "after" hIAPP structu...UF scientists restore sight to chickens with blinding disease
...e this disease," Semple-Rowland said. "Often parents will notice that their child doesn't seem to be smiling at or looking at faces. Children may also poke or rub their eyes, behaviors clinically known as oculo-digital signs that may produce sensations of sight." Work remains to refine the viral delive...Trial success for diabetic nerve therapy
... Life Sciences. "Our approach to gene therapy is quite different to previous attempts at treatment: we use a DNA-binding protein called ZFP TFTM to poke life into the patient's own genes and produce a growth factor that has a role in nerve protection and regeneration. "As the data in the paper demon...Chemical guidance of T cells leads to immunologic memory and long-term immunity
...a or viruses--a process known as cell-mediated immunity. When these CD8+ T cells encounter an infected cell, they unleash a torrent of substances that poke holes in the cell's membrane, chew up its proteins and ultimately cause it to die. They also produce molecules such as interferon-gamma that help acti...Common bacteria pirate natural mechanism to get inside cells
...ns to make this move. "When there is a signal, the plasma membrane on the cell surface invaginates ?think of a plasma membrane as a balloon and you poke your finger in it," he says. "The protein, dynamin, comes along and forms a necklace around the neck of that balloon, then chops it off," he says of t...'Underground' tunnels discovered as means for communication between immune system cells
... in large part to an accidental observation, that giving just the slightest poke to a single cell can set off a chain reaction whereby cell after cell disch...um. Returning to dendritic cells, they found that by giving a deliberate poke with an empty microinjection tip it caused the same reaction. But why some ...Charging ahead: University of Houston team revealing secrets of electricity-producing materials
...e altered by flexoelectricity-caused electrical activity by poking the material with a sophisticated needle. "We basically predicted that when you poke it, because of this electrical activity, depending upon how big a crater you create, your elastic behavior will change. It's not supposed to. Ordinari...CU scientists create world's thinnest balloon -- just one atom thick
...image biological materials in solution through a nearly invisible wall without subjecting the microscope to the wet environment. Or, researchers could poke atomic-sized holes in the membrane and use the system to study how single atoms or ions pass through the opening. "This could serve as sort of an a...What to do when your tech employer doesnt know what you do
...e all day is worth a couple laughs with your buddies in the lab or over a round of drinks at the bar. In other ways, though, its not ideal. We can poke fun all day at the clueless suits who know Jack about technology, but if your boss is in the dark about the nature of your work, the fact is youre at ...