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Function of molecular switch pinpointed in severe congenital neutropenia

CINCINNATI Researchers have for the first time cleared an important hurdle to clarifying the molecular mechanics behind Severe Congenital Neutropenia (SCN), a deadly disease characterized by a deficiency of neutrophils a type of mature white blood cell important to fighting infection and disease...

Treatment Target for Herpes Pinpointed

Study finds VP16 is molecular key that unlocks the virus from latent state FRIDAY, March 27 (HealthDay News) -- Researchers have identified a potential new target in the ongoing quest for a treatment, and possibly a cure, for the herpes virus. A viral protein known as VP16 is appare...

Possible Cause of Postpartum Depression Pinpointed

Mouse study implicates GABA receptors in the central nervous system WEDNESDAY, July 30 (HealthDay News) -- Researchers have uncovered a potential cause for postpartum depression, at least in mice. According to the study, from assistant researcher Jamie Maguire and lead researcher Is...

Diagnostic tools and innovative therapies improve patient prognosis

...of patients via a metabolic pathway present in the tumor cells. "Now that we have a better understanding of the origin of these compounds and have pinpointed their presence with a large degree of accuracy, we hope to use this information to develop a test that examines the exhaled breath of patients for ear...

Gloomy Days Dim Cognitive Powers of the Depressed

... think some of the same physiological mechanisms that affect depression also affect cognitive function," Kent said. In particular, the authors have pinpointed the melatonin and serotonin hormonal systems as culprits. Both of these systems are also implicated in depression. "These same hormone systems have...

Researchers map how staph infections alter immune system

... profiling, a process that summarizes how individual genes are being activated or suppressed in response to the infection, UT Southwestern researchers pinpointed how an individual's immune system responds to a S. aureus infection at the genetic level. "The beauty of our study is that we were able to use e...

HIV 'Atlas' Shows Virus Targeting Minorities

...a; New Haven and Hartford counties, Conn; Multnomah (Portland) Ore; and Denver (Denver) Colo. In New York City, data on HIV prevalence has now been pinpointed to the zip-code level, although other locales were "more comfortable" providing data at the wider, county level, Puckrein said. Puckrein emphasized...

SailPoint and Cyber-Ark Partner to Prevent Insider Threats

...'s network, planting malware bombs to disable the entire IT infrastructure or stealing sensitive customer data. Many of these security breaches can be pinpointed to a privileged account, but only after the damage is done. By partnering with an industry leader like Cyber-Ark, we're able to provide customers with...

InfoLogix and HIA Advise Hospitals How to Obtain Maximum Share of $19B Healthcare Stimulus

...matics Associates, an InfoLogix company. "Based on the hundreds of EMR module implementations that HIA has conducted over the past two decades, we've pinpointed six action steps that hospitals need to take today in order to position themselves to receive the maximum ARRA stimulus funding available, and we're p...

Discovery Sheds Light on Huntington's Disease

... Researchers identify protein that could lead to treatment or prevention THURSDAY, June 4 (HealthDay News) -- Scientists have pinpointed a protein that plays a key role in cell death in Huntingdon's disease, a degenerative disorder that leads to uncontrolled movements and loss of intell...
pinpointed in Medical Technology

Mutant Genes in High-Risk Childhood Leukemias Identified

...t of new diagnostic tools and a new therapeutic target in high-risk disease MEMPHIS, Tenn., May 19 /PRNewswire-USNewswire/ -- A research team has pinpointed a new class of gene mutations, which identify cases of childhood acute lymphoblastic leukemia (ALL) that have a high risk of relapse and death. The fi...

Autism Genes Discovered; Help Shape Connections Among Brain Cells

...ogy research progressed a few decades ago with the discovery of specific genes that give rise to cancers. Our extensive pediatric genomics program has pinpointed particular genes and biological pathways, and this discovery provides a starting point for translating biological knowledge into future autism treatme...

Potential Early Warning System for Lung Cancer Identified

... CHICAGO, Oct. 25 /PRNewswire/ -- Today the British Midlands Development Corporation announced that new research from The University of Nottingham has pinpointed a potential early warning system for lung cancer. The study, published in the journal Thorax, found that changes in the blood can be detected which s...

Positive Clinical Results for DG041 Lead Product Development Highlights at deCODE R&D Event

..., dose-dependent lowering of the production of leukotriene B4, the end product of the leukotriene pathway which deCODE's genetics and biology work has pinpointed as a key means of modulating risk of heart attack. DG051's pharmacokinetic profile supports its development with once-a-day dosing, with a very satisf...
pinpointed in Medical Products

RoamAlert Integrity Plus

Description:...ert ECO and RoamAlert Integrity in one way: it is active at all times, and regularly transmitting. This means that the location of any resident can be pinpointed at any time. RoamAlert Integrity Plus supports emergency pendants which enable staff and residents to call for help; and asset tags to protect wheelch...
Company:VeriChip Corporation
pinpointed in Medical Definition

Unsolved problems in medicine

...real-time, providing measurable results with a variety of experimental inputs? Chronic Urticaria . What is the cause of such a disease? Can it be pinpointed as an autoimmunity or is it frankly idiopathic? Can it be cured or can the symptoms merely be controlled? Spinal cord injury . Is it possible to co...
pinpointed in Biological News

UT pathologists believe they have pinpointed Achilles heel of HIV

Human Immunodeficiency Virus (HIV) researchers at The University of Texas Medical School at Houston believe they have uncovered the Achilles heel in the armor of the virus that continues to kill millions. The weak spot is hidden in the HIV envelope protein gp120. This protein is essential for H...

Parasites ready to jump

... protein "Loquacious". In Drosophila, Loquacious can bind to specific RNA molecules that serve as precursors of the endo-siRNAs. Furthermore, the team pinpointed an entirely novel feature of this system: Repression of transposon activity was also detectable when multiple copies of a mobile element were present ...

Dogs, humans, put heads together to find cure for brain cancer

...ect, sharing samples of canine meningiomas for research. Their results were published in the Journal of Neurooncology . Previous researchers had pinpointed a particular tumor-suppressing gene on human chromosome 22, known as NF2, as a possible contributor to meningioma. They believed that the deletion of ...

Policy transparency key to saving world's fisheries

... In this study, Mora and his colleagues analyzed a set of attributes upon which country-level fisheries could be evaluated. The attributes that they pinpointed included the scientific quality of management recommendations, the transparency of converting scientific recommendations into policy, the enforcement ...

Two new studies on circadian rhythms

...o demonstrate how phosphorylation controls circadian rhythm. Using a heavy isotope labeling method and quantitative mass spectrometry, the researchers pinpointed a near record number of modifications on FRQ and described how each appears and disappears over the day. Moreover, their methods facilitated the ...

Flow of potassium into cells implicated in schizophrenia

...neighborhood of KCNH2, the researchers analyzed the gene's association with the illness in 5 independent samples comprising hundreds of families. This pinpointed 4 variations associated with schizophrenia within a small region of the KCNH2 gene. "Yet this statistical association didn't imply a mechanism," sa...

Poison: It's what's for dinner

...ns under elevated CO2 conditions because these toxins are built from carbon atoms." Dearing says once the actual creosote-detoxification genes are pinpointed among the 24 candidates identified by the new study, those genes someday might be used to modify cattle, sheep or other grazing animals so they could ...

Poison: It's what's for dinner

...ns under elevated CO2 conditions because these toxins are built from carbon atoms." Dearing says once the actual creosote-detoxification genes are pinpointed among the 24 candidates identified by the new study, those genes someday might be used to modify cattle, sheep or other grazing animals so they could ...

Stanford scientists find new solutions for the arsenic-poisoning crisis in Asia

..., according to the World Health Organization. Some health experts call it the biggest mass poisoning in history. More than 15 years ago, scientists pinpointed the source of the contamination in the Himalaya Mountains, where sediments containing naturally occurring arsenic were carried downstream to heavily p...

Mayo Clinic researchers suspect a novel gene is causing restless legs syndrome in a large family

...says the study's lead investigator, Carles Vilario-Gell, Ph.D., a neuroscientist at Mayo Clinic's campus in Jacksonville. The researchers have not yet pinpointed the culprit gene, but say they are getting close. This study is important, Dr. Vilario-Gell says, because this family is one of the largest with re...
pinpointed in Biological Technology

New cow genome sequence released

...lege of Medicine (BCM4). A new, expanded cow-human synteny map increases the number of syntenic breakpoints by approximately 30%. Salzberg's team also pinpointed a portion of the Bos taurus Y chromosome for the first time. "Until the assembly is truly finished - a state that no mammalian genome, including ...

Governor Rendell Says Life Science Industry Will Fuel New Breakthroughs, Generate Jobs for Decades to Come

...s an engine of job creation and economic development," Governor Rendell said today during a Best and Brightest forum here. "We purposefully pinpointed the life sciences industry to be a key piece in Pennsylvania's strategic and economic growth. Our programs are directing support and funding for compa...

Scientists peel away the mystery behind gold's catalytic prowess

... nanoparticles function as catalysts. Now, researchers from Lehigh University in Bethlehem, Pa., and Cardiff University in the UK believe they have pinpointed the active species at which the critical oxidation reaction occurs when gold is supported on iron oxide. In an article to be published in Science, ...

New approach may render disease-causing staph harmless

...oth in Taipei, used X-ray crystallography to determine the structure of the enzyme and how it interacts with the inhibitors. Our structural studies pinpointed how these drug candidates bound to the bacterial enzyme to shut off pigment production, Wang said. The new findings are particularly promising becau...

UW-Madison helps Imago carry out its big vision for seeing small

... zero and then pulling atoms from them one by one. The atoms next fly to a detector, where they are identified and their positions in three dimensions pinpointed all at the rocketing pace of 50 million atoms per hour. Known officially as the local electrode atom probe (LEAP) microscope, this remarkable mach...
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