Platelet

Novel therapeutic approaches may improve patient outcomes in several platelet disorders

(SAN FRANCISCO, December 6, 2008) Four studies that highlight significant advances in treatment and survival outcomes for patients with various forms of thrombocytopenia, a group of bleeding disorders characterized by a low number of platelets in the blood, will be presented in a press conference...

Cardiogenesis Announces Preliminary Results Combining TMR + Platelet Rich Plasma (PRP)

IRVINE, Calif., June 18 /PRNewswire-FirstCall/ -- Cardiogenesis Corporation (Pink Sheets: CGCP), a leading developer of surgical products for cardiac revascularization today announced an upcoming scientific presentation that describes the use of combining transmyocardial revascularization (TMR...

GlaxoSmithKline Files for FDA Approval of PROMACTA(TM) (eltrombopag) to be the First Oral Platelet Growth Factor for Rare Blood Disorder

Application Data Show PROMACTA Significantly Raised Platelet Counts and Lowered Bleeding Risk in Clinical Trials for the Short-Term Treatment of Patients with Chronic Idiopathic Thrombocytopenic Purpura (ITP) PHILADELPHIA and LONDON, Dec. 20 /PRNewswire-FirstCall/ -- GlaxoSmithKline (NYSE:...

Rigel R788 Raises Platelet Counts in Immune Thrombocytopenic Purpura (ITP) Patients in Phase 2 Study

SOUTH SAN FRANCISCO, Calif., Nov. 9 /PRNewswire-FirstCall/ -- Rigel Pharmaceuticals, Inc. (Nasdaq: RIGL ) today announced results of its Phase 2 clinical study of R788, a novel, oral Syk kinase inhibitor, in patients with Immune Thrombocytopenic Purpura (ITP). The single-center, open-label, d...

Falling Platelet Counts May Signal HIV-Linked Dementia

Study finds a strong correlation, with risk doubling as blood cells decline THURSDAY, Sept. 13 (HealthDay News) -- HIV-infected patients with declining blood platelet counts may be at increased risk for HIV-associated dementia, which causes a number of cognitive, behavioral and motor skill probl...

Improved Platelet Life Span Increases Better Patient Care

A study by Drs Benjamin Kile and David Huang found that two important molecules control the life span of platelets. This discovery is sure //to raise the hope of formulating a new drug that will extend the life span of platelets stored in blood banks. This will in turn increase the availability of ...

More>>

Platelet in Medical Technology

New Research Suggests Platelet 'Stickiness' May be the Single Most Important Risk Factor in Patients Treated with Coronary Stents - Findings May be Applicable to Anyone with Vascular Disease

BALTIMORE, Jan. 27 /PRNewswire/ -- Most Americans know their cholesterol level, but do they know how "sticky" their platelets are? Research findings from Dr. Paul A. Gurbel, an interventional cardiologist and Director of the Sinai Center for Thrombosis Research based at Sinai Hospital of Baltimor...

Long-term Follow Up Interim Data Show Nplate(TM) Increased and Sustained Platelet Counts in Adult Chronic ITP Patients

SAN FRANCISCO, Dec. 8 /PRNewswire-FirstCall/ -- Amgen Inc. (Nasdaq: AMGN ) today released updated results from the ongoing, open-label extension study of the long-term safety and efficacy of Nplate(TM) (romiplostim) in adult patients with chronic immune thrombocytopenic purpura (ITP). Chronic IT...

Novel Therapeutic Approaches May Transform Treatment and Improve Patient Outcomes in Several Platelet Disorders

SAN FRANCISCO, Dec. 6 /PRNewswire-USNewswire/ -- Four studies that highlight significant advances in treatment and survival outcomes for patients with various forms of thrombocytopenia, a group of bleeding disorders characterized by a low number of platelets in the blood, will be presented in a pr...

GSK Reports PROMACTA(R) (eltrombopag) Significantly Increased Platelet Counts and Reduced Bleeding in Long-Term Study of Patients With Chronic ITP

PHILADELPHIA, Dec. 6 /PRNewswire-FirstCall/ -- GlaxoSmithKline (NYSE: GSK ) announced positive safety and efficacy results from RAISE (RAndomized placebo- controlled ITP Study with Eltrombopag), a Phase III study of PROMACTA(R) (eltrombopag) in adults with chronic immune (idiopathic) thrombocyto...

FDA Approves Promacta(R) (Eltrombopag), the First Oral Medication to Increase Platelet Production for People With Serious Blood Disorder

PHILADELPHIA, Nov. 20 /PRNewswire-FirstCall/ --GlaxoSmithKline (NYSE: GSK ) today announced that the United States Food and Drug Administration (FDA) granted accelerated approval for PROMACTA(R) (eltrombopag) for the treatment of thrombocytopenia in patients with chronic immu...

DG041 Blocks Platelet Aggregation Through a Novel Mechanism and does not Increase Bleeding Time When Given Alone or with Plavix(TM) or Aspirin

REYKJAVIK, Iceland, June 30 /PRNewswire-FirstCall/ -- deCODE genetics (Nasdaq: DCGN ) today announced positive topline results from its latest clinical pharmacology study of DG041, the company's first-in-class antagonist of the EP3 receptor for prostaglandin E2, developed as a next-generation...

Platelet in Medical Products

Platelet Antibody Identification-Refer to Platelet Antibodies Indirect (0051050). Platelet antibody detection must be performed first.

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Partial Thromboplastin Time with Reflex to PTT 1:1 Mix & Platelet Neutralization Procedure

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

CBC with Platelet Count & Automated Differential

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

CBC with Platelet Count

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Sonoclot Coagulation & Platelet Function Analyzer

Description: The Sonoclot Analyzer is a versatile instrument for measuring coagulation and platelet function in whole blood or plasma. It is used worldwide to manage anticoagulant therapy, assess platelet function, control blood product usage, differentiate mechanical versus hemostatic bleeders, identify hyperc...
Company:Sienco, Inc.

Magellan™ Autologous Platelet Separator

Description: Medtronic has been a key participant in the area of blood component therapies for more than a decade. Previous Medtronic autotransfusion systems allowed clinicians to implement applications for concentrated platelets, as well as to determine requirements for a new, dedicated system for producing pl...
Company:Medtronic

More>>

Platelet in Medical Dictionary

Platelet

Platelets, or thrombocytes, are small, irregularly-shaped anuclear cells, 2-3 µm in diameter, which are derived from fragmentation of precursor megakaryocytes.  The average lifespan of a platelet is between 8 and 12 days.... Describes how the platelet count test is used, when a platelet c...

Thrombocyte

...blood clotting. ... thrombocyte ( ) n. See platelet . A nucleated, spindle-shaped cell of nonmammal...tting ... is a thrombocyte not a natural ... platelet n. A minute, nonnucleated, disklike cytoplasmic bo... blood plasma of ... thrombocyte . What does platelet blood look like? Read answer... thrombocyt...

Thrombocytopenia

...iew covers symptoms, causes, treatment of a low platelet count. ... Thrombocytopenia usually improves by...iew covers symptoms, causes, treatment of a low platelet count. ... Mild thrombocytopenia typically has ..... of factors can cause thrombocytopenia (a low platelet count) ... List of 378 disease causes of T...

Purpura

...e less than 3... Purpura is the result of hemorrhage into the skin or mucosal membrane. ... Purpura may be secondary to thrombocytopenia, platelet dysfunction, coagulation ... Henoch-Schönlein purpura is an IgA-mediated, autoimmune, hypersensitivity ... Purpura may be defined as visible,...

Platelet count

... A normal platelet count in a healthy individual is between 150... Ninety-five percent of healthy people will have platelet counts in this range. ... A platelet count is a test to measure how many platelets y...

Itp

... Idiopathic thrombocytopenic purpura ( ITP ) is the condition of having a low platelet count of no known cause (idiopathic). As most causes appear to be related to antibodies against platelets, ITP is also known as immune thrombocyt...

Platelet in Biological News

MiRNA fingerprint identified in platelet formation

Scientists have identified a handful of microRNAs (miRNAs) that appear to play a significant role in the development of platelets ?blood cells critical to the body's ability to form clots following an injury. They also say some of these same miRNAs, when acting abnormally, may contribute to certain...

Genetic factors may predict depression in heart disease patients

...ion in medical literature. The genes include those related to inflammation; platelet aggregation, or clumping; endothelial function involving the cells that lin...dysfunction a hallmark for vascular diseases, such as atherosclerosis and platelet aggregation appear to contribute to depressive symptoms. Specifically, ...

American Chemical Society's Weekly PressPac -- May 13, 2009

...tic and healthy individuals, the researchers say. ARTICLE #4 FOR IMMEDIATE RELEASE "Platelet Proteome Changes Associated with Diabetes and during platelet Storage for Transfusion" DOWNLOAD FULL TEXT ARTICLE: http://pubs.acs.org/stoken/presspac/presspac/full/10.1021/pr800885j CONTACT: David Spri...

The first DFG research centers to be funded for another four years

...e proven itself to be competitive and visible on an international level. Considered particularly interesting and significant is its work on cancer and platelet research, as is the high number of patents that have come from the research, of which 18 were registered in the last four years. In addition to the...

Lancet study supports new, highly effective treatment for blood disorder

...nding pediatrician and director of the Program for platelet Disorders at NewYork-Presbyterian Hospital/Weill C...l showed that eltrombopag was effective in raising platelet counts and lowering bleeding in adult subjects wit...59 percent of subjects receiving Promacta achieved platelet counts at or over 50,000 per L of blood, compared ...

Researchers explore new driver of transplant rejection: Platelets

...splants, Morrell and his team noted that increased platelet interactions led to increased and prolonged white ...ade in reaction to the transplanted tissue sparked platelet activation and white cell recruitment. Studies ... immune system. The newest kid on the block is the platelet and it represents an opportunity to target the eff...

Platelet in Biological Technology

Verax Biomedical Receives 510 (k) Clearance from FDA for Platelet PGD Test

First rapid test cleared for the detection of bacterial contamination in platelets WORCESTER, Mass., Sept. 19 /PRNewswire/ -- Verax Biomedical Inc., a leading developer of rapid tests for detecting bacterial contaminants in blood cells and tissue, has received 510...

Isolation of Low Molecular Weight Digestion Products of the Human Platelet Thromboxane A2 Receptor, Rev A

Joseph W. Turek and Guy C. Le Breton, Department of Pharmacology, University of Illinois at Chicago, College of Medicine, Chicago, IL 60612. Address correspondence to: Joseph W. Turek, 835 South Wolcott, Department of Pharmacology M/C 868, University of Illinois at Chicago, Chi...

Cardium Announces New Orthobiologics Product Initiative Extending Gene Activated Matrix Technology to Deliver Bone Growth Factors

...ities in the fields of wound healing and cardiovascular disease, the Company has access to a portfolio of protein-producing DNA sequences that include platelet Derived Growth Factor-B (PDGF-B), Insulin like Growth Factor-I (IGF-I) and Fibroblast Growth Factor-4 (FGF-4). In addition, researchers at Car...

Cardiogenesis Corporation Makes Pre-IDE Submission for PHOENIX Combination Delivery System

...portant step towards initiating the feasibility trial in the United States." The company plans to evaluate the therapeutic effect of delivering platelet Rich Plasma (PRP) in combination with TMR. PRP is derived from the patient's own circulating blood and is well documented in clinical applications fo...

Improving Transfusion Safety: Fenwal, Verax Biomedical Sign Agreement for Rapid, Point-of-Care Bacteria Test

...safeguard immediately prior to transfusion. More than 5 million platelet doses are transfused annually worldwide. Platelets are tiny cells in blood...some chemotherapy treatments. An estimated one in 2,000 to 3,000 platelet units may contain bacteria, and up to 50 percent of bacteria-contaminated p...

Former Secretary of Veterans Affairs James Peake to Join the Cellphire Board of Directors

...t appropriate clinical trials to evaluate and ultimately field this product," said Dr. Peake. Cellphire is committed to developing a freeze-dried platelet product, Thrombosomes(R), which could potentially be effective in stopping uncontrollable bleeding on the battlefield or in trauma. Platelets can only...

Platelet in Biological Products

Prostaglandin E1-d4 from Cayman Chemical

Description:...r animals. Its pharmacology includes vasodilation, hypotension, and anti-platelet activities. The IC50 of PGE1 for the inhibition of ADP-induced human platelet aggregation is 40 nM. The vasorelaxant and anti-hypertensive effects of PGE1 are used to treat male erectile dysfunction and to provide emergency vaso...
Company:Cayman Chemical

8-iso Prostaglandin E2 from Cayman Chemical

Description:...roduced from arachidonic acid during lipid peroxidation. It is a potent renal vasoconstrictor in the rat. 8-iso PGE2 inhibits U-46619 or I-BOP-induced platelet aggregation with IC50 values of 0.5 and 5 µM, respectively. When infused into the renal artery of the rat at a concentration of 4 mg/kg/min, 8-...
Company:Cayman Chemical

Human / Mouse / Rat Blood Vessels (CD31 / Von Willebrand Factor (vWF)) IHC staining Kit from CHEMICON

Description:...thelial cells synthesize von Willebrand factor, therefore a small percentage of these vascular-rich tumors might not stain with this antibody. CD31 or platelet endothelial adhesion molecule (PECAM-1), is a type I integral membrane glycoprotein and a member of the immunoglobulin super family of cell surface re...
Company:CHEMICON

Platelet in Biological Definition

Full blood count

...information about other cells that are not normally present in peripheral blood, but may be released in certain disease processes. Platelets platelet numbers are given, as well as information about their size and the range of sizes in the blood. ...

Platelet in Biological Dictionary

Ubiquitin

...ion protein gene shares several structural ... "Effect of ubiquitin on platelet functions: possible identity with platelet ... This classical function of ubiquitin is associated with housekeepi...

Thrombocytes

...l, irregularly-shaped anuclear cells, 2-3 µm in diameter, which are derived from fragmentation of precursor megakaryocytes.  The average lifespan of a platelet is between 8 and 12 days.... Indication for HLA-selected or HPA-selected thrombocytes . Method of administration ... Thrombocytes are essential ...

Sarcoplasmic reticulum

...ntains large stores of calcium, ... sarcoplasmic reticulum and human blood platelets using a monoclonal antibody, FIIlb5. ... The 190 kDa platelet and sarcoplasmic reticulum proteins were ... The sarcoplasmic reticulum was first obtained as paniculate material from ... Since the iden...

Quantitative trait loci

...ion, and more. ... Quantitative Trait Loci Summary ... QTL resources - Quantitative trait loci maps, baseline white blood cell count, platelet count, mapping of PLTP, links to other publications. formed quantitative trait locus / loci (QTL) analyses ... 7. Chen J, Harrison DE (2002...

Platelets

...ecursor megakaryocytes.  The average lifespan of a platelet is between 8 and 12 days. ... A 250 ml bag of n...rated from donated whole blood is called a " platelet concentrate" ... Find out what you need t...e of low blood platelets , how to get tested for platelet count, and the common causes of low platelets . ...

Blood count

...Erythrocytes. RBC or ERCS. 4.00 - 6.00. 1012 / Litre ... ... Low blood platelet count , Infection-prevention guidelines for ... LOW RED BLOOD CELL COUN...od cell count measures your body's ability to fight infection. ... The platelet count looks at the cells that help your blood to clot. ... Informa...